Published in Proc Natl Acad Sci U S A on December 01, 1988
Adenosine augmentation therapies (AATs) for epilepsy: prospect of cell and gene therapies. Epilepsy Res (2009) 1.17
Recent advancements in stem cell and gene therapies for neurological disorders and intractable epilepsy. Neuropharmacology (2010) 0.94
GABAergic interneuron transplants to study development and treat disease. Trends Neurosci (2014) 0.94
The promise of an interneuron-based cell therapy for epilepsy. Dev Neurobiol (2011) 0.91
Embryonic stem cell-derived neural precursor grafts for treatment of temporal lobe epilepsy. Neurotherapeutics (2009) 0.86
After the storm: from windswept to spiny trees. Epilepsy Curr (2011) 0.75
NEUROD1 Instructs Neuronal Conversion in Non-Reactive Astrocytes. Stem Cell Reports (2017) 0.75
Color modification of diaminobenzidine (DAB) precipitation by metallic ions and its application for double immunohistochemistry. J Histochem Cytochem (1982) 3.88
Cellular mechanism of neuronal synchronization in epilepsy. Science (1982) 3.19
An autoradiographic analysis of the differential ascending projections of the dorsal and median raphe nuclei in the rat. J Comp Neurol (1978) 2.63
Histamine and noradrenaline decrease calcium-activated potassium conductance in hippocampal pyramidal cells. Nature (1983) 2.06
Cellular and field potential properties of epileptogenic hippocampal slices. Brain Res (1978) 1.97
Inhibitory control of local excitatory circuits in the guinea-pig hippocampus. J Physiol (1987) 1.86
The connections of the septal region in the rat. J Comp Neurol (1979) 1.85
Synchronized burst discharge in disinhibited hippocampal slice. I. Initiation in CA2-CA3 region. J Neurophysiol (1983) 1.72
Actions of noradrenaline recorded intracellularly in rat hippocampal CA1 pyramidal neurones, in vitro. J Physiol (1986) 1.69
The organization of the ascending catecholamine neuron systems in the rat brain as revealed by the glyoxylic acid fluorescence method. Acta Physiol Scand Suppl (1974) 1.56
Cellular mechanisms of epilepsy: a status report. Science (1987) 1.55
Neurophysiology of epilepsy. Annu Rev Neurosci (1978) 1.44
Temporal lobe seizures and the technic of subtotal temporal lobectomy. Ann Surg (1952) 1.42
Reduced inhibition during epileptiform activity in the in vitro hippocampal slice. J Physiol (1980) 1.41
An analysis of the origins of the cholinergic and noncholinergic septal projections to the hippocampal formation of the rat. J Comp Neurol (1985) 1.28
CLINICAL APPLICATIONS OF STUDIES ON STEREOTACTICALLY IMPLANTED ELECTRODES IN TEMPORAL-LOBE EPILEPSY. J Neurosurg (1963) 1.13
The action of norepinephrine in the rat hippocampus. II. Activation of the input pathway. Brain Res (1974) 1.05
A study of subcortical afferents to the hippocampal formation in the rat. Neuroscience (1979) 1.04
Antisera to gamma-aminobutyric acid. I. Production and characterization using a new model system. J Histochem Cytochem (1985) 0.95
Kindling mechanisms: current progress on an experimental epilepsy model. Prog Neurobiol (1986) 0.94
Axon terminals of GABAergic chandelier cells are lost at epileptic foci. Brain Res (1985) 0.92
Analysis of extracellular firing patterns of deep temporal lobe structures in man. Electroencephalogr Clin Neurophysiol (1973) 0.90
Functional reinnervation of rat hippocampus by locus coeruleus implants. Brain Res (1979) 0.90
Functional activity of substantia nigra grafts reinnervating the striatum: neurotransmitter metabolism and [14C]2-deoxy-D-glucose autoradiography. J Neurochem (1982) 0.89
GABAergic neurons in rat hippocampal culture. Brain Res (1986) 0.85
Neurotransmitter and neuromodulator function in the kindled seizure and state. Prog Neurobiol (1982) 0.85
Potentiation of amygdaloid kindling and metrazol-induced seizures by 6-hydroxydopamine in rats. Exp Neurol (1974) 0.84
Electrophysiology and cytology of hippocampal formation transplants in the anterior chamber of the eye. II. Cholinergic mechanisms. Brain Res (1977) 0.83
Behavioral dependence of the electrical activity of intracerebrally transplanted fetal hippocampus. Brain Res (1987) 0.83
Depth electroencephalography in selection of refractory epilepsy for surgery. Ann Neurol (1981) 0.82
Grafted noradrenergic neurons suppress seizure development in kindling-induced epilepsy. Proc Natl Acad Sci U S A (1987) 0.81
