Published in Science on February 08, 1985
Methylation of HpaII and HhaI sites near the polymorphic CAG repeat in the human androgen-receptor gene correlates with X chromosome inactivation. Am J Hum Genet (1992) 11.38
Etiology and pathogenesis of uterine leiomyomas: a review. Environ Health Perspect (2003) 2.98
Monoclonal endothelial cell proliferation is present in primary but not secondary pulmonary hypertension. J Clin Invest (1998) 2.54
X-linked clonality testing: interpretation and limitations. Blood (2007) 2.04
Hematopoiesis is not clonal in healthy elderly women. Blood (2008) 1.95
Clonality in myeloproliferative disorders: analysis by means of the polymerase chain reaction. Proc Natl Acad Sci U S A (1991) 1.95
Epidemiology and pathogenesis of Kaposi's sarcoma-associated herpesvirus. Philos Trans R Soc Lond B Biol Sci (2001) 1.64
Genomic heterogeneity in synchronous hepatocellular carcinomas. Gut (1999) 1.44
Detection of clonal histiocytes in Langerhans cell histiocytosis: biology and clinical significance. Br J Cancer Suppl (1994) 1.35
Monoclonality of parathyroid tumors in chronic renal failure and in primary parathyroid hyperplasia. J Clin Invest (1995) 1.34
X-inactivation patch size in human female tissue confounds the assessment of tumor clonality. Proc Natl Acad Sci U S A (2003) 1.30
No evidence that skewing of X chromosome inactivation patterns is transmitted to offspring in humans. J Clin Invest (2008) 1.30
A polymerase chain reaction assay for non-random X chromosome inactivation identifies monoclonal endometrial cancers and precancers. Am J Pathol (1995) 1.30
Duchenne muscular dystrophy in one of monozygotic twin girls. J Med Genet (1986) 1.28
Clinically nonfunctioning pituitary tumors are monoclonal in origin. J Clin Invest (1990) 1.27
Selection against lethal alleles in females heterozygous for incontinentia pigmenti. Am J Hum Genet (1989) 1.21
Monoclonality of both pale cells and cuboidal cells of sclerosing hemangioma of the lung. Am J Pathol (1998) 1.17
An expression based clonality assay at the human androgen receptor locus (HUMARA) on chromosome X. Nucleic Acids Res (1994) 1.15
Molecular analysis of clonality in Kaposi's sarcoma. J Clin Pathol (1997) 1.05
The clonal origin and clonal evolution of epithelial tumours. Int J Exp Pathol (2000) 1.04
Lithium chloride regulates the proliferation of stem-like cells in retinoblastoma cell lines: a potential role for the canonical Wnt signaling pathway. Mol Vis (2010) 1.03
Complete reactivation of X chromosomes from human chorionic villi with a switch to early DNA replication. Proc Natl Acad Sci U S A (1986) 1.03
The role of colorectal cancer stem cells in metastatic disease and therapeutic response. Cancers (Basel) (2011) 1.02
X inactivation as a mechanism of selection against lethal alleles: further investigation of incontinentia pigmenti and X linked lymphoproliferative disease. J Med Genet (1992) 1.01
Monoclonality of atypical adenomatous hyperplasia of the lung. Am J Pathol (1999) 0.98
Alterations in DNA methylation are early, but not initial, events in ovarian tumorigenesis. Br J Cancer (1997) 0.95
Assessment of clonality in gastrointestinal cancer by DNA fingerprinting. J Clin Invest (1988) 0.93
Clonal composition of benign and malignant human thyroid tumors. J Clin Invest (1990) 0.92
X inactivation patterns in females with Alport's syndrome: a means of selecting against a deleterious gene? J Med Genet (1992) 0.92
Phyllodes Tumor of the Breast: Pathology, Histogenesis, Diagnosis, and Treatment. Breast Cancer (1996) 0.91
Clonal analysis of human tumors with M27 beta, a highly informative polymorphic X chromosomal probe. J Clin Invest (1992) 0.90
Retroviral transduction of the human c-Ha-ras-1 oncogene into midgestation mouse embryos promotes rapid epithelial hyperplasia. Mol Cell Biol (1989) 0.90
Detection of monoclonal microsatellite alterations in atypical breast hyperplasia. J Clin Invest (1996) 0.90
Clonal analysis of solitary follicular nodules in the thyroid. Am J Pathol (1990) 0.90
Evidence for clonal origin of neoplastic neuronal and glial cells in gangliogliomas. Am J Pathol (1997) 0.90
Occult progression by Apc-deficient intestinal crypts as a target for chemoprevention. Carcinogenesis (2013) 0.89
Rapid determination of clonality by detection of two closely-linked X chromosome exonic polymorphisms using allele-specific PCR. J Clin Invest (1997) 0.88
Analysis of gene alterations of mitochondrial DNA D-loop regions to determine breast cancer clonality. Br J Cancer (2012) 0.87
The neurofibroma in von Recklinghausen neurofibromatosis has a unicellular origin. Am J Hum Genet (1991) 0.86
