Published in Nature on December 17, 1983
The influence of intracellular calcium concentration on degranulation of dialysed mast cells from rat peritoneum. J Physiol (1988) 3.03
Gaining access to the cytosol: the technique and some applications of electropermeabilization. Biochem J (1986) 3.00
Inositol trisphosphate-induced calcium release and contraction in vascular smooth muscle. Proc Natl Acad Sci U S A (1985) 2.89
Pertussis toxin inhibits fMet-Leu-Phe- but not phorbol ester-stimulated changes in rabbit neutrophils: role of G proteins in excitation response coupling. Proc Natl Acad Sci U S A (1985) 2.05
Fc receptor-mediated phagocytosis occurs in macrophages at exceedingly low cytosolic Ca2+ levels. J Cell Biol (1988) 1.95
Deduced primary structure of the alpha subunit of the GTP-binding stimulatory protein of adenylate cyclase. Proc Natl Acad Sci U S A (1986) 1.86
Pertussis toxin does not inhibit muscarinic-receptor-mediated phosphoinositide hydrolysis or calcium mobilization. Biochem J (1985) 1.83
Two G-proteins act in series to control stimulus-secretion coupling in mast cells: use of neomycin to distinguish between G-proteins controlling polyphosphoinositide phosphodiesterase and exocytosis. J Cell Biol (1987) 1.75
A guanine nucleotide-binding protein mediates the inhibition of voltage-dependent calcium current by somatostatin in a pituitary cell line. Proc Natl Acad Sci U S A (1986) 1.62
Pertussis toxin inhibits chemotactic peptide-stimulated generation of inositol phosphates and lysosomal enzyme secretion in human leukemic (HL-60) cells. Proc Natl Acad Sci U S A (1985) 1.59
Chemotactic peptide activation of human neutrophils and HL-60 cells. Pertussis toxin reveals correlation between inositol trisphosphate generation, calcium ion transients, and cellular activation. J Clin Invest (1985) 1.58
Pertussis toxin inhibition of chemotactic factor-induced calcium mobilization and function in human polymorphonuclear leukocytes. J Exp Med (1985) 1.54
Regulation of P2y-purinoceptor-mediated prostacyclin release from human endothelial cells by cytoplasmic calcium concentration. Br J Pharmacol (1988) 1.48
Adenosine triphosphate stimulates inositol phospholipid metabolism and prostacyclin formation in adrenal medullary endothelial cells by means of P2-purinergic receptors. Proc Natl Acad Sci U S A (1987) 1.48
Extracellular ATP induces a large nonselective conductance in macrophage plasma membranes. Proc Natl Acad Sci U S A (1988) 1.46
Regulation of cortical vesicle exocytosis in sea urchin eggs by inositol 1,4,5-trisphosphate and GTP-binding protein. J Cell Biol (1986) 1.43
Transition from metaphase to anaphase is accompanied by local changes in cytoplasmic free calcium in Pt K2 kidney epithelial cells. Proc Natl Acad Sci U S A (1986) 1.40
Differential control of azurophilic and specific granule exocytosis in Sendai-virus-permeabilized rabbit neutrophils. J Physiol (1987) 1.37
Muscarinic-receptor-mediated changes in intracellular Ca2+ and inositol 1,4,5-trisphosphate mass in a human neuroblastoma cell line, SH-SY5Y. Biochem J (1990) 1.29
ATP-induced pore formation in the plasma membrane of rat peritoneal mast cells. J Gen Physiol (1990) 1.29
The effect of GTP on inositol 1,4,5-trisphosphate-stimulated Ca2+ efflux from a rat liver microsomal fraction. Is a GTP-dependent protein phosphorylation involved? Biochem J (1986) 1.28
Simultaneous measurements of cytosolic calcium and secretion in single bovine adrenal chromaffin cells by fluorescent imaging of fura-2 in cocultured cells. J Cell Biol (1989) 1.27
Guanine nucleotide regulation of agonist binding to muscarinic cholinergic receptors. Relation to efficacy of agonists for stimulation of phosphoinositide breakdown and Ca2+ mobilization. Biochem J (1985) 1.27
Guanine nucleotide-induced polymerization of actin in electropermeabilized human neutrophils. J Cell Biol (1989) 1.21
