Published in Proc Natl Acad Sci U S A on August 01, 1985
Biphasic Ca2+ dependence of inositol 1,4,5-trisphosphate-induced Ca release in smooth muscle cells of the guinea pig taenia caeci. J Gen Physiol (1990) 4.32
Role of calcium stores and membrane voltage in the generation of slow wave action potentials in guinea-pig gastric pylorus. J Physiol (2000) 2.25
Free-calcium and force transients during depolarization and pharmacomechanical coupling in guinea-pig smooth muscle. J Physiol (1988) 2.11
Properties of spontaneous depolarizations in circular smooth muscle cells of rabbit urethra. Br J Pharmacol (1996) 2.11
Isolation and characterization of the inositol trisphosphate receptor from smooth muscle. Proc Natl Acad Sci U S A (1990) 2.04
ATP-activated channels gate calcium entry in single smooth muscle cells dissociated from rabbit ear artery. J Physiol (1989) 2.01
Differential regulation of two types of intracellular calcium release channels during end-stage heart failure. J Clin Invest (1995) 1.78
Fat-storing cells as liver-specific pericytes. Spatial dynamics of agonist-stimulated intracellular calcium transients. J Clin Invest (1992) 1.71
Effects of cyclopiazonic acid, a novel Ca(2+)-ATPase inhibitor, on contractile responses in skinned ileal smooth muscle. Br J Pharmacol (1992) 1.71
Near-membrane [Ca2+] transients resolved using the Ca2+ indicator FFP18. Proc Natl Acad Sci U S A (1996) 1.59
Desensitization to cytoplasmic Ca2+ and Ca2+ sensitivities of guinea-pig ileum and rabbit pulmonary artery smooth muscle. J Physiol (1989) 1.36
Effects of a phorbol ester on acetylcholine-induced Ca2+ mobilization and contraction in the porcine coronary artery. J Physiol (1988) 1.26
Stretch-induced calcium release in smooth muscle. J Gen Physiol (2002) 1.23
Effects of guanosine nucleotides on skinned smooth muscle tissue of the rabbit mesenteric artery. J Physiol (1989) 1.19
Human inositol 1,4,5-trisphosphate type-1 receptor, InsP3R1: structure, function, regulation of expression and chromosomal localization. Biochem J (1994) 1.17
Purification and characterization of inositol 1,4,5-trisphosphate 3-kinase from pig aortic smooth muscle. Biochem J (1988) 1.16
Interstitial cells of Cajal in the urethra. J Cell Mol Med (2006) 1.14
pH dependence of inositol 1,4,5-trisphosphate-induced Ca2+ release in permeabilized smooth muscle cells of the guinea-pig. J Physiol (1994) 1.09
Calmodulin activates inositol 1,4,5-trisphosphate 3-kinase activity in pig aortic smooth muscle. Biochem J (1987) 1.09
Cholinergic stimulation activates a non-selective cation current in canine pyloric circular muscle cells. J Physiol (1990) 1.07
Protein kinase C translocation in intact vascular smooth muscle strips. Biochem J (1990) 1.06
Mechanism of endothelin-induced contraction in guinea-pig trachea: comparison with rat aorta. Br J Pharmacol (1990) 1.05
Knockout of Na+/Ca2+ exchanger in smooth muscle attenuates vasoconstriction and L-type Ca2+ channel current and lowers blood pressure. Am J Physiol Heart Circ Physiol (2010) 1.05
Effects of lead on vascular reactivity. Environ Health Perspect (1988) 1.03
Mitochondrial Ca2+ homeostasis during Ca2+ influx and Ca2+ release in gastric myocytes from Bufo marinus. J Physiol (2000) 1.03
Guanine nucleotide- and inositol 1,4,5-trisphosphate-induced calcium release in rabbit main pulmonary artery. J Physiol (1988) 1.02
Abnormal vascular phosphoinositide hydrolysis in the spontaneously hypertensive rat. Br J Pharmacol (1986) 1.01
Ca2+ entry activated by emptying of intracellular Ca2+ stores in ileal smooth muscle of the rat. Br J Pharmacol (1995) 0.99
Opsonic human antibodies from an endemic population specific for a conserved epitope on the M protein of group A streptococci. Immunology (1996) 0.98