The ras and myc oncogenes cooperate in tumor induction in many tissues when introduced into midgestation mouse embryos by retroviral vectors. Proc Natl Acad Sci U S A (1989) 0.84
Isolation of colorectal cancer stem-like cells. Cytotechnology (2014) 0.84
Passenger mutations as a marker of clonal cell lineages in emerging neoplasia. Semin Cancer Biol (2010) 0.83
Clonal analysis of isolated intestinal metaplastic glands of stomach using X linked polymorphism. Gut (1998) 0.82
Monoclonal origin of vulvar intraepithelial neoplasia and some vulvar hyperplasias. Am J Pathol (1997) 0.82
Putative precursor cancer cells in human colorectal cancer tissue. Int J Clin Exp Pathol (2008) 0.81
Brother/sister pairs affected with early-onset, progressive muscular dystrophy: molecular studies reveal etiologic heterogeneity. Am J Hum Genet (1989) 0.81
Transient suppression of clonal hemopoiesis associated with pregnancy in a patient with a myeloproliferative disorder. J Clin Invest (1988) 0.78
A restriction-fragment-length difference detected by the anonymous probe DXS199 exhibits non-Mendelian inheritance. Am J Hum Genet (1988) 0.78
Analysis of promoter region of X-linked pgk-1 gene polymorphisms: evidence for polyclonality of adult mouse gastric glands. Dig Dis Sci (2004) 0.78
A human lymphoma cell line with multiple immunoglobulin rearrangements. J Clin Invest (1992) 0.77
Clonal analysis of solitary intraductal papilloma of the breast by means of polymerase chain reaction. Am J Pathol (1994) 0.75
A case of ataxia telangiectasia with unbalanced glucose 6-phosphate dehydrogenase mosaicism in the granulocytic/monocytic lineages. Am J Hum Genet (1987) 0.75
A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity. Anal Biochem (1983) 206.01
"A technique for radiolabeling DNA restriction endonuclease fragments to high specific activity". Addendum. Anal Biochem (1984) 66.58
Serial analysis of gene expression. Science (1995) 60.15
A genetic model for colorectal tumorigenesis. Cell (1990) 44.37
WAF1, a potential mediator of p53 tumor suppression. Cell (1993) 38.72
Surfing the p53 network. Nature (2000) 35.36
p53 mutations in human cancers. Science (1991) 31.96
Preparative and analytical purification of DNA from agarose. Proc Natl Acad Sci U S A (1979) 27.20
Genetic alterations during colorectal-tumor development. N Engl J Med (1988) 26.82
Lessons from hereditary colorectal cancer. Cell (1996) 25.73
Activation of beta-catenin-Tcf signaling in colon cancer by mutations in beta-catenin or APC. Science (1997) 24.61
A simplified system for generating recombinant adenoviruses. Proc Natl Acad Sci U S A (1998) 24.58
Identification of c-MYC as a target of the APC pathway. Science (1998) 24.25
Constitutive transcriptional activation by a beta-catenin-Tcf complex in APC-/- colon carcinoma. Science (1997) 22.80
Genetic instabilities in human cancers. Nature (1998) 22.76
A mammalian cell cycle checkpoint pathway utilizing p53 and GADD45 is defective in ataxia-telangiectasia. Cell (1992) 19.87
Requirement for p53 and p21 to sustain G2 arrest after DNA damage. Science (1998) 17.91
Amplification of a gene encoding a p53-associated protein in human sarcomas. Nature (1992) 17.40
Participation of p53 protein in the cellular response to DNA damage. Cancer Res (1991) 16.00
Clues to the pathogenesis of familial colorectal cancer. Science (1993) 14.52
Epigenetic memory in induced pluripotent stem cells. Nature (2010) 14.31
Inactivation of the type II TGF-beta receptor in colon cancer cells with microsatellite instability. Science (1995) 13.15
Definition of a consensus binding site for p53. Nat Genet (1992) 12.76
Genetic instability in colorectal cancers. Nature (1997) 12.51
Chromosome 17 deletions and p53 gene mutations in colorectal carcinomas. Science (1989) 11.53
Identification of FAP locus genes from chromosome 5q21. Science (1991) 11.41
A model for p53-induced apoptosis. Nature (1997) 11.38
Characterization of the yeast transcriptome. Cell (1997) 11.33
Mutations of mitotic checkpoint genes in human cancers. Nature (1998) 11.20
Suppression of human colorectal carcinoma cell growth by wild-type p53. Science (1990) 11.18
Genes expressed in human tumor endothelium. Science (2000) 10.75
Multiple intestinal neoplasia caused by a mutation in the murine homolog of the APC gene. Science (1992) 10.12
Incidence and functional consequences of hMLH1 promoter hypermethylation in colorectal carcinoma. Proc Natl Acad Sci U S A (1998) 9.66
Gene expression profiles in normal and cancer cells. Science (1997) 9.65
APC mutations occur early during colorectal tumorigenesis. Nature (1992) 9.50
Hypomethylation distinguishes genes of some human cancers from their normal counterparts. Nature (1983) 9.28
Prevalence of ras gene mutations in human colorectal cancers. Nature (1987) 9.23