Role of calcium and phosphoinositides in the actions of certain hormones and neurotransmitters. J Clin Invest (1985) 1.21
Platelet activating factor and U44069 stimulate a GTPase activity in human platelets which is distinct from the guanine nucleotide regulatory proteins, Ns and Ni. Biochem J (1986) 1.21
Guanine nucleotides stimulate production of inositol trisphosphate in rat cortical membranes. Biochem J (1985) 1.19
Extracellular ATP causes lysis of mouse thymocytes and activates a plasma membrane ion channel. Biochem J (1991) 1.17
Pertussis toxin differentiates between two mechanisms of attenuation of cyclic AMP accumulation by muscarinic cholinergic receptors. Proc Natl Acad Sci U S A (1984) 1.16
Exocytosis in mast cells by basic secretagogues: evidence for direct activation of GTP-binding proteins. J Cell Biol (1990) 1.16
Guanine nucleotide-dependent pertussis-toxin-insensitive stimulation of inositol phosphate formation by carbachol in a membrane preparation from human astrocytoma cells. Biochem J (1986) 1.15
Thrombin, unlike vasopressin, appears to stimulate two distinct guanine nucleotide regulatory proteins in human platelets. Biochem J (1986) 1.13
Studies on the receptor mediating cyclic AMP-independent enhancement by adenosine of IgE-dependent mediator release from rat mast cells. Br J Pharmacol (1986) 1.07
NIH-3T3 cells transformed by the EJ-ras oncogene exhibit reduced platelet-derived growth factor-mediated Ca2+ mobilization. Proc Natl Acad Sci U S A (1988) 1.04
Antagonist effects on human P2X(7) receptor-mediated cellular accumulation of YO-PRO-1. Br J Pharmacol (2000) 1.02
Cholera toxin potentiates IgE-coupled inositol phospholipid hydrolysis and mediator secretion by RBL-2H3 cells. Proc Natl Acad Sci U S A (1988) 1.01
Synergistic signals in the mechanism of antigen-induced exocytosis in 2H3 cells: evidence for an unidentified signal required for histamine release. J Cell Biol (1987) 1.01
Sensitization of regulated exocytosis by protein kinase C. Proc Natl Acad Sci U S A (2002) 1.00
Guanine nucleotide binding protein involved in muscarinic responses in the pig coronary artery is insensitive to islet-activating protein. Biochem J (1986) 0.99
Guanosine 5'-[beta-thio]triphosphate selectively activates calcium signaling in mast cells. Proc Natl Acad Sci U S A (1991) 0.98
Further evidence that muscarinic cholinergic receptors of 1321N1 astrocytoma cells couple to a guanine nucleotide regulatory protein that is not Ni. Biochem J (1985) 0.97
Stimulation of exocytosis without a calcium signal. J Physiol (1999) 0.97
Different effects of phorbol ester on angiotensin II- and stable GTP analogue-induced activation of polyphosphoinositide phosphodiesterase in membranes isolated from rat renal mesangial cells. Biochem J (1987) 0.97
Is a guanine nucleotide-binding protein involved in excitation-contraction coupling in skeletal muscle? EMBO J (1986) 0.97
Regulation of anaphase chromosome motion in Tradescantia stamen hair cells by calcium and related signaling agents. J Cell Biol (1990) 0.96
Cytosolic free calcium and cell spreading decrease in fibroblasts from aged and Alzheimer donors. Proc Natl Acad Sci U S A (1986) 0.94
Short-term desensitization of guinea-pig taenia caecum induced by carbachol occurs at intracellular Ca stores and that by histamine at H1-receptors. Br J Pharmacol (1988) 0.94
Characterization of the cytotoxic effect of extracellular ATP in J774 mouse macrophages. Biochem J (1992) 0.92
The phosphoinositides exist in multiple metabolic pools in rabbit platelets. Biochem J (1986) 0.92
Time-dependent conversion of alpha 1- to beta-adrenoceptor-mediated glycogenolysis in isolated rat liver cells: role of membrane phospholipase A2. Proc Natl Acad Sci U S A (1984) 0.88
Muscarinic-agonist and guanine nucleotide activation of polyphosphoinositide phosphodiesterase in isolated islet-cell membranes. Biochem J (1986) 0.88
Neomycin is a potent secretagogue of mast cells that directly activates a GTP-binding protein involved in exocytosis. J Cell Biol (1990) 0.88
