Published in Nucleic Acids Res on April 25, 1986
Oligonucleotide duplexes containing inosine, 7-deazainosine, tubercidin, nebularine and 7-deazanebularine as substrates for restriction endonucleases HindII, SalI and TaqI. Nucleic Acids Res (1986) 1.31
Real time kinetics of restriction endonuclease cleavage monitored by fluorescence resonance energy transfer. Nucleic Acids Res (1994) 1.25
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A new approach to the synthesis of a protected 2-aminopurine derivative and its incorporation into oligodeoxynucleotides containing the Eco RI and Bam HI recognition sites. Nucleic Acids Res (1988) 1.17
Thymine methyls and DNA-protein interactions. Nucleic Acids Res (1987) 1.13
The synthesis of 2-pyrimidinone nucleosides and their incorporation into oligodeoxynucleotides. Nucleic Acids Res (1989) 1.11
Molecular recognition in the minor groove of the DNA helix. Studies on the synthesis of oligonucleotides and polynucleotides containing 3-deaza-2'-deoxyadenosine. Interaction of the oligonucleotides with the restriction endonuclease EcoRV. Nucleic Acids Res (1990) 1.08
Analysis of the recognition mechanism involved in the EcoRV catalyzed cleavage of DNA using modified oligodeoxynucleotides. Nucleic Acids Res (1988) 1.08
Synthesis of decadeoxyribonucleotides containing 5-modified uracils and their interactions with restriction endonucleases Bgl II, Sau 3AI and Mbo I (nucleosides and nucleotides 82). Nucleic Acids Res (1988) 0.87
Solid-phase methods for sequencing nucleic acids. VIII. CCS paper-supported degradation of oligodeoxyribonucleotides containing 2'-deoxytubercidin. Nucleic Acids Res (1988) 0.83
Some restriction endonucleases tolerate single mismatches of the pyrimidine.purine type. Nucleic Acids Res (1990) 0.80
Sequence-dependent effects on DNA stability resulting from guanosine replacements by inosine. Nucleic Acids Res (1994) 0.79
Enzymatic cleavage of type II restriction endonucleases on the 2'-O-methyl nucleotide and phosphorothioate substituted DNA. PLoS One (2013) 0.76
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Ultrafast sequencing of oligodeoxyribonucleotides by FAB-mass spectrometry. Nucleic Acids Res (1982) 1.53
Solid-phase methods for sequencing of nucleic acids I. Simultaneous sequencing of different oligodeoxyribonucleotides using a new, mechanically stable anion-exchange paper. Nucleic Acids Res (1985) 1.44
Interaction of EcoRII restriction and modification enzymes with synthetic DNA fragments. VI. The binding and cleavage of substrates containing nucleotide analogs. Nucleic Acids Res (1985) 1.40
The effects of substituted pyrimidines in DNAs on cleavage by sequence-specific endonucleases. J Biol Chem (1979) 1.38
Purification and crystallization of the EcoRV restriction endonuclease. J Biol Chem (1985) 1.37
The influence of sequences adjacent to the recognition site on the cleavage of oligodeoxynucleotides by the EcoRI endonuclease. Eur J Biochem (1984) 1.30
Cleavage of Nonglucosylated Bacteriophage T4 deoxyribonucleic acid by Restriction Endonuclease Eco RI. J Biol Chem (1975) 1.15
Role of the 2-amino group of deoxyguanosine in sequence recognition by EcoRI restriction and modification enzymes. J Biol Chem (1977) 1.14
A comparison of the structural requirements for DNA cleavage by the isoschizomers HaeIII, BspRI and BsuRI. Eur J Biochem (1985) 1.14
Digestion of 5-bromodeoxyuridine-substituted lambda-DNA by restriction endonucleases. J Biol Chem (1978) 1.14
Preferential site-dependent cleavage by restriction endonuclease PstI. Nucleic Acids Res (1982) 1.08
