Published in Science on March 21, 1986
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Stable association of pp60src and pp59fyn with the focal adhesion-associated protein tyrosine kinase, pp125FAK. Mol Cell Biol (1994) 4.11
Transformation-specific tyrosine phosphorylation of a novel cellular protein in chicken cells expressing oncogenic variants of the avian cellular src gene. Mol Cell Biol (1989) 4.08
Dephosphorylation or antibody binding to the carboxy terminus stimulates pp60c-src. Mol Cell Biol (1986) 3.99
A tyrosine-phosphorylated carboxy-terminal peptide of the fibroblast growth factor receptor (Flg) is a binding site for the SH2 domain of phospholipase C-gamma 1. Mol Cell Biol (1991) 3.13
cDNA cloning and sequencing of the protein-tyrosine kinase substrate, ezrin, reveals homology to band 4.1. EMBO J (1989) 3.10
Molecular and biochemical characterization of the human trk proto-oncogene. Mol Cell Biol (1989) 3.10
Neoplastic transformation induced by an activated lymphocyte-specific protein tyrosine kinase (pp56lck). Mol Cell Biol (1988) 2.80
Rapid activation of the T-cell tyrosine protein kinase pp56lck by the CD45 phosphotyrosine phosphatase. Proc Natl Acad Sci U S A (1989) 2.70
Activation of the oncogenic potential of the avian cellular src protein by specific structural alteration of the carboxy terminus. EMBO J (1987) 2.67
Mutation of a site of tyrosine phosphorylation in the lymphocyte-specific tyrosine protein kinase, p56lck, reveals its oncogenic potential in fibroblasts. Proc Natl Acad Sci U S A (1988) 2.60
Oncogenic activation of the neu-encoded receptor protein by point mutation and deletion. EMBO J (1988) 2.59
Identification of a human gene (HCK) that encodes a protein-tyrosine kinase and is expressed in hemopoietic cells. Mol Cell Biol (1987) 2.59
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Novel protein-tyrosine kinase gene (hck) preferentially expressed in cells of hematopoietic origin. Mol Cell Biol (1987) 2.52
Stable association of activated pp60src with two tyrosine-phosphorylated cellular proteins. Mol Cell Biol (1989) 2.49
The yes-related cellular gene lyn encodes a possible tyrosine kinase similar to p56lck. Mol Cell Biol (1987) 2.44
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Altered sites of tyrosine phosphorylation in pp60c-src associated with polyomavirus middle tumor antigen. Mol Cell Biol (1986) 2.32
Novel tyrosine kinase identified by phosphotyrosine antibody screening of cDNA libraries. Mol Cell Biol (1988) 2.31
Identification and characterization of p59fyn (a src-like protein tyrosine kinase) in normal and polyoma virus transformed cells. EMBO J (1988) 2.28
Peptide antibodies to the human c-fyn gene product demonstrate pp59c-fyn is capable of complex formation with the middle-T antigen of polyomavirus. EMBO J (1988) 2.25
Platelet-derived growth factor induces multisite phosphorylation of pp60c-src and increases its protein-tyrosine kinase activity. Mol Cell Biol (1988) 2.22
Isolation of a src homology 2-containing tyrosine phosphatase. Proc Natl Acad Sci U S A (1992) 2.22
EGF-stimulated tyrosine phosphorylation of p185neu: a potential model for receptor interactions. EMBO J (1988) 2.15
Ligand and protein kinase C downmodulate the colony-stimulating factor 1 receptor by independent mechanisms. Mol Cell Biol (1989) 2.12
Characterization of cDNA clones for the human c-yes gene. Mol Cell Biol (1987) 2.11
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Mouse disabled (mDab1): a Src binding protein implicated in neuronal development. EMBO J (1997) 1.95
Redistribution of activated pp60c-src to integrin-dependent cytoskeletal complexes in thrombin-stimulated platelets. Mol Cell Biol (1993) 1.94
Thymic tumorigenesis induced by overexpression of p56lck. Proc Natl Acad Sci U S A (1991) 1.93
Activation of pp60c-src protein kinase activity in human colon carcinoma. Proc Natl Acad Sci U S A (1987) 1.92
Alterations of the lymphocyte-specific protein tyrosine kinase (p56lck) during T-cell activation. Mol Cell Biol (1988) 1.90
Potential positive and negative autoregulation of p60c-src by intermolecular autophosphorylation. Proc Natl Acad Sci U S A (1988) 1.80