Role of G-proteins in T cell activation: non-hydrolysable GTP analogues induce early ornithine decarboxylase activity in human T lymphocytes. EMBO J (1986) 0.87
Some characteristics of Ca2+- regulated force production in EGTA-treated muscles from rat heart. J Gen Physiol (1984) 0.87
Bradykinin-activated membrane-associated phospholipase C in Madin-Darby canine kidney cells. J Clin Invest (1988) 0.85
Histamine and a guanine nucleotide increase calcium permeability in pig aortic microsomal fractions. Biochem J (1990) 0.85
Characterization of G1 transit induced by the mitogenic-oncogenic viral Ki-ras gene product. Mol Cell Biol (1986) 0.84
Thyrotropin-releasing hormone stimulates GTP hydrolysis by membranes from GH4C1 rat pituitary tumor cells. Proc Natl Acad Sci U S A (1984) 0.82
Guanine nucleotide regulation of [3H]vasopressin binding to liver plasma membranes and solubilized receptors. Evidence for the involvement of a guanine nucleotide regulatory protein. Biochem J (1986) 0.82
Regulation of retinal transducin by C-terminal peptides of rhodopsin. Biochem J (1985) 0.81
Rat basophilic leukaemia (RBL) cells overexpressing Rab3a have a reversible block in antigen-stimulated exocytosis. Biochem J (1997) 0.80
Action of guanosine 5'-[beta-thio]diphosphate on thrombin-induced activation and Ca2+ mobilization in saponin-permeabilized and intact human platelets. Biochem J (1988) 0.80
Inhibition of prostaglandin E2-induced phosphoinositide metabolism by phorbol ester in bovine adrenal chromaffin cells. Biochem J (1988) 0.79
Effects of botulinum toxin type D on secretion of tumor necrosis factor from human monocytes. Mol Cell Biol (1989) 0.79
ATP-induced P2X Receptor-Dependent Large Pore Formation: How Much Do We Know? Front Pharmacol (2016) 0.78
Evidence that guanosine 5'-[gamma-thio]triphosphate stimulates plasma membrane Ca2+ inflow when introduced into hepatocytes. Biochem J (1989) 0.78
Fluorescence-activated sorting of rat hepatocytes based on their mixed function oxidase activities towards diethoxyfluorescein. Biochem J (1987) 0.78
Inhibition of luteinizing-hormone exocytosis by guanosine 5'-[gamma-thio]triphosphate reveals involvement of a GTP-binding protein distal to second-messenger generation. Biochem J (1991) 0.77
Micromolar free calcium exposes ouabain-binding sites in digitonin-permeabilized Xenopus laevis oocytes. Biochem J (1990) 0.77
Effect of cholera toxin on histamine release from bone marrow-derived mouse mast cells. Proc Natl Acad Sci U S A (1988) 0.77
Exocytosis: the role of Ca2+, GTP and ATP as regulators and modulators in the rat mast cell model. J Exp Pathol (Oxford) (1990) 0.76
Somatostatin alters beta-adrenergic receptor-effector coupling in cultured rat astrocytes. EMBO J (1985) 0.76
Thyroliberin action in pituitary cells is not inhibited by pertussis toxin. Biochem J (1986) 0.75
Calcium ionophores and movement of calcium ions following the physiological stimulus to a secretory process. Nature (1973) 6.09
Capacitance measurements reveal stepwise fusion events in degranulating mast cells. Nature (1985) 5.41
Role of guanine nucleotide binding protein in the activation of polyphosphoinositide phosphodiesterase. Nature (1985) 5.10
Two roles for guanine nucleotides in the stimulus-secretion sequence of neutrophils. Nature (1986) 2.50
ATP induces nucleotide permeability in rat mast cells. Nature (1979) 2.05
Essential synergy between Ca2+ and guanine nucleotides in exocytotic secretion from permeabilized rat mast cells. J Cell Biol (1987) 2.05
A possible role for cyclic AMP in the regulation of histamine secretion and the action of cromoglycate. Biochem Pharmacol (1975) 1.80
Two G-proteins act in series to control stimulus-secretion coupling in mast cells: use of neomycin to distinguish between G-proteins controlling polyphosphoinositide phosphodiesterase and exocytosis. J Cell Biol (1987) 1.75
