Published in DNA on April 01, 1986
A mutation in mouse rad51 results in an early embryonic lethal that is suppressed by a mutation in p53. Mol Cell Biol (1996) 5.75
Target frequency and integration pattern for insertion and replacement vectors in embryonic stem cells. Mol Cell Biol (1991) 3.25
Splicing promotes rapid and efficient mRNA export in mammalian cells. Proc Natl Acad Sci U S A (2008) 1.98
Assembly of a polyadenylation-specific 25S ribonucleoprotein complex in vitro. Mol Cell Biol (1988) 1.28
Reduction of target gene expression by a modified U1 snRNA. Mol Cell Biol (2001) 1.18
Gene transactivation mediated by the TAT gene of human immunodeficiency virus in transgenic mice. Nucleic Acids Res (1988) 1.15
Gene therapy for choroideremia using an adeno-associated viral (AAV) vector. Cold Spring Harb Perspect Med (2014) 1.06
A 22-kd protein (sorcin/V19) encoded by an amplified gene in multidrug-resistant cells, is homologous to the calcium-binding light chain of calpain. EMBO J (1986) 1.05
Induction of sensitivity to the cytotoxic action of tumor necrosis factor alpha by adenovirus E1A is independent of transformation and transcriptional activation. J Virol (1990) 1.04
Murine beta 1,4-galactosyltransferase: both the amounts and structure of the mRNA are regulated during spermatogenesis. Proc Natl Acad Sci U S A (1990) 1.04
SRp40 and SRp55 promote the translation of unspliced human immunodeficiency virus type 1 RNA. J Virol (2010) 0.98
Characterization of murine monoclonal antibodies to the tat protein from human immunodeficiency virus type 1. J Virol (1990) 0.97
Highly conserved RNA sequences that are sensors of environmental stress. Mol Cell Biol (1998) 0.95
Alterations in the pre-mRNA topology of the bovine growth hormone polyadenylation region decrease poly(A) site efficiency. Nucleic Acids Res (1989) 0.91
Expression of RNA virus proteins by RNA polymerase II dependent expression plasmids is hindered at multiple steps. Virol J (2007) 0.90
Deletions in the SV40 late polyadenylation region downstream of the AATAAA mediate similar effects on expression in various mammalian cell lines. Nucleic Acids Res (1988) 0.86
Computational tools and algorithms for designing customized synthetic genes. Front Bioeng Biotechnol (2014) 0.81
The phenotype of FancB-mutant mouse embryonic stem cells. Mutat Res (2011) 0.81
One-step knockin for inducible expression in mouse embryonic stem cells. Genesis (2011) 0.75
Regulatory sequences involved in the promotion and termination of RNA transcription. Annu Rev Genet (1979) 54.83
A system to study promoter and terminator signals recognized by Escherichia coli RNA polymerase. Gene Amplif Anal (1981) 8.21
Identification of critical staphylococcal genes using conditional phenotypes generated by antisense RNA. Science (2001) 5.40
The relationship between function and DNA sequence in an intercistronic regulatory region in phage lambda. Nature (1978) 5.38
Diverse spermatogenic defects in humans caused by Y chromosome deletions encompassing a novel RNA-binding protein gene. Nat Genet (1995) 5.02
Crystal structure of an HIV-binding recombinant fragment of human CD4. Nature (1990) 4.81
The product of ras is a GTPase and the T24 oncogenic mutant is deficient in this activity. Nature (1984) 4.61
Purified lambda regulatory protein cII positively activates promoters for lysogenic development. Nature (1981) 4.60
Molecular characterization of the mouse agouti locus. Cell (1992) 4.55
Termination of transcription in E. coli. Cell (1983) 4.42
General splicing factor SF2/ASF promotes alternative splicing by binding to an exonic splicing enhancer. Genes Dev (1993) 4.40
Efficient expression of Escherichia coli galactokinase gene in mammalian cells. Proc Natl Acad Sci U S A (1982) 4.25
Ferritin: a cytoprotective antioxidant strategem of endothelium. J Biol Chem (1992) 4.22
Clinical and immunologic criteria for the diagnosis of allergic bronchopulmonary aspergillosis. Ann Intern Med (1977) 4.14
Efficient translation of prokaryotic mRNAs in a eukaryotic cell-free system requires addition of a cap structure. Nature (1979) 4.11
The use of pKc30 and its derivatives for controlled expression of genes. Methods Enzymol (1983) 3.90
Development of a humanized monoclonal antibody (MEDI-493) with potent in vitro and in vivo activity against respiratory syncytial virus. J Infect Dis (1997) 3.88
Osteoprotegerin is a receptor for the cytotoxic ligand TRAIL. J Biol Chem (1998) 3.88
Microinjection of the oncogene form of the human H-ras (T-24) protein results in rapid proliferation of quiescent cells. Cell (1984) 3.81
The Oak Ridge Polycystic Kidney (orpk) disease gene is required for left-right axis determination. Development (2000) 3.74
