Published in J Biol Chem on January 15, 1987
GTPase acceleration as the rate-limiting step in Arabidopsis G protein-coupled sugar signaling. Proc Natl Acad Sci U S A (2007) 2.05
Mechanisms of modulation of voltage-dependent calcium channels by G proteins. J Physiol (1998) 1.80
Mechanism of muscarinic receptor-induced K+ channel activation as revealed by hydrolysis-resistant GTP analogues. J Gen Physiol (1988) 1.64
Acute dynamin inhibition dissects synaptic vesicle recycling pathways that drive spontaneous and evoked neurotransmission. J Neurosci (2010) 1.62
Activator of G protein signaling 3 is a guanine dissociation inhibitor for Galpha i subunits. Proc Natl Acad Sci U S A (2000) 1.53
G protein activation without a GEF in the plant kingdom. PLoS Genet (2012) 1.43
Signalling functions and biochemical properties of pertussis toxin-resistant G-proteins. Biochem J (1997) 1.42
The crystal structure of a self-activating G protein alpha subunit reveals its distinct mechanism of signal initiation. Sci Signal (2011) 1.40
The role of G proteins in transmembrane signalling. Biochem J (1990) 1.34
The arflike gene encodes an essential GTP-binding protein in Drosophila. Proc Natl Acad Sci U S A (1991) 1.34
Mechanism of GTP hydrolysis by G-protein alpha subunits. Proc Natl Acad Sci U S A (1994) 1.32
Structural basis for ARF1-mediated recruitment of ARHGAP21 to Golgi membranes. EMBO J (2007) 1.24
Regulation of spontaneous opening of muscarinic K+ channels in rabbit atrium. J Physiol (1991) 1.22
Effects of anions on the G protein-mediated activation of the muscarinic K+ channel in the cardiac atrial cell membrane. Intracellular chloride inhibition of the GTPase activity of GK. J Gen Physiol (1992) 1.15
GTP hydrolysis is not important for Ypt1 GTPase function in vesicular transport. Mol Cell Biol (1998) 1.15
Identification of regulators for Ypt1 GTPase nucleotide cycling. Mol Biol Cell (1998) 1.14
RGS7 and -11 complexes accelerate the ON-bipolar cell light response. Invest Ophthalmol Vis Sci (2009) 1.10
Natural polyamines stimulate G-proteins. Biochem J (1992) 1.10
Specificity of action of guanine nucleotide-binding regulatory protein subunits on the cardiac muscarinic K+ channel. Proc Natl Acad Sci U S A (1988) 1.07
Functional reconstitution of an atypical G protein heterotrimer and regulator of G protein signaling protein (RGS1) from Arabidopsis thaliana. J Biol Chem (2011) 1.06
Receptor kinase-dependent desensitization of the muscarinic K+ current in rat atrial cells. J Physiol (1995) 1.02
ATP binding by proteasomal ATPases regulates cellular assembly and substrate-induced functions of the 26 S proteasome. J Biol Chem (2012) 1.00
Molecular basis of a novel oncogenic mutation in GNAO1. Oncogene (2011) 1.00
Distinct Mg(2+)-dependent steps rate limit opening and closing of a single CFTR Cl(-) channel. J Gen Physiol (2002) 0.98
Dynamin 2 mutants linked to centronuclear myopathies form abnormally stable polymers. J Biol Chem (2010) 0.98
R9AP stabilizes RGS11-G beta5 and accelerates the early light response of ON-bipolar cells. Vis Neurosci (2010) 0.95
A conserved phenylalanine as a relay between the α5 helix and the GDP binding region of heterotrimeric Gi protein α subunit. J Biol Chem (2014) 0.94
Human G(salpha) mutant causes pseudohypoparathyroidism type Ia/neonatal diarrhea, a potential cell-specific role of the palmitoylation cycle. Proc Natl Acad Sci U S A (2007) 0.93
Interactions of the ras-like protein p25rab3A with Mg2+ and guanine nucleotides. Biochem J (1992) 0.92
A recombinant peptide model of the first nucleotide-binding fold of the cystic fibrosis transmembrane conductance regulator: comparison of wild-type and delta F508 mutant forms. Protein Sci (1996) 0.91
Dimeric endophilin A2 stimulates assembly and GTPase activity of dynamin 2. Biophys J (2011) 0.91
Cytotoxic necrotizing factor type 2 produced by pathogenic Escherichia coli deamidates a gln residue in the conserved G-3 domain of the rho family and preferentially inhibits the GTPase activity of RhoA and rac1. Infect Immun (1999) 0.91
Uncoupling conformational change from GTP hydrolysis in a heterotrimeric G protein alpha-subunit. Proc Natl Acad Sci U S A (2004) 0.90