EcoRI cleavage and methylation of DNAs containing modified pyrimidines in the recogintion sequence. J Biol Chem (1977) 1.08
Site-dependent cleavage of pBR322 DNA by restriction endonuclease HinfI. Nucleic Acids Res (1983) 1.03
Sequence-specific responses of restriction endonucleases to bromodeoxyuridine substitution in mammalian DNA. Nucleic Acids Res (1983) 1.00
Recognition by restriction endonuclease EcoRI of deoxyoctanucleotides containing modified sugar moieties. Eur J Biochem (1984) 0.99
Influence of uracil defect on DNA structure: 1H NMR investigation at 500 MHz. Nucleic Acids Res (1985) 0.92
Conformation in aqueous medium of the neutral, protonated and anionic forms of 9-beta-D-arabinofuranosyladenine. Biochim Biophys Acta (1976) 0.86
Initial sequencing and analysis of the human genome. Nature (2001) 212.86
Predicting DNA duplex stability from the base sequence. Proc Natl Acad Sci U S A (1986) 21.73
Isolation and direct complete nucleotide determination of entire genes. Characterization of a gene coding for 16S ribosomal RNA. Nucleic Acids Res (1989) 19.85
Molecular cloning of the plasmid RP4 primase region in a multi-host-range tacP expression vector. Gene (1986) 13.92
Detection and identification of mycobacteria by amplification of rRNA. J Clin Microbiol (1990) 12.41
A physical map of the human genome. Nature (2001) 12.39
The DNA sequence of human chromosome 21. Nature (2000) 10.66
The genome of the social amoeba Dictyostelium discoideum. Nature (2005) 9.18
Cyclin/PCNA is the auxiliary protein of DNA polymerase-delta. Nature (1987) 8.28
Activating Smoothened mutations in sporadic basal-cell carcinoma. Nature (1998) 7.43
Mice lacking alpha-synuclein display functional deficits in the nigrostriatal dopamine system. Neuron (2000) 6.92
Molecular basis of symbiosis between Rhizobium and legumes. Nature (1997) 6.66
Right ventricular dysplasia: a report of 24 adult cases. Circulation (1982) 6.54
Bisulfite genomic sequencing: systematic investigation of critical experimental parameters. Nucleic Acids Res (2001) 5.89
The tumour-suppressor gene patched encodes a candidate receptor for Sonic hedgehog. Nature (1996) 5.69
Beta-COP, a 110 kd protein associated with non-clathrin-coated vesicles and the Golgi complex, shows homology to beta-adaptin. Cell (1991) 5.10
Sequence and analysis of chromosome 4 of the plant Arabidopsis thaliana. Nature (1999) 5.03
Sensitization of T cells to CD95-mediated apoptosis by HIV-1 Tat and gp120. Nature (1995) 4.95
Pseudoautosomal deletions encompassing a novel homeobox gene cause growth failure in idiopathic short stature and Turner syndrome. Nat Genet (1997) 4.95
A yeast nucleolar protein related to mammalian fibrillarin is associated with small nucleolar RNA and is essential for viability. EMBO J (1989) 4.91
Nibrin, a novel DNA double-strand break repair protein, is mutated in Nijmegen breakage syndrome. Cell (1998) 4.72
DNA sequences required for regulated expression of beta-globin genes in murine erythroleukemia cells. Cell (1984) 4.42
Genome sequence, comparative analysis, and population genetics of the domestic horse. Science (2009) 4.41
DNA sequence and comparative analysis of chimpanzee chromosome 22. Nature (2004) 4.12
Renal and neuronal abnormalities in mice lacking GDNF. Nature (1996) 4.06
Homology of 54K protein of signal-recognition particle, docking protein and two E. coli proteins with putative GTP-binding domains. Nature (1989) 4.05
Positional cloning of the gene for X-linked retinitis pigmentosa 2. Nat Genet (1998) 4.01
Toward a catalog of human genes and proteins: sequencing and analysis of 500 novel complete protein coding human cDNAs. Genome Res (2001) 3.97
