Published in Cancer Res on September 15, 1987
Methylation of HpaII and HhaI sites near the polymorphic CAG repeat in the human androgen-receptor gene correlates with X chromosome inactivation. Am J Hum Genet (1992) 11.38
Structural alterations of the epidermal growth factor receptor gene in human gliomas. Proc Natl Acad Sci U S A (1992) 6.58
PCR bias in amplification of androgen receptor alleles, a trinucleotide repeat marker used in clonality studies. Nucleic Acids Res (1995) 3.16
Etiology and pathogenesis of uterine leiomyomas: a review. Environ Health Perspect (2003) 2.98
The GLI-Kruppel family of human genes. Mol Cell Biol (1988) 2.52
X chromosome-inactivation patterns of 1,005 phenotypically unaffected females. Am J Hum Genet (2006) 2.33
Familial skewed X inactivation: a molecular trait associated with high spontaneous-abortion rate maps to Xq28. Am J Hum Genet (1997) 1.99
Clonality in myeloproliferative disorders: analysis by means of the polymerase chain reaction. Proc Natl Acad Sci U S A (1991) 1.95
Transactivation of interleukin 2 and its receptor induces immune activation in human T-cell lymphotropic virus type I-associated myelopathy: pathogenic implications and a rationale for immunotherapy. Proc Natl Acad Sci U S A (1990) 1.93
Skewing of X-inactivation ratios in blood cells of aging women is confirmed by independent methodologies. Blood (2009) 1.78
X-linked alpha-thalassemia/mental retardation (ATR-X) syndrome: localization to Xq12-q21.31 by X inactivation and linkage analysis. Am J Hum Genet (1992) 1.72
Detection of new paternal dystrophin gene mutations in isolated cases of dystrophinopathy in females. Am J Hum Genet (1994) 1.70
Detection of clonal histiocytes in Langerhans cell histiocytosis: biology and clinical significance. Br J Cancer Suppl (1994) 1.35
No evidence that skewing of X chromosome inactivation patterns is transmitted to offspring in humans. J Clin Invest (2008) 1.30
A polymerase chain reaction assay for non-random X chromosome inactivation identifies monoclonal endometrial cancers and precancers. Am J Pathol (1995) 1.30
Clinically nonfunctioning pituitary tumors are monoclonal in origin. J Clin Invest (1990) 1.27
X-linked severe combined immunodeficiency: localization within the region Xq13.1-q21.1 by linkage and deletion analysis. Am J Hum Genet (1989) 1.26
Skewed X-chromosome inactivation in female carriers of dyskeratosis congenita. Am J Hum Genet (1997) 1.25
X-linked hypohidrotic ectodermal dysplasia: localization within the region Xq11-21.1 by linkage analysis and implications for carrier detection and prenatal diagnosis. Am J Hum Genet (1988) 1.21
Selection against lethal alleles in females heterozygous for incontinentia pigmenti. Am J Hum Genet (1989) 1.21
Studies on clonality by PCR analysis of the PGK-1 gene. Nucleic Acids Res (1991) 1.16
Evidence for multiclonality in multicentric Kaposi's sarcoma. Proc Natl Acad Sci U S A (1998) 1.12
Different patterns of X inactivation in MZ twins discordant for red-green color-vision deficiency. Am J Hum Genet (1992) 1.06
Genetic tagging of tumor cells with retrovirus vectors: clonal analysis of tumor growth and metastasis in vivo. Mol Cell Biol (1988) 1.06
Germ-line mosaicism simulates genetic heterogeneity in Wiskott-Aldrich syndrome. Am J Hum Genet (1990) 1.05
Molecular analysis of clonality in Kaposi's sarcoma. J Clin Pathol (1997) 1.05
Dystonia-parkinsonism syndrome (XDP) locus: flanking markers in Xq12-q21.1. Am J Hum Genet (1992) 1.04
The clonal origin and clonal evolution of epithelial tumours. Int J Exp Pathol (2000) 1.04
X chromosome inactivation and the diagnosis of X linked disease in females. J Med Genet (1993) 1.02
X inactivation as a mechanism of selection against lethal alleles: further investigation of incontinentia pigmenti and X linked lymphoproliferative disease. J Med Genet (1992) 1.01
Missense mutation in exon 7 of the common gamma chain gene causes a moderate form of X-linked combined immunodeficiency. J Clin Invest (1995) 1.01
Severe alport phenotype in a woman with two missense mutations in the same COL4A5 gene and preponderant inactivation of the X chromosome carrying the normal allele. J Clin Invest (1995) 1.00
