Published in EMBO J on September 01, 1993
Three-dimensional structure of a complex between the death domains of Pelle and Tube. Cell (1999) 2.39
Interleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL-1 signaling pathway. Mol Cell Biol (2001) 1.93
Regulated assembly of the Toll signaling complex drives Drosophila dorsoventral patterning. EMBO J (2003) 1.35
Tube Is an IRAK-4 homolog in a Toll pathway adapted for development and immunity. J Innate Immun (2009) 1.14
A multimeric complex and the nuclear targeting of the Drosophila Rel protein Dorsal. Proc Natl Acad Sci U S A (1997) 0.87
The IRAK homolog Pelle is the functional counterpart of IκB kinase in the Drosophila Toll pathway. PLoS One (2013) 0.80
Molecular evolution and structural features of IRAK family members. PLoS One (2012) 0.80
Combinatorial effects of transposable elements on gene expression and phenotypic robustness in Drosophila melanogaster development. G3 (Bethesda) (2013) 0.77
Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature (1970) 1528.65
DNA sequencing with chain-terminating inhibitors. Proc Natl Acad Sci U S A (1977) 790.54
A comprehensive set of sequence analysis programs for the VAX. Nucleic Acids Res (1984) 181.98
Detection of polymorphisms of human DNA by gel electrophoresis as single-strand conformation polymorphisms. Proc Natl Acad Sci U S A (1989) 18.26
A stable genomic source of P element transposase in Drosophila melanogaster. Genetics (1988) 15.43
RNA splice junctions of different classes of eukaryotes: sequence statistics and functional implications in gene expression. Nucleic Acids Res (1987) 14.53
Biochemical evolution. Annu Rev Biochem (1977) 12.74
A compensatory base change in U1 snRNA suppresses a 5' splice site mutation. Cell (1986) 9.65
The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling. Cell (1992) 8.20
The origin of pattern and polarity in the Drosophila embryo. Cell (1992) 7.40
Signal transduction pathways involving protein phosphorylation in prokaryotes. Annu Rev Biochem (1991) 6.84
Functional cDNA libraries from Drosophila embryos. J Mol Biol (1988) 6.69
C. elegans cell-signalling gene sem-5 encodes a protein with SH2 and SH3 domains. Nature (1992) 5.59
A minimal intron length but no specific internal sequence is required for splicing the large rabbit beta-globin intron. Cell (1984) 5.37
Splice junctions, branch point sites, and exons: sequence statistics, identification, and applications to genome project. Methods Enzymol (1990) 5.35
Splicing signals in Drosophila: intron size, information content, and consensus sequences. Nucleic Acids Res (1992) 4.93
The Toll gene of Drosophila, required for dorsal-ventral embryonic polarity, appears to encode a transmembrane protein. Cell (1988) 4.36
A gradient of nuclear localization of the dorsal protein determines dorsoventral pattern in the Drosophila embryo. Cell (1989) 4.17
Molecular evolution in Drosophila and the higher Diptera II. A time scale for fly evolution. J Mol Evol (1984) 3.98
The graded distribution of the dorsal morphogen is initiated by selective nuclear transport in Drosophila. Cell (1989) 3.77
Female sterile mutations on the second chromosome of Drosophila melanogaster. I. Maternal effect mutations. Genetics (1989) 3.75
Dorsal, an embryonic polarity gene in Drosophila, is homologous to the vertebrate proto-oncogene, c-rel. Science (1987) 3.74
Dominant and recessive mutations define functional domains of Toll, a transmembrane protein required for dorsal-ventral polarity in the Drosophila embryo. Genes Dev (1991) 2.98
Relocalization of the dorsal protein from the cytoplasm to the nucleus correlates with its function. Cell (1989) 2.85
Information for the dorsal--ventral pattern of the Drosophila embryo is stored as maternal mRNA. Nature (1984) 2.60
Drosophila Toll and IL-1 receptor. Nature (1991) 2.33
Establishment of dorsal-ventral polarity in the Drosophila embryo: the induction of polarity by the Toll gene product. Cell (1985) 2.22
Characterization of the Drosophila cactus locus and analysis of interactions between cactus and dorsal proteins. Cell (1992) 2.21
cactus, a maternal gene required for proper formation of the dorsoventral morphogen gradient in Drosophila embryos. Development (1991) 2.16
cactus, a gene involved in dorsoventral pattern formation of Drosophila, is related to the I kappa B gene family of vertebrates. Cell (1992) 2.12
Zygotic expression and activity of the Drosophila Toll gene, a gene required maternally for embryonic dorsal-ventral pattern formation. Genetics (1988) 1.99
