Published in Proc Natl Acad Sci U S A on August 01, 1979
Discrete stages of human intrathymic differentiation: analysis of normal thymocytes and leukemic lymphoblasts of T-cell lineage. Proc Natl Acad Sci U S A (1980) 11.23
Clonotypic structures involved in antigen-specific human T cell function. Relationship to the T3 molecular complex. J Exp Med (1983) 9.23
Evolutionary conservation of surface molecules that distinguish T lymphocyte helper/inducer and cytotoxic/suppressor subpopulations in mouse and man. J Exp Med (1981) 6.82
Clonal analysis of human cytotoxic T lymphocytes: T4+ and T8+ effector T cells recognize products of different major histocompatibility complex regions. Proc Natl Acad Sci U S A (1982) 5.85
Ia determinants on human T-cell subsets defined by monoclonal antibody. Activation stimuli required for expression. J Exp Med (1979) 5.19
Ia expression by vascular endothelium is inducible by activated T cells and by human gamma interferon. J Exp Med (1983) 4.92
Triggering of the T3-Ti antigen-receptor complex results in clonal T-cell proliferation through an interleukin 2-dependent autocrine pathway. Proc Natl Acad Sci U S A (1984) 4.78
Thymus-dependent membrane antigens in man: inhibition of cell-mediated lympholysis by monoclonal antibodies to TH2 antigen. Proc Natl Acad Sci U S A (1981) 4.38
Human lymphocytes bearing T cell receptor gamma/delta are phenotypically diverse and evenly distributed throughout the lymphoid system. J Exp Med (1989) 3.70
Distribution of T cell subsets in human lymph nodes. J Exp Med (1981) 3.64
Reactivity of Langerhans cells with hybridoma antibody. Proc Natl Acad Sci U S A (1981) 3.62
Foreign glycoproteins expressed from recombinant vesicular stomatitis viruses are incorporated efficiently into virus particles. Proc Natl Acad Sci U S A (1996) 3.54
Location of T cell and major histocompatibility complex antigens in the human thymus. J Exp Med (1980) 3.41
Absence of gamma interferon and interleukin 2 production during active visceral leishmaniasis. J Clin Invest (1985) 3.41
A retention signal necessary and sufficient for endoplasmic reticulum localization maps to the transmembrane domain of hepatitis C virus glycoprotein E2. J Virol (1998) 3.13
Does OKT3 monoclonal antibody react with an antigen-recognition structure on human T cells? Proc Natl Acad Sci U S A (1981) 3.09
Human T lymphocyte subpopulations defined by Fc receptors and monoclonal antibodies. A comparison. J Exp Med (1980) 3.03
Simple and rapid measurement of human T lymphocytes and their subclasses in peripheral blood. Proc Natl Acad Sci U S A (1980) 2.96
Antibodies to membrane structures that distinguish suppressor/cytotoxic and helper T lymphocyte subpopulations block the mixed leukocyte reaction in man. J Exp Med (1981) 2.93
Generation of monoclonal antibodies to a human natural killer clone. Characterization of two natural killer-associated antigens, NKH1A and NKH2, expressed on subsets of large granular lymphocytes. J Clin Invest (1985) 2.77
Fluorescent phycobiliprotein conjugates for analyses of cells and molecules. J Cell Biol (1982) 2.73
T lymphocyte subsets in human intestinal mucosa: the distribution and relationship to MHC-derived antigens. Clin Exp Immunol (1981) 2.68
Perturbation of the T4 molecule transmits a negative signal to T cells. J Exp Med (1985) 2.66
Functional analysis of human T cell subsets defined by monoclonal antibodies. IV. Induction of suppressor cells within the OKT4+ population. J Exp Med (1981) 2.35
Monoclonal antibody analysis of human T lymphocyte subpopulations exhibiting autologous mixed lymphocyte reaction. Proc Natl Acad Sci U S A (1981) 2.16
Immunoregulatory subsets of the T helper and T suppressor cell populations in homosexual men with chronic unexplained lymphadenopathy. J Clin Invest (1984) 2.07