Measurement of cytoplasmic free Ca2+ concentration in rabbit aorta using the photoprotein, aequorin. Effect of atrial natriuretic peptide on agonist-induced Ca2+ signal generation. J Clin Invest (1987) 0.98
Calcium transients evoked by electrical stimulation of smooth muscle from guinea-pig ileum recorded by the use of Fura-2. J Physiol (1988) 0.96
Desensitization of swine arterial smooth muscle to transplasmalemmal Ca2+ influx. J Physiol (1989) 0.95
Properties of intracellular calcium stores in pregnant rat myometrium. Br J Pharmacol (1988) 0.94
The inhibitory action of cyclic AMP on responses to carbachol dependent on calcium stores in rat gastric smooth muscle. J Physiol (1992) 0.91
Inward current activated by carbachol in rat intestinal smooth muscle cells. J Physiol (1993) 0.91
Temporal changes in the calcium-force relation during histamine-induced contractions of strips of the coronary artery of the pig. Br J Pharmacol (1991) 0.90
Molecular characterization of a major nephritogenic domain in the autoantigen of anti-tubular basement membrane disease. Proc Natl Acad Sci U S A (1991) 0.89
Receptor-coupled shortening of alpha-toxin-permeabilized single smooth muscle cells from the guinea-pig stomach. Br J Pharmacol (1992) 0.89
Inhibitory action of alpha-human atrial natriuretic peptide on noradrenaline-induced synthesis of myo-inositol 1,4,5-trisphosphate in the smooth muscle cells of rabbit aorta. Br J Pharmacol (1990) 0.88
Early events in inositol phosphate metabolism in longitudinal smooth muscle from guinea-pig intestine stimulated with carbachol. Biochem J (1988) 0.87
Gestational changes in the utilization of intracellularly stored calcium in the myometrium of guinea-pigs. J Physiol (1988) 0.85
Inhibitory effects of procaine on contraction and calcium movement in vascular and intestinal smooth muscles. Br J Pharmacol (1988) 0.85
Histamine and a guanine nucleotide increase calcium permeability in pig aortic microsomal fractions. Biochem J (1990) 0.85
D-myo-inositol 1,4,5-trisphosphate phosphatase in skeletal muscle. Biochem J (1988) 0.85
Noradrenaline stimulation of the phosphoinositide system: evidence for a novel hydrophobic inositol-containing compound in resistance arterioles. Br J Pharmacol (1988) 0.83
Inositol 1,4,5-trisphosphate (IP3) receptor up-regulation in hypertension is associated with sensitization of Ca2+ release and vascular smooth muscle contractility. J Biol Chem (2013) 0.83
Effects of heptanol on the neurogenic and myogenic contractions of the guinea-pig vas deferens. Br J Pharmacol (1999) 0.82
Relationship between stimulated phosphatidic acid production and inositol lipid hydrolysis in intestinal longitudinal smooth muscle from guinea pig. Biochem J (1987) 0.82
Effects of insulin and prior exercise on prostaglandin release from perfused rat muscle. Evidence that prostaglandins do not mediate changes in glucose uptake. Biochem J (1986) 0.82
[Ca2+]i-sensitive, IP3-independent Ca2+ influx in smooth muscle of rat vas deferens revealed by procaine. Br J Pharmacol (1993) 0.82
InsP3, but not novel Ca2+ releasers, contributes to agonist-initiated contraction in rabbit airway smooth muscle. J Physiol (1998) 0.81
Differences in inositol phosphate production in blood vessels of normotensive and spontaneously hypertensive rats. Br J Pharmacol (1991) 0.81
Phorbol ester effects on coupling mechanisms during cholinergic contraction of swine tracheal smooth muscle. J Physiol (1989) 0.81
Insulin attenuates agonist-mediated calcium mobilization in cultured rat vascular smooth muscle cells. J Clin Invest (1993) 0.80
Ketamine-induced relaxation in intact and skinned smooth muscles of the rabbit ear artery. Br J Pharmacol (1989) 0.80