pelle encodes a protein kinase required to establish dorsoventral polarity in the Drosophila embryo. Cell (1993) 1.81
The polarity of the dorsoventral axis in the Drosophila embryo is defined by an extracellular signal. Cell (1991) 1.69
Genetic and molecular characterization of tube, a Drosophila gene maternally required for embryonic dorsoventral polarity. Proc Natl Acad Sci U S A (1991) 1.63
Hierarchy for 5' splice site preference determined in vivo. J Mol Biol (1990) 1.60
Signal transduction in bacterial chemotaxis. J Biol Chem (1992) 1.55
Multiple extracellular activities in Drosophila egg perivitelline fluid are required for establishment of embryonic dorsal-ventral polarity. Cell (1992) 1.51
Chemiluminescence detection of proteins from single cells. Proc Natl Acad Sci U S A (1991) 1.25
Organizational analysis of elav gene and functional analysis of ELAV protein of Drosophila melanogaster and Drosophila virilis. Mol Cell Biol (1991) 0.96
Structure of the murine fifth complement component (C5) gene. A large, highly interrupted gene with a variant donor splice site and organizational homology with the third and fourth complement component genes. J Biol Chem (1991) 0.89
Rates and implications of caesarean sections in Latin America: ecological study. BMJ (1999) 9.86
Immunogenic structure of the influenza virus hemagglutinin. Cell (1982) 8.93
endo-beta-N-acetylglucosaminidase F: endoglycosidase from Flavobacterium meningosepticum that cleaves both high-mannose and complex glycoproteins. Proc Natl Acad Sci U S A (1982) 6.64
Toward a molecular genetic analysis of spermatogenesis in Drosophila melanogaster: characterization of male-sterile mutants generated by single P element mutagenesis. Genetics (1993) 3.75
Control of male sexual behavior and sexual orientation in Drosophila by the fruitless gene. Cell (1996) 3.30
Demonstration of peptide:N-glycosidase F activity in endo-beta-N-acetylglucosaminidase F preparations. J Biol Chem (1984) 3.26
Diaphanous is required for cytokinesis in Drosophila and shares domains of similarity with the products of the limb deformity gene. Development (1994) 3.05
Randomised controlled trial of routine cervical examinations in pregnancy. European Community Collaborative Study Group on Prenatal Screening. Lancet (1994) 2.74
Meiotic cell cycle requirement for a fly homologue of human Deleted in Azoospermia. Nature (1996) 2.57
Three-dimensional structure of a complex between the death domains of Pelle and Tube. Cell (1999) 2.39
Biochemical topology: applications to DNA recombination and replication. Science (1986) 2.17
Impaired cytokine signaling in mice lacking the IL-1 receptor-associated kinase. J Immunol (1999) 2.11
Peritoneal catheters and exit-site practices toward optimum peritoneal access: 1998 update. (Official report from the International Society for Peritoneal Dialysis) Perit Dial Int (1998) 2.06
Discovery of a predicted DNA knot substantiates a model for site-specific recombination. Science (1985) 2.01
Consensus guidelines for the treatment of peritonitis in pediatric patients receiving peritoneal dialysis. Perit Dial Int (2001) 1.99
The T3 complex on human T lymphocytes involves four structurally distinct glycoproteins. J Biol Chem (1983) 1.94
Variation in human T lymphotropic virus III (HTLV-III) antibodies in homosexual men: decline before onset of illness related to acquired immune deficiency syndrome (AIDS). Br Med J (Clin Res Ed) (1985) 1.93
Immunohistochemistry of matrix metalloproteinases in reperfusion injury to rat brain: activation of MMP-9 linked to stromelysin-1 and microglia in cell cultures. Brain Res (2001) 1.90
pelle encodes a protein kinase required to establish dorsoventral polarity in the Drosophila embryo. Cell (1993) 1.81
Routine formal fetal movement counting and risk of antepartum late death in normally formed singletons. Lancet (1989) 1.78
Carbohydrate dramatically influences immune reactivity of antisera to viral glycoprotein antigens. Science (1984) 1.77
Post-transcriptional regulation of the meiotic Cdc25 protein Twine by the Dazl orthologue Boule. Nat Cell Biol (1999) 1.74
CCR5- and CXCR4-utilizing strains of human immunodeficiency virus type 1 exhibit differential tropism and pathogenesis in vivo. J Virol (1998) 1.72
A real-time quadriplex PCR assay for the diagnosis of rectal lymphogranuloma venereum and non-lymphogranuloma venereum Chlamydia trachomatis infections. Sex Transm Infect (2008) 1.70
Two alanine racemase genes in Salmonella typhimurium that differ in structure and function. J Bacteriol (1983) 1.65
A Xenopus DAZ-like gene encodes an RNA component of germ plasm and is a functional homologue of Drosophila boule. Development (1998) 1.64