A novel GTP-dependent mechanism of ileal muscarinic metabotropic channel desensitization. Br J Pharmacol (1996) 0.90
Identification of an extracellular motif involved in the binding of guanine nucleotides by a glutamate receptor. EMBO J (1996) 0.89
Expression, purification, and characterization of a novel G protein, SGP, from Streptococcus mutans. Infect Immun (1995) 0.87
GDP release preferentially occurs on the phosphate side in heterotrimeric G-proteins. PLoS Comput Biol (2012) 0.85
Different biochemical properties explain why two equivalent Gα subunit mutants cause unrelated diseases. J Biol Chem (2014) 0.83
Kinetic characterization of guanine-nucleotide-induced exocytosis from permeabilized rat mast cells. Biochem J (1993) 0.82
Attenuation of GTPase activity of recombinant G(o) alpha by peptides representing sequence permutations of mastoparan. Proc Natl Acad Sci U S A (1992) 0.80
Trp fluorescence reveals an activation-dependent cation-pi interaction in the Switch II region of Galphai proteins. Protein Sci (2009) 0.79
Integration of Fourier Transform Infrared Spectroscopy, Fluorescence Spectroscopy, Steady-state Kinetics and Molecular Dynamics Simulations of Gαi1 Distinguishes between the GTP Hydrolysis and GDP Release Mechanism. J Biol Chem (2015) 0.79
High- and low-affinity sites for sodium in δ-OR-Gi1α (Cys (351)-Ile (351)) fusion protein stably expressed in HEK293 cells; functional significance and correlation with biophysical state of plasma membrane. Naunyn Schmiedebergs Arch Pharmacol (2014) 0.79
RGS9 knockout causes a short delay in light responses of ON-bipolar cells. PLoS One (2011) 0.79
Gsalpha contains an unidentified covalent modification that increases its affinity for adenylyl cyclase. Proc Natl Acad Sci U S A (1997) 0.79
Enhancement of dynamin polymerization and GTPase activity by Arc/Arg3.1. Biochim Biophys Acta (2015) 0.77
Invited review: Activation of G proteins by GTP and the mechanism of Gα-catalyzed GTP hydrolysis. Biopolymers (2016) 0.77
Slow inhibition of N-type calcium channels with GTP gamma S reflects the basal G protein-GDP turnover rate. Pflugers Arch (2003) 0.77
A Conserved Hydrophobic Core in Gαi1 Regulates G Protein Activation and Release from Activated Receptor. J Biol Chem (2016) 0.76
Dissociated GαGTP and Gβγ protein subunits are the major activated form of heterotrimeric Gi/o proteins. J Biol Chem (2013) 0.76
Contribution of each Trp residue toward the intrinsic fluorescence of the Giα1 protein. Protein Sci (2014) 0.75
Beta-adrenergic-receptor-mediated dissociation and membrane release of the Gs protein in S49 lymphoma-cell membranes. Dependence on Mg2+ and GTP. Biochem J (1992) 0.75
G proteins: transducers of receptor-generated signals. Annu Rev Biochem (1987) 27.41
A protein binding assay for adenosine 3':5'-cyclic monophosphate. Proc Natl Acad Sci U S A (1970) 23.79
Cyclic adenosine monophosphate and alteration of Chinese hamster ovary cell morphology: a rapid, sensitive in vitro assay for the enterotoxins of Vibrio cholerae and Escherichia coli. Infect Immun (1974) 12.51
G proteins and dual control of adenylate cyclase. Cell (1984) 11.05
The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2. Cell (1995) 7.66
Regulation of axon formation by clonal lines of a neural tumor. Proc Natl Acad Sci U S A (1970) 5.12
GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits. Cell (1996) 4.76
Structure of RGS4 bound to AlF4--activated G(i alpha1): stabilization of the transition state for GTP hydrolysis. Cell (1997) 4.74
Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13. Science (1998) 4.62
Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS. Science (1997) 4.52
Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis. Science (1994) 4.43
p115 RhoGEF, a GTPase activating protein for Galpha12 and Galpha13. Science (1998) 4.32
Signal-dependent membrane targeting by pleckstrin homology (PH) domains. Biochem J (2000) 4.26
Specific and high-affinity binding of inositol phosphates to an isolated pleckstrin homology domain. Proc Natl Acad Sci U S A (1995) 4.10
Homologies between signal transducing G proteins and ras gene products. Science (1984) 3.85
Biochemical properties of hormone-sensitive adenylate cyclase. Annu Rev Biochem (1980) 3.79
G proteins. Trends Biochem Sci (1992) 3.79