Cell suspension grafts of noradrenergic locus coeruleus neurons in rat hippocampus and spinal cord: reinnervation and transmitter turnover. Neuroscience (1986) 0.81
Effects of atropine, reserpine, 6-hydroxydopamine, and handling on seizure development in the rat. Exp Neurol (1973) 0.81
Cellular activity of intracerebrally transplanted fetal hippocampus during behavior. Neuroscience (1987) 0.80
Axon initial segments of the granule cell in the rat dentate gyrus: synaptic contacts on bundles of axon initial segments. Brain Res (1983) 0.79
GABAergic nonpyramidal neurons in intracerebral transplants of the rat hippocampus and fascia dentata: a combined light and electron microscopic immunocytochemical study. J Comp Neurol (1987) 0.78
A substantial number of asymmetric axosomatic synapses is a characteristic of the granule cells of the hippocampal dentate gyrus. Neurosci Lett (1985) 0.77
In vivo gene delivery and stable transduction of nondividing cells by a lentiviral vector. Science (1996) 28.95
Neurogenesis in the adult human hippocampus. Nat Med (1998) 17.53
Running increases cell proliferation and neurogenesis in the adult mouse dentate gyrus. Nat Neurosci (1999) 12.50
Direct isolation of human central nervous system stem cells. Proc Natl Acad Sci U S A (2000) 10.88
More hippocampal neurons in adult mice living in an enriched environment. Nature (1997) 10.06
Neurogenesis in the dentate gyrus of the adult rat: age-related decrease of neuronal progenitor proliferation. J Neurosci (1996) 9.84
Efficient transfer, integration, and sustained long-term expression of the transgene in adult rat brains injected with a lentiviral vector. Proc Natl Acad Sci U S A (1996) 9.15
Running enhances neurogenesis, learning, and long-term potentiation in mice. Proc Natl Acad Sci U S A (1999) 8.83
Vascular niche for adult hippocampal neurogenesis. J Comp Neurol (2000) 7.19
Neural consequences of environmental enrichment. Nat Rev Neurosci (2000) 6.79
A functional role for adult hippocampal neurogenesis in spatial pattern separation. Science (2009) 6.62
Development of a self-inactivating lentivirus vector. J Virol (1998) 6.60
Reactive astrocytes: cellular and molecular cues to biological function. Trends Neurosci (1997) 4.92
Sustained expression of genes delivered directly into liver and muscle by lentiviral vectors. Nat Genet (1997) 4.26
The adult rat hippocampus contains primordial neural stem cells. Mol Cell Neurosci (1997) 4.07
Experience-induced neurogenesis in the senescent dentate gyrus. J Neurosci (1998) 3.71
Fibroblast growth factor-2 activates a latent neurogenic program in neural stem cells from diverse regions of the adult CNS. J Neurosci (1999) 3.61
Epidermal growth factor and fibroblast growth factor-2 have different effects on neural progenitors in the adult rat brain. J Neurosci (1997) 3.61
Stable and efficient gene transfer into the retina using an HIV-based lentiviral vector. Proc Natl Acad Sci U S A (1997) 3.40
Proliferation and differentiation of progenitor cells throughout the intact adult rat spinal cord. J Neurosci (2000) 3.40
Highly efficient and sustained gene transfer in adult neurons with a lentivirus vector. J Virol (1997) 3.37
Genetic influence on neurogenesis in the dentate gyrus of adult mice. Proc Natl Acad Sci U S A (1997) 2.96
Adult brain neurogenesis and psychiatry: a novel theory of depression. Mol Psychiatry (2000) 2.87
Regenerating the damaged central nervous system. Nature (2000) 2.85
Effects of voluntary exercise on synaptic plasticity and gene expression in the dentate gyrus of adult male Sprague-Dawley rats in vivo. Neuroscience (2004) 2.81
Nucleus basalis and thalamic control of neocortical activity in the freely moving rat. J Neurosci (1988) 2.73
Altered synaptic physiology and reduced susceptibility to kainate-induced seizures in GluR6-deficient mice. Nature (1998) 2.72
Cell culture. Progenitor cells from human brain after death. Nature (2001) 2.63
Delivery of the Cre recombinase by a self-deleting lentiviral vector: efficient gene targeting in vivo. Proc Natl Acad Sci U S A (2001) 2.48
FGF-2-responsive neuronal progenitors reside in proliferative and quiescent regions of the adult rodent brain. Mol Cell Neurosci (1995) 2.45