Alterations in immunoregulatory T cell subsets in active systemic lupus erythematosus. J Clin Invest (1980) 2.06
Identification of a novel surface protein on activated CD4+ T cells that induces contact-dependent B cell differentiation (help). J Exp Med (1992) 2.03
The transmembrane domain of hepatitis C virus glycoprotein E1 is a signal for static retention in the endoplasmic reticulum. J Virol (1999) 1.97
Peptide and nucleotide sequences of rat CD4 (W3/25) antigen: evidence for derivation from a structure with four immunoglobulin-related domains. Proc Natl Acad Sci U S A (1987) 1.95
Immunologic abnormalities in chronic fatigue syndrome. J Clin Microbiol (1990) 1.94
T cell subsets in leprosy lesions: in situ characterization using monoclonal antibodies. Clin Exp Immunol (1983) 1.93
Human Mycobacterium tuberculosis-reactive CD4+ T-cell clones: heterogeneity in antigen recognition, cytokine production, and cytotoxicity for mononuclear phagocytes. Infect Immun (1991) 1.89
Subcellular localization and topology of the p7 polypeptide of hepatitis C virus. J Virol (2002) 1.89
Characterization of a monoclonal antibody that defines an immunoregulatory T cell subset for immunoglobulin synthesis in humans. Proc Natl Acad Sci U S A (1980) 1.81
Characterization by a monoclonal antibody and functional analysis of a subset of bovine T lymphocytes that express BoT8, a molecule analogous to human CD8. Immunology (1986) 1.75
In situ identification of T lymphocyte subsets and HLA-DR expressing cells in the human skin tuberculin reaction. Clin Exp Immunol (1982) 1.71
Fc gamma receptor type III (CD16) is included in the zeta NK receptor complex expressed by human natural killer cells. Proc Natl Acad Sci U S A (1990) 1.66
Cellular and molecular mechanisms for reduced interleukin 4 and interferon-gamma production by neonatal T cells. J Clin Invest (1991) 1.64
Interstitial mononuclear cell populations in renal graft rejection. Identification by monoclonal antibodies in tissue sections. J Exp Med (1982) 1.59
Immunoelectron microscopic study of the distribution of T cell subsets in rheumatoid synovium. J Exp Med (1983) 1.57
The MRC OX-44 antigen marks a functionally relevant subset among rat thymocytes. J Exp Med (1987) 1.54
Antigen-specific immunosuppression in visceral leishmaniasis is cell mediated. J Clin Invest (1989) 1.51
Abnormalities of T cell maturation and regulation in human beings with immunodeficiency disorders. J Clin Invest (1981) 1.50
Spontaneous release of the Leu-2 (T8) molecule from human T cells. J Exp Med (1983) 1.48
Stages of renal ontogenesis identified by monoclonal antibodies reactive with lymphohemopoietic differentiation antigens. J Exp Med (1983) 1.48
Cytolytic CD4(+) T cells in viral immunity. Expert Rev Vaccines (2010) 1.47
In vitro translation and assembly of a complete T cell receptor-CD3 complex. J Exp Med (1997) 1.45
Interleukin 2 receptor expression in unstimulated murine splenic T cells. Localization to L3T4+ cells and regulation by non-H-2-linked genes. J Exp Med (1986) 1.44
Reconstitution after transplantation with T-lymphocyte-depleted HLA haplotype-mismatched bone marrow for severe combined immunodeficiency. Proc Natl Acad Sci U S A (1982) 1.44
Inhibition of specific cell-mediated cytotoxicity by monoclonal antibodies to human T cell antigens. Proc Natl Acad Sci U S A (1981) 1.41
Human CD3+ T lymphocytes that express neither CD4 nor CD8 antigens. J Exp Med (1986) 1.40
Responder cells in the human autologous mixed lymphocyte reaction. J Clin Invest (1981) 1.37
Autoantibody to an immunoregulatory inducer population in patients with juvenile rheumatoid arthritis. J Clin Invest (1981) 1.37
Unusual phenotype and function of an expanded subpopulation of T cells in patients with haemopoietic disorders. Clin Exp Immunol (1981) 1.35