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ASAP1, a phospholipid-dependent arf GTPase-activating protein that associates with and is phosphorylated by Src. Mol Cell Biol (1998) 1.73
The role of Src in solid tumors. Oncologist (2009) 1.72
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Activation of c-Src in cells bearing v-Crk and its suppression by Csk. Mol Cell Biol (1992) 1.67
Acquisition of transforming properties by FYN, a normal SRC-related human gene. Proc Natl Acad Sci U S A (1988) 1.60
Mitogenic stimulation of thymocytes results in the calcium-dependent phosphorylation of c-ets-1 proteins. EMBO J (1988) 1.58
Activation of p56lck through mutation of a regulatory carboxy-terminal tyrosine residue requires intact sites of autophosphorylation and myristylation. Mol Cell Biol (1990) 1.57
Lessons in signaling and tumorigenesis from polyomavirus middle T antigen. Microbiol Mol Biol Rev (2009) 1.48
Primary structure of the human fgr proto-oncogene product p55c-fgr. Mol Cell Biol (1988) 1.48
Molecular cloning and expression of chicken C-terminal Src kinase: lack of stable association with c-Src protein. Proc Natl Acad Sci U S A (1992) 1.46
Binding of the Src SH2 domain to phosphopeptides is determined by residues in both the SH2 domain and the phosphopeptides. Mol Cell Biol (1993) 1.45
Suppression of c-Src activity by C-terminal Src kinase involves the c-Src SH2 and SH3 domains: analysis with Saccharomyces cerevisiae. Mol Cell Biol (1993) 1.44
Medium tumor antigen of polyomavirus transformation-defective mutant NG59 is associated with 73-kilodalton heat shock protein. J Virol (1987) 1.43
Rat c-raf oncogene activation by a rearrangement that produces a fused protein. Mol Cell Biol (1987) 1.42
Investigation of factors that influence phosphorylation of pp60c-src on tyrosine 527. Mol Cell Biol (1988) 1.38
Early phosphorylation events following the treatment of Swiss 3T3 cells with bombesin and the mammalian bombesin-related peptide, gastrin-releasing peptide. EMBO J (1986) 1.38
Regulation of the SRC family kinases by Csk. Int J Biol Sci (2012) 1.36
Alterations in pp60c-src accompany differentiation of neurons from rat embryo striatum. Mol Cell Biol (1987) 1.35
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E-cadherin adhesion activates c-Src signaling at cell-cell contacts. Mol Biol Cell (2007) 1.33
Regulation of SRC family kinases in human cancers. J Signal Transduct (2011) 1.32
Enzymatic activation of Fujinami sarcoma virus gag-fps transforming proteins by autophosphorylation at tyrosine. EMBO J (1987) 1.30
An electrostatic network and long-range regulation of Src kinases. Protein Sci (2008) 1.30
Regulation of pp60c-src and its interaction with polyomavirus middle T antigen in insect cells. J Virol (1990) 1.29
Primary sequence and developmental expression of a novel Drosophila melanogaster src gene. Mol Cell Biol (1987) 1.28
Characterization of avian and viral p60src proteins expressed in yeast. Proc Natl Acad Sci U S A (1987) 1.28
Direct and specific inactivation of protein tyrosine kinases in the Src and FGFR families by reversible cysteine oxidation. Proc Natl Acad Sci U S A (2009) 1.27
The carboxy terminus of pp60c-src is a regulatory domain and is involved in complex formation with the middle-T antigen of polyomavirus. Mol Cell Biol (1988) 1.26
Identification of tyrosine 706 in the kinase insert as the major colony-stimulating factor 1 (CSF-1)-stimulated autophosphorylation site in the CSF-1 receptor in a murine macrophage cell line. Mol Cell Biol (1990) 1.25
Deletions within the amino-terminal half of the c-src gene product that alter the functional activity of the protein. Mol Cell Biol (1989) 1.25
Structural differences between repressed and derepressed forms of p60c-src. Mol Cell Biol (1989) 1.23
Treatment for chronic myelogenous leukemia: the long road to imatinib. J Clin Invest (2007) 1.22
Polyomavirus middle T antigen downregulates junctional cell-to-cell communication. Mol Cell Biol (1987) 1.22
Lessons from polyoma middle T antigen on signaling and transformation: A DNA tumor virus contribution to the war on cancer. Virology (2008) 1.20
