Published in J Clin Invest on August 01, 1986
Secretory products of macrophages. J Clin Invest (1987) 10.33
Increased expression of matrix metalloproteinases and matrix degrading activity in vulnerable regions of human atherosclerotic plaques. J Clin Invest (1994) 7.25
Acute inflammation and a Shwartzman-like reaction induced by interleukin-1 and tumor necrosis factor. Synergistic action of the cytokines in the induction of inflammation and microvascular injury. Am J Pathol (1987) 2.27
Two monokines, interleukin 1 and tumor necrosis factor, render cultured vascular endothelial cells susceptible to lysis by antibodies circulating during Kawasaki syndrome. J Exp Med (1986) 1.74
Effects of interleukin-1, lipopolysaccharide, and streptococci on procoagulant activity of cultured human cardiac valve endothelial and stromal cells. Infect Immun (1989) 1.71
Type 1 plasminogen activator inhibitor gene: functional analysis and glucocorticoid regulation of its promoter. Proc Natl Acad Sci U S A (1988) 1.64
American Association of Pathologists president's address. New roles for the endothelium in inflammation and immunity. Am J Pathol (1987) 1.55
Cellular localization of type 1 plasminogen activator inhibitor messenger RNA and protein in murine renal tissue. Am J Pathol (1993) 1.52
Tumor necrosis factor-mediated release of platelet-derived growth factor from cultured endothelial cells. J Exp Med (1987) 1.50
The c-myc-regulated gene mrl encodes plasminogen activator inhibitor 1. Mol Cell Biol (1990) 1.49
Immunohistochemical study of vascular injury in acute multiple sclerosis. J Clin Pathol (1994) 1.46
Plasminogen activator inhibitor is associated with the extracellular matrix of cultured bovine smooth muscle cells. J Clin Invest (1987) 1.28
Bleeding diathesis due to decreased functional activity of type 1 plasminogen activator inhibitor. J Clin Invest (1989) 1.22
Coordinated induction of plasminogen activator inhibitor-1 (PAI-1) and inhibition of plasminogen activator gene expression by hypoxia promotes pulmonary vascular fibrin deposition. J Clin Invest (1998) 1.20
Interleukin-1 gene expression in rabbit vascular tissue in vivo. Am J Pathol (1991) 1.19
Macrophages contain 92-kd gelatinase (MMP-9) at the site of degenerated internal elastic lamina in temporal arteritis. Am J Pathol (1996) 1.13
Fibrinolytic response to tumor necrosis factor in healthy subjects. J Exp Med (1991) 1.11
Placenta growth factor (PlGF), a novel inducer of plasminogen activator inhibitor-1 (PAI-1) in sickle cell disease (SCD). J Biol Chem (2010) 0.98
The addition of endothelial cell growth factor and heparin to human umbilical vein endothelial cell cultures decreases plasminogen activator inhibitor-1 expression. J Clin Invest (1988) 0.89
The regulatory region of the human plasminogen activator inhibitor type-1 (PAI-1) gene. Nucleic Acids Res (1988) 0.88
Intestinal microvascular endothelium and innate immunity in inflammatory bowel disease: a second line of defense? Infect Immun (2006) 0.87
Targeted venous occlusion using pulsed high-intensity focused ultrasound. IEEE Trans Biomed Eng (2009) 0.83
Cytokines. 1. Overview. Thorax (1993) 0.81
Plasminogen activator-1 overexpression decreases experimental postthrombotic vein wall fibrosis by a non-vitronectin-dependent mechanism. J Thromb Haemost (2014) 0.81
Alterations in plasminogen activation correlate with epithelial cell dysplasia grading in colorectal adenomas. Br J Cancer (1998) 0.81
Immunoelectron microscopic localization of type 1 plasminogen activator inhibitor on the surface of activated endothelial cells. J Cell Biol (1991) 0.80
Atheromatous plaque macrophages produce plasminogen activator inhibitor type-1 and stimulate its production by endothelial cells and vascular smooth muscle cells. Am J Pathol (1993) 0.79
Adhesion-independent synergy of monocytes and endothelial cells in cytokine production: regulation of IL-6 and GM-CSF production by PAF. Mediators Inflamm (1996) 0.75