The human immunodeficiency virus type 1 (HIV-1) CD4 receptor and its central role in promotion of HIV-1 infection. Microbiol Rev (1995) 1.34
Human lymphocytes with either the OKT4 or OKT8 phenotype produce interleukin 2 in culture. J Clin Invest (1982) 1.33
Relationship between systemic lupus erythematosus T cell subsets, anti-T cell antibodies, and T cell functions. J Clin Invest (1984) 1.32
Characterization of immunoregulatory T lymphocytes during ageing by monoclonal antibodies. Clin Exp Immunol (1982) 1.31
Regulation of T cell autocrine growth. T4+ cells become refractory to interleukin 2. J Exp Med (1986) 1.26
Analysis of T cell subsets by monoclonal antibodies in patients with tuberculosis after in vitro stimulation with purified protein derivative of tuberculin. Clin Exp Immunol (1984) 1.25
Monoclonal anti-human T-lymphocyte antibodies: enumeration and characterization of T-cell subsets. Immunology (1981) 1.23
Human T lymphocyte subsets. Functional heterogeneity and surface recognition structures. J Clin Invest (1984) 1.23
Studies on T cell subsets and functions in leprosy. Clin Exp Immunol (1981) 1.22
Disorders of B cells and helper T cells in the pathogenesis of the immunoglobulin deficiency of patients with ataxia telangiectasia. J Clin Invest (1983) 1.21
Pathogenesis of Mooren's ulcer: some new concepts. Br J Ophthalmol (1984) 1.21
Asymmetric thymocyte death underlies the CD4:CD8 T-cell ratio in the adaptive immune system. Proc Natl Acad Sci U S A (2013) 1.21
Heterogeneity of concanavalin A-induced suppressor T cells in man defined with monoclonal antibodies. Clin Exp Immunol (1982) 1.19
Selective loss of a subset of T helper cells in active multiple sclerosis. Proc Natl Acad Sci U S A (1985) 1.19
Alterations of T-cell subsets in primary biliary cirrhosis. Clin Exp Immunol (1982) 1.16
Depressed immune response in burn patients: use of monoclonal antibodies and functional assays to define the role of suppressor cells. Ann Surg (1982) 1.13
The cellular content of non Hodgkin lymphomas: a comprehensive analysis using monoclonal antibodies and other surface marker techniques. Br J Cancer (1983) 1.13
Increase in activated T cells and reduction in suppressor inducer T cells in systemic sclerosis. Ann Rheum Dis (1990) 1.12
Differentiation antigens identify subpopulations of rabbit T and B lymphocytes. Definition by flow cytometry. J Exp Med (1983) 1.11
Immune function in severe, active rheumatoid arthritis. A relationship between peripheral blood mononuclear cell proliferation to soluble antigens and synovial tissue immunohistologic characteristics. J Clin Invest (1984) 1.11
Human monoclonal antibodies to lung-cancer antigens. Br J Cancer (1981) 1.10
Medical immunology: a new journal for a new subspecialty. Med Immunol (2002) 1.10
Specific targeting of human peripheral blood T cells by heteroaggregates containing anti-T3 crosslinked to anti-target cell antibodies. J Exp Med (1986) 1.09
Pharmacological modification of immunoregulatory T lymphocytes . II. Modulation of T lymphocyte cell surface characteristics. Clin Exp Immunol (1982) 1.07
Delineation of an extended surface contact area on human CD4 involved in class II major histocompatibility complex binding. Proc Natl Acad Sci U S A (1993) 1.07
Killing of measles virus-infected cells by human cytotoxic T cells. Infect Immun (1982) 1.06
Lymphocyte abnormality associated with HLA-B8 in healthy young adults. J Exp Med (1982) 1.05
Oligomerization of CD4 is required for stable binding to class II major histocompatibility complex proteins but not for interaction with human immunodeficiency virus gp120. Proc Natl Acad Sci U S A (1995) 1.05
Human immunodeficiency virus gp120 binding C'C" ridge of CD4 domain 1 is also involved in interaction with class II major histocompatibility complex molecules. Proc Natl Acad Sci U S A (1992) 1.04