A public database for gene expression in human cancers. Cancer Res (1999) 8.81
Methylation of the oestrogen receptor CpG island links ageing and neoplasia in human colon. Nat Genet (1994) 8.34
Identification of a chromosome 18q gene that is altered in colorectal cancers. Science (1990) 8.32
Dysplasia in inflammatory bowel disease: standardized classification with provisional clinical applications. Hum Pathol (1983) 8.24
PUMA induces the rapid apoptosis of colorectal cancer cells. Mol Cell (2001) 7.95
Oncoprotein MDM2 conceals the activation domain of tumour suppressor p53. Nature (1993) 7.90
14-3-3 sigma is a p53-regulated inhibitor of G2/M progression. Mol Cell (1997) 7.20
Association of the APC tumor suppressor protein with catenins. Science (1993) 7.17
Increased expression of the epidermal growth factor receptor gene in malignant gliomas is invariably associated with gene amplification. Proc Natl Acad Sci U S A (1987) 7.12
Oncogenic forms of p53 inhibit p53-regulated gene expression. Science (1992) 6.73
p21 is necessary for the p53-mediated G1 arrest in human cancer cells. Cancer Res (1995) 6.66
Hypermutability and mismatch repair deficiency in RER+ tumor cells. Cell (1993) 6.61
Identification of p53 as a sequence-specific DNA-binding protein. Science (1991) 6.60
Structural alterations of the epidermal growth factor receptor gene in human gliomas. Proc Natl Acad Sci U S A (1992) 6.58
Purification of DNA from formaldehyde fixed and paraffin embedded human tissue. Biochem Biophys Res Commun (1985) 6.57
Mitogenic signaling mediated by oxidants in Ras-transformed fibroblasts. Science (1997) 6.50
Beta-globin locus is linked to the parathyroid hormone (PTH) locus and lies between the insulin and PTH loci in man. Proc Natl Acad Sci U S A (1983) 6.50
Germline mutations of the gene encoding bone morphogenetic protein receptor 1A in juvenile polyposis. Nat Genet (2001) 6.36
Identification of a gene located at chromosome 5q21 that is mutated in colorectal cancers. Science (1991) 6.15
Disruption of p53 in human cancer cells alters the responses to therapeutic agents. J Clin Invest (1999) 6.13
Treatment of colonic and rectal adenomas with sulindac in familial adenomatous polyposis. N Engl J Med (1993) 6.13
Uncoupling of S phase and mitosis induced by anticancer agents in cells lacking p21. Nature (1996) 6.11
Inactivation of the DNA repair gene O6-methylguanine-DNA methyltransferase by promoter hypermethylation is a common event in primary human neoplasia. Cancer Res (1999) 6.10
Human Smad3 and Smad4 are sequence-specific transcription activators. Mol Cell (1998) 5.88
Cancer-susceptibility genes. Gatekeepers and caretakers. Nature (1997) 5.87
Mutational analysis of the APC/beta-catenin/Tcf pathway in colorectal cancer. Cancer Res (1998) 5.80
p53 gene mutations occur in combination with 17p allelic deletions as late events in colorectal tumorigenesis. Cancer Res (1990) 5.70
Prognostic factors in colorectal cancer. College of American Pathologists Consensus Statement 1999. Arch Pathol Lab Med (2000) 5.68
A National Cancer Institute Workshop on Hereditary Nonpolyposis Colorectal Cancer Syndrome: meeting highlights and Bethesda guidelines. J Natl Cancer Inst (1997) 5.68
p53-dependent and independent expression of p21 during cell growth, differentiation, and DNA damage. Genes Dev (1995) 5.63
Allelotype of colorectal carcinomas. Science (1989) 5.54
14-3-3Sigma is required to prevent mitotic catastrophe after DNA damage. Nature (1999) 5.44
Microsatellite instability and mutations of the transforming growth factor beta type II receptor gene in colorectal cancer. Cancer Res (1995) 5.26
Molecular predictors of survival after adjuvant chemotherapy for colon cancer. N Engl J Med (2001) 5.22
p53 functions as a cell cycle control protein in osteosarcomas. Mol Cell Biol (1990) 5.20
Allelic loss of chromosome 18q and prognosis in colorectal cancer. N Engl J Med (1994) 5.12
PPARdelta is an APC-regulated target of nonsteroidal anti-inflammatory drugs. Cell (1999) 5.12
Role of BAX in the apoptotic response to anticancer agents. Science (2000) 5.07
Analysis of mismatch repair genes in hereditary non-polyposis colorectal cancer patients. Nat Med (1996) 4.87
Familial colorectal cancer in Ashkenazim due to a hypermutable tract in APC. Nat Genet (1997) 4.86
Mutation spectrum and genotype-phenotype analyses in Cowden disease and Bannayan-Zonana syndrome, two hamartoma syndromes with germline PTEN mutation. Hum Mol Genet (1998) 4.72
Somatic mutations of the mitochondrial genome in human colorectal tumours. Nat Genet (1998) 4.67
The use and interpretation of commercial APC gene testing for familial adenomatous polyposis. N Engl J Med (1997) 4.66