Alterations of the lymphocyte-specific protein tyrosine kinase (p56lck) during T-cell activation.

PubWeight™: 1.90‹?› | Rank: Top 3%

🔗 View Article (PMC 365508)

Published in Mol Cell Biol on October 01, 1988

Authors

A Veillette1, I D Horak, E M Horak, M A Bookman, J B Bolen

Author Affiliations

1: Laboratory of Tumor Virus Biology, National Cancer Institute, Bethesda, Maryland 20892.

Articles citing this

Expression of CD45 alters phosphorylation of the lck-encoded tyrosine protein kinase in murine lymphoma T-cell lines. Proc Natl Acad Sci U S A (1989) 2.99

The CD4 and CD8 antigens are coupled to a protein-tyrosine kinase (p56lck) that phosphorylates the CD3 complex. Proc Natl Acad Sci U S A (1989) 2.80

The level of c-fgr RNA is increased by EBNA-2, an Epstein-Barr virus gene required for B-cell immortalization. J Virol (1990) 2.75

Rapid activation of the T-cell tyrosine protein kinase pp56lck by the CD45 phosphotyrosine phosphatase. Proc Natl Acad Sci U S A (1989) 2.70

Exclusion of CD45 inhibits activity of p56lck associated with glycolipid-enriched membrane domains. J Cell Biol (1996) 2.19

The human p50csk tyrosine kinase phosphorylates p56lck at Tyr-505 and down regulates its catalytic activity. EMBO J (1992) 2.16

T-lymphocyte interleukin 2-dependent tyrosine protein kinase signal transduction involves the activation of p56lck. Proc Natl Acad Sci U S A (1991) 2.03

Temporal differences in the activation of three classes of non-transmembrane protein tyrosine kinases following B-cell antigen receptor surface engagement. Proc Natl Acad Sci U S A (1994) 1.83

Phosphorylation of eukaryotic translation initiation factor 4E is increased in Src-transformed cell lines. Mol Cell Biol (1991) 1.78

Polyunsaturated fatty acids inhibit T cell signal transduction by modification of detergent-insoluble membrane domains. J Cell Biol (1998) 1.63

Activation of p56lck through mutation of a regulatory carboxy-terminal tyrosine residue requires intact sites of autophosphorylation and myristylation. Mol Cell Biol (1990) 1.57

Alterations in tyrosine protein phosphorylation induced by antibody-mediated cross-linking of the CD4 receptor of T lymphocytes. Mol Cell Biol (1989) 1.55

Correlation between Src family member regulation by the protein-tyrosine-phosphatase CD45 and transmembrane signaling through the T-cell receptor. Proc Natl Acad Sci U S A (1993) 1.54

Association of p56lck with IL-2 receptor beta chain is critical for the IL-2-induced activation of p56lck. EMBO J (1993) 1.48

CD45 specifically modulates binding of Lck to a phosphopeptide encompassing the negative regulatory tyrosine of Lck. EMBO J (1993) 1.37

Phosphorylation of translation initiation factor eIF-4E is induced in a ras-dependent manner during nerve growth factor-mediated PC12 cell differentiation. Mol Cell Biol (1992) 1.36

The human immunodeficiency virus type 1 (HIV-1) CD4 receptor and its central role in promotion of HIV-1 infection. Microbiol Rev (1995) 1.34

Signaling defects in anti-tumor T cells. Immunol Rev (2008) 1.28

Functional coupling of the src-family protein tyrosine kinases p59fyn and p53/56lyn with the interleukin 2 receptor: implications for redundancy and pleiotropism in cytokine signal transduction. Proc Natl Acad Sci U S A (1993) 1.27

Structural requirements for enhancement of T-cell responsiveness by the lymphocyte-specific tyrosine protein kinase p56lck. Mol Cell Biol (1992) 1.20

Kinetics of p56lck and p60src Src homology 2 domain binding to tyrosine-phosphorylated peptides determined by a competition assay or surface plasmon resonance. Proc Natl Acad Sci U S A (1993) 1.18