Activation and inhibition of calcium-dependent histamine secretion by ATP ions applied to rat mast cells. J Physiol (1979) 1.70
The ATP4- receptor of rat mast cells. Biochem J (1980) 1.67
Rat mast cells permeabilised with streptolysin O secrete histamine in response to Ca2+ at concentrations buffered in the micromolar range. Biochim Biophys Acta (1987) 1.63
Use of cytochalasin B to distinguish between early and late events in neutrophil activation. Biochim Biophys Acta (1980) 1.56
Rat mast cells permeabilized with ATP secrete histamine in response to calcium ions buffered in the micromolar range. J Physiol (1981) 1.52
Stimulus-secretion coupling in rabbit neutrophils is not mediated by phosphatidylinositol breakdown. Nature (1980) 1.47
Evidence for a role of phosphatidylinositol turnover in stimulus-secretion coupling. Studies with rat peritoneal mast cells. Biochem J (1979) 1.47
Effect of flavone inhibitors of transport ATPases on histamine secretion from rat mast cells. Nature (1977) 1.43
The dependence on Ca2+ of phosphatidylinositol breakdown and enzyme secretion in rabbit neutrophils stimulated by formylmethionyl-leucylphenylalanine or ionomycin. Biochem J (1981) 1.41
Differential control of azurophilic and specific granule exocytosis in Sendai-virus-permeabilized rabbit neutrophils. J Physiol (1987) 1.37
Techniques and concepts in exocytosis: focus on mast cells. Biochim Biophys Acta (1991) 1.37
Quercetin: a novel inhibitor of Ca2+ influx and exocytosis in rat peritoneal mast cells. Biochim Biophys Acta (1977) 1.37
Ionomycin stimulates mast cell histamine secretion by forming a lipid-soluble calcium complex. Nature (1980) 1.31
Changes in the state of actin during the exocytotic reaction of permeabilized rat mast cells. J Cell Biol (1990) 1.27
Characterisation of the ATP4- receptor that mediates permeabilisation of rat mast cells. Eur J Pharmacol (1988) 1.24
f-MetLeuPhe-induced phosphatidylinositol turnover in rabbit neutrophils is dependent on extracellular calcium. FEBS Lett (1980) 1.21
Protein phosphorylation and the dependence on Ca2+ and GTP-gamma-S for exocytosis from permeabilised mast cells. Cell Signal (1989) 1.20
Breakdown and synthesis of polyphosphoinositides in fMetLeuPhe-stimulated neutrophils. FEBS Lett (1985) 1.18
Soluble proteins as modulators of the exocytotic reaction of permeabilised rat mast cells. J Cell Sci (1989) 1.13
Dual role for guanine nucleotides in stimulus-secretion coupling. Fed Proc (1986) 1.12
Induction of exocytosis from permeabilized mast cells by the guanosine triphosphatases Rac and Cdc42. Mol Biol Cell (1998) 1.07
ATP inhibits onset of exocytosis in permeabilised mast cells. Biosci Rep (1989) 1.07
Intracellular application of guanosine-5'-O-(3-thiotriphosphate) induces exocytotic granule fusion in guinea pig eosinophils. J Exp Med (1990) 1.03
Demonstration of an enzyme variant in a case of congenital methaemoglobinaemia. Br Med J (1967) 1.02
Inhibitory effects of natural flavonoids on secretion from mast cells and neutrophils. Arzneimittelforschung (1981) 1.00
Purification and identification of FOAD-II, a cytosolic protein that regulates secretion in streptolysin-O permeabilized mast cells, as a rac/rhoGDI complex. Mol Biol Cell (1996) 0.99
Rat mast cells permeabilized with Sendai virus secrete histamine in response to Ca2+ buffered in the micromolar range. Biochem J (1983) 0.97
Degranulation of individual mast cells in response to Ca2+ and guanine nucleotides: an all-or-none event. J Cell Biol (1993) 0.97
Guanine nucleotide is essential and Ca2+ is a modulator in the exocytotic reaction of permeabilized rat mast cells. Biochem J (1992) 0.94
ATP-dependent and ATP-independent pathways of exocytosis revealed by interchanging glutamate and chloride as the major anion in permeabilized mast cells. Cell Regul (1990) 0.94
Plasma-membrane location of phosphatidylinositol hydrolysis in rabbit neutrophils stimulated with formylmethionyl-leucylphenylalanine. Biochem J (1982) 0.93
