Published in N Engl J Med on December 03, 1981
Advances in chemical carcinogenesis: a historical review and prospective. Cancer Res (2008) 1.83
Genomic hypomethylation and far-5' sequence alterations are associated with carcinogen-induced activation of the hamster thymidine kinase gene. Mol Cell Biol (1986) 1.48
Chemicals, cancer and cancer biology. West J Med (1983) 1.46
Achlorhydria: hypergastrinaemia: carcinoids--a flawed hypothesis? Gut (1987) 1.32
Phthalate esters as peroxisome proliferator carcinogens. Environ Health Perspect (1982) 0.98
Debrisoquine oxidation phenotype and susceptibility to lung cancer. Br J Clin Pharmacol (1990) 0.97
DNA damage related to increased hydrogen peroxide generation by hypolipidemic drug-induced liver peroxisomes. Proc Natl Acad Sci U S A (1984) 0.91
The effects of intracolonic EGF on mucosal growth and experimental carcinogenesis. Br J Cancer (1991) 0.91
Genetic predisposition to lung cancer. Br J Cancer (1990) 0.88
Oral oncoprevention by phytochemicals - a systematic review disclosing the therapeutic dilemma. Adv Pharm Bull (2014) 0.78
Nutrition and cancer. Can Fam Physician (1984) 0.75
Effects of chrysotile co-exposure on BaP binding in normal human fibroblasts. Environ Health Perspect (1983) 0.75
Science and politics: the possible regulation of cancer promoters. Environ Health Perspect (1983) 0.75
Chemical carcinogens: a review of the science and its associated principles. U.S. Interagency Staff Group on Carcinogens. Environ Health Perspect (1986) 0.75
Chemicals and the development of cancer. West J Med (1983) 0.75
Rapid emergence of carcinogen-induced hyperplastic lesions in a new model for the sequential analysis of liver carcinogenesis. Am J Pathol (1977) 2.45
The sequential analysis of cancer development. Adv Cancer Res (1980) 2.28
Cell proliferation is not a major risk factor for cancer. Mod Pathol (1996) 2.05
The multistep nature of cancer development. Cancer Res (1984) 1.93
Hepatocarcinogenesis: a dynamic cellular perspective. Lab Invest (1987) 1.82
Cellular biochemistry of the stepwise development of cancer with chemicals: G. H. A. Clowes memorial lecture. Cancer Res (1984) 1.70
The resistance of putative premalignant liver cell populations, hyperplastic nodules, to the acute cytotoxic effects of some hepatocarcinogens. Cancer Res (1976) 1.58
Studies on the proliferation and fate of oval cells in the liver of rats treated with 2-acetylaminofluorene and partial hepatectomy. Am J Pathol (1984) 1.48
The sequential analysis of liver cancer induction. Biochim Biophys Acta (1980) 1.46
Studies on DNA repair in human lymphocytes treated with proximate carcinogens and alkylating agents. Cancer Res (1971) 1.44
Induction of resistant hepatocytes as a new principle for a possible short-term in vivo test for carcinogens. Cancer Res (1980) 1.42
Carcinogenesis--cellular evolution as a unifying thread: Presidential address. Cancer Res (1973) 1.30
The inhibition of liver ribonucleic acid synthesis by ethionine. J Biol Chem (1966) 1.30
Patterns of transfer RNA in normal rat liver and during hepatic carcinogenesis. Proc Natl Acad Sci U S A (1967) 1.27
Chemical carcinogenesis: a biologic perspective. Am J Pathol (1982) 1.26
A relative deficiency of cytochrome P-450 and aryl hydrocarbon [benzo(a)pyrene] hydroxylase in hyperplastic nodules induced by 2-acetylaminofluorene in rat liver. Cancer Res (1976) 1.26
Ethionine fatty liver. Adv Lipid Res (1967) 1.26
Initiation of chemical carcinogenesis requires cell proliferation. Nature (1978) 1.25