Identification and structural analysis of residues in the V1 region of CD4 involved in interaction with human immunodeficiency virus envelope glycoprotein gp120 and class II major histocompatibility complex molecules. Proc Natl Acad Sci U S A (1990) 1.03
T-lymphocyte heterogeneity: wheat germ agglutinin labeling of transmembrane glycoproteins. Proc Natl Acad Sci U S A (1982) 1.03
Cell membrane perturbation of resting T cells and thymocytes causes display of activation antigens. J Exp Med (1983) 1.03
The T-cell accessory molecule CD4 recognizes a monomorphic determinant on isolated Ia. Proc Natl Acad Sci U S A (1988) 1.01
Activation of antigen-specific suppressor T cells in the presence of cyclosporin requires interactions between T cells of inducer and suppressor lineage. J Clin Invest (1983) 1.00
A comparative study of streptococcal antigen-binding human T8+ cells and monocytes, in relation to the HLA-DRw6 locus and the helper, suppressor and contrasuppressor functions. Immunology (1984) 1.00
Lymphocyte subpopulations in Down's syndrome: high percentage of circulating HNK-1+, Leu 2a+ cells. Clin Exp Immunol (1984) 1.00
Cytotoxic antibodies to cloned rat islet cells in serum of patients with diabetes mellitus. J Clin Invest (1981) 0.97
L3T4 antigen expression by hemopoietic precursor cells. J Exp Med (1989) 0.96
Transferrin synthesis by inducer T lymphocytes. J Clin Invest (1986) 0.96
The fine structure of normal lymphocyte subpopulations--a study with monoclonal antibodies and the immunogold technique. Clin Exp Immunol (1982) 0.96
Pharmacological modification of immunoregulatory T lymphocytes. I. Effect of adenosine, H1 and H2 histamine agonists upon T lymphocyte regulation of B lymphocyte differentiation in vitro. Clin Exp Immunol (1982) 0.96
Requirement for OKT8+ suppressor cell proliferation for suppression by human newborn T cells. Clin Exp Immunol (1981) 0.95
Continuous cultures of fused cells secreting antibody of predefined specificity. Nature (1975) 83.56
Functional subclasses of T lymphocytes bearing different Ly antigens. II. Cooperation between subclasses of Ly+ cells in the generation of killer activity. J Exp Med (1975) 13.69
Immunologic functions of isolated human lymphocyte subpopulations. I. Quantitative isolation of human T and B cells and response to mitogens. J Immunol (1974) 5.50
Fluorescence activated cell sorting. Rev Sci Instrum (1972) 4.81
Subpopulations of human T cells identified by receptors for immunoglobulins and mitogen responsiveness. J Immunol (1976) 4.64
Two functionally distinct subpopulations of human T cells that collaborate in the generation of cytotoxic cells responsible for cell-mediated lympholysis. J Immunol (1978) 4.33
Technical aspects of the rosette tests used to detect human complement receptor (B) and sheep erythrocyte-binding (T) lymphocytes. J Immunol (1973) 3.45
Somatic cell hybridization of mouse myeloma cells. Cell (1976) 3.17
Aberrations of suppressor T cells in human graft-versus-host disease. N Engl J Med (1979) 3.10
Con A-inducible suppression of MLC: evidence for mediation by the TH2 + T cell subset in man. J Immunol (1979) 2.63
Direct evidence for loss of human suppressor cells during active autoimmune disease. Proc Natl Acad Sci U S A (1978) 2.32
Isolation and characterization of naturally occurring subclasses of human peripheral blood T cells with regulatory functions. J Immunol (1978) 2.30
Phenotypic and functional distinctions between the TH2+ and JRA+ T cell subsets in man. J Immunol (1979) 2.06
Immunologic functions of isolated human lymphocyte subpopulations. III. Specific allogeneic lympholysis mediated by human T cells alone. J Immunol (1975) 1.83
