Published in J Biol Chem on June 10, 1983
Repetitive segmental structure of the transducin beta subunit: homology with the CDC4 gene and identification of related mRNAs. Proc Natl Acad Sci U S A (1986) 3.59
Antisera of designed specificity for subunits of guanine nucleotide-binding regulatory proteins. Proc Natl Acad Sci U S A (1986) 2.87
Molecular cloning and sequence determination of cDNAs for alpha subunits of the guanine nucleotide-binding proteins Gs, Gi, and Go from rat brain. Proc Natl Acad Sci U S A (1986) 2.83
Amino acid sequence of the alpha subunit of transducin deduced from the cDNA sequence. Proc Natl Acad Sci U S A (1985) 2.34
Isolation and characterization of a cDNA clone for the gamma subunit of bovine retinal transducin. Proc Natl Acad Sci U S A (1984) 2.12
GTPase of bovine rod outer segments: the amino acid sequence of the alpha subunit as derived from the cDNA sequence. Proc Natl Acad Sci U S A (1985) 2.09
Calcium channel currents and their inhibition by (-)-baclofen in rat sensory neurones: modulation by guanine nucleotides. J Physiol (1987) 2.00
Distinct forms of the beta subunit of GTP-binding regulatory proteins identified by molecular cloning. Proc Natl Acad Sci U S A (1987) 1.87
Deduced primary structure of the alpha subunit of the GTP-binding stimulatory protein of adenylate cyclase. Proc Natl Acad Sci U S A (1986) 1.86
Techniques used in the identification and analysis of function of pertussis toxin-sensitive guanine nucleotide binding proteins. Biochem J (1988) 1.86
Guanine nucleotide-binding regulatory proteins and dual control of adenylate cyclase. J Clin Invest (1984) 1.60
Antisera against a guanine nucleotide binding protein from retina cross-react with the beta subunit of the adenylyl cyclase-associated guanine nucleotide binding proteins, Ns and Ni. Proc Natl Acad Sci U S A (1985) 1.54
Pertussis toxin inhibition of chemotactic factor-induced calcium mobilization and function in human polymorphonuclear leukocytes. J Exp Med (1985) 1.54
Insulin inhibits the cholera-toxin-catalysed ribosylation of a Mr-25000 protein in rat liver plasma membranes. Biochem J (1985) 1.35
Antibodies against the carboxyl-terminal 5-kDa peptide of the alpha subunit of transducin crossreact with the 40-kDa but not the 39-kDa guanine nucleotide binding protein from brain. Proc Natl Acad Sci U S A (1985) 1.30
Multisite phosphorylation of the alpha subunit of transducin by the insulin receptor kinase and protein kinase C. Proc Natl Acad Sci U S A (1986) 1.28
A second form of the beta subunit of signal-transducing G proteins. Proc Natl Acad Sci U S A (1987) 1.21
cDNA-derived amino acid sequence of the gamma subunit of GTPase from bovine rod outer segments. Proc Natl Acad Sci U S A (1985) 1.21
Prostacyclin analogues reduce ADP-ribosylation of the alpha-subunit of the regulatory Gs-protein and diminish adenosine (A2) responsiveness of platelets. Br J Pharmacol (1987) 1.20
Squid rhodopsin and GTP-binding protein crossreact with vertebrate photoreceptor enzymes. Proc Natl Acad Sci U S A (1984) 1.17
Deduced amino acid sequence of bovine retinal Go alpha: similarities to other guanine nucleotide-binding proteins. Proc Natl Acad Sci U S A (1987) 1.17
Pertussis toxin differentiates between two mechanisms of attenuation of cyclic AMP accumulation by muscarinic cholinergic receptors. Proc Natl Acad Sci U S A (1984) 1.16
Islet-activating protein blocks glucagon desensitization in intact hepatocytes. Biochem J (1984) 1.13