Inducible release of an endothelial cell-specific protein. Am J Pathol (1991) 0.75
Targeted long-term venous occlusion using pulsed high-intensity focused ultrasound combined with a pro-inflammatory agent. Ultrasound Med Biol (2011) 0.75
The reliability of molecular weight determinations by dodecyl sulfate-polyacrylamide gel electrophoresis. J Biol Chem (1969) 142.11
Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs. Nature (1985) 9.94
Nucleotide sequence of human monocyte interleukin 1 precursor cDNA. Proc Natl Acad Sci U S A (1984) 8.84
Culture of vascular endothelium. Prog Hemost Thromb (1976) 7.05
Interleukin 1 (IL-1) induces biosynthesis and cell surface expression of procoagulant activity in human vascular endothelial cells. J Exp Med (1984) 5.89
Recombinant tumor necrosis factor induces procoagulant activity in cultured human vascular endothelium: characterization and comparison with the actions of interleukin 1. Proc Natl Acad Sci U S A (1986) 5.83
Cultured human endothelial cells generate tissue factor in response to endotoxin. J Clin Invest (1983) 3.47
Self-regulation of procoagulant events on the endothelial cell surface. J Exp Med (1985) 3.16
Interleukin-1 activation of vascular endothelium. Effects on procoagulant activity and leukocyte adhesion. Am J Pathol (1985) 2.59
Endothelial cells produce a latent inhibitor of plasminogen activators that can be activated by denaturants. J Biol Chem (1985) 2.23
Purification of an inhibitor of plasminogen activator (antiactivator) synthesized by endothelial cells. J Biol Chem (1984) 2.22
Prostacyclin synthesis induced in vascular cells by interleukin-1. Science (1985) 2.13
Cellular cooperation in endothelial cell thromboplastin synthesis. Br J Haematol (1983) 2.05
Generation in plasma of a fast-acting inhibitor of plasminogen activator in response to endotoxin stimulation. J Clin Invest (1985) 1.97
Exaggerated human vascular cell prostaglandin biosynthesis mediated by monocytes: role of monokines and interleukin 1. J Immunol (1985) 1.76
Interleukin 1 induces endothelial cell synthesis of plasminogen activator inhibitor. J Exp Med (1986) 1.68
Interleukin 1 and lipopolysaccharide induce an inhibitor of tissue-type plasminogen activator in vivo and in cultured endothelial cells. J Exp Med (1986) 1.64
Thrombin induction of plasminogen activator-inhibitor in cultured human endothelial cells. J Clin Invest (1986) 1.60
Reverse fibrin autography: a method to detect and partially characterize protease inhibitors after sodium dodecyl sulfate--polyacrylamide gel electrophoresis. Anal Biochem (1984) 1.59
The primary plasminogen-activator inhibitors in endothelial cells, platelets, serum, and plasma are immunologically related. Proc Natl Acad Sci U S A (1985) 1.46
The fibrinolytic system of the vascular wall. Clin Haematol (1985) 1.25
Two different mechanisms in patients with venous thrombosis and defective fibrinolysis: low concentration of plasminogen activator or increased concentration of plasminogen activator inhibitor. Br Med J (Clin Res Ed) (1985) 1.19
Immunoradiometric assay to measure the binding of a specific inhibitor to tissue-type plasminogen activator. J Lab Clin Med (1985) 1.09
Endotoxin induction of an inhibitor of plasminogen activator in bovine pulmonary artery endothelial cells. J Biol Chem (1986) 1.00
Characterization of two monoclonal antibodies against human tissue-type plasminogen activator. Thromb Haemost (1985) 0.96
Alternative sites for screening blood for antibodies to AIDS virus. N Engl J Med (1985) 0.82
Endothelial leukocyte adhesion molecule 1: an inducible receptor for neutrophils related to complement regulatory proteins and lectins. Science (1989) 10.70
Identification of an inducible endothelial-leukocyte adhesion molecule. Proc Natl Acad Sci U S A (1987) 10.43