Human immunodeficiency virus protease expressed in Escherichia coli exhibits autoprocessing and specific maturation of the gag precursor. Proc Natl Acad Sci U S A (1987) 3.72
Termination of transcription in bacteriophage lambda. Heterogeneous, 3'-terminal oligo-adenylate additions and the effects of rho factor. J Biol Chem (1975) 3.71
Agouti protein is an antagonist of the melanocyte-stimulating-hormone receptor. Nature (1994) 3.70
Surveillance and prevention of residential-fire injuries. N Engl J Med (1996) 3.60
Translational coupling at an intercistronic boundary of the Escherichia coli galactose operon. Cell (1982) 3.56
Tissue-specific and differentiation-specific expression of a human K14 keratin gene in transgenic mice. Proc Natl Acad Sci U S A (1989) 3.55
A genomic analysis of two-component signal transduction in Streptococcus pneumoniae. Mol Microbiol (2000) 3.50
Candidate gene associated with a mutation causing recessive polycystic kidney disease in mice. Science (1994) 3.31
Highly reiterated sequences of SIMIANSIMIANSIMIANSIMIANSIMIAN. Science (1978) 3.29
Expression and characterization of the human c-myc DNA-binding protein. Mol Cell Biol (1985) 3.24
Constitutive function of a positively regulated promoter reveals new sequences essential for activity. J Biol Chem (1987) 3.23
An inherited limb deformity created by insertional mutagenesis in a transgenic mouse. Nature (1985) 3.05
c-erbB activation in ALV-induced erythroblastosis: novel RNA processing and promoter insertion result in expression of an amino-truncated EGF receptor. Cell (1985) 3.00
Role of adherence in growth of Acinetobacter calcoaceticus RAG-1 on hexadecane. J Bacteriol (1981) 2.96
Cloning and nucleotide sequencing of the bovine growth hormone gene. Nucleic Acids Res (1982) 2.91
gridlock, an HLH gene required for assembly of the aorta in zebrafish. Science (2000) 2.90
Purification and cDNA cloning of the AdoMet-binding subunit of the human mRNA (N6-adenosine)-methyltransferase. RNA (1997) 2.89
Nucleotide sequence homology at the 3' termini of RNA from vesicular stomatitis virus and its defective interfering particles. Proc Natl Acad Sci U S A (1978) 2.82
Sequence of Cro gene of bacteriophage lambda. Nature (1977) 2.78
Copper metallothionein of yeast, structure of the gene, and regulation of expression. Proc Natl Acad Sci U S A (1984) 2.74
Adherence of Acinetobacter calcoaceticus RAG-1 to human epithelial cells and to hexadecane. Infect Immun (1981) 2.74
Bacterial adherence to polystyrene: a replica method of screening for bacterial hydrophobicity. Appl Environ Microbiol (1981) 2.73
E1A 13S and 12S mRNA products made in Escherichia coli both function as nucleus-localized transcription activators but do not directly bind DNA. Mol Cell Biol (1985) 2.68
Endocytosis in Chang liver cells. Quantitation by sucrose- 3 H uptake and inhibition by cytochalasin B. J Cell Biol (1971) 2.63
A rho-dependent termination site in the gene coding for tyrosine tRNA su3 of Escherichia coli. Nature (1978) 2.58
Affecting gene expression by altering the length and sequence of the 5' leader. Proc Natl Acad Sci U S A (1984) 2.58
Requirement for the 3' flanking region of the bovine growth hormone gene for accurate polyadenylylation. Proc Natl Acad Sci U S A (1984) 2.58
Nucleotide sequence of the operator-promoter region of the galactose operon of Escherichia coli. Proc Natl Acad Sci U S A (1977) 2.57
Microinjected c-myc as a competence factor. Science (1985) 2.56
Evolution of two-component signal transduction. Mol Biol Evol (2000) 2.55
Envelope glycoproteins from biologically diverse isolates of immunodeficiency viruses have widely different affinities for CD4. Proc Natl Acad Sci U S A (1991) 2.54
Identification, evolution, and essentiality of the mevalonate pathway for isopentenyl diphosphate biosynthesis in gram-positive cocci. J Bacteriol (2000) 2.50
The mouse Ames waltzer hearing-loss mutant is caused by mutation of Pcdh15, a novel protocadherin gene. Nat Genet (2001) 2.50
Mutations in the novel protocadherin PCDH15 cause Usher syndrome type 1F. Hum Mol Genet (2001) 2.48
Hormone-mediated repression: a negative glucocorticoid response element from the bovine prolactin gene. Genes Dev (1988) 2.47
Differential expression of a new dominant agouti allele (Aiapy) is correlated with methylation state and is influenced by parental lineage. Genes Dev (1994) 2.41
Adenovirus E1a gene product expressed at high levels in Escherichia coli is functional. Science (1984) 2.38
Structure and function of the cy control region of bacteriophage lambda. J Mol Biol (1980) 2.37
A promoter of pBR322 activated by cAMP receptor protein. Nucleic Acids Res (1981) 2.37
Pentapeptide nuclear localization signal in adenovirus E1a. Mol Cell Biol (1987) 2.30
Genotype-based screen for ENU-induced mutations in mouse embryonic stem cells. Nat Genet (2000) 2.24