Adenomatous polyposis coli gene mutation alters proliferation through its beta-catenin-regulatory function in aggressive fibromatosis (desmoid tumor). Am J Pathol (1998) 1.16

Phosphorylation of Ser-42 and Ser-59 in the N-terminal region of the tyrosine kinase p56lck. Proc Natl Acad Sci U S A (1993) 1.14

Structure of the two promoters of the human lck gene: differential accumulation of two classes of lck transcripts in T cells. Mol Cell Biol (1989) 1.10

Interleukin 2 regulates the activity of the lyn protein-tyrosine kinase in a B-cell line. Proc Natl Acad Sci U S A (1992) 1.09

Defective expression of p56lck in an infant with severe combined immunodeficiency. J Clin Invest (1998) 1.05

Functional phenotype of transformed human alphabeta and gammadelta T cells determined by different subgroup C strains of herpesvirus Saimiri. J Virol (1997) 1.02

Purification and initial characterization of the lymphoid-cell protein-tyrosine kinase p56lck from a baculovirus expression system. Proc Natl Acad Sci U S A (1991) 1.01

Selective expression of alternative lck mRNAs in human malignant cell lines. Mol Cell Biol (1989) 0.95

Inhibition of lymphoid tyrosine phosphatase by benzofuran salicylic acids. J Med Chem (2010) 0.94

Purification and characterization of a higher-molecular-mass form of protein phosphotyrosine phosphatase (PTP 1B) from placental membranes. Biochem J (1991) 0.90

Autonomous roles for the cytoplasmic domains of the CD2 and CD4 T cell surface antigens. EMBO J (1991) 0.89

Down-regulation of lck mRNA by T cell activation involves transcriptional and post-transcriptional mechanisms. Nucleic Acids Res (1991) 0.88

Herpes simplex virus requires VP11/12 to induce phosphorylation of the activation loop tyrosine (Y394) of the Src family kinase Lck in T lymphocytes. J Virol (2009) 0.87

PreTCR and TCRγδ signal initiation in thymocyte progenitors does not require domains implicated in receptor oligomerization. Sci Signal (2011) 0.80

Partial purification and characterization of the lck protein-tyrosine kinase from bovine thymus. Biochem J (1991) 0.78

Integrin-mediated tyrosine phosphorylation of Shc in T cells is regulated by protein kinase C-dependent phosphorylations of Lck. Mol Biol Cell (2003) 0.78

Recruitment of calcineurin to the TCR positively regulates T cell activation. Nat Immunol (2016) 0.77

Modulating p56Lck in T-Cells by a Chimeric Peptide Comprising Two Functionally Different Motifs of Tip from Herpesvirus saimiri. J Immunol Res (2015) 0.75

Induction of a cytoplasmic activator of DNA synthesis in lymphocytes is mediated through a membrane-associated protein kinase. Cell Regul (1990) 0.75

Articles cited by this

Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry (1979) 180.95

The role of protein kinase C in cell surface signal transduction and tumour promotion. Nature (1984) 28.58

Transforming gene product of Rous sarcoma virus phosphorylates tyrosine. Proc Natl Acad Sci U S A (1980) 22.30

Identification of a monoclonal antibody specific for a murine T3 polypeptide. Proc Natl Acad Sci U S A (1987) 14.24

The role of the T3/antigen receptor complex in T-cell activation. Annu Rev Immunol (1986) 5.67

Cloning and expression of murine immune interferon cDNA. Proc Natl Acad Sci U S A (1983) 5.25

A lymphocyte-specific protein-tyrosine kinase gene is rearranged and overexpressed in the murine T cell lymphoma LSTRA. Cell (1985) 5.21

Tyr527 is phosphorylated in pp60c-src: implications for regulation. Science (1986) 4.99

Evidence implicating L3T4 in class II MHC antigen reactivity; monoclonal antibody GK1.5 (anti-L3T4a) blocks class II MHC antigen-specific proliferation, release of lymphokines, and binding by cloned murine helper T lymphocyte lines. J Immunol (1983) 4.28

Antigen-like effects of monoclonal antibodies directed at receptors on human T cell clones. J Exp Med (1983) 4.10