GDNF: a potent survival factor for motoneurons present in peripheral nerve and muscle. Science (1994) 3.63
The liver-specific transcription factor LF-B1 contains a highly diverged homeobox DNA binding domain. Cell (1989) 3.51
Inducible expression vectors incorporating the Escherichia coli atpE translational initiation region. Gene (1987) 3.46
The return of Phineas Gage: clues about the brain from the skull of a famous patient. Science (1994) 3.40
FGF and Shh signals control dopaminergic and serotonergic cell fate in the anterior neural plate. Cell (1998) 3.33
Regulation of fast inactivation of cloned mammalian IK(A) channels by cysteine oxidation. Nature (1991) 3.30
DNA chain length markers and the influence of base composition on electrophoretic mobility of oligodeoxyribonucleotides in polyacrylamide-gels. Nucleic Acids Res (1979) 3.17
Sequence requirements for the transcription of the rabbit beta-globin gene in vivo: the -80 region. Nucleic Acids Res (1982) 3.11
Synthesis and characterization of an octanucleotide containing the EcoRI recognition sequence with a phosphorothioate group at the cleavage site. Biochemistry (1984) 3.03
Topical ketorolac tromethamine 0.5% ophthalmic solution in ocular inflammation after cataract surgery. Ophthalmology (2001) 3.01
Characterization of a multicomponent receptor for GDNF. Nature (1996) 2.92
Drinks like a fish: zebra fish (Danio rerio) as a behavior genetic model to study alcohol effects. Pharmacol Biochem Behav (2000) 2.83
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Cloned neuronal IK(A) channels reopen during recovery from inactivation. Nature (1991) 2.65
Purification of a NF1-like DNA-binding protein from rat liver and cloning of the corresponding cDNA. EMBO J (1988) 2.60
Partial purification and characterization of early and late endosomes from yeast. Identification of four novel proteins. J Biol Chem (1993) 2.55
X-linked spastic paraplegia (SPG1), MASA syndrome and X-linked hydrocephalus result from mutations in the L1 gene. Nat Genet (1994) 2.53
An L-type calcium-channel gene mutated in incomplete X-linked congenital stationary night blindness. Nat Genet (1998) 2.48
A new general approach for the simultaneous chemical synthesis of large numbers of oligonucleotides: segmental solid supports. Nucleic Acids Res (1983) 2.48
N-myc downstream-regulated gene 1 is mutated in hereditary motor and sensory neuropathy-Lom. Am J Hum Genet (2000) 2.47
Flexural rigidity of microtubules measured with the use of optical tweezers. J Cell Sci (1996) 2.44
Clinical pharmacology and therapeutic applications of the antiarrhythmic agent amiodarone. Am Heart J (1981) 2.41
Expression in rat fibroblasts of a human transforming growth factor-alpha cDNA results in transformation. Cell (1986) 2.41
Noninvasive tests in the initial evaluation of heart murmurs in children. N Engl J Med (1983) 2.39
Evidence of apoptosis in arrhythmogenic right ventricular dysplasia. N Engl J Med (1996) 2.37
GFRalpha1 is an essential receptor component for GDNF in the developing nervous system and kidney. Neuron (1998) 2.34
Continuous subcutaenous administration of deferoxamine in patients with iron overload. N Engl J Med (1977) 2.31
Simian immunodeficiency virus disease course is predicted by the extent of virus replication during primary infection. J Virol (1999) 2.29
Efficient construction of cDNA libraries in plasmid expression vectors using an adaptor strategy. Nucleic Acids Res (1986) 2.28
Interrupted aortic arch: surgical treatment. Am J Cardiol (1971) 2.24
Mutations in a new gene, encoding a zinc-finger protein, cause tricho-rhino-phalangeal syndrome type I. Nat Genet (2000) 2.23