Interleukin 1 acts on cultured human vascular endothelium to increase the adhesion of polymorphonuclear leukocytes, monocytes, and related leukocyte cell lines. J Clin Invest (1985) 8.70
Overlapping patterns of activation of human endothelial cells by interleukin 1, tumor necrosis factor, and immune interferon. J Immunol (1986) 8.22
Culture of vascular endothelium. Prog Hemost Thromb (1976) 7.05
The MAD-related protein Smad7 associates with the TGFbeta receptor and functions as an antagonist of TGFbeta signaling. Cell (1997) 6.34
An assay for transforming growth factor-beta using cells transfected with a plasminogen activator inhibitor-1 promoter-luciferase construct. Anal Biochem (1994) 6.31
Human vascular endothelial cells in culture. Growth and DNA synthesis. J Cell Biol (1974) 5.95
Interleukin 1 (IL-1) induces biosynthesis and cell surface expression of procoagulant activity in human vascular endothelial cells. J Exp Med (1984) 5.89
Recombinant tumor necrosis factor induces procoagulant activity in cultured human vascular endothelium: characterization and comparison with the actions of interleukin 1. Proc Natl Acad Sci U S A (1986) 5.83
Endothelial expression of a mononuclear leukocyte adhesion molecule during atherogenesis. Science (1991) 5.76
Rapid neutrophil adhesion to activated endothelium mediated by GMP-140. Nature (1990) 5.17
Nitric oxide decreases cytokine-induced endothelial activation. Nitric oxide selectively reduces endothelial expression of adhesion molecules and proinflammatory cytokines. J Clin Invest (1995) 5.09
Ia expression by vascular endothelium is inducible by activated T cells and by human gamma interferon. J Exp Med (1983) 4.92
Immune interferon activates multiple class II major histocompatibility complex genes and the associated invariant chain gene in human endothelial cells and dermal fibroblasts. Proc Natl Acad Sci U S A (1984) 4.43
Tumor dormancy in vivo by prevention of neovascularization. J Exp Med (1972) 4.34
The dynamic response of vascular endothelial cells to fluid shear stress. J Biomech Eng (1981) 4.27
MCP-1 and IL-8 trigger firm adhesion of monocytes to vascular endothelium under flow conditions. Nature (1999) 4.19
Lymphocytes recognize human vascular endothelial and dermal fibroblast Ia antigens induced by recombinant immune interferon. Nature (1983) 4.16
Tumor growth and neovascularization: an experimental model using the rabbit cornea. J Natl Cancer Inst (1974) 4.05
An inducible endothelial cell surface glycoprotein mediates melanoma adhesion. Science (1989) 4.01
Identification of vascular endothelial genes differentially responsive to fluid mechanical stimuli: cyclooxygenase-2, manganese superoxide dismutase, and endothelial cell nitric oxide synthase are selectively up-regulated by steady laminar shear stress. Proc Natl Acad Sci U S A (1996) 3.93
Receptors for cold-insoluble globulin (plasma fibronectin) on human monocytes. J Exp Med (1981) 3.93
Activated macrophages induce vascular proliferation. Nature (1977) 3.74
Induction and detection of a human endothelial activation antigen in vivo. J Exp Med (1986) 3.66
Inducible cell adhesion molecule 110 (INCAM-110) is an endothelial receptor for lymphocytes. A CD11/CD18-independent adhesion mechanism. J Exp Med (1990) 3.55
Activation of cultured human endothelial cells by recombinant lymphotoxin: comparison with tumor necrosis factor and interleukin 1 species. J Immunol (1987) 3.06
Leukocyte adhesion molecule-1 (LAM-1, L-selectin) interacts with an inducible endothelial cell ligand to support leukocyte adhesion. J Immunol (1991) 3.05
Monocyte rolling, arrest and spreading on IL-4-activated vascular endothelium under flow is mediated via sequential action of L-selectin, beta 1-integrins, and beta 2-integrins. J Cell Biol (1994) 3.02
Bacterial lipopolysaccharide and inflammatory mediators augment IL-6 secretion by human endothelial cells. J Immunol (1989) 3.01