Regulation of the affinity state of the N-formylated peptide receptor of neutrophils: role of guanine nucleotide-binding proteins and the cytoskeleton. J Cell Biol (1987) 1.05
Molecular cloning and characterization of cDNA encoding the GTP-binding protein alpha i and identification of a related protein, alpha h. Proc Natl Acad Sci U S A (1986) 1.05
G-proteins of fat-cells. Role in hormonal regulation of intracellular inositol 1,4,5-trisphosphate. Biochem J (1986) 1.05
The action of islet activating protein (pertussis toxin) on insulin's ability to inhibit adenylate cyclase and activate cyclic AMP phosphodiesterases in hepatocytes. Biochem J (1986) 0.95
Muscarinic-agonist and guanine nucleotide activation of polyphosphoinositide phosphodiesterase in isolated islet-cell membranes. Biochem J (1986) 0.88
Inhibition of hormonally regulated adenylate cyclase by the beta gamma subunit of transducin. EMBO J (1985) 0.85
Thyrotropin-releasing hormone stimulates GTP hydrolysis by membranes from GH4C1 rat pituitary tumor cells. Proc Natl Acad Sci U S A (1984) 0.82
Interspecies conservation of retinal guanosine 5'-triphosphatase. Characterization by photoaffinity labelling and tryptic-peptide mapping. Biochem J (1985) 0.82
Homologous desensitization of beta-adrenergic receptors in lymphoma cells is not altered by the inactivation of Ni (Gi), the inhibitory guanine nucleotide regulatory protein. Biochem J (1986) 0.79
G protein and diacylglycerol regulate metamorphosis of planktonic molluscan larvae. Proc Natl Acad Sci U S A (1987) 0.79
Decreased physiological sensitivity mediated by newly synthesized muscarinic acetylcholine receptors in embryonic chicken heart. Proc Natl Acad Sci U S A (1984) 0.79
Development of muscarinic-cholinergic stimulation of inositol phosphate production in cultured embryonic chick atrial cells. Evidence for a switch in guanine-nucleotide-binding protein coupling. Biochem J (1990) 0.78
Inhibition of the GTPase activity of transducin by an NAD+:arginine ADP-ribosyltransferase from turkey erythrocytes. Biochem J (1987) 0.75
Monoclonal antibodies to the guanine-nucleotide binding proteins of adenylate cyclase. Biochem J (1986) 0.75
Glucagon-stimulable adenylyl cyclase in rat liver. Effects of chronic uremia and intermittent glucagon administration. J Clin Invest (1984) 0.75
G proteins: transducers of receptor-generated signals. Annu Rev Biochem (1987) 27.41
A protein binding assay for adenosine 3':5'-cyclic monophosphate. Proc Natl Acad Sci U S A (1970) 23.79
Cyclic adenosine monophosphate and alteration of Chinese hamster ovary cell morphology: a rapid, sensitive in vitro assay for the enterotoxins of Vibrio cholerae and Escherichia coli. Infect Immun (1974) 12.51
G proteins and dual control of adenylate cyclase. Cell (1984) 11.05
The structure of the G protein heterotrimer Gi alpha 1 beta 1 gamma 2. Cell (1995) 7.66
Regulation of axon formation by clonal lines of a neural tumor. Proc Natl Acad Sci U S A (1970) 5.12
GAIP and RGS4 are GTPase-activating proteins for the Gi subfamily of G protein alpha subunits. Cell (1996) 4.76
Structure of RGS4 bound to AlF4--activated G(i alpha1): stabilization of the transition state for GTP hydrolysis. Cell (1997) 4.74
Direct stimulation of the guanine nucleotide exchange activity of p115 RhoGEF by Galpha13. Science (1998) 4.62
Crystal structure of the catalytic domains of adenylyl cyclase in a complex with Gsalpha.GTPgammaS. Science (1997) 4.52
Structures of active conformations of Gi alpha 1 and the mechanism of GTP hydrolysis. Science (1994) 4.43
p115 RhoGEF, a GTPase activating protein for Galpha12 and Galpha13. Science (1998) 4.32