Translation arrest by oligodeoxynucleotides complementary to mRNA coding sequences yields polypeptides of predetermined length. Nucleic Acids Res (1986) 2.21
Sequence and analysis of chromosome 3 of the plant Arabidopsis thaliana. Nature (2000) 2.17
Molecular characterization of a common fragile site (FRA7H) on human chromosome 7 by the cloning of a simian virus 40 integration site. Proc Natl Acad Sci U S A (1998) 2.16
The disabled 1 phosphotyrosine-binding domain binds to the internalization signals of transmembrane glycoproteins and to phospholipids. Mol Cell Biol (1999) 2.15
Detection of paroxysmal atrial fibrillation with transtelephonic EKG in TIA or stroke patients. Neurology (2010) 2.14
Molecular interaction between the Strep-tag affinity peptide and its cognate target, streptavidin. J Mol Biol (1996) 2.10
Discovery of new human beta-defensins using a genomics-based approach. Gene (2001) 2.08
Molecular characterization of two-component systems of Helicobacter pylori. J Bacteriol (2000) 2.08
Induction of midbrain dopaminergic neurons by Sonic hedgehog. Neuron (1995) 2.08
A genome-wide survey of RAS transformation targets. Nat Genet (2000) 2.06
Specificity determinants of substrate recognition by the protein kinase DYRK1A. J Biol Chem (2000) 2.05
The serum-inducible mouse gene Krox-24 encodes a sequence-specific transcriptional activator. Mol Cell Biol (1990) 2.04
Neurotrophin-5: a novel neurotrophic factor that activates trk and trkB. Neuron (1991) 2.03
Large-scale methylation analysis of human genomic DNA reveals tissue-specific differences between the methylation profiles of genes and pseudogenes. Hum Mol Genet (2000) 2.02
HIV-1 Tat potentiates TNF-induced NF-kappa B activation and cytotoxicity by altering the cellular redox state. EMBO J (1995) 2.01
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Membrane glycoproteins involved in neurite fasciculation. J Cell Biol (1987) 1.93
Sepsis and congenital asplenia. J Pediatr (1977) 1.93
The nucleotide sequence of Saccharomyces cerevisiae chromosome IV. Nature (1997) 1.92
Assessing depression in primary medical and psychiatric practices. Arch Gen Psychiatry (1985) 1.91
Structure of gene and pseudogenes of human apoferritin H. Nucleic Acids Res (1986) 1.91
Sequence, structure, and evolution of a complete human olfactory receptor gene cluster. Genomics (2000) 1.88
A regulator of transcriptional elongation controls vertebrate neuronal development. Nature (2000) 1.87
The adhesion molecule on glia (AMOG) is a homologue of the beta subunit of the Na,K-ATPase. J Cell Biol (1990) 1.87
Domains of neuronal microtubule-associated proteins and flexural rigidity of microtubules. J Cell Biol (1997) 1.84
Cardiotrophin-1. Biological activities and binding to the leukemia inhibitory factor receptor/gp130 signaling complex. J Biol Chem (1995) 1.83
Three-dimensional in vivo mapping of brain lesions in humans. Arch Neurol (1992) 1.83
Horizontal gene transfer contributes to the wide distribution and evolution of type II restriction-modification systems. J Mol Evol (1996) 1.82
Sonic hedgehog signaling by the patched-smoothened receptor complex. Curr Biol (1999) 1.79
Mesencephalic dopaminergic neurons protected by GDNF from axotomy-induced degeneration in the adult brain. Nature (1995) 1.79
Encircling endocardial ventriculotomy: a new surgical treatment for life-threatening ventricular tachycardias resistant to medical treatment following myocardial infarction. Ann Thorac Surg (1978) 1.77
Activation of expression of hedgehog target genes in basal cell carcinomas. J Invest Dermatol (2001) 1.77