Genetic and molecular characterization of tube, a Drosophila gene maternally required for embryonic dorsoventral polarity. Proc Natl Acad Sci U S A (1991) 1.63
Gonorrhoea treatment failures to cefixime and azithromycin in England, 2010. Euro Surveill (2011) 1.61
Functional analysis of the Drosophila diaphanous FH protein in early embryonic development. Development (2000) 1.61
Rectal chlamydia--a reservoir of undiagnosed infection in men who have sex with men. Sex Transm Infect (2009) 1.59
Chronic neurodegenerative disease associated with HTLV-II infection. Lancet (1992) 1.58
UbcD1, a Drosophila ubiquitin-conjugating enzyme required for proper telomere behavior. Genes Dev (1997) 1.54
Variations in policies for management of the third stage of labour and the immediate management of postpartum haemorrhage in Europe. BJOG (2007) 1.51
The pros and cons of implementing PACS and speech recognition systems. J Digit Imaging (2001) 1.48
An activity-dependent network of interactions links the Rel protein Dorsal with its cytoplasmic regulators. Development (1997) 1.46
Neutrophil elastase promotes lung microvascular injury and proteolysis of endothelial cadherins. Am J Physiol (1998) 1.44
Maternal mortality in developed countries: not just a concern of the past. Obstet Gynecol (1995) 1.41
Experimental evacuation of the bladder by means of implanted electrodes. Br J Surg (1965) 1.40
Closure of the urinary sphincter mechanism in anaesthetized dogs by means of electrical stimulation of the perineal muscles. Br J Surg (1966) 1.39
Prospective study of the SI-40NB foldable silicone intraocular lens. J Cataract Refract Surg (1996) 1.39
The prevalence of lymphogranuloma venereum infection in men who have sex with men: results of a multicentre case finding study. Sex Transm Infect (2009) 1.37
A conserved idiotype and antibodies to retroviral proteins in systemic lupus erythematosus. J Clin Invest (1990) 1.35
Interaction of the pelle kinase with the membrane-associated protein tube is required for transduction of the dorsoventral signal in Drosophila embryos. Development (1995) 1.34
Factors predictive of sustained growth in children after renal transplantation. The North American Pediatric Renal Transplant Cooperative Study. J Pediatr (1993) 1.28
Comparison of the curative antimalarial activities and toxicities of primaquine and its d and l isomers. Antimicrob Agents Chemother (1977) 1.28
Dorsal, a Drosophila Rel-like protein, is phosphorylated upon activation of the transmembrane protein Toll. Mol Cell Biol (1994) 1.28
Severe illness associated with appearance of antibody to human immunodeficiency virus in an African. Br Med J (Clin Res Ed) (1986) 1.27
Anemia during pregnancy and birth outcome: a meta-analysis. Am J Perinatol (2000) 1.27
Mutants of Dictyostelium discoideum blocked in expression of all members of the developmentally regulated discoidin multigene family. Cell (1983) 1.26
Indeterminate human immunodeficiency virus type 1 western blots: seroconversion risk, specificity of supplemental tests, and an algorithm for evaluation. J Infect Dis (1991) 1.24
A gradient of cactus protein degradation establishes dorsoventral polarity in the Drosophila embryo. Dev Biol (1996) 1.24
Promising early outcomes with a novel, complete steroid avoidance immunosuppression protocol in pediatric renal transplantation. Transplantation (2001) 1.19
fumble encodes a pantothenate kinase homolog required for proper mitosis and meiosis in Drosophila melanogaster. Genetics (2001) 1.19
Catabolic alanine racemase from Salmonella typhimurium: DNA sequence, enzyme purification, and characterization. Biochemistry (1984) 1.18
Cerebral hyperperfusion syndrome following carotid endarterectomy. QJM (2007) 1.16
Myeloma presenting with Pancoast's syndrome. Br Med J (1979) 1.15
Essential role for estrogen in protection against Vibrio vulnificus-induced endotoxic shock. Infect Immun (2001) 1.15
Alpha7-acetylcholine receptor antibodies in two patients with Rasmussen encephalitis. Neurology (2005) 1.14
The pelota locus encodes a protein required for meiotic cell division: an analysis of G2/M arrest in Drosophila spermatogenesis. Development (1995) 1.13
Intracranial metastases in the initial staging of bronchogenic carcinoma. Chest (1984) 1.11
Captopril inhibits the 72 kDa and 92 kDa matrix metalloproteinases. Kidney Int (1993) 1.11
An Australia-wide epidemic of Pseudomonas pickettii bacteraemia due to contaminated "sterile" water for injection. Med J Aust (1990) 1.11