Effect of Extremely Low Frequency Electromagnetic Fields (EMF) on Phospholipase Activity in the Cultured Cells. Korean J Physiol Pharmacol (2010) 0.80
Existence of two components in the tonic contraction of rat aorta mediated by alpha 1-adrenoceptor activation. Br J Pharmacol (1991) 0.79
5-hydroxytryptamine-stimulated accumulation of 1,2-diacylglycerol in the rabbit basilar artery: a role for protein kinase C in smooth muscle contraction. Br J Pharmacol (1991) 0.79
Contractile effects of substance P and other tachykinins on the mouse isolated distal colon. Br J Pharmacol (1989) 0.77
Intracellular Ca Mobilization and Beta-hexosaminidase Release Are Not Influenced by 60 Hz-electromagnetic Fields (EMF) in RBL 2H3 Cells. Korean J Physiol Pharmacol (2011) 0.77
The effect of relaxants working through different transduction mechanisms on the tonic contraction produced in rat aorta by 4 beta-phorbol dibutyrate. Br J Pharmacol (1989) 0.77
Vasoconstrictor agonists activate G-protein-dependent receptor-operated calcium channels in pig aortic microsomes. Biochem J (1992) 0.77
Cerebral artery signal transduction mechanisms: developmental changes in dynamics and Ca2+ sensitivity. Curr Vasc Pharmacol (2013) 0.77
The properties of ryanodine-sensitive Ca(2+) release in mouse gastric smooth muscle cells. Br J Pharmacol (2001) 0.77
Different patterns of protein kinase C redistribution mediated by alpha 1-adrenoceptor stimulation and phorbol ester in rat isolated left ventricular papillary muscle. Br J Pharmacol (1992) 0.77
The role of calcium in the cyclic AMP response to histamine in rabbit cerebral cortical slices. Br J Pharmacol (1987) 0.76
Effects of GTP gamma S on muscarinic receptor-stimulated inositol phospholipid hydrolysis in permeabilized smooth muscle from the small intestine. Br J Pharmacol (1995) 0.76
Purification and characterization of protein kinase C from rabbit iris smooth muscle. Myosin light-chain phosphorylation in vitro and in intact muscle. Biochem J (1988) 0.75
Lithium dampens neurotransmitter response in smooth muscle: relevance to action in affective illness. Proc Natl Acad Sci U S A (1986) 0.75
Jabuticaba-Induced Endothelium-Independent Vasodilating Effect on Isolated Arteries. Arq Bras Cardiol (2016) 0.75
Characterization of musclin as a new target for treatment of hypertension. Biomed Res Int (2014) 0.75
Effects of 8-bromoguanosine 3':5'-cyclic monophosphate on phenylephrine-induced phosphatidylinositol hydrolysis and contraction in rat caudal artery. Br J Pharmacol (1995) 0.75
Inositol trisphosphate, a novel second messenger in cellular signal transduction. Nature (1984) 25.71
Calculator programs for computing the composition of the solutions containing multiple metals and ligands used for experiments in skinned muscle cells. J Physiol (Paris) (1979) 15.30
Release of Ca2+ from a nonmitochondrial intracellular store in pancreatic acinar cells by inositol-1,4,5-trisphosphate. Nature (1983) 10.90
Electromechanical and pharmacomechanical coupling in vascular smooth muscle. J Pharmacol Exp Ther (1968) 4.28
Inositol trisphosphates in carbachol-stimulated rat parotid glands. Biochem J (1984) 4.05
Sarcoplasmic reticulum and excitation-contraction coupling in mammalian smooth muscles. J Cell Biol (1972) 3.28
Involvement of guanine nucleotide-binding protein in the gating of Ca2+ by receptors. Nature (1983) 3.21
Inositol 1,4,5-trisphosphate releases Ca2+ from intracellular store sites in skinned single cells of porcine coronary artery. Biochem Biophys Res Commun (1984) 2.71
Enzyme secretion and the incorporation of P32 into phospholipides of pancreas slices. J Biol Chem (1953) 2.68
Differences and similarities in the noradrenaline- and caffeine-induced mechanical responses in the rabbit mesenteric artery. J Physiol (1983) 2.26