Homologies between signal transducing G proteins and ras gene products. Science (1984) 3.85
Biochemical properties of hormone-sensitive adenylate cyclase. Annu Rev Biochem (1980) 3.79
G proteins. Trends Biochem Sci (1992) 3.79
Aluminum: a requirement for activation of the regulatory component of adenylate cyclase by fluoride. Proc Natl Acad Sci U S A (1982) 3.73
Recombinant G-protein beta gamma-subunits activate the muscarinic-gated atrial potassium channel. Nature (1994) 3.54
The protein cofactor necessary for ADP-ribosylation of Gs by cholera toxin is itself a GTP binding protein. J Biol Chem (1986) 3.54
Purification and characterization of smooth muscle cell caveolae. J Cell Biol (1994) 3.18
Identification of the predominant substrate for ADP-ribosylation by islet activating protein. J Biol Chem (1983) 3.11
The guanine nucleotide activating site of the regulatory component of adenylate cyclase. Identification by ligand binding. J Biol Chem (1982) 3.09
Protein kinase C phosphorylates the inhibitory guanine-nucleotide-binding regulatory component and apparently suppresses its function in hormonal inhibition of adenylate cyclase. Eur J Biochem (1985) 3.04
Type-specific regulation of adenylyl cyclase by G protein beta gamma subunits. Science (1991) 3.00
Relationship between the beta-adrenergic receptor and adenylate cyclase. J Biol Chem (1977) 2.99
Inhibition of receptor-mediated release of arachidonic acid by pertussis toxin. Cell (1984) 2.96
Mammalian membrane-bound adenylyl cyclases. J Biol Chem (1995) 2.93
Myristoylated alpha subunits of guanine nucleotide-binding regulatory proteins. Proc Natl Acad Sci U S A (1987) 2.93
Antisera of designed specificity for subunits of guanine nucleotide-binding regulatory proteins. Proc Natl Acad Sci U S A (1986) 2.87
Purification of the regulatory component of adenylate cyclase. Proc Natl Acad Sci U S A (1980) 2.81
Complexity and diversity of mammalian adenylyl cyclases. Annu Rev Pharmacol Toxicol (1996) 2.70
The regulatory component of adenylate cyclase. Purification and properties. J Biol Chem (1981) 2.69
Crystal structure of the adenylyl cyclase activator Gsalpha. Science (1997) 2.68
Reconstitution of hormone-sensitive adenylate cyclase activity with resolved components of the enzyme. J Biol Chem (1978) 2.64
Tertiary and quaternary structural changes in Gi alpha 1 induced by GTP hydrolysis. Science (1995) 2.64
Purification of recombinant G proteins from Sf9 cells by hexahistidine tagging of associated subunits. Characterization of alpha 12 and inhibition of adenylyl cyclase by alpha z. J Biol Chem (1995) 2.61
Adenylyl cyclase amino acid sequence: possible channel- or transporter-like structure. Science (1989) 2.59
Purification and properties of the inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. J Biol Chem (1984) 2.56
The GTPase-activating protein RGS4 stabilizes the transition state for nucleotide hydrolysis. J Biol Chem (1996) 2.48
Purification of a protein cofactor required for ADP-ribosylation of the stimulatory regulatory component of adenylate cyclase by cholera toxin. J Biol Chem (1984) 2.43
Expression of G-protein alpha subunits in Escherichia coli. Methods Enzymol (1994) 2.39
G protein involvement in receptor-effector coupling. J Biol Chem (1988) 2.38
A cytoplasmic acyl-protein thioesterase that removes palmitate from G protein alpha subunits and p21(RAS). J Biol Chem (1998) 2.36
Molecular basis for two forms of the G protein that stimulates adenylate cyclase. J Biol Chem (1986) 2.35