X-linked sideroblastic anemia and ataxia: linkage to phosphoglycerate kinase at Xq13. Am J Hum Genet (1991) 1.00
Telomere length is severely and similarly reduced in JAK2V617F-positive and -negative myeloproliferative neoplasms. Leukemia (2008) 1.00
X-linked severe combined immunodeficiency. Diagnosis in males with sporadic severe combined immunodeficiency and clarification of clinical findings. J Clin Invest (1990) 0.98
Desmoids in familial adenomatous polyposis are monoclonal proliferations. Br J Cancer (2000) 0.96
Non-specific X linked mental retardation with aphasia exhibiting genetic linkage to chromosomal region Xp11. J Med Genet (1992) 0.96
Characterization of N-myc amplification units in human neuroblastoma cells. Mol Cell Biol (1988) 0.96
Evidence for monoclonal expansion of epithelial cells in ovarian endometrial cysts. Am J Pathol (1997) 0.94
Clonal composition of benign and malignant human thyroid tumors. J Clin Invest (1990) 0.92
X inactivation patterns in females with Alport's syndrome: a means of selecting against a deleterious gene? J Med Genet (1992) 0.92
Molecular genetic evidence for monoclonal origin of bilateral ovarian serous borderline tumors. Am J Pathol (2003) 0.91
Clonal analysis of human tumors with M27 beta, a highly informative polymorphic X chromosomal probe. J Clin Invest (1992) 0.90
Clonal analysis of solitary follicular nodules in the thyroid. Am J Pathol (1990) 0.90
Evidence for clonal origin of neoplastic neuronal and glial cells in gangliogliomas. Am J Pathol (1997) 0.90
Clonality in Langerhans' cell histiocytosis. BMJ (1995) 0.89
Mutations in the X-linked E1 alpha subunit of pyruvate dehydrogenase: exon skipping, insertion of duplicate sequence, and missense mutations leading to the deficiency of the pyruvate dehydrogenase complex. Am J Hum Genet (1995) 0.89
Rapid determination of clonality by detection of two closely-linked X chromosome exonic polymorphisms using allele-specific PCR. J Clin Invest (1997) 0.88
The human androgen receptor X-chromosome inactivation assay for clonality diagnostics of natural killer cell proliferations. J Mol Diagn (2007) 0.87
Resistance mechanisms of gastrointestinal cancers: why does conventional chemotherapy fail? Int J Colorectal Dis (2003) 0.87
DNA methylation in the promoter region of the p16 (CDKN2/MTS-1/INK4A) gene in human breast tumours. Br J Cancer (1999) 0.86
The neurofibroma in von Recklinghausen neurofibromatosis has a unicellular origin. Am J Hum Genet (1991) 0.86
Mixed medullary and follicular carcinoma of the thyroid. On the search for its histogenesis. Am J Pathol (1999) 0.85
The postulated X-inactivation center at Xq27 is most reasonably explained by ascertainment bias: heterozygous expression of recessive mutations is a powerful means of detecting unbalanced X inactivation. Am J Hum Genet (1993) 0.84
Interaction of incontinentia pigmenti and factor VIII mutations in a female with biased X inactivation, resulting in haemophilia. J Med Genet (1993) 0.82
Skewed X-chromosome inactivation in patients with esophageal carcinoma. Diagn Pathol (2013) 0.80
Clonality of CD3 negative large granular lymphocyte proliferations determined by PCR based X-inactivation studies. J Clin Pathol (1994) 0.79
High frequency of the X-chromosome inactivation in young female patients with high-grade glioma. Diagn Pathol (2013) 0.79
Genetics of human X-linked immunodeficiency diseases. Clin Exp Immunol (1991) 0.79
Clonality analysis of combined Brenner and mucinous tumours of the ovary reveals their monoclonal origin. J Pathol (2015) 0.78
Clonal analysis of childhood acute lymphoblastic leukemia with "cytogenetically independent" cell populations. J Clin Invest (1989) 0.78
The identification of monoclonality in fibrous dysplasia by methylation-specific polymerase chain reaction for the human androgen receptor gene. Virchows Arch (2003) 0.78
Transient suppression of clonal hemopoiesis associated with pregnancy in a patient with a myeloproliferative disorder. J Clin Invest (1988) 0.78
Prader-Willi syndrome in a child with mosaic trisomy 15 and mosaic triplo-X: a molecular analysis. J Med Genet (1997) 0.78
RFLPs in human X-linked PGK1: a new probe for the PstI RFLP demonstrates strong linkage disequilibrium with the BgII RFLP. Nucleic Acids Res (1989) 0.78