Ca2+ homeostasis in permeabilized human neutrophils. Characterization of Ca2+-sequestering pools and the action of inositol 1,4,5-triphosphate. J Biol Chem (1984) 2.20
Mechanisms of Ca2+ release from sarcoplasmic reticulum of skeletal muscle. Physiol Rev (1984) 2.03
Release and recycling of calcium by the sarcoplasmic reticulum in guinea-pig portal vein smooth muscle. J Physiol (1984) 1.88
The cytoskeleton of digitonin-treated rat hepatocytes. Proc Natl Acad Sci U S A (1980) 1.74
Sarcoplasmic reticulum and the temperature-dependent contraction of smooth muscle in calcium-free solutions. J Cell Biol (1971) 1.74
The effects of caffeine on the noradrenaline-sensitive calcium store in rabbit aorta. J Physiol (1984) 1.70
Pharmacomechanical coupling in smooth muscle may involve phosphatidylinositol metabolism. Proc Natl Acad Sci U S A (1984) 1.58
Membrane potential-dependent and-independent tension in the canine tracheal muscle. J Pharmacol Exp Ther (1977) 1.48
Excitation-contraction coupling and electrical events in two types of vascular smooth muscle. Microvasc Res (1969) 1.38
Cell physiology: cellular site of calcium regulation. Nature (1984) 1.27
Demonstration of a (Ca2+ + Mg2+)-ATPase activity probably related to Ca2+ transport in the microsomal fraction of porcine coronary artery smooth muscle. Biochim Biophys Acta (1980) 1.23
Calcium and monovalent ions in smooth muscle. Fed Proc (1982) 1.19
Electro- and pharmacomechanical coupling in vascular smooth muscle. Chest (1980) 1.08
Tension-pCa relation and sarcoplasmic reticulum responses in chemically skinned smooth muscle fibers. Fed Proc (1982) 1.04
Inositol phospholipids in stimulated smooth muscles. Cell Calcium (1982) 0.91
Effect of adrenergic agonists on phosphatidylinositol labelling in heart and aorta. Biochim Biophys Acta (1976) 0.89
Assessment of outcome after severe brain damage. Lancet (1975) 27.39
Two mRNAs can be produced from a single immunoglobulin mu gene by alternative RNA processing pathways. Cell (1980) 9.86
Signal transduction and regulation in smooth muscle. Nature (1994) 7.25
Two mRNAs with different 3' ends encode membrane-bound and secreted forms of immunoglobulin mu chain. Cell (1980) 6.32
TNM staging of foregut (neuro)endocrine tumors: a consensus proposal including a grading system. Virchows Arch (2006) 5.86
A national evaluation of specialists' clinics in primary care settings. Br J Gen Pract (2001) 5.28
Signal transduction by G-proteins, rho-kinase and protein phosphatase to smooth muscle and non-muscle myosin II. J Physiol (2000) 5.24
Ionized calcium concentrations in squid axons. J Gen Physiol (1976) 4.76
Calcium release and ionic changes in the sarcoplasmic reticulum of tetanized muscle: an electron-probe study. J Cell Biol (1981) 4.42
Electromechanical and pharmacomechanical coupling in vascular smooth muscle. J Pharmacol Exp Ther (1968) 4.28
TNM staging of midgut and hindgut (neuro) endocrine tumors: a consensus proposal including a grading system. Virchows Arch (2007) 3.89
A Study of the Variations in the Chemical Composition of Normal Human Colostrum and Early Milk. Biochem J (1927) 3.72
A study of the composition of human milk in the later periods of lactation and a comparison with that of early milk. Biochem J (1930) 3.65
TRAPP, a highly conserved novel complex on the cis-Golgi that mediates vesicle docking and fusion. EMBO J (1998) 3.49
Vascular smooth muscle. I. Normal structure, pathology, biochemistry, and biophysics. Pharmacol Rev (1968) 3.46
Mucinous cystic tumors of the pancreas: clinicopathological features, prognosis, and relationship to other mucinous cystic tumors. Am J Surg Pathol (1999) 3.36
Specific microRNAs are downregulated in human thyroid anaplastic carcinomas. Oncogene (2007) 3.29