The influence of age, diagnosis, and gender on proper use of metered-dose inhalers. Am J Respir Crit Care Med (1994) 2.23
Promoter for the establishment of repressor synthesis in bacteriophage lambda. Proc Natl Acad Sci U S A (1980) 2.23
Efficient expression of influenza virus NS1 nonstructural proteins in Escherichia coli. Proc Natl Acad Sci U S A (1983) 2.19
Removal of a terminator structure by RNA processing regulates int gene expression. J Mol Biol (1984) 2.13
Bacteriophage lambda protein cII binds promoters on the opposite face of the DNA helix from RNA polymerase. Nature (1983) 2.13
Nucleotide sequences of the 5' and 3' termini of bacteriophage T7 early messenger RNAs synthesized in vivo: evidence for sequence specificity in RNA processing. J Mol Biol (1974) 2.10
Mapping of N6-methyladenosine residues in bovine prolactin mRNA. Proc Natl Acad Sci U S A (1984) 2.08
Molecular analysis of reverse mutations from nonagouti (a) to black-and-tan (a(t)) and white-bellied agouti (Aw) reveals alternative forms of agouti transcripts. Genes Dev (1994) 2.07
Nucleotide sequence of bovine prolactin messenger RNA. Evidence for sequence polymorphism. J Biol Chem (1982) 2.05
Interaction between FKBP12-rapamycin and TOR involves a conserved serine residue. J Biol Chem (1994) 2.04
The effects of a 5-lipoxygenase inhibitor on asthma induced by cold, dry air. N Engl J Med (1990) 2.03
Alternative processing of bovine growth hormone mRNA is influenced by downstream exon sequences. Mol Cell Biol (1989) 2.02
The expression in yeast of the Escherichia coli galK gene on CYC1::galK fusion plasmids. Gene (1983) 1.98
Characterization of short tandem repeats from thirty-one human telomeres. Genome Res (1997) 1.96
Characterization of Novikoff hepatoma mRNA methylation and heterogeneity in the methylated 5' terminus. Biochemistry (1975) 1.96
Functions of purified E1A protein microinjected into mammalian cells. Proc Natl Acad Sci U S A (1984) 1.92
Tissue-specific expression and dietary regulation of a chimeric phosphoenolpyruvate carboxykinase/bovine growth hormone gene in transgenic mice. J Biol Chem (1988) 1.91
Synthesis of the complete trans-activation gene product of human T-lymphotropic virus type III in Escherichia coli: demonstration of immunogenicity in vivo and expression in vitro. Proc Natl Acad Sci U S A (1986) 1.90
Regulated antisense RNA eliminates alpha-toxin virulence in Staphylococcus aureus infection. J Bacteriol (1999) 1.88
Differential translation efficiency explains discoordinate expression of the galactose operon. Cell (1981) 1.87
Microarray-based identification of htrA, a Streptococcus pneumoniae gene that is regulated by the CiaRH two-component system and contributes to nasopharyngeal colonization. Infect Immun (2002) 1.87
Activation of human immunodeficiency virus type 1 by DNA damage in human cells. Nature (1988) 1.85
The 289-amino acid E1A protein of adenovirus binds zinc in a region that is important for trans-activation. Proc Natl Acad Sci U S A (1988) 1.84
The embryonic lethality of homozygous lethal yellow mice (Ay/Ay) is associated with the disruption of a novel RNA-binding protein. Genes Dev (1993) 1.80
Two promoters, one inducible and one constitutive, control transcription of the Streptomyces lividans galactose operon. Proc Natl Acad Sci U S A (1987) 1.79
A spliced leader is present on a subset of mRNAs from the human parasite Schistosoma mansoni. Proc Natl Acad Sci U S A (1990) 1.79
Purification and characterization of human H-ras proteins expressed in Escherichia coli. Mol Cell Biol (1985) 1.77
Impaired nuclear transport of a human variant tRNAiMet. Nature (1982) 1.75
A purine-rich exon sequence enhances alternative splicing of bovine growth hormone pre-mRNA. J Biol Chem (1994) 1.73
Inhibition of bacterial adherence to hydrocarbons and epithelial cells by emulsan. Infect Immun (1983) 1.71
Trimellitic anhydride-induced airway syndromes: clinical and immunologic studies. J Allergy Clin Immunol (1977) 1.71
Ectopic expression of the agouti gene in transgenic mice causes obesity, features of type II diabetes, and yellow fur. Proc Natl Acad Sci U S A (1995) 1.69
A molecular model for the genetic and phenotypic characteristics of the mouse lethal yellow (Ay) mutation. Proc Natl Acad Sci U S A (1994) 1.67
Microbicides--evaluating multiple formulations of C31G. Contraception (2002) 1.67
Studying promoters and terminators by gene fusion. Science (1983) 1.64
Serum IgE and IgG antibody activity against Aspergillus fumigatus as a diagnostic aid in allergic bronchopulmonary aspergillosis. Am Rev Respir Dis (1978) 1.62
Envelope proteins from clinical isolates of human immunodeficiency virus type 1 that are refractory to neutralization by soluble CD4 possess high affinity for the CD4 receptor. Proc Natl Acad Sci U S A (1991) 1.62