Expression of a new tyrosine protein kinase is stimulated by retrovirus promoter insertion. Nature (1986) 3.00

Neoplastic transformation induced by an activated lymphocyte-specific protein tyrosine kinase (pp56lck). Mol Cell Biol (1988) 2.80

Protein kinase C phosphorylates pp60src at a novel site. Cell (1985) 2.63

Crosslinking of surface antigens causes mobilization of intracellular ionized calcium in T lymphocytes. Proc Natl Acad Sci U S A (1987) 2.53

A novel phorbol ester receptor/protein kinase, nPKC, distantly related to the protein kinase C family. Cell (1988) 2.44

Translational activation of the lck proto-oncogene. Nature (1988) 2.41

The product of the protooncogene c-src is modified during the cellular response to platelet-derived growth factor. Proc Natl Acad Sci U S A (1985) 2.19

Mitogens increase phosphorylation of phosphoinositides in thymocytes. Nature (1985) 2.18

Post-translational alterations of the tyrosine kinase p56lck in response to activators of protein kinase C. Oncogene Res (1988) 1.80

Regulation of pp56lck during T-cell activation: functional implications for the src-like protein tyrosine kinases. EMBO J (1987) 1.80

The role of protein kinase C in transmembrane signaling by the T cell antigen receptor complex. Effects of stimulation with soluble or immobilized CD3 antibodies. J Immunol (1987) 1.70

Acquisition of transforming properties by FYN, a normal SRC-related human gene. Proc Natl Acad Sci U S A (1988) 1.60

Expression of the lck tyrosine kinase gene in human colon carcinoma and other non-lymphoid human tumor cell lines. Oncogene Res (1988) 1.53

A lymphoma cell line expressing elevated levels of tyrosine protein kinase activity. J Biol Chem (1983) 1.45

Stimulation of T cells through the CD3/T-cell receptor complex: role of cytoplasmic calcium, protein kinase C translocation, and phosphorylation of pp60c-src in the activation pathway. Mol Cell Biol (1987) 1.32

Analysis of pp60c-src in human colon carcinoma and normal human colon mucosal cells. Oncogene Res (1987) 1.29

The role of the L3T4 molecule in mitogen and antigen-activated signal transduction. Cell (1987) 1.25

Distinct signals are required for proliferation and lymphokine gene expression in murine T cell clones. J Immunol (1986) 1.11

Sites of in vivo phosphorylation of the T cell tyrosine protein kinase in LSTRA cells and their alteration by tumor-promoting phorbol esters. J Biol Chem (1987) 1.09

Adoptive chemoimmunotherapy of murine leukemia with helper T lymphocyte clones. J Immunol (1987) 1.09

Tumor promoters cause changes in the state of phosphorylation and apparent molecular weight of a tyrosine protein kinase in T lymphocytes. J Biol Chem (1986) 1.07

Expression of the human T-cell-specific tyrosine kinase YT16 (lck) message in leukemic T-cell lines. Cancer Res (1988) 0.99

Adoptive immunotherapy of syngeneic murine leukemia is enhanced by the combination of recombinant IFN-gamma and a tumor-specific cytotoxic T cell clone. J Immunol (1988) 0.84

Articles by these authors

The CD4 and CD8 T cell surface antigens are associated with the internal membrane tyrosine-protein kinase p56lck. Cell (1988) 10.47

Signal transduction through the CD4 receptor involves the activation of the internal membrane tyrosine-protein kinase p56lck. Nature (1989) 5.20

Isolation and functional characterization of human intestinal mucosal lymphoid cells. J Clin Invest (1977) 5.09

Enhancement of cellular src gene product associated tyrosyl kinase activity following polyoma virus infection and transformation. Cell (1984) 5.05

Syk tyrosine kinase required for mouse viability and B-cell development. Nature (1995) 3.87

Stimulation of simian virus 40 late gene expression by simian virus 40 tumor antigen. Proc Natl Acad Sci U S A (1984) 3.80