Gamma-glutamyltransferase in putative premalignant liver cell populations during hepatocarcinogenesis. Cancer Res (1978) 1.24
The rapid acceleration of hepatic nuclear ribonucleic acid breakdown by actinomycin but not by ethionine. J Biol Chem (1968) 1.21
Carcinogen-induced mdr overexpression is associated with xenobiotic resistance in rat preneoplastic liver nodules and hepatocellular carcinomas. Proc Natl Acad Sci U S A (1987) 1.21
Differences in growth of transplants of liver, liver hyperplastic nodules, and hepatocellular carcinomas in the mammary fat pad. Am J Pathol (1977) 1.20
Reversal by adenine of the ethionine-induced lipid accumulation in the endoplasmic reticulum of the rat liver. A preliminary report. J Cell Biol (1965) 1.19
On the mechanism of induction of hepatic adenosine triphosphate deficiency by ethionine. J Biol Chem (1966) 1.19
On the molecular pathology of ischemic renal cell death. Reversible and irreversible cellular and mitochondrial metabolic alterations. Am J Pathol (1968) 1.19
Role of acute hepatic necrosis in the induction of early steps in liver carcinogenesis by diethylnitrosamine. Cancer Res (1981) 1.17
Cycloheximide, an inhibitor of peptide chain termination or release in liver in vivo and in vitro. Biochem Biophys Res Commun (1971) 1.17
Pre-cancerous steps in carcinogenesis. Their physiological adaptive nature. Biochim Biophys Acta (1984) 1.16
Biochemistry of carcinogenesis. Cancer Res (1968) 1.15
Intestinal metaplasia as a common option of oval cells in relation to cholangiofibrosis in liver of rats exposed to 2-acetylaminofluorene. Lab Invest (1985) 1.10
The induction of liver cancer by dietary deficiency of choline and methionine without added carcinogens. Carcinogenesis (1984) 1.08
Phenotypic diversity as an early property of putative preneoplastic hepatocyte populations in liver carcinogenesis. Cancer Res (1980) 1.08
ATP and cell integrity. Fed Proc (1973) 1.07
Chemicals, evolution, and cancer development: Rous-Whipple Award Lecture. Am J Pathol (1982) 1.07
The biochemistry of preneoplastic liver: a common metabolic pattern in hepatocyte nodules. Can J Biochem Cell Biol (1984) 1.06
Nonrandom nature of in vivo methylation of dimethylnitrosamine and the subsequent removal of methylated products from rat liver chromatin DNA. Cancer Res (1976) 1.06
Effect of cycloheximide on the cell cycle of the crypts of the small intestine of the rat. J Cell Biol (1967) 1.06
Cellular analysis of liver carcinogenesis: the induction of large hyperplastic nodules in the liver with 2-fluorenylacetamide or ethionine and some aspects of their morphology and glycogen metabolism. Cancer Res (1967) 1.04
Newer insights into the pathogenesis of liver cancer. Am J Pathol (1977) 1.04
Hyperplastic areas, hyperplastic nodules, and hyperbasophilic areas as putative precursor lesions. Cancer Res (1976) 1.03
A common biochemical pattern in preneoplastic hepatocyte nodules generated in four different models in the rat. Cancer Res (1985) 1.02
Molecular pathology of in-vivo inhibition of protein synthesis. Electron microscopy of rat pancreatic acinar cells in puromycin-induced necrosis. Am J Pathol (1968) 1.02
Evidence for ethylation of rat liver deoxyribonucleic acid after administration of ethionine. Biochem J (1971) 0.98
The cancer-initiating potential of the fumonisin B mycotoxins. Carcinogenesis (1992) 0.97
Promotion of liver cancer development by brief exposure to dietary 2-acetylaminofluorene plus partial hepatectomy or carbon tetrachloride. Cancer Res (1983) 0.97
Biochemical pathology. Annu Rev Pharmacol (1971) 0.97
