Published in Am J Physiol on January 01, 1989
Type 2 iodothyronine deiodinase is highly expressed in human thyroid. J Clin Invest (1996) 1.26
Adrenergic control of induction of type II iodothyronine 5'-deiodinase activity in cultured mouse brown adipocytes. Biochem J (1993) 0.77
Coupling between Nutrient Availability and Thyroid Hormone Activation. J Biol Chem (2015) 0.76
Recognition of UGA as a selenocysteine codon in type I deiodinase requires sequences in the 3' untranslated region. Nature (1991) 4.63
Functional characterization of the eukaryotic SECIS elements which direct selenocysteine insertion at UGA codons. EMBO J (1993) 3.14
Screening for congenital hypothyroidism: results of screening one million North American infants. J Pediatr (1979) 3.07
Type I iodothyronine deiodinase is a selenocysteine-containing enzyme. Nature (1991) 3.06
Levothyroxine therapy in patients with thyroid disease. Ann Intern Med (1993) 2.96
Relationships between circulating and intracellular thyroid hormones: physiological and clinical implications. Endocr Rev (1981) 2.78
The type 2 iodothyronine deiodinase is essential for adaptive thermogenesis in brown adipose tissue. J Clin Invest (2001) 2.77
Inhibition of thyroid hormone action by a non-hormone binding c-erbA protein generated by alternative mRNA splicing. Nature (1989) 2.46
Maternal and fetal thyroid function. N Engl J Med (1994) 2.43
Identification of a thyroid hormone receptor that is pituitary-specific. Science (1989) 2.37
Thyroid-pituitary interaction: feedback regulation of thyrotropin secretion by thyroid hormones. N Engl J Med (1982) 2.12
Increased need for thyroxine during pregnancy in women with primary hypothyroidism. N Engl J Med (1990) 2.03
Adrenergic activation of triiodothyronine production in brown adipose tissue. Nature (1983) 1.97
Usefulness of ultrasonography in the management of nodular thyroid disease. Ann Intern Med (2000) 1.88
Direct immunoassay of triiodothyronine in human serum. J Clin Invest (1972) 1.87
Substitution of cysteine for selenocysteine in type I iodothyronine deiodinase reduces the catalytic efficiency of the protein but enhances its translation. Endocrinology (1992) 1.80
Mutations of the rat growth hormone promoter which increase and decrease response to thyroid hormone define a consensus thyroid hormone response element. Mol Endocrinol (1989) 1.73
Severe hypothyroidism caused by type 3 iodothyronine deiodinase in infantile hemangiomas. N Engl J Med (2000) 1.72
Intracellular conversion of thyroxine to triiodothyronine is required for the optimal thermogenic function of brown adipose tissue. J Clin Invest (1987) 1.67
Pituitary nuclear 3,5,3'-triiodothyronine and thyrotropin secretion: an explanation for the effect of thyroxine. Science (1977) 1.61
An analysis of the sources and quantity of 3,5,3'-triiodothyronine specifically bound to nuclear receptors in rat cerebral cortex and cerebellum. Endocrinology (1982) 1.58
Selenocysteine confers the biochemical properties characteristic of the type I iodothyronine deiodinase. J Biol Chem (1991) 1.55
Repression mediates cell-type-specific expression of the rat growth hormone gene. Proc Natl Acad Sci U S A (1986) 1.53
The effect of diphenylhydantoin on thyroxine metabolism in man. J Clin Invest (1970) 1.47
The contribution of local tissue thyroxine monodeiodination to the nuclear 3,5,3'-triiodothyronine in pituitary, liver, and kidney of euthyroid rats. Endocrinology (1978) 1.46
Isolation of a cDNA clone encoding a biologically active thyroid hormone receptor. Proc Natl Acad Sci U S A (1988) 1.46
Resting energy expenditure is sensitive to small dose changes in patients on chronic thyroid hormone replacement. J Clin Endocrinol Metab (1997) 1.46
Evidence for two tissue-specific pathways for in vivo thyroxine 5'-deiodination in the rat. J Clin Invest (1982) 1.46
Thyroid hormone aporeceptor represses T3-inducible promoters and blocks activity of the retinoic acid receptor. New Biol (1989) 1.45
Neonatal thyroid function in congenital hypothyroidism. J Pediatr (1976) 1.45