Sarcoplasmic reticulum and excitation-contraction coupling in mammalian smooth muscles. J Cell Biol (1972) 3.28
Antipyrylazo III, a "middle range" Ca2+ metallochromic indicator. Biochemistry (1978) 2.96
A study of the antenatal secretion of the human mammary gland and a comparison between this and the secretion obtained directly after birth. Biochem J (1935) 2.89
Receptor-coupled, permeabilized smooth muscle. Role of the phosphatidylinositol cascade, G-proteins, and modulation of the contractile response to Ca2+. J Biol Chem (1989) 2.81
Kinetics of smooth and skeletal muscle activation by laser pulse photolysis of caged inositol 1,4,5-trisphosphate. Nature (1987) 2.74
Genetic profile of 22 pancreatic carcinoma cell lines. Analysis of K-ras, p53, p16 and DPC4/Smad4. Virchows Arch (2001) 2.73
G-protein-mediated Ca2+ sensitization of smooth muscle contraction through myosin light chain phosphorylation. J Biol Chem (1991) 2.69
L-type voltage-gated Ca2+ channels modulate expression of smooth muscle differentiation marker genes via a rho kinase/myocardin/SRF-dependent mechanism. Circ Res (2004) 2.55
Golgi organelle response to the antibiotic X537A. J Cell Biol (1975) 2.41
Myosin light chain kinase functions downstream of Ras/ERK to promote migration of urokinase-type plasminogen activator-stimulated cells in an integrin-selective manner. J Cell Biol (1999) 2.35
Quantitative electron probe microanalysis of biological thin sections: methods and validity. Ultramicroscopy (1977) 2.32
Vascular smooth muscle. II. Pharmacology of normal and hypotensive vessels. Pharmacol Rev (1970) 2.31
Cytosolic heparin inhibits muscarinic and alpha-adrenergic Ca2+ release in smooth muscle. Physiological role of inositol 1,4,5-trisphosphate in pharmacomechanical coupling. J Biol Chem (1989) 2.30
Short Form 36 (SF-36) Health Survey questionnaire: which normative data should be used? Comparisons between the norms provided by the Omnibus Survey in Britain, the Health Survey for England and the Oxford Healthy Life Survey. J Public Health Med (1999) 2.29
Smooth muscle differentiation marker gene expression is regulated by RhoA-mediated actin polymerization. J Biol Chem (2001) 2.28
Elemental distribution in striated muscle and the effects of hypertonicity. Electron probe analysis of cryo sections. J Cell Biol (1977) 2.26
Intracellular calcium buffering capacity in isolated squid axons. J Gen Physiol (1977) 2.26
A direct analysis of lamellar x-ray diffraction from hydrated oriented multilayers of fully functional sarcoplasmic reticulum. Biophys J (1977) 2.26
G protein-mediated inhibition of myosin light-chain phosphatase in vascular smooth muscle. Proc Natl Acad Sci U S A (1991) 2.21
Calcium content of mitochondria and endoplasmic reticulum in liver frozen rapidly in vivo. Nature (1985) 2.21
Intranuclear defect in beta-globin mRNA accumulation due to a premature translation termination codon. Blood (1984) 2.20
Regulation of cellular magnesium. Front Biosci (2000) 2.19
Infection with Pseudomonas cepacia in chronic granulomatous disease: role of nonoxidative killing by neutrophils in host defense. J Infect Dis (1994) 2.12
Free-calcium and force transients during depolarization and pharmacomechanical coupling in guinea-pig smooth muscle. J Physiol (1988) 2.11
Evaluation of specialists' outreach clinics in general practice in England: process and acceptability to patients, specialists, and general practitioners. J Epidemiol Community Health (1997) 2.10
Electron probe analysis of vascular smooth muscle. Composition of mitochondria, nuclei, and cytoplasm. J Cell Biol (1979) 2.06
Decreased SLIM1 expression and increased gelsolin expression in failing human hearts measured by high-density oligonucleotide arrays. Circulation (2000) 2.04
Filament organization in vertebrate smooth muscle. Philos Trans R Soc Lond B Biol Sci (1973) 2.02