Clonality analysis suggests that early-onset acute lymphoblastic leukaemia is of single-cell origin and implies no major role for germ cell mutations in parents. Br J Cancer (1999) 0.78
Endothelial progenitor cells display clonal restriction in multiple myeloma. BMC Cancer (2006) 0.77
Evaluation of X-Chromosome Inactivation Patterns in Patients with Acute Myeloid Leukemia during Remission. ISRN Hematol (2012) 0.75
Molecular analysis of ovarian mucinous carcinoma reveals different cell of origins. Oncotarget (2015) 0.75
Methylation analysis by means of PCR SSCP: application to clonality studies. Nucleic Acids Res (1993) 0.75
Evidence that X-linked severe combined immunodeficiency is not a differentiation defect of T lymphocytes. Clin Exp Immunol (1991) 0.75
Erythroid colony growth from peripheral blood and bone marrow in polycythaemia. J Clin Pathol (1990) 0.75
Expression of p53 and p21(WAF-1), apoptosis, and proliferation of smooth muscle cells in normal myometrium during the menstrual cycle: implication of DNA damage and repair for leiomyoma development. Med Mol Morphol (2012) 0.75
A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal Biochem (1983) 206.01
"A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum. Anal Biochem (1984) 66.58
Serial analysis of gene expression. Science (1995) 60.15
A genetic model for colorectal tumorigenesis. Cell (1990) 44.37
WAF1, a potential mediator of p53 tumor suppression. Cell (1993) 38.72
Surfing the p53 network. Nature (2000) 35.36
p53 mutations in human cancers. Science (1991) 31.96
Preparative and analytical purification of DNA from agarose. Proc Natl Acad Sci U S A (1979) 27.20
Genetic alterations during colorectal-tumor development. N Engl J Med (1988) 26.82
Lessons from hereditary colorectal cancer. Cell (1996) 25.73
Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science (1997) 24.61
A simplified system for generating recombinant adenoviruses. Proc Natl Acad Sci U S A (1998) 24.58
Identification of c-MYC as a target of the APC pathway. Science (1998) 24.25
Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma. Science (1997) 22.80
Genetic instabilities in human cancers. Nature (1998) 22.76
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell (1992) 19.87
Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science (1998) 17.91
Amplification of a gene encoding a p53-associated protein in human sarcomas. Nature (1992) 17.40
Participation of p53 protein in the cellular response to DNA damage. Cancer Res (1991) 16.00
Clues to the pathogenesis of familial colorectal cancer. Science (1993) 14.52
Epigenetic memory in induced pluripotent stem cells. Nature (2010) 14.31
DNA methylation and gene function. Science (1980) 14.01
Mutations in the p53 gene occur in diverse human tumour types. Nature (1989) 13.62
Lac repressor-operator interaction. I. Equilibrium studies. J Mol Biol (1970) 13.32
Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability. Science (1995) 13.15
Definition of a consensus binding site for p53. Nat Genet (1992) 12.76
Genetic instability in colorectal cancers. Nature (1997) 12.51
Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas. Science (1989) 11.53
Identification of FAP locus genes from chromosome 5q21. Science (1991) 11.41
A model for p53-induced apoptosis. Nature (1997) 11.38
Characterization of the yeast transcriptome. Cell (1997) 11.33
Mutations of mitotic checkpoint genes in human cancers. Nature (1998) 11.20
Suppression of human colorectal carcinoma cell growth by wild-type p53. Science (1990) 11.18
Genes expressed in human tumor endothelium. Science (2000) 10.75
Erythroid differentiation in chimaeric mice blocked by a targeted mutation in the gene for transcription factor GATA-1. Nature (1991) 10.30
Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene. Science (1992) 10.12
The lac repressor-operator interaction. 3. Kinetic studies. J Mol Biol (1970) 10.07
Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc Natl Acad Sci U S A (1998) 9.66
Gene expression profiles in normal and cancer cells. Science (1997) 9.65
APC mutations occur early during colorectal tumorigenesis. Nature (1992) 9.50