Anti-immunoglobulin stimulation of B lymphocytes activates src-related protein-tyrosine kinases. Proc Natl Acad Sci U S A (1991) 3.57

Engagement of the high-affinity IgE receptor activates src protein-related tyrosine kinases. Nature (1992) 2.95

Membrane glycoprotein IV (CD36) is physically associated with the Fyn, Lyn, and Yes protein-tyrosine kinases in human platelets. Proc Natl Acad Sci U S A (1991) 2.93

High affinity restricts the localization and tumor penetration of single-chain fv antibody molecules. Cancer Res (2001) 2.90

Integral membrane protein 2 of Epstein-Barr virus regulates reactivation from latency through dominant negative effects on protein-tyrosine kinases. Immunity (1995) 2.74

Adults and children with small non-cleaved-cell lymphoma have a similar excellent outcome when treated with the same chemotherapy regimen. J Clin Oncol (1996) 2.05

T-lymphocyte interleukin 2-dependent tyrosine protein kinase signal transduction involves the activation of p56lck. Proc Natl Acad Sci U S A (1991) 2.03

Tyrosine phosphorylation within the amino-terminal domain of pp60c-src molecules associated with polyoma virus middle-sized tumor antigen. Proc Natl Acad Sci U S A (1985) 1.96

Lipopolysaccharide induces activation of CD14-associated protein tyrosine kinase p53/56lyn. J Biol Chem (1993) 1.95

src-related tyrosine protein kinases as signaling components in hematopoietic cells. Cancer Cells (1990) 1.92

Activation of pp60c-src protein kinase activity in human colon carcinoma. Proc Natl Acad Sci U S A (1987) 1.92

Hematopoietic cells express two forms of lyn kinase differing by 21 amino acids in the amino terminus. Mol Cell Biol (1991) 1.84

Temporal differences in the activation of three classes of non-transmembrane protein tyrosine kinases following B-cell antigen receptor surface engagement. Proc Natl Acad Sci U S A (1994) 1.83

Suppression of tumorigenicity of glioblastoma cells by adenovirus-mediated MMAC1/PTEN gene transfer. Cancer Res (1998) 1.83

Characteristics of isolated intestinal mucosal lymphoid cells in inflammatory bowel disease. Gastroenterology (1979) 1.81

Post-translational alterations of the tyrosine kinase p56lck in response to activators of protein kinase C. Oncogene Res (1988) 1.80

Syk protein-tyrosine kinase is regulated by tyrosine-phosphorylated Ig alpha/Ig beta immunoreceptor tyrosine activation motif binding and autophosphorylation. J Biol Chem (1995) 1.78

An Epstein-Barr virus transformation-associated membrane protein interacts with src family tyrosine kinases. J Virol (1992) 1.74

Signal transduction by immunoglobulin is mediated through Ig alpha and Ig beta. J Exp Med (1993) 1.73

Transcriptional analysis of the PTEN/MMAC1 pseudogene, psiPTEN. Oncogene (1999) 1.72

Middle tumor antigen of polyomavirus transformation-defective mutant NG59 is associated with pp60c-src. J Virol (1985) 1.71

Analysis of pp60c-src protein kinase activity in human tumor cell lines and tissues. J Biol Chem (1986) 1.67

Inability of CD8 alpha' polypeptides to associate with p56lck correlates with impaired function in vitro and lack of expression in vivo. Nature (1989) 1.66

The product of the Herpesvirus saimiri open reading frame 1 (tip) interacts with T cell-specific kinase p56lck in transformed cells. J Biol Chem (1995) 1.65

Phosphorylation sites of the E2 transcriptional regulatory proteins of bovine papillomavirus type 1. J Virol (1989) 1.65

Differences in the subpopulations of the structural proteins of polyoma virions and capsids: biological functions of the multiple VP1 species. J Virol (1981) 1.64

Identification of a novel neuronal C-SRC exon expressed in human brain. Mol Cell Biol (1990) 1.63

Differential adsorption of polyoma virions and capsids to mouse kidney cells and guinea pig erythrocytes. J Virol (1979) 1.59