Aluminum: a requirement for activation of the regulatory component of adenylate cyclase by fluoride. Proc Natl Acad Sci U S A (1982) 3.73
The protein cofactor necessary for ADP-ribosylation of Gs by cholera toxin is itself a GTP binding protein. J Biol Chem (1986) 3.54
Recombinant G-protein beta gamma-subunits activate the muscarinic-gated atrial potassium channel. Nature (1994) 3.54
PH domains: diverse sequences with a common fold recruit signaling molecules to the cell surface. Cell (1996) 3.35
Purification and characterization of smooth muscle cell caveolae. J Cell Biol (1994) 3.18
Identification of the predominant substrate for ADP-ribosylation by islet activating protein. J Biol Chem (1983) 3.11
The guanine nucleotide activating site of the regulatory component of adenylate cyclase. Identification by ligand binding. J Biol Chem (1982) 3.09
Protein kinase C phosphorylates the inhibitory guanine-nucleotide-binding regulatory component and apparently suppresses its function in hormonal inhibition of adenylate cyclase. Eur J Biochem (1985) 3.04
Type-specific regulation of adenylyl cyclase by G protein beta gamma subunits. Science (1991) 3.00
Relationship between the beta-adrenergic receptor and adenylate cyclase. J Biol Chem (1977) 2.99
Inhibition of receptor-mediated release of arachidonic acid by pertussis toxin. Cell (1984) 2.96
Mammalian membrane-bound adenylyl cyclases. J Biol Chem (1995) 2.93
Myristoylated alpha subunits of guanine nucleotide-binding regulatory proteins. Proc Natl Acad Sci U S A (1987) 2.93
Antisera of designed specificity for subunits of guanine nucleotide-binding regulatory proteins. Proc Natl Acad Sci U S A (1986) 2.87
Purification of the regulatory component of adenylate cyclase. Proc Natl Acad Sci U S A (1980) 2.81
Identification and analysis of PH domain-containing targets of phosphatidylinositol 3-kinase using a novel in vivo assay in yeast. EMBO J (1998) 2.75
Complexity and diversity of mammalian adenylyl cyclases. Annu Rev Pharmacol Toxicol (1996) 2.70
The regulatory component of adenylate cyclase. Purification and properties. J Biol Chem (1981) 2.69
Crystal structure of the adenylyl cyclase activator Gsalpha. Science (1997) 2.68
Reconstitution of hormone-sensitive adenylate cyclase activity with resolved components of the enzyme. J Biol Chem (1978) 2.64
Tertiary and quaternary structural changes in Gi alpha 1 induced by GTP hydrolysis. Science (1995) 2.64
Purification of recombinant G proteins from Sf9 cells by hexahistidine tagging of associated subunits. Characterization of alpha 12 and inhibition of adenylyl cyclase by alpha z. J Biol Chem (1995) 2.61
Adenylyl cyclase amino acid sequence: possible channel- or transporter-like structure. Science (1989) 2.59
Rigorous feedback control of cAMP levels in Saccharomyces cerevisiae. Genes Dev (1987) 2.58
Purification and properties of the inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. J Biol Chem (1984) 2.56
The GTPase-activating protein RGS4 stabilizes the transition state for nucleotide hydrolysis. J Biol Chem (1996) 2.48
Purification of a protein cofactor required for ADP-ribosylation of the stimulatory regulatory component of adenylate cyclase by cholera toxin. J Biol Chem (1984) 2.43
Expression of G-protein alpha subunits in Escherichia coli. Methods Enzymol (1994) 2.39
G protein involvement in receptor-effector coupling. J Biol Chem (1988) 2.38
A cytoplasmic acyl-protein thioesterase that removes palmitate from G protein alpha subunits and p21(RAS). J Biol Chem (1998) 2.36
Molecular basis for two forms of the G protein that stimulates adenylate cyclase. J Biol Chem (1986) 2.35
Molecular cloning of complementary DNA for the alpha subunit of the G protein that stimulates adenylate cyclase. Science (1985) 2.35
Mammalian RGS proteins: barbarians at the gate. J Biol Chem (1998) 2.34
Lipid modifications of G proteins: alpha subunits are palmitoylated. Proc Natl Acad Sci U S A (1993) 2.32
G protein gamma subunits contain a 20-carbon isoprenoid. Proc Natl Acad Sci U S A (1990) 2.32
Two-metal-Ion catalysis in adenylyl cyclase. Science (1999) 2.31
G proteins control diverse pathways of transmembrane signaling. FASEB J (1989) 2.21