Vascular and nonvascular expression of INCAM-110. A target for mononuclear leukocyte adhesion in normal and inflamed human tissues. Am J Pathol (1991) 2.98
IL-4 induces adherence of human eosinophils and basophils but not neutrophils to endothelium. Association with expression of VCAM-1. J Immunol (1992) 2.89
Biomechanical activation of vascular endothelium as a determinant of its functional phenotype. Proc Natl Acad Sci U S A (2001) 2.89
Synthesis of a fibrinolytic activator and inhibitor by endothelial cells. Proc Natl Acad Sci U S A (1977) 2.83
A role for smad6 in development and homeostasis of the cardiovascular system. Nat Genet (2000) 2.80
An atherogenic diet rapidly induces VCAM-1, a cytokine-regulatable mononuclear leukocyte adhesion molecule, in rabbit aortic endothelium. Arterioscler Thromb (1993) 2.77
Adhesion of human basophils, eosinophils, and neutrophils to interleukin 1-activated human vascular endothelial cells: contributions of endothelial cell adhesion molecules. J Exp Med (1991) 2.76
Turbulent fluid shear stress induces vascular endothelial cell turnover in vitro. Proc Natl Acad Sci U S A (1986) 2.73
Adhesion of human B cells to germinal centers in vitro involves VLA-4 and INCAM-110. Science (1990) 2.69
Interleukin-1 activation of vascular endothelium. Effects on procoagulant activity and leukocyte adhesion. Am J Pathol (1985) 2.59
Identification of regulatory sequences in the type 1 plasminogen activator inhibitor gene responsive to transforming growth factor beta. J Biol Chem (1991) 2.52
Platelet-derived growth factor B chain promoter contains a cis-acting fluid shear-stress-responsive element. Proc Natl Acad Sci U S A (1993) 2.48
Lysophosphatidylcholine, a component of atherogenic lipoproteins, induces mononuclear leukocyte adhesion molecules in cultured human and rabbit arterial endothelial cells. J Clin Invest (1992) 2.45
Human vascular smooth muscle in culture. Growth and ultrastructure. Lab Invest (1975) 2.41
Shear stress selectively upregulates intercellular adhesion molecule-1 expression in cultured human vascular endothelial cells. J Clin Invest (1994) 2.35
Sustained diacylglycerol formation from inositol phospholipids in angiotensin II-stimulated vascular smooth muscle cells. J Biol Chem (1986) 2.33
Angiotensin II stimulation of prostaglandin production in cultured human vascular endothelium. Science (1975) 2.24
Endothelial cells produce a latent inhibitor of plasminogen activators that can be activated by denaturants. J Biol Chem (1985) 2.23
Hemodynamic forces are complex regulators of endothelial gene expression. FASEB J (1995) 2.23
Functional angiotensin II receptors in cultured vascular smooth muscle cells. J Cell Biol (1982) 2.22
Purification of an inhibitor of plasminogen activator (antiactivator) synthesized by endothelial cells. J Biol Chem (1984) 2.22
Vascular endothelium responds to fluid shear stress gradients. Arterioscler Thromb (1992) 2.21
Is plasminogen activator inhibitor-1 the molecular switch that governs urokinase receptor-mediated cell adhesion and release? J Cell Biol (1996) 2.21
Detection of an unusually stable fibrinolytic inhibitor produced by bovine endothelial cells. Proc Natl Acad Sci U S A (1983) 2.20
Stimulation of nonlymphoid mesenchymal cell proliferation by a macrophage-derived growth factor. J Immunol (1981) 2.18
Preservation of vascular integrity in organs perfused in vitro with a platelet-rich medium. Nature (1969) 2.16
Vascular MADs: two novel MAD-related genes selectively inducible by flow in human vascular endothelium. Proc Natl Acad Sci U S A (1997) 2.15
Fine structure of vascular endothelium in culture. J Ultrastruct Res (1975) 2.15
Intravascular IL-8. Inhibitor of polymorphonuclear leukocyte accumulation at sites of acute inflammation. J Immunol (1991) 2.10
Cytokine activation of vascular endothelium. Effects on tissue-type plasminogen activator and type 1 plasminogen activator inhibitor. J Biol Chem (1988) 2.04