Dilated cardiomyopathy in homozygous myosin-binding protein-C mutant mice. J Clin Invest (1999) 2.02
The contractile apparatus of vascular smooth muscle: intermediate high voltage stereo electron microscopy. J Mol Biol (1975) 2.01
Internal pH of isolated chromaffin vesicles. J Biol Chem (1976) 2.00
Regulation of cell magnesium. Arch Biochem Biophys (1992) 1.90
Identification of the endogenous smooth muscle myosin phosphatase-associated kinase. Proc Natl Acad Sci U S A (2001) 1.89
Mechanisms for intracellular calcium regulation in heart. I. Stopped-flow measurements of Ca++ uptake by cardiac mitochondria. J Gen Physiol (1973) 1.89
The giant cardiac membrane patch method: stimulation of outward Na(+)-Ca2+ exchange current by MgATP. J Physiol (1992) 1.89
Release and recycling of calcium by the sarcoplasmic reticulum in guinea-pig portal vein smooth muscle. J Physiol (1984) 1.88
Role of guanine nucleotide-binding proteins--ras-family or trimeric proteins or both--in Ca2+ sensitization of smooth muscle. Proc Natl Acad Sci U S A (1996) 1.87
AKT1(E17K) in human solid tumours. Oncogene (2008) 1.87
Effects of cytochaslasin B and colcemide on myogenic cultures. Proc Natl Acad Sci U S A (1975) 1.86
Satisfying solutions? A review of some unresolved issues in the measurement of patient satisfaction. J Adv Nurs (1995) 1.85
Bridging structures spanning the junctioning gap at the triad of skeletal muscle. J Cell Biol (1979) 1.80
The effect of calcium ionophores on fragmented sarcoplasmic reticulum. J Gen Physiol (1972) 1.79
Myosin light chain phosphatase activities and the effects of phosphatase inhibitors in tonic and phasic smooth muscle. J Biol Chem (1992) 1.79
Detection of 31P nuclear magnetic resonance signals in brain by in vivo and freeze-trapped assays. Proc Natl Acad Sci U S A (1978) 1.78
Investigation of the increased incidence of gonorrhoea diagnosed in genitourinary medicine clinics in England, 1994-6. Sex Transm Infect (2000) 1.78
Calcium uptake and membrane potential in mitochondria. Biochemistry (1974) 1.76
Ionized magnesium concentration in axoplasm of dialyzed squid axons. FEBS Lett (1975) 1.76
Purification and characterization of the mammalian myosin light chain phosphatase holoenzyme. The differential effects of the holoenzyme and its subunits on smooth muscle. J Biol Chem (1994) 1.76
The separate profile structures of the functional calcium pump protein and the phospholipid bilayer within isolated sarcoplasmic reticulum membranes determined by X-ray and neutron diffraction. Biochim Biophys Acta (1985) 1.75
Sarcoplasmic reticulum and the temperature-dependent contraction of smooth muscle in calcium-free solutions. J Cell Biol (1971) 1.74
Parallel stimulation of glucose and Mg(2+) accumulation by insulin in rat hearts and cardiac ventricular myocytes. Circ Res (2000) 1.73
Rho-kinase inhibitor retards migration and in vivo dissemination of human prostate cancer cells. Biochem Biophys Res Commun (2000) 1.73
Increased carotid intima-media thickness in children-adolescents, and young adults with a parental history of premature myocardial infarction. Eur Heart J (2002) 1.73
Measurements of cation transport with metallochromic indicators. Methods Enzymol (1979) 1.72
Gene expression profiles of pancreatic cancer and stromal desmoplasia. Oncogene (2001) 1.68
Arachidonic acid inhibits myosin light chain phosphatase and sensitizes smooth muscle to calcium. J Biol Chem (1992) 1.67
Equity in access to exercise tolerance testing, coronary angiography, and coronary artery bypass grafting by age, sex and clinical indications. Heart (2001) 1.66
TNM staging of neoplasms of the endocrine pancreas: results from a large international cohort study. J Natl Cancer Inst (2012) 1.65