Resolution of some components of adenylate cyclase necessary for catalytic activity. J Biol Chem (1977) 2.20
RGS4 and GAIP are GTPase-activating proteins for Gq alpha and block activation of phospholipase C beta by gamma-thio-GTP-Gq alpha. Proc Natl Acad Sci U S A (1997) 2.14
G-protein alpha-subunit expression, myristoylation, and membrane association in COS cells. Proc Natl Acad Sci U S A (1990) 2.13
Synthesis in Escherichia coli of GTPase-deficient mutants of Gs alpha. J Biol Chem (1989) 2.12
The regulatory components of adenylate cyclase and transducin. A family of structurally homologous guanine nucleotide-binding proteins. J Biol Chem (1983) 2.12
The subunits of the stimulatory regulatory component of adenylate cyclase. Resolution of the activated 45,000-dalton (alpha) subunit. J Biol Chem (1983) 2.06
Reconstitution of agonist-stimulated phosphatidylinositol 4,5-bisphosphate hydrolysis using purified m1 muscarinic receptor, Gq/11, and phospholipase C-beta 1. J Biol Chem (1992) 2.06
The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Properties and function of the purified protein. J Biol Chem (1984) 2.05
Effects of Mg2+ and the beta gamma-subunit complex on the interactions of guanine nucleotides with G proteins. J Biol Chem (1987) 2.02
Adenylyl cyclases. Cell (1992) 1.96
Expression and characterization of calmodulin-activated (type I) adenylylcyclase. J Biol Chem (1991) 1.94
A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits. Proc Natl Acad Sci U S A (1998) 1.94
Receptor regulation of G-protein palmitoylation. Proc Natl Acad Sci U S A (1994) 1.93
Inhibition of adenylyl cyclase by Gi alpha. Science (1993) 1.87
Deduced primary structure of the alpha subunit of the GTP-binding stimulatory protein of adenylate cyclase. Proc Natl Acad Sci U S A (1986) 1.86
The influence of bound GDP on the kinetics of guanine nucleotide binding to G proteins. J Biol Chem (1986) 1.83
ADP-ribosylation of transducin by islet-activation protein. Identification of asparagine as the site of ADP-ribosylation. J Biol Chem (1984) 1.83
Selective regulation of Galpha(q/11) by an RGS domain in the G protein-coupled receptor kinase, GRK2. J Biol Chem (1999) 1.82
G protein beta gamma subunits synthesized in Sf9 cells. Functional characterization and the significance of prenylation of gamma. J Biol Chem (1992) 1.75
Mutations of GS alpha designed to alter the reactivity of the protein with bacterial toxins. Substitutions at ARG187 result in loss of GTPase activity. J Biol Chem (1989) 1.75
Purification from Sf9 cells and characterization of recombinant Gq alpha and G11 alpha. Activation of purified phospholipase C isozymes by G alpha subunits. J Biol Chem (1993) 1.74
Expression of Gs alpha in Escherichia coli. Purification and properties of two forms of the protein. J Biol Chem (1989) 1.73
Hydrodynamic properties of the beta-adrenergic receptor and adenylate cyclase from wild type and varient S49 lymphoma cells. J Biol Chem (1977) 1.71
Purification of the catalyst of adenylate cyclase. J Biol Chem (1986) 1.70
Lipid modifications of G protein subunits. Myristoylation of Go alpha increases its affinity for beta gamma. J Biol Chem (1991) 1.70
Binding of (125I)iodohydroxybenzylpindolol to putative beta-adrenergic receptors of rat glioma cells and other cell clones. J Biol Chem (1976) 1.69
The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Subunit dissociation and guanine nucleotide-dependent hormonal inhibition. J Biol Chem (1984) 1.69
Purification and characterization of Go alpha and three types of Gi alpha after expression in Escherichia coli. J Biol Chem (1990) 1.69
Gz, a guanine nucleotide-binding protein with unique biochemical properties. J Biol Chem (1990) 1.67
Reconstitution of catecholamine-sensitive adenylate cyclase. Association of a regulatory component of the enzyme with membranes containing the catalytic protein and beta-adrenergic receptors. J Biol Chem (1979) 1.67
Exchange of substrate and inhibitor specificities between adenylyl and guanylyl cyclases. J Biol Chem (1998) 1.66
Effect of catecholamines on the adenosine 3':5'-cyclic monophosphate concentrations of clonal satellite cells of neurons. Proc Natl Acad Sci U S A (1971) 1.65
Autoacylation of G protein alpha subunits. J Biol Chem (1996) 1.64