Identification and characterization of a new subset of rat T lymphocytes. J Immunol (1978) 1.43
The differentiation and function of human T lymphocytes. Cell (1980) 11.88
Discrete stages of human intrathymic differentiation: analysis of normal thymocytes and leukemic lymphoblasts of T-cell lineage. Proc Natl Acad Sci U S A (1980) 11.23
Monoclonal antibodies defining distinctive human T cell surface antigens. Science (1979) 10.50
Clonotypic structures involved in antigen-specific human T cell function. Relationship to the T3 molecular complex. J Exp Med (1983) 9.23
Chromatographic purification of tetramethylrhodamine-immune globulin conjugates and their use in the cellular localization of rabbit gamma-globulin polypeptide chains. J Immunol (1965) 8.88
Identification of the C3bi receptor of human monocytes and macrophages by using monoclonal antibodies. Proc Natl Acad Sci U S A (1983) 8.57
An alternative pathway of T-cell activation: a functional role for the 50 kd T11 sheep erythrocyte receptor protein. Cell (1984) 7.56
A monoclonal antibody reactive with human peripheral blood monocytes. J Immunol (1980) 6.96
The isolation and characterization of the human suppressor inducer T cell subset. J Immunol (1985) 6.69
Specific purification of lymphocyte populations on a digestible immunoabsorbent. J Immunol (1973) 6.64
Rheumatoid arthritis: a disease of T-lymphocyte/macrophage immunoregulation. Lancet (1981) 6.62
A monoclonal antibody with selective reactivity with functionally mature human thymocytes and all peripheral human T cells. J Immunol (1979) 6.08
A monoclonal antibody reactive with the human cytotoxic/suppressor T cell subset previously defined by a heteroantiserum termed TH2. J Immunol (1980) 6.05
Clonal analysis of human cytotoxic T lymphocytes: T4+ and T8+ effector T cells recognize products of different major histocompatibility complex regions. Proc Natl Acad Sci U S A (1982) 5.85
Fluorescent antibody staining. 3. Preparation of fluorescein-isothiocyanate-labeled antibodies. J Immunol (1965) 5.82
Characterization of a human B lymphocyte-specific antigen. J Immunol (1980) 5.76
The CD4 receptor is complexed in detergent lysates to a protein-tyrosine kinase (pp58) from human T lymphocytes. Proc Natl Acad Sci U S A (1988) 5.75
A polyadenylate binding protein localized to the granules of cytolytic lymphocytes induces DNA fragmentation in target cells. Cell (1991) 5.65
Further characterization of the human inducer T cell subset defined by monoclonal antibody. J Immunol (1979) 5.63
Immunologic functions of isolated human lymphocyte subpopulations. I. Quantitative isolation of human T and B cells and response to mitogens. J Immunol (1974) 5.50
The isolation and characterization of the human helper inducer T cell subset. J Immunol (1985) 5.21
Ia determinants on human T-cell subsets defined by monoclonal antibody. Activation stimuli required for expression. J Exp Med (1979) 5.19
Evidence for the T3-associated 90K heterodimer as the T-cell antigen receptor. Nature (1983) 4.96
Antigen recognition by human T lymphocytes is linked to surface expression of the T3 molecular complex. Cell (1982) 4.86
Current concepts in immunology: Regulation of the immune response--inducer and suppressor T-lymphocyte subsets in human beings. N Engl J Med (1980) 4.80
Triggering of the T3-Ti antigen-receptor complex results in clonal T-cell proliferation through an interleukin 2-dependent autocrine pathway. Proc Natl Acad Sci U S A (1984) 4.78
Atomic structure of a fragment of human CD4 containing two immunoglobulin-like domains. Nature (1990) 4.70
Antigens on human monocytes identified by monoclonal antibodies. J Immunol (1981) 4.67
Peripheral human T cells sensitized in mixed leukocyte culture synthesize and express Ia-like antigens. J Exp Med (1978) 4.51