The biochemical pathology of inhibition of protein synthesis in vivo. The effects of cycloheximide on hepatic parenchymal cell ultrastructure. Lab Invest (1969) 0.97
Choline deficiency, lipotrope deficiency and the development of liver disease including liver cancer: a new perspective. Lab Invest (1993) 0.96
The disorganization of hepatic cell nucleoli induced by ethionine and its reversal by adenine. J Cell Biol (1968) 0.96
Kinetics of phenotypic maturation of remodeling of hyperplastic nodules during liver carcinogenesis. Cancer Res (1982) 0.96
In vitro measurement of carcinogen-resistant liver cells during hepatocarcinogenesis. Int J Cancer (1978) 0.95
Acute pancreatic necrosis induced by puromycin. Lab Invest (1967) 0.95
Redifferentiation as a basis for remodeling of carcinogen-induced hepatocyte nodules to normal appearing liver. Cancer Res (1983) 0.95
The effect of cycloheximide on the interaction between mitochondrial respiration and gluconeogenesis in guinea pig and rat liver. J Biol Chem (1973) 0.95
Alternative methods of selecting rat hepatocellular nodules resistant to 2-acetylaminofluorene. Int J Cancer (1987) 0.95
Sequential analysis of hepatic carcinogenesis: a comparative study of the ultrastructure of preneoplastic, malignant, prenatal, postnatal, and regenerating liver. Lab Invest (1979) 0.94
Cell cycle kinetics of rat hepatocytes in early putative preneoplastic lesions in hepatocarcinogenesis. Cancer Res (1984) 0.94
Inhibition of protein synthesis in rat liver by D-galactosamine. Res Commun Chem Pathol Pharmacol (1973) 0.94
Distinctive biochemical pattern associated with resistance of hepatocytes in hepatocyte nodules during liver carcinogenesis. Environ Health Perspect (1983) 0.94
Nature of early appearing, carcinogen-induced liver lesions to iron accumulation. J Natl Cancer Inst (1976) 0.93
Deoxyribonucleoside incorporation and the role of hydroxyurea in a model lymphocyte system for studying DNA repair in carcinogenesis. Cancer Res (1971) 0.93
Sequential alterations in growth control and cell dynamics of rat hepatocytes in early precancerous steps in hepatocarcinogenesis. Cancer Res (1986) 0.93
A probable role for protein synthesis in intestinal epithelial cell damage induced in vivo by cytosine arabinoside, nitrogen mustard, or X-irradiation. Cancer Res (1970) 0.93
The biochemical pathology of ethionine-induced pancreatic damage: ethionine incorporation into proteins, and ATP levels in pancreas of rats. Arch Biochem Biophys (1968) 0.92
The binding of 2-acetylaminofluorene to rat liver ribonucleic acid in vivo. Cancer Res (1965) 0.92
Rapid lipid peroxidation in the nuclear fraction of rat liver induced by a diet deficient in choline and methionine. Cancer Lett (1984) 0.91
Effects of ethionine on adenosine triphosphate levels and ionic composition of liver cell nuclei. J Biol Chem (1968) 0.91
Chordoma: a case report. Surg Neurol (1997) 0.91
Initiation and selection of resistant hepatocyte nodules in rats given the pyrrolizidine alkaloids lasiocarpine and senecionine. Cancer Res (1985) 0.90
Highly selective in vivo ethylation of rat liver nuclear protein by ethionine. Biochem Biophys Res Commun (1969) 0.90
The effects of cycloheximide on energy transfer in rat and guinea pig liver mitochondria. J Biol Chem (1973) 0.90
Sequential analysis of hepatic carcinogenesis: the comparative architecture of preneoplastic, malignant, prenatal, postnatal and regenerating liver. Br J Cancer (1979) 0.90
Multiplicity of induction patterns of rat liver microsomal mono-oxygenases and other polypeptides produced by administration of various xenobiotics. Biochem J (1979) 0.90