Linkage of beta-thalassaemia mutations and beta-globin gene polymorphisms with DNA polymorphisms in human beta-globin gene cluster. Nature (1982) 9.47
Hypomethylation distinguishes genes of some human cancers from their normal counterparts. Nature (1983) 9.28
Expression in Escherichia coli of a chemically synthesized gene for the hormone somatostatin. Science (1977) 9.28
Prevalence of ras gene mutations in human colorectal cancers. Nature (1987) 9.23
Cloning of cDNA for the major DNA-binding protein of the erythroid lineage through expression in mammalian cells. Nature (1989) 9.08
A public database for gene expression in human cancers. Cancer Res (1999) 8.81
X inactivation, differentiation, and DNA methylation. Cytogenet Cell Genet (1975) 8.74
An early haematopoietic defect in mice lacking the transcription factor GATA-2. Nature (1994) 8.60
On the mechanism of DNA replication in mammalian chromosomes. J Mol Biol (1968) 8.34
Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon. Nat Genet (1994) 8.34
Identification of a chromosome 18q gene that is altered in colorectal cancers. Science (1990) 8.32
Dysplasia in inflammatory bowel disease: standardized classification with provisional clinical applications. Hum Pathol (1983) 8.24
A gene from the region of the human X inactivation centre is expressed exclusively from the inactive X chromosome. Nature (1991) 8.22
The human XIST gene: analysis of a 17 kb inactive X-specific RNA that contains conserved repeats and is highly localized within the nucleus. Cell (1992) 8.05
PUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell (2001) 7.95
Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53. Nature (1993) 7.90
Genomic sequencing and methylation analysis by ligation mediated PCR. Science (1989) 7.38
Mouse model of X-linked chronic granulomatous disease, an inherited defect in phagocyte superoxide production. Nat Genet (1995) 7.34
14-3-3 sigma is a p53-regulated inhibitor of G2/M progression. Mol Cell (1997) 7.20
Association of the APC tumor suppressor protein with catenins. Science (1993) 7.17
Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification. Proc Natl Acad Sci U S A (1987) 7.12
Oncogenic forms of p53 inhibit p53-regulated gene expression. Science (1992) 6.73
p21 is necessary for the p53-mediated G1 arrest in human cancer cells. Cancer Res (1995) 6.66
Hypermutability and mismatch repair deficiency in RER+ tumor cells. Cell (1993) 6.61
Identification of p53 as a sequence-specific DNA-binding protein. Science (1991) 6.60
A first-generation X-inactivation profile of the human X chromosome. Proc Natl Acad Sci U S A (1999) 6.59
Structural alterations of the epidermal growth factor receptor gene in human gliomas. Proc Natl Acad Sci U S A (1992) 6.58
Purification of DNA from formaldehyde fixed and paraffin embedded human tissue. Biochem Biophys Res Commun (1985) 6.57
Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts. Science (1997) 6.50
Beta-globin locus is linked to the parathyroid hormone (PTH) locus and lies between the insulin and PTH loci in man. Proc Natl Acad Sci U S A (1983) 6.50
Specific transcription and RNA splicing defects in five cloned beta-thalassaemia genes. Nature (1983) 6.48
Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis. Nat Genet (2001) 6.36
Cloning the gene for an inherited human disorder--chronic granulomatous disease--on the basis of its chromosomal location. Nature (1986) 6.34
Improved reporter strain for monitoring Cre recombinase-mediated DNA excisions in mice. Proc Natl Acad Sci U S A (1999) 6.29
Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers. Science (1991) 6.15
Disruption of p53 in human cancer cells alters the responses to therapeutic agents. J Clin Invest (1999) 6.13
Treatment of colonic and rectal adenomas with sulindac in familial adenomatous polyposis. N Engl J Med (1993) 6.13
Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21. Nature (1996) 6.11
Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia. Cancer Res (1999) 6.10
Human Smad3 and Smad4 are sequence-specific transcription activators. Mol Cell (1998) 5.88
Cancer-susceptibility genes. Gatekeepers and caretakers. Nature (1997) 5.87