Two functionally distinct subpopulations of human T cells that collaborate in the generation of cytotoxic cells responsible for cell-mediated lympholysis. J Immunol (1978) 4.33
A soluble CD4 protein selectively inhibits HIV replication and syncytium formation. Nature (1988) 4.15
Antigen-like effects of monoclonal antibodies directed at receptors on human T cell clones. J Exp Med (1983) 4.10
Distribution of Ia-like molecules on the surface of normal and leukemic human cells. Proc Natl Acad Sci U S A (1976) 4.05
A monoclonal antibody to human acute lymphoblastic leukaemia antigen. Nature (1980) 3.90
Distribution of T cell subsets in human lymph nodes. J Exp Med (1981) 3.64
Use of monoclonal antibodies to T-cell subsets for immunologic monitoring and treatment in recipients of renal allografts. N Engl J Med (1981) 3.63
Conformation and function of the N-linked glycan in the adhesion domain of human CD2. Science (1995) 3.62
Reactivity of Langerhans cells with hybridoma antibody. Proc Natl Acad Sci U S A (1981) 3.62
The cellular basis for viral-induced immunodeficiency: analysis by monoclonal antibodies. J Immunol (1980) 3.49
Location of T cell and major histocompatibility complex antigens in the human thymus. J Exp Med (1980) 3.41
Studies on mediator production by highly purified human T and B lymphocytes. J Exp Med (1974) 3.38
A monoclonal antibody blocking human T cell function. Eur J Immunol (1980) 3.33
Analysis of host-virus interactions in AIDS with anti-gp120 T cell clones: effect of HIV sequence variation and a mechanism for CD4+ cell depletion. Cell (1988) 3.25
Inhibition of phagocytosis of complement C3- or immunoglobulin G-coated particles and of C3bi binding by monoclonal antibodies to a monocyte-granulocyte membrane glycoprotein (Mol). J Clin Invest (1983) 3.23
Differential usage of three exons generates at least five different mRNAs encoding human leukocyte common antigens. J Exp Med (1987) 3.14
Aberrations of suppressor T cells in human graft-versus-host disease. N Engl J Med (1979) 3.10
Does OKT3 monoclonal antibody react with an antigen-recognition structure on human T cells? Proc Natl Acad Sci U S A (1981) 3.09
B4, a human B lymphocyte-associated antigen expressed on normal, mitogen-activated, and malignant B lymphocytes. J Immunol (1983) 3.09
The human T cell receptor: appearance in ontogeny and biochemical relationship of alpha and beta subunits on IL-2 dependent clones and T cell tumors. Cell (1983) 3.07
Human T lymphocyte subpopulations defined by Fc receptors and monoclonal antibodies. A comparison. J Exp Med (1980) 3.03
Simple and rapid measurement of human T lymphocytes and their subclasses in peripheral blood. Proc Natl Acad Sci U S A (1980) 2.96
Restoration of T cell development in RAG-2-deficient mice by functional TCR transgenes. Science (1993) 2.93
Functional analysis of human T cell subsets defined by monoclonal antibodies. I. Collaborative T-T interactions in the immunoregulation of B cell differentiation. J Immunol (1980) 2.93
Comparison of T3-associated 49- and 43-kilodalton cell surface molecules on individual human T-cell clones: evidence for peptide variability in T-cell receptor structures. Proc Natl Acad Sci U S A (1983) 2.93
Structural analysis of differentiation antigens Mo1 and Mo2 on human monocytes. Hybridoma (1982) 2.92
Multiple sclerosis: distribution of T cell subsets within active chronic lesions. Science (1983) 2.91
Functional interaction between human T-cell protein CD4 and the major histocompatibility complex HLA-DR antigen. Nature (1987) 2.89
Characterization of a human B cell-specific antigen (B2) distinct from B1. J Immunol (1981) 2.86
Possible involvement of the OKT4 molecule in T cell recognition of class II HLA antigens. Evidence from studies of cytotoxic T lymphocytes specific for SB antigens. J Exp Med (1982) 2.81