Tumor angiogenesis: iris neovascularization at a distance from experimental intraocular tumors. J Natl Cancer Inst (1973) 1.95
Nuclear factor-kappa B interacts functionally with the platelet-derived growth factor B-chain shear-stress response element in vascular endothelial cells exposed to fluid shear stress. J Clin Invest (1995) 1.94
Regulation of mRNAs for type-1 plasminogen activator inhibitor, fibronectin, and type I procollagen by transforming growth factor-beta. Divergent responses in lung fibroblasts and carcinoma cells. J Biol Chem (1988) 1.93
Regulation of type 1 plasminogen activator inhibitor gene expression in cultured bovine aortic endothelial cells. Induction by transforming growth factor-beta, lipopolysaccharide, and tumor necrosis factor-alpha. J Biol Chem (1989) 1.92
Elevated expression of transforming growth factor-beta in adipose tissue from obese mice. Mol Med (1997) 1.92
Leukotriene B4 stimulates polymorphonuclear leukocyte adhesion to cultured vascular endothelial cells. J Clin Invest (1984) 1.88
Expression of Ia-like antigens by human vascular endothelial cells is inducible in vitro: demonstration by monoclonal antibody binding and immunoprecipitation. Proc Natl Acad Sci U S A (1982) 1.87
Cloning and sequence of a cDNA coding for the human beta-migrating endothelial-cell-type plasminogen activator inhibitor. Proc Natl Acad Sci U S A (1986) 1.85
Regulation of murine type 1 plasminogen activator inhibitor gene expression in vivo. Tissue specificity and induction by lipopolysaccharide, tumor necrosis factor-alpha, and transforming growth factor-beta. J Clin Invest (1991) 1.85
Gene structure, chromosomal location, and basis for alternative mRNA splicing of the human VCAM1 gene. Proc Natl Acad Sci U S A (1991) 1.79
Cultured bovine endothelial cells produce both urokinase and tissue-type plasminogen activators. J Cell Biol (1982) 1.77
Influence of hemodynamic forces on vascular endothelial function. In vitro studies of shear stress and pinocytosis in bovine aortic cells. J Clin Invest (1984) 1.77
Increased type 1 plasminogen activator inhibitor gene expression in atherosclerotic human arteries. Proc Natl Acad Sci U S A (1992) 1.76
Blood flow and vascular gene expression: fluid shear stress as a modulator of endothelial phenotype. Mol Med Today (1999) 1.75
Vascular endothelial cells respond to spatial gradients in fluid shear stress by enhanced activation of transcription factors. Arterioscler Thromb Vasc Biol (1999) 1.75
Human cytolytic T lymphocyte interactions with vascular endothelium and fibroblasts: role of effector and target cell molecules. J Immunol (1984) 1.75
Endothelial and leukocyte forms of IL-8. Conversion by thrombin and interactions with neutrophils. J Immunol (1990) 1.69
Heparin oligosaccharides bind L- and P-selectin and inhibit acute inflammation. Blood (1993) 1.67
Structure and chromosomal location of the gene for endothelial-leukocyte adhesion molecule 1. J Biol Chem (1991) 1.66
Distribution and regulation of plasminogen activator inhibitor-1 in murine adipose tissue in vivo. Induction by tumor necrosis factor-alpha and lipopolysaccharide. J Clin Invest (1996) 1.65
Inducible expression of class II major histocompatibility complex antigens and the immunogenicity of vascular endothelium. Transplantation (1986) 1.64
Type 1 plasminogen activator inhibitor gene: functional analysis and glucocorticoid regulation of its promoter. Proc Natl Acad Sci U S A (1988) 1.64
Induced expression of endothelial-leukocyte adhesion molecules in human cardiac allografts. Transplantation (1991) 1.62
Vasoconstriction: a new activity for platelet-derived growth factor. Science (1986) 1.61
Fluid shear stress modulates cytosolic free calcium in vascular endothelial cells. Am J Physiol (1992) 1.61
Reverse fibrin autography: a method to detect and partially characterize protease inhibitors after sodium dodecyl sulfate--polyacrylamide gel electrophoresis. Anal Biochem (1984) 1.59