Kinetics of p56lck and p60src Src homology 2 domain binding to tyrosine-phosphorylated peptides determined by a competition assay or surface plasmon resonance. Proc Natl Acad Sci U S A (1993) 1.18
Drosophila C-terminal Src kinase negatively regulates organ growth and cell proliferation through inhibition of the Src, Jun N-terminal kinase, and STAT pathways. Mol Cell Biol (2004) 1.18
Features of the pp60v-src carboxyl terminus that are required for transformation. Mol Cell Biol (1986) 1.17
Isolation and sequence of a cDNA corresponding to a src-related gene expressed in murine hemopoietic cells. Proc Natl Acad Sci U S A (1987) 1.17
Alternative splicing within the chicken c-ets-1 locus: implications for transduction within the E26 retrovirus of the c-ets proto-oncogene. J Virol (1988) 1.17
Transformation of NIH 3T3 fibroblasts by an activated form of p59hck. Mol Cell Biol (1989) 1.17
Biological and biochemical properties of the c-src+ gene product overexpressed in chicken embryo fibroblasts. Mol Cell Biol (1989) 1.16
Phosphorylation process induced by epidermal growth factor alters the oncogenic and cellular neu (NGL) gene products. Proc Natl Acad Sci U S A (1988) 1.14
Differing Src signaling levels have distinct outcomes in Drosophila. Cancer Res (2007) 1.13
The v-fms oncogene induces factor-independent growth and transformation of the interleukin-3-dependent myeloid cell line FDC-P1. Mol Cell Biol (1987) 1.13
Pim-1 levels determine the size of early B lymphoid compartments in bone marrow. J Exp Med (1993) 1.12
p56lck protein-tyrosine kinase is cytoskeletal and does not bind to polyomavirus middle T antigen. J Virol (1988) 1.12
Gain control of N-methyl-D-aspartate receptor activity by receptor-like protein tyrosine phosphatase alpha. EMBO J (2002) 1.11
Temporally sequenced anticancer drugs overcome adaptive resistance by targeting a vulnerable chemotherapy-induced phenotypic transition. Nat Commun (2015) 1.11
Rapid and efficient purification of Src homology 2 domain-containing proteins: Fyn, Csk and phosphatidylinositol 3-kinase p85. Biochem J (1994) 1.10
Structure of the two promoters of the human lck gene: differential accumulation of two classes of lck transcripts in T cells. Mol Cell Biol (1989) 1.10
Nucleic acid sequence and oncogenic properties of the HZ2 feline sarcoma virus v-abl insert. J Virol (1987) 1.10
Functional heterogeneity of proto-oncogene tyrosine kinases: the C terminus of the human epidermal growth factor receptor facilitates cell proliferation. Mol Cell Biol (1989) 1.09
Role of p34cdc2-mediated phosphorylations in two-step activation of pp60c-src during mitosis. Proc Natl Acad Sci U S A (1992) 1.09
The human c-fps/fes gene product expressed ectopically in rat fibroblasts is nontransforming and has restrained protein-tyrosine kinase activity. Mol Cell Biol (1988) 1.09
Identification of c-Src tyrosine kinase substrates using mass spectrometry and peptide microarrays. J Proteome Res (2008) 1.06
Identification of c-Src tyrosine kinase substrates in platelet-derived growth factor receptor signaling. Mol Oncol (2009) 1.05
Myristylation is required for Tyr-527 dephosphorylation and activation of pp60c-src in mitosis. Mol Cell Biol (1993) 1.04
OipA plays a role in Helicobacter pylori-induced focal adhesion kinase activation and cytoskeletal re-organization. Cell Microbiol (2007) 1.03
pp60c-src variants containing lesions that affect phosphorylation at tyrosines 416 and 527. Mol Cell Biol (1989) 1.03
Src activity increases and Yes activity decreases during mitosis of human colon carcinoma cells. Mol Cell Biol (1995) 1.03
Structural elements that regulate pp59c-fyn catalytic activity, transforming potential, and ability to associate with polyomavirus middle-T antigen. J Virol (1991) 1.03
Control of excitatory synaptic transmission by C-terminal Src kinase. J Biol Chem (2008) 1.03
pp60c-src has less affinity for the detergent-insoluble cellular matrix than do pp60v-src and other viral protein-tyrosine kinases. J Virol (1987) 1.02
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