Starvation in the rat. II. Effect of age and obesity on protein sparing and fuel metabolism. Am J Physiol (1980) 1.43
Regional distribution of type 2 thyroxine deiodinase messenger ribonucleic acid in rat hypothalamus and pituitary and its regulation by thyroid hormone. Endocrinology (1997) 1.41
Functional characterization of the rat growth hormone promoter elements required for induction by thyroid hormone with and without a co-transfected beta type thyroid hormone receptor. J Biol Chem (1989) 1.39
Thyroid hormone regulation of gene expression. Annu Rev Physiol (1991) 1.39
Triiodothyronine: review of recent studies of its physiology and pathophysiology in man. Metabolism (1972) 1.37
Plasma T4 and T3 levels in naturally metamorphosing Eurycea bislineata (Amphibia; Plethodontidae). Gen Comp Endocrinol (1986) 1.37
Kinetic evidence suggesting two mechanisms for iodothyronine 5'-deiodination in rat cerebral cortex. Proc Natl Acad Sci U S A (1982) 1.37
Screening for congenital hypothyroidism. Results in the newborn population of New England. JAMA (1978) 1.35
Selective proteolysis of human type 2 deiodinase: a novel ubiquitin-proteasomal mediated mechanism for regulation of hormone activation. Mol Endocrinol (2000) 1.35
Inhibition of intrapituitary thyroxine to 3.5.3'-triiodothyronine conversion prevents the acute suppression of thyrotropin release by thyroxine in hypothyroid rats. J Clin Invest (1979) 1.34
Potential of brown adipose tissue type II thyroxine 5'-deiodinase as a local and systemic source of triiodothyronine in rats. J Clin Invest (1985) 1.34
Molecular biological and biochemical characterization of the human type 2 selenodeiodinase. Endocrinology (1996) 1.33
Technical aspects of the estimation of triiodothyronine in human serum: evidence of conversion of thyroxine to triiodothyronine during assay. Metabolism (1971) 1.31
Thyroid hormone receptor binds to a site in the rat growth hormone promoter required for induction by thyroid hormone. Proc Natl Acad Sci U S A (1987) 1.31
Evidence for two pathways of iodothyronine 5'-deiodination in rat pituitary that differ in kinetics, propylthiouracil sensitivity, and response to hypothyroidism. J Clin Invest (1983) 1.30
Triiodothyronine amplifies norepinephrine stimulation of uncoupling protein gene transcription by a mechanism not requiring protein synthesis. J Biol Chem (1988) 1.30
Cerebral cortex responds rapidly to thyroid hormones. Science (1981) 1.29
Type 2 iodothyronin deiodinase transgene expression in the mouse heart causes cardiac-specific thyrotoxicosis. Endocrinology (2001) 1.27
Type 2 iodothyronine deiodinase is highly expressed in human thyroid. J Clin Invest (1996) 1.26
Isolation of labeled triiodothyronine from serum using affinity chromatography: application to the extimation of the peripheral T4 to T3 conversion in rats. Metabolism (1978) 1.25
The human type 2 iodothyronine deiodinase is a selenoprotein highly expressed in a mesothelioma cell line. J Biol Chem (2001) 1.23
Thyroxine 5'-deiodinase activity in brown adipose tissue. Endocrinology (1983) 1.23
Distinct subcellular localization of transiently expressed types 1 and 2 iodothyronine deiodinases as determined by immunofluorescence confocal microscopy. Endocrinology (2000) 1.23
Physiological and pharmacological influences on thyroxine to 3,5,3'-triiodothyronine conversion and nuclear 3,5,3'-triiodothyronine binding in rat anterior pituitary. J Clin Invest (1979) 1.23
Comparison of the biological effects of thyroxine and triiodothyronine in the rat. Endocrinology (1977) 1.20
Type 3 lodothyronine deiodinase: cloning, in vitro expression, and functional analysis of the placental selenoenzyme. J Clin Invest (1995) 1.19
Triiodothyronine and thyroxine in hyperthyroidism. Comparison of the acute changes during therapy with antithyroid agents. J Clin Invest (1974) 1.19
Salicylate-induced increases in free triiodothyronine in human serum. Evidence of inhibition of triiodothyronine binding to thyroxine-binding globulin and thyroxine-binding prealbumin. J Clin Invest (1972) 1.18