Molecular cloning of complementary DNA for the alpha subunit of the G protein that stimulates adenylate cyclase. Science (1985) 2.35
Mammalian RGS proteins: barbarians at the gate. J Biol Chem (1998) 2.34
Lipid modifications of G proteins: alpha subunits are palmitoylated. Proc Natl Acad Sci U S A (1993) 2.32
G protein gamma subunits contain a 20-carbon isoprenoid. Proc Natl Acad Sci U S A (1990) 2.32
Two-metal-Ion catalysis in adenylyl cyclase. Science (1999) 2.31
G proteins control diverse pathways of transmembrane signaling. FASEB J (1989) 2.21
Resolution of some components of adenylate cyclase necessary for catalytic activity. J Biol Chem (1977) 2.20
RGS4 and GAIP are GTPase-activating proteins for Gq alpha and block activation of phospholipase C beta by gamma-thio-GTP-Gq alpha. Proc Natl Acad Sci U S A (1997) 2.14
G-protein alpha-subunit expression, myristoylation, and membrane association in COS cells. Proc Natl Acad Sci U S A (1990) 2.13
Synthesis in Escherichia coli of GTPase-deficient mutants of Gs alpha. J Biol Chem (1989) 2.12
The subunits of the stimulatory regulatory component of adenylate cyclase. Resolution of the activated 45,000-dalton (alpha) subunit. J Biol Chem (1983) 2.06
The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Properties and function of the purified protein. J Biol Chem (1984) 2.05
Effects of Mg2+ and the beta gamma-subunit complex on the interactions of guanine nucleotides with G proteins. J Biol Chem (1987) 2.02
Adenylyl cyclases. Cell (1992) 1.96
Expression and characterization of calmodulin-activated (type I) adenylylcyclase. J Biol Chem (1991) 1.94
A G protein gamma subunit-like domain shared between RGS11 and other RGS proteins specifies binding to Gbeta5 subunits. Proc Natl Acad Sci U S A (1998) 1.94
Receptor regulation of G-protein palmitoylation. Proc Natl Acad Sci U S A (1994) 1.93
Differential coupling of the sphingosine 1-phosphate receptors Edg-1, Edg-3, and H218/Edg-5 to the G(i), G(q), and G(12) families of heterotrimeric G proteins. J Biol Chem (1999) 1.90
Inhibition of adenylyl cyclase by Gi alpha. Science (1993) 1.87
Deduced primary structure of the alpha subunit of the GTP-binding stimulatory protein of adenylate cyclase. Proc Natl Acad Sci U S A (1986) 1.86
The effect of GTP and Mg2+ on the GTPase activity and the fluorescent properties of Go. J Biol Chem (1987) 1.85
The influence of bound GDP on the kinetics of guanine nucleotide binding to G proteins. J Biol Chem (1986) 1.83
ADP-ribosylation of transducin by islet-activation protein. Identification of asparagine as the site of ADP-ribosylation. J Biol Chem (1984) 1.83
Selective regulation of Galpha(q/11) by an RGS domain in the G protein-coupled receptor kinase, GRK2. J Biol Chem (1999) 1.82
G protein beta gamma subunits synthesized in Sf9 cells. Functional characterization and the significance of prenylation of gamma. J Biol Chem (1992) 1.75
Mutations of GS alpha designed to alter the reactivity of the protein with bacterial toxins. Substitutions at ARG187 result in loss of GTPase activity. J Biol Chem (1989) 1.75
Purification from Sf9 cells and characterization of recombinant Gq alpha and G11 alpha. Activation of purified phospholipase C isozymes by G alpha subunits. J Biol Chem (1993) 1.74
Expression of Gs alpha in Escherichia coli. Purification and properties of two forms of the protein. J Biol Chem (1989) 1.73
Hydrodynamic properties of the beta-adrenergic receptor and adenylate cyclase from wild type and varient S49 lymphoma cells. J Biol Chem (1977) 1.71