Engagement of CD4 and CD8 expressed on immature thymocytes induces activation of intracellular tyrosine phosphorylation pathways. J Exp Med (1989) 1.58

Alterations in tyrosine protein phosphorylation induced by antibody-mediated cross-linking of the CD4 receptor of T lymphocytes. Mol Cell Biol (1989) 1.55

Clinical evaluation of intraperitoneal Pseudomonas exotoxin immunoconjugate OVB3-PE in patients with ovarian cancer. J Clin Oncol (1991) 1.53

Expression of the lck tyrosine kinase gene in human colon carcinoma and other non-lymphoid human tumor cell lines. Oncogene Res (1988) 1.53

Increased pp60c-src tyrosyl kinase activity in human neuroblastomas is associated with amino-terminal tyrosine phosphorylation of the src gene product. Proc Natl Acad Sci U S A (1985) 1.52

Generation of diversity in T cell receptor repertoire specific for pigeon cytochrome c. J Exp Med (1987) 1.52

Association of p60fyn with middle tumor antigen in murine polyomavirus-transformed rat cells. J Virol (1989) 1.47

Second-line treatment of ovarian cancer. Oncologist (2000) 1.45

Interactions of p59fyn and ZAP-70 with T-cell receptor activation motifs: defining the nature of a signalling motif. Mol Cell Biol (1994) 1.45

Integrin-mediated tyrosine phosphorylation and cytokine message induction in monocytic cells. A possible signaling role for the Syk tyrosine kinase. J Biol Chem (1995) 1.44

Lymphocytic lymphoma of intermediate differentiation--mantle zone lymphoma: a distinct subtype of B-cell lymphoma. Hum Pathol (1987) 1.44

Src family protein tyrosine kinases induce autoactivation of Bruton's tyrosine kinase. Mol Cell Biol (1995) 1.44

Phase I and pharmacokinetic study of farnesyl protein transferase inhibitor R115777 in advanced cancer. J Clin Oncol (2000) 1.43

Granulocyte colony-stimulating factor receptor signaling involves the formation of a three-component complex with Lyn and Syk protein-tyrosine kinases. Proc Natl Acad Sci U S A (1994) 1.42

In vitro and in vivo characterization of a human anti-c-erbB-2 single-chain Fv isolated from a filamentous phage antibody library. Immunotechnology (1995) 1.38

Physical and functional association of Src-related protein tyrosine kinases with Fc gamma RII in monocytic THP-1 cells. J Biol Chem (1994) 1.38

CD45 specifically modulates binding of Lck to a phosphopeptide encompassing the negative regulatory tyrosine of Lck. EMBO J (1993) 1.37

Activation of tyrosine kinase p60fyn following T cell antigen receptor cross-linking. J Biol Chem (1992) 1.32

Separation of neutralizing and hemagglutination-inhibiting antibody activities and specificity of antisera to sodium dodecyl sulfate-derived polypeptides of polyoma virions. J Virol (1980) 1.32

Cross-linking of Fc gamma receptor I (Fc gamma RI) and receptor II (Fc gamma RII) on monocytic cells activates a signal transduction pathway common to both Fc receptors that involves the stimulation of p72 Syk protein tyrosine kinase. J Biol Chem (1993) 1.32

Temporal regulation of non-transmembrane protein tyrosine kinase enzyme activity following T cell antigen receptor engagement. J Biol Chem (1994) 1.31

Phase II trial of yttrium-90-DOTA-biotin pretargeted by NR-LU-10 antibody/streptavidin in patients with metastatic colon cancer. Clin Cancer Res (2000) 1.30

A conditional form of Bruton's tyrosine kinase is sufficient to activate multiple downstream signaling pathways via PLC Gamma 2 in B cells. BMC Immunol (2001) 1.29

Granulocyte macrophage-colony stimulating factor stimulates both association and activation of phosphoinositide 3OH-kinase and src-related tyrosine kinase(s) in human myeloid derived cells. EMBO J (1993) 1.29

Interaction of p72syk with the gamma and beta subunits of the high-affinity receptor for immunoglobulin E, Fc epsilon RI. Mol Cell Biol (1995) 1.26