Regional expression of the type 3 iodothyronine deiodinase messenger ribonucleic acid in the rat central nervous system and its regulation by thyroid hormone. Endocrinology (1999) 1.16
Thyroid hypofunction after exposure to fallout from a hydrogen bomb explosion. JAMA (1982) 1.16
Qualitative and quantitative differences in the pathways of extrathyroidal triiodothyronine generation between euthyroid and hypothyroid rats. J Clin Invest (1984) 1.15
Relation of severity of maternal hypothyroidism to cognitive development of offspring. J Med Screen (2001) 1.13
Is there a negative TRE in the luciferase reporter cDNA? Thyroid (1996) 1.12
Correlation of sequential changes in serum thyroglobulin, triiodothyronine, and thyroxine in patients with Graves' disease and subacute thyroiditis. Metabolism (1978) 1.11
Neonatal hypothyroidism detected by the Northwest Regional Screening Program. Pediatrics (1979) 1.11
Substrate-induced down-regulation of human type 2 deiodinase (hD2) is mediated through proteasomal degradation and requires interaction with the enzyme's active center. Endocrinology (2000) 1.10
Characterization of the 5'-flanking and 5'-untranslated regions of the cyclic adenosine 3',5'-monophosphate-responsive human type 2 iodothyronine deiodinase gene. Endocrinology (2000) 1.09
A novel retinoid X receptor-independent thyroid hormone response element is present in the human type 1 deiodinase gene. Mol Cell Biol (1995) 1.09
Delineation of thyroid hormone-responsive sequences within a critical enhancer in the rat uncoupling protein gene. Endocrinology (1995) 1.08
Optimal response of key enzymes and uncoupling protein to cold in BAT depends on local T3 generation. Am J Physiol (1987) 1.08
Type 2 iodothyronine deiodinase in rat pituitary tumor cells is inactivated in proteasomes. J Clin Invest (1998) 1.07
Rapid thyroxine to 3,5,3'-triiodothyronine conversion and nuclear 3,5,3'-triiodothyronine binding in rat cerebral cortex and cerebellum. J Clin Invest (1980) 1.06
Total and free triiodothyronine and thyroxine in early infancy. J Clin Endocrinol Metab (1974) 1.05
The cost-effectiveness of preoperative testing (basic office assessment vs. urodynamics) for stress urinary incontinence in women. BJU Int (2002) 1.05
Correlation of serum triiodothyronine (T3) and thyroxine (T4) with biologic effects of thyroid hormone replacement in propylthiouracil-treated rats. Metabolism (1975) 1.05
Production rates and turnover of triiodothyronine in rat-developing cerebral cortex and cerebellum. Responses to hypothyroidism. J Clin Invest (1984) 1.05
Metabolic clearance of endogenous and radioiodinated thyroglobulin in rats. Endocrinology (1978) 1.04
Cold exposure rapidly induces virtual saturation of brown adipose tissue nuclear T3 receptors. Am J Physiol (1988) 1.04
Regulation of rat cerebrocortical and adenohypophyseal type II 5'-deiodinase by thyroxine, triiodothyronine, and reverse triiodothyronine. Endocrinology (1985) 1.03
Inhibition of triiodothyronine (T3) binding to thyroxine-binding globulin by sodium salicylate and its application to immunoassay of T3 in human serum. Metabolism (1971) 1.03
Effects of thyroid hormone on norepinephrine signaling in brown adipose tissue. I. Beta 1- and beta 2-adrenergic receptors and cyclic adenosine 3',5'-monophosphate generation. Endocrinology (1995) 1.03
Comparison of iodothyronine 5'-deiodinase and other thyroid-hormone-dependent enzyme activities in the cerebral cortex of hypothyroid neonatal rat. Evidence for adaptation to hypothyroidism. J Clin Invest (1982) 1.03
Thyroid hormone and norepinephrine signaling in brown adipose tissue. II: Differential effects of thyroid hormone on beta 3-adrenergic receptors in brown and white adipose tissue. Endocrinology (1995) 1.02
Multiple sequences encoding potential thyroid hormone receptors isolated from mouse skeletal muscle cDNA libraries. Nucleic Acids Res (1988) 1.01
Immunoassay of thyroxine in unextracted human serum. J Clin Endocrinol Metab (1973) 1.01