Amelioration of cholinergic neuron atrophy and spatial memory impairment in aged rats by nerve growth factor. Nature (1987) 2.33
Differentiation of adult hippocampus-derived progenitors into olfactory neurons in vivo. Nature (1996) 2.33
The signal-dependent coactivator CBP is a nuclear target for pp90RSK. Cell (1996) 2.26
Adult spinal cord stem cells generate neurons after transplantation in the adult dentate gyrus. J Neurosci (2000) 2.24
Attenuation of age-related changes in mouse neuromuscular synapses by caloric restriction and exercise. Proc Natl Acad Sci U S A (2010) 2.22
Adult-generated neurons in the dentate gyrus send axonal projections to field CA3 and are surrounded by synaptic vesicles. J Comp Neurol (1999) 2.21
Neurotrophin-3 and brain-derived neurotrophic factor induce oligodendrocyte proliferation and myelination of regenerating axons in the contused adult rat spinal cord. J Neurosci (1998) 2.17
Can stem cells cross lineage boundaries? Nat Med (2001) 2.08
Neuronal differentiation and morphological integration of hippocampal progenitor cells transplanted to the retina of immature and mature dystrophic rats. Mol Cell Neurosci (2000) 2.07
Cellular delivery of neurotrophin-3 promotes corticospinal axonal growth and partial functional recovery after spinal cord injury. J Neurosci (1997) 2.07
Proliferation, differentiation, and long-term culture of primary hippocampal neurons. Proc Natl Acad Sci U S A (1993) 2.00
Transcriptional profiling reveals strict boundaries between hippocampal subregions. J Comp Neurol (2001) 1.98
Rituximab inhibits structural joint damage in patients with rheumatoid arthritis with an inadequate response to tumour necrosis factor inhibitor therapies. Ann Rheum Dis (2008) 1.84
Retinoic acid and neurotrophins collaborate to regulate neurogenesis in adult-derived neural stem cell cultures. J Neurobiol (1999) 1.79
Continuous infusion of nerve growth factor prevents basal forebrain neuronal death after fimbria fornix transection. Proc Natl Acad Sci U S A (1986) 1.77
Nurr1, an orphan nuclear receptor, is a transcriptional activator of endogenous tyrosine hydroxylase in neural progenitor cells derived from the adult brain. Development (1999) 1.73
Essential role of neocortical acetylcholine in spatial memory. Nature (1995) 1.68
Genetic determinants of adult hippocampal neurogenesis correlate with acquisition, but not probe trial performance, in the water maze task. Eur J Neurosci (2002) 1.67
Synergistic inhibition of hepadnaviral replication by lamivudine in combination with penciclovir in vitro. Hepatology (1997) 1.64
Rescue from photoreceptor degeneration in the rd mouse by human immunodeficiency virus vector-mediated gene transfer. J Virol (1999) 1.64
Widespread integration and survival of adult-derived neural progenitor cells in the developing optic retina. Mol Cell Neurosci (1998) 1.62
Spatial learning and motor deficits in aged rats. Neurobiol Aging (1984) 1.60
An essential role for retinoid receptors RARbeta and RXRgamma in long-term potentiation and depression. Neuron (1998) 1.58
Hepatitis B virus polymerase mutations during antiviral therapy in a patient following liver transplantation. J Hepatol (1997) 1.56
Hippocampal connections and spatial discrimination. Brain Res (1978) 1.54
Truncated BRCA2 is cytoplasmic: implications for cancer-linked mutations. Proc Natl Acad Sci U S A (1999) 1.54
Environmental stimulation of 129/SvJ mice causes increased cell proliferation and neurogenesis in the adult dentate gyrus. Curr Biol (1998) 1.51
FGF-2-responsive neural stem cell proliferation requires CCg, a novel autocrine/paracrine cofactor. Neuron (2000) 1.50
A packaging cell line for lentivirus vectors. J Virol (1999) 1.48
Staffing in cardiology in the United Kingdom 1990. Sixth biennial survey: with data on facilities in cardiology in England and Wales 1989. Br Heart J (1991) 1.48
New nerve cells for the adult brain. Sci Am (1999) 1.47
Identities of sequestered proteins in aggregates from cells with induced polyglutamine expression. J Cell Biol (2001) 1.42
Grafting genetically modified cells to the damaged brain: restorative effects of NGF expression. Science (1988) 1.42
Nicotinic receptor-induced apoptotic cell death of hippocampal progenitor cells. J Neurosci (1998) 1.42
Alzheimer's disease and spirochetes; a questionable relationship. Neuroreport (1993) 1.41