Regulation of exocytosis from rat peritoneal mast cells by G protein beta gamma-subunits. EMBO J (1998) 0.91
Ultrastructural characterization of tannic acid-arrested degranulation of permeabilized guinea pig eosinophils stimulated with GTP-gamma-S. Eur J Cell Biol (1996) 0.90
Nucleotides and divalent cations as effectors and modulators of exocytosis in permeabilized rat mast cells. Philos Trans R Soc Lond B Biol Sci (1992) 0.88
Early events in the activation of Ca2+ dependent secretion: studies with rat peritoneal mast cells. J Physiol (Paris) (1980) 0.86
Evidence for protein dephosphorylation as a permissive step in GTP-gamma-S-induced exocytosis from permeabilized mast cells. Cell Regul (1990) 0.86
Non-T cell-mediated cytolysis of antibody-coated sheep red blood cells requires Mg++ but not Ca++: An argument against a conventional "stimulus-secretion" mechanism for cytolysis. J Immunol (1975) 0.85
Potentiation and inhibition of secretion from neutrophils by phorbol ester. FEBS Lett (1986) 0.85
A survey of GTP-binding proteins and other potential key regulators of exocytotic secretion in eosinophils. Apparent absence of rab3 and vesicle fusion protein homologues. J Cell Sci (1995) 0.85
Cytosol Mg2+ modulates Ca2+ ionophore induced secretion from rabbit neutrophils. FEBS Lett (1983) 0.85
Mechanisms of granule enzyme secretion from permeabilized guinea pig eosinophils. Dependence on Ca2+ and guanine nucleotides. J Immunol (1991) 0.84
Relationship between arachidonate generation and exocytosis in permeabilized mast cells. Biochem J (1990) 0.84
Stimulation of exocytotic degranulation by microinjection of the ras oncogene protein into rat mast cells. Oncogene (1988) 0.83
The relationship between anaphylactic histamine secretion and the permability of the mast cell membrane to calcium. Int Arch Allergy Appl Immunol (1975) 0.83
Modulation of the exocytotic reaction of permeabilised rat mast cells by ATP, other nucleotides and Mg2+. Biochim Biophys Acta (1991) 0.83
Kinetic characterization of guanine-nucleotide-induced exocytosis from permeabilized rat mast cells. Biochem J (1993) 0.82
Practical considerations regarding the use of streptolysin-O as a permeabilising agent for cells in the investigation of exocytosis. Biosci Rep (1996) 0.82
Thirty years of stimulus-secretion coupling: from Ca(2+) toGTP in the regulation of exocytosis. Biochimie (2000) 0.81
Late events in regulated exocytosis. Bioessays (1991) 0.80
Phosphatidylinositol transfer proteins and protein kinase C make separate but non-interacting contributions to the phosphorylation state necessary for secretory competence in rat mast cells. Biochem J (2001) 0.79
A cell-physiological description of GE, a GTP-binding protein that mediates exocytosis. Ciba Found Symp (1993) 0.79
Ionophore monensin induces Na+-dependent secretion from rabbit neutrophils. requirement for intracellular Ca2+ stores. Biochim Biophys Acta (1983) 0.79
Rat mast cells degranulate in response to microinjection of guanine nucleotide. J Cell Sci (1991) 0.79
Inhibition by cromoglycate and some flavonoids of nucleoside diphosphate kinase and of exocytosis from permeabilized mast cells. Br J Pharmacol (1995) 0.78
Mobile carrier ionophores for Fe(II). Biochim Biophys Acta (1977) 0.77
A synthetic ionophore for Ca2+: studies with model and biological systems. Eur J Biochem (1981) 0.77
Detergent solubilisation of the rabbit neutrophil receptor for chemotactic formyl peptides. Eur J Biochem (1983) 0.76
Complex pattern of inhibition by Mg2+ of exocytosis from permeabilised eosinophils. Cell Calcium (1997) 0.76
Adrenocentenary. Nature (1994) 0.75
Vectorial aspects of 2,3-diphospho-D-glycerate: 2-phosphohydrolase in the human red cell membrane. Folia Haematol Int Mag Klin Morphol Blutforsch (1968) 0.75
The time course of phosphorus incorporation in human red cells. Biochim Biophys Acta (1969) 0.75