Post-therapy serum prostate-specific antigen level and survival in patients with androgen-independent prostate cancer. J Natl Cancer Inst (1999) 1.25

The Syk protein tyrosine kinase can function independently of CD45 or Lck in T cell antigen receptor signaling. EMBO J (1996) 1.24

The interleukin-2 receptor: a target for monoclonal antibody treatment of human T-cell lymphotrophic virus I-induced adult T-cell leukemia. Blood (1993) 1.22

Paired immunoglobulin-like receptor B (PIR-B) inhibits BCR-induced activation of Syk and Btk by SHP-1. Oncogene (1999) 1.22

TCR activation of ZAP70 is impaired in CD4+CD8+ thymocytes as a consequence of intrathymic interactions that diminish available p56lck. Immunity (1996) 1.19

Highly specific in vivo tumor targeting by monovalent and divalent forms of 741F8 anti-c-erbB-2 single-chain Fv. Cancer Res (1993) 1.18

Salmonella typhimurium enteritis and bacteremia in the acquired immunodeficiency syndrome. Ann Intern Med (1985) 1.15

Expression of p60fyn in human platelets. Oncogene (1990) 1.15

Regulation of pp60c-src synthesis by inducible RNA complementary to c-src mRNA in polyomavirus-transformed rat cells. Mol Cell Biol (1986) 1.15

Selective activation of T cell kinase p56lck by Herpesvirus saimiri protein tip. J Biol Chem (1996) 1.15

RANTES induces tyrosine kinase activity of stably complexed p125FAK and ZAP-70 in human T cells. J Exp Med (1996) 1.15

Down-modulation of cancer targets using locked nucleic acid (LNA)-based antisense oligonucleotides without transfection. Gene Ther (2010) 1.14

Cross-linking of surface immunoglobulin activates src-related tyrosine kinases in WEHI 231 cells. Biochem Biophys Res Commun (1992) 1.12

Reconstitution of Btk signaling by the atypical tec family tyrosine kinases Bmx and Txk. J Biol Chem (1999) 1.10

Lymphocytic lymphoma of intermediate differentiation. Morphologic and immunophenotypic spectrum and clinical correlations. Am J Surg Pathol (1990) 1.10

Production and characterization of a monoclonal antibody that binds Reed-Sternberg cells. J Immunol (1985) 1.10

In vitro association and phosphorylation of polyoma virus middle T antigen by cellular tyrosyl kinase activity. J Biol Chem (1984) 1.10

Isolation and characterization of polyoma uncoating intermediates from the nuclei of infected mouse cells. J Virol (1980) 1.09

Ctk: a protein-tyrosine kinase related to Csk that defines an enzyme family. Proc Natl Acad Sci U S A (1994) 1.08

Endogenous reactive oxygen intermediates activate tyrosine kinases in human neutrophils. J Biol Chem (1996) 1.08

Phase I trial of buthionine sulfoximine in combination with melphalan in patients with cancer. J Clin Oncol (1996) 1.07

ZAP-70 tyrosine kinase, CD45, and T cell receptor involvement in UV- and H2O2-induced T cell signal transduction. J Biol Chem (1994) 1.06

Endogenous knockdown of survivin improves chemotherapeutic response in ALL models. Leukemia (2011) 1.06

Epstein-Barr virus protein LMP2A regulates reactivation from latency by negatively regulating tyrosine kinases involved in sIg-mediated signal transduction. Infect Agents Dis (1995) 1.05

The Raf-1 serine-threonine kinase is a substrate for the p56lck protein tyrosine kinase in human T-cells. Cell Growth Differ (1991) 1.04

Specific association of tyrosine-phosphorylated c-Cbl with Fyn tyrosine kinase in T cells. J Biol Chem (1996) 1.03

No T-cell tyrosine protein kinase signalling or calcium mobilization after CD4 association with HIV-1 or HIV-1 gp120. Nature (1990) 1.03

A determinant of polyomavirus virulence enhances virus growth in cells of renal origin. J Virol (1985) 1.03