Lentiviral vectors: regulated gene expression. Mol Ther (2000) 1.39
Where now? The anaesthetist's development in management. Anaesthesia (1993) 1.38
Ataxia telangiectasia mutated is essential during adult neurogenesis. Genes Dev (2001) 1.35
Differentiation of the immortalized adult neuronal progenitor cell line HC2S2 into neurons by regulatable suppression of the v-myc oncogene. Proc Natl Acad Sci U S A (1996) 1.35
Adult neurogenesis and neurite outgrowth are impaired in LRRK2 G2019S mice. Neurobiol Dis (2010) 1.35
Development of anti-tumor immunity following thymidine kinase-mediated killing of experimental brain tumors. Proc Natl Acad Sci U S A (1994) 1.34
Activity-dependent regulation of neuronal plasticity and self repair. Prog Brain Res (2000) 1.29
Nerve growth factor delivery by gene transfer induces differential outgrowth of sensory, motor, and noradrenergic neurites after adult spinal cord injury. Exp Neurol (1996) 1.26
Measurement of the density of human platelets and its relationship to volume. Br J Haematol (1983) 1.24
FGF-2 is sufficient to isolate progenitors found in the adult mammalian spinal cord. Exp Neurol (1997) 1.23
Chronic liver injury in rats and humans upregulates the novel enzyme angiotensin converting enzyme 2. Gut (2005) 1.23
Genetic approaches to neurotrauma research: opportunities and potential pitfalls of murine models. Exp Neurol (1999) 1.23
Experience-dependent regulation of adult hippocampal neurogenesis: effects of long-term stimulation and stimulus withdrawal. Hippocampus (1999) 1.22
In vitro susceptibilities of wild-type or drug-resistant hepatitis B virus to (-)-beta-D-2,6-diaminopurine dioxolane and 2'-fluoro-5-methyl-beta-L-arabinofuranosyluracil. Antimicrob Agents Chemother (2001) 1.18
Neurogenesis in the adult hippocampus. Novartis Found Symp (2000) 1.18
Nerve growth factor infusion in the primate brain reduces lesion-induced cholinergic neuronal degeneration. J Neurosci (1990) 1.17
Progressive decline in spatial learning and integrity of forebrain cholinergic neurons in rats during aging. Neurobiol Aging (1992) 1.17
Zinc chelation induces rapid depletion of the X-linked inhibitor of apoptosis and sensitizes prostate cancer cells to TRAIL-mediated apoptosis. Cell Death Differ (2008) 1.17
Resistance of hepatitis B virus to antiviral drugs: current aspects and directions for future investigation. Antivir Chem Chemother (2001) 1.16
Fibroblasts genetically modified to produce nerve growth factor induce robust neuritic ingrowth after grafting to the spinal cord. Exp Neurol (1994) 1.15
Age-associated neuronal atrophy occurs in the primate brain and is reversible by growth factor gene therapy. Proc Natl Acad Sci U S A (1999) 1.14
Modeling psychiatric disorders at the cellular and network levels. Mol Psychiatry (2012) 1.14
Partial lesion of the substantia nigra: relation between extent of lesion and rotational behavior. Brain Res (1991) 1.11
An antiaggregation gene therapy strategy for Lewy body disease utilizing beta-synuclein lentivirus in a transgenic model. Gene Ther (2004) 1.10
Regional changes in brain glucose metabolism reflect cognitive impairments in aged rats. J Neurosci (1984) 1.10
Human amnion membrane serves as a substratum for growing axons in vitro and in vivo. Science (1987) 1.10
Perforant path damage results in progressive neuronal death and somal atrophy in layer II of entorhinal cortex and functional impairment with increasing postdamage age. J Neurosci (1994) 1.09
Cross-resistance testing of antihepadnaviral compounds using novel recombinant baculoviruses which encode drug-resistant strains of hepatitis B virus. Antimicrob Agents Chemother (2001) 1.09
Synaptic loss in cognitively impaired aged rats is ameliorated by chronic human nerve growth factor infusion. Neuroscience (1995) 1.07
Observations on the epidemiology of ephemeral fever in Kenya. J Hyg (Lond) (1975) 1.06
Evidence for amelioration of ischaemic neuronal damage in the hippocampal formation by lesions of the perforant path. Neurol Res (1985) 1.06
NGF improves spatial memory in aged rodents as a function of age. J Neurosci (1991) 1.06
Gene therapy in the adult primate brain: intraparenchymal grafts of cells genetically modified to produce nerve growth factor prevent cholinergic neuronal degeneration. Gene Ther (1996) 1.05