Evaluation of the quality of care for severe obstetrical haemorrhage in three French regions. BJOG (2001) 1.10
Molecular basis for resistance to the anticancer drug cisplatin in Dictyostelium. Microbiology (2000) 1.10
Differential mitochondrial distribution in human pronuclear embryos leads to disproportionate inheritance between blastomeres: relationship to microtubular organization, ATP content and competence. Hum Reprod (2000) 1.09
Filmless in 60 days: the impact of picture archiving and communications systems within a large urban hospital. J Digit Imaging (2001) 1.09
The European Perinatal Health Report: comparing the health and care of pregnant women and newborn babies in Europe. J Epidemiol Community Health (2009) 1.08
Pediatric Lassa fever: a review of 33 Liberian cases. Am J Trop Med Hyg (1987) 1.07
Multiple signal transduction pathways regulate discoidin I gene expression in Dictyostelium discoideum. Differentiation (1995) 1.06
Biphasic subcellular localization of the DAZL-related protein boule in Drosophila spermatogenesis. Dev Biol (1998) 1.06
Two novel annexins from Drosophila melanogaster. Cloning, characterization, and differential expression in development. J Biol Chem (1990) 1.05
Electrical control of urinary incontinence: a clinical appraisal. Br J Surg (1970) 1.05
The protein kinase Pelle mediates feedback regulation in the Drosophila Toll signaling pathway. Development (2001) 1.05
Age-related increase in muscle sympathetic nerve activity is associated with abdominal adiposity. Am J Physiol (1997) 1.04
Regional variation in prevalence of antibody against human T-lymphotropic virus types I and III in Kenya, East Africa. Int J Cancer (1985) 1.04
A role for CKII phosphorylation of the cactus PEST domain in dorsoventral patterning of the Drosophila embryo. Genes Dev (1997) 1.03
Determination of the stereostructure of the product of Tn3 resolvase by a general method. Proc Natl Acad Sci U S A (1985) 1.03
Endoglycosidases from Flavobacterium meningosepticum application to biological problems. Methods Enzymol (1989) 1.02
Decreased premature ventricular contractions through use of the relaxation response in patients with stable ischaemic heart-disease. Lancet (1975) 1.01
Anal intercourse as a possible factor in heterosexual transmission of HTLV-III to spouses of hemophiliacs. N Engl J Med (1985) 1.01
Molecular characterization of multiresistant strains of Salmonella typhi from South Asia isolated in Ontario, Canada. Can J Microbiol (1998) 1.00
Promoting positive affect and diminishing loneliness of widowed seniors through a support intervention. Public Health Nurs (2001) 0.99
Mycoplasma genitalium in asymptomatic patients: implications for screening. Sex Transm Infect (2009) 0.99
Migrant women's utilization of prenatal care: a systematic review. Matern Child Health J (2013) 0.99
Carbohydrate side chains of Rauscher leukemia virus envelope glycoproteins are not required to elicit a neutralizing antibody response. J Virol (1986) 0.99
Recruitment of Tube and Pelle to signaling sites at the surface of the Drosophila embryo. Development (1998) 0.99
Classification differences and maternal mortality: a European study. MOMS Group. MOthers' Mortality and Severe morbidity. Int J Epidemiol (1999) 0.99
Causal relationships between HIV-1 coreceptor utilization, tropism, and pathogenesis in human thymus. AIDS Res Hum Retroviruses (2000) 0.98
A microscopic and biochemical study of fragmentation phenotypes in stage-appropriate human embryos. Hum Reprod (2001) 0.98
Successful transplantation of adult-sized kidneys into infants requires maintenance of high aortic blood flow. Transplantation (1998) 0.97
The Drosophila tumor necrosis factor receptor-associated factor-1 (DTRAF1) interacts with Pelle and regulates NFkappaB activity. J Biol Chem (2000) 0.97
Prophylactic therapy with Fibrogammin P is associated with a decreased incidence of bleeding episodes: a retrospective study. Haemophilia (2009) 0.96
Retroperitoneal neurilemmoma. Urology (1978) 0.96
Steroid-free immunosuppression since 1999: 129 pediatric renal transplants with sustained graft and patient benefits. Am J Transplant (2009) 0.96
Variation in rates of postterm birth in Europe: reality or artefact? BJOG (2007) 0.96
Sphingosine-1-phosphate lyase has a central role in the development of Dictyostelium discoideum. Development (2001) 0.95
Lymphogranuloma venereum proctitis masquerading as inflammatory bowel disease in 12 homosexual men. Aliment Pharmacol Ther (2010) 0.95
Scanning electron microscopic observations on cell surface changes during aggregation of Dictyostelium discoideum. Exp Cell Res (1974) 0.94