Lipid modifications of G protein subunits. Myristoylation of Go alpha increases its affinity for beta gamma. J Biol Chem (1991) 1.70
Binding of (125I)iodohydroxybenzylpindolol to putative beta-adrenergic receptors of rat glioma cells and other cell clones. J Biol Chem (1976) 1.69
The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Subunit dissociation and guanine nucleotide-dependent hormonal inhibition. J Biol Chem (1984) 1.69
Purification and characterization of Go alpha and three types of Gi alpha after expression in Escherichia coli. J Biol Chem (1990) 1.69
Gz, a guanine nucleotide-binding protein with unique biochemical properties. J Biol Chem (1990) 1.67
Reconstitution of catecholamine-sensitive adenylate cyclase. Association of a regulatory component of the enzyme with membranes containing the catalytic protein and beta-adrenergic receptors. J Biol Chem (1979) 1.67
Exchange of substrate and inhibitor specificities between adenylyl and guanylyl cyclases. J Biol Chem (1998) 1.66
Effect of catecholamines on the adenosine 3':5'-cyclic monophosphate concentrations of clonal satellite cells of neurons. Proc Natl Acad Sci U S A (1971) 1.65
Autoacylation of G protein alpha subunits. J Biol Chem (1996) 1.64
The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Subunit dissociation and the inhibition of adenylate cyclase in S49 lymphoma cyc- and wild type membranes. J Biol Chem (1984) 1.62
Dynamic regulation of RGS2 suggests a novel mechanism in G-protein signaling and neuronal plasticity. J Neurosci (1998) 1.62
The effect of activating ligands on the intrinsic fluorescence of guanine nucleotide-binding regulatory proteins. J Biol Chem (1987) 1.61
Guanine nucleotide-binding regulatory proteins and dual control of adenylate cyclase. J Clin Invest (1984) 1.60
Construction of a soluble adenylyl cyclase activated by Gs alpha and forskolin. Science (1995) 1.60
The subunits of the stimulatory regulatory component of adenylate cyclase. Resolution, activity, and properties of the 35,000-dalton (beta) subunit. J Biol Chem (1983) 1.60
An agonist-specific effect of guanine nucleotides on binding to the beta adrenergic receptor. Mol Pharmacol (1976) 1.59
Reconstitution of catecholamine-sensitive adenylate cyclase. Reconstitution of the uncoupled variant of the S40 lymphoma cell. J Biol Chem (1979) 1.52
Influence of gamma subunit prenylation on association of guanine nucleotide-binding regulatory proteins with membranes. Mol Biol Cell (1992) 1.52
Molecular cloning and characterization of a Ca2+/calmodulin-insensitive adenylyl cyclase from rat brain. Proc Natl Acad Sci U S A (1991) 1.50
Cloning and expression of a widely distributed (type IV) adenylyl cyclase. Proc Natl Acad Sci U S A (1991) 1.50
Truncation and alanine-scanning mutants of type I adenylyl cyclase. Biochemistry (1995) 1.48
Synthetic peptide antisera with determined specificity for G protein alpha or beta subunits. Methods Enzymol (1991) 1.46
G protein beta gamma subunits from bovine brain and retina: equivalent catalytic support of ADP-ribosylation of alpha subunits by pertussis toxin but differential interactions with Gs alpha. Biochemistry (1989) 1.46
GTPase activating specificity of RGS12 and binding specificity of an alternatively spliced PDZ (PSD-95/Dlg/ZO-1) domain. J Biol Chem (1998) 1.45
ADP-ribosylation of Gs promotes the dissociation of its alpha and beta subunits. J Biol Chem (1984) 1.45
Binding of (3H)prostaglandin E1 to putative receptors linked to adenylate cyclase of cultured cell clones. J Biol Chem (1976) 1.44