Comparison of the blood supply to diethylnitrosamine-induced hyperplastic nodules and hepatomas and to the surrounding liver. Cancer Res (1977) 0.90
Putative precursor lesions: summary and some analytical considerations. Cancer Res (1976) 0.89
Morphologic and metabolic alterations in hepatic cell nucleoli induced by varying doses of actinomycin D. Cancer Res (1969) 0.89
Chemical carcinogenesis: persistence of bound forms of 2-fluorenylacetamide. Science (1968) 0.89
Interaction between ethionine and rat liver ribonucleic acid and protein in vivo. Cancer Res (1967) 0.88
A characteristic electrophoretic pattern of cytosolic polypeptides from hepatocyte nodules generated during liver carcinogenesis in several models. Biochem Biophys Res Commun (1983) 0.88
The effects of inosine and aminoimidazole carboxamide upon the ethionine fatty liver. Biochem Pharmacol (1965) 0.88
Allogeneic hepatocyte transplantation in the rat spleen under cyclosporine immunosuppression. Transplantation (1986) 0.88
A new common marker for premalignant and malignant hepatocytes induced in the rat by chemical carcinogens. J Natl Cancer Inst (1975) 0.88
Dynamics of liver cell injury and repair. I. Spontaneous reformation of the nucleolus and polyribosomes in the presence of extensive cytoplasmic damage induced by ethionine. Lab Invest (1970) 0.87
The rapid induction of liver cell death in rats fed a choline-deficient methionine-low diet. Am J Pathol (1983) 0.87
Localization of alpha-fetoprotein by immunofluorescence in hyperplastic nodules during hepatocarcinogenesis induced by 2-acetylaminofluorene. Cancer Res (1974) 0.86
Inverse relationship between epidermal growth factor induced proliferation and expression of high affinity surface epidermal growth factor receptors in rat hepatocytes. Lab Invest (1989) 0.86
Transitory DNA hypomethylation during liver cell proliferation induced by a single dose of lead nitrate. Arch Biochem Biophys (1991) 0.86
Resistant hepatocytes as early changes in liver induced by polycyclic aromatic hydrocarbons. Int J Cancer (1980) 0.86
Differential effects of hydroxyurea on survival of proliferating cells in vivo. Cancer Res (1969) 0.85
Chemical carcinogenesis: a current biological perspective. Carcinogenesis (1984) 0.85
Gamma-glutamyl transpeptidase: a positive marker for cultured rat liver cells derived from putative premalignant and malignant lesions. J Natl Cancer Inst (1978) 0.85
A choline-devoid diet, carcinogenic in the rat, induces DNA damage and repair. Carcinogenesis (1986) 0.84
Resistance of liver polysomes to ATP deficiency in the male rat. Biochim Biophys Acta (1969) 0.84
Identification of a characteristic cytosolic polypeptide of rat preneoplastic hepatocyte nodules as placental glutathione S-transferase. Biochem Biophys Res Commun (1987) 0.84
Preneoplastic antigen as a marker for endoplasmic reticulum of putative premalignant hepatocytes during liver carcinogenesis. Cancer Res (1977) 0.84
Transfer of viable putative preneoplastic hepatocytes to the livers of syngeneic host rats. J Natl Cancer Inst (1978) 0.84
Chemical carcinogenesis: the liver as a model. Pathol Immunopathol Res (1986) 0.84
Cellular analysis of liver carcinogenesis. 3. Comparison of the ultrastructure of hyperplastic liver nodules and hepatocellular carcinomas induced in rat liver by 2-fluorenylacetamide. J Natl Cancer Inst (1969) 0.84
Pathogenesis of liver cancer. Arch Pathol (1974) 0.84
Evidence for the hormone dependency of hepatic hyperplastic nodules: inhibition of malignant transformation after exogenous 17 beta-estradiol and tamoxifen. Hepatology (1983) 0.84