Published in Cell on January 01, 1981
Patterns of integration of DNA microinjected into cultured mammalian cells: evidence for homologous recombination between injected plasmid DNA molecules. Mol Cell Biol (1982) 7.49
Nonhomologous recombination in mammalian cells: role for short sequence homologies in the joining reaction. Mol Cell Biol (1986) 5.25
Genetic analysis of bovine papillomavirus type 1 trans-acting replication factors. J Virol (1985) 4.74
Somatic cells efficiently join unrelated DNA segments end-to-end. Mol Cell Biol (1982) 4.13
Integration, transcription, and control of a Drosophila heat shock gene in mouse cells. Proc Natl Acad Sci U S A (1981) 3.70
Cre-stimulated recombination at loxP-containing DNA sequences placed into the mammalian genome. Nucleic Acids Res (1989) 3.63
Localization of human immunoglobulin kappa light chain variable region genes to the short arm of chromosome 2 by in situ hybridization. Proc Natl Acad Sci U S A (1982) 3.07
Two human c-onc genes are located on the long arm of chromosome 8. Proc Natl Acad Sci U S A (1982) 3.02
The human beta-globin gene and a functional viral thymidine kinase gene in developing mice. Proc Natl Acad Sci U S A (1981) 2.93
How damaged is the biologically active subpopulation of transfected DNA? Mol Cell Biol (1984) 2.88
Expression of abbreviated mouse dihydrofolate reductase genes in cultured hamster cells. Proc Natl Acad Sci U S A (1982) 2.45
DNA looping by Ku and the DNA-dependent protein kinase. Proc Natl Acad Sci U S A (1997) 2.39
RNA-mediated gene duplication: the rat preproinsulin I gene is a functional retroposon. Mol Cell Biol (1985) 2.35
Mapping functional domains in the promoter region of the herpes thymidine kinase gene. Proc Natl Acad Sci U S A (1981) 2.29
Single-copy and amplified CAD genes in Syrian hamster chromosomes localized by a highly sensitive method for in situ hybridization. Mol Cell Biol (1982) 2.21
Functional immunoglobulin M production after transfection of cloned immunoglobulin heavy and light chain genes into lymphoid cells. Proc Natl Acad Sci U S A (1983) 2.03
The Z-DNA motif d(TG)30 promotes reception of information during gene conversion events while stimulating homologous recombination in human cells in culture. Mol Cell Biol (1990) 1.91
Homologous recombination between overlapping thymidine kinase gene fragments stably inserted into a mouse cell genome. Mol Cell Biol (1984) 1.88
Repeat array in Epstein-Barr virus DNA is related to cell DNA sequences interspersed on human chromosomes. Proc Natl Acad Sci U S A (1982) 1.81
Stable transformation of mouse L cells for human membrane T-cell differentiation antigens, HLA and beta 2-microglobulin: selection by fluorescence-activated cell sorting. Proc Natl Acad Sci U S A (1983) 1.80
A DNA-mediated transformation system for Dictyostelium discoideum. Proc Natl Acad Sci U S A (1982) 1.80
Differentiation, not determination, regulates muscle gene activation: transfection of troponin I genes into multipotential and muscle lineages of 10T1/2 cells. Mol Cell Biol (1985) 1.59
Micrococcal nuclease digestion of nuclei reveals extended nucleosome ladders having anomalous DNA lengths for chromatin assembled on non-replicating plasmids in transfected cells. Nucleic Acids Res (1994) 1.58
Characterization of an episome produced in hamster cells that amplify a transfected CAD gene at high frequency: functional evidence for a mammalian replication origin. Mol Cell Biol (1987) 1.58
High-frequency illegitimate integration of transfected DNA at preintegrated target sites in a mammalian genome. Mol Cell Biol (1996) 1.50
Isolation of the gene encoding the human T-lymphocyte differentiation antigen Leu-2 (T8) by gene transfer and cDNA subtraction. Proc Natl Acad Sci U S A (1984) 1.47
The Chinese hamster dihydrofolate reductase replication origin beta is active at multiple ectopic chromosomal locations and requires specific DNA sequence elements for activity. Mol Cell Biol (2001) 1.47
Gene disruption by transformation in Neurospora crassa. Mol Cell Biol (1985) 1.43
Transformation by iontophoretic microinjection of DNA: multiple integrations without tandem insertions. Mol Cell Biol (1983) 1.37
Evolution of chromosomal regions containing transfected and amplified dihydrofolate reductase sequences. Mol Cell Biol (1983) 1.35
Co-amplification of double minute chromosomes, multiple drug resistance, and cell surface P-glycoprotein in DNA-mediated transformants of mouse cells. Mol Cell Biol (1984) 1.34
DNA-mediated gene transfer without carrier DNA. J Cell Biol (1981) 1.25
Formation of an inverted duplication can be an initial step in gene amplification. Mol Cell Biol (1988) 1.24
Recombination events during integration of transfected DNA into normal human cells. Nucleic Acids Res (1990) 1.21
Analysis of the integrant in MyK-103 transgenic mice in which males fail to transmit the integrant. Mol Cell Biol (1987) 1.21
Characterization of DNA end joining in a mammalian cell nuclear extract: junction formation is accompanied by nucleotide loss, which is limited and uniform but not site specific. Mol Cell Biol (1994) 1.20
Transfer of nonselectable genes into mouse teratocarcinoma cells and transcription of the transferred human beta-globin gene. Mol Cell Biol (1982) 1.19
Foreign DNA introduced by calcium phosphate is integrated into repetitive DNA elements of the mouse L cell genome. Mol Cell Biol (1986) 1.18
Retroviral transduction of oncogenic sequences involves viral DNA instead of RNA. Proc Natl Acad Sci U S A (1988) 1.17
Activation of a system for the joining of nonhomologous DNA ends during Xenopus egg maturation. Mol Cell Biol (1992) 1.17
High-frequency structural gene deletion as the basis for functional hemizygosity of the adenine phosphoribosyltransferase locus in Chinese hamster ovary cells. Proc Natl Acad Sci U S A (1983) 1.09
Characterization of a tumor necrosis factor-responsive element which down-regulates the human osteocalcin gene. Mol Cell Biol (1993) 1.08
Acquisition of telomere repeat sequences by transfected DNA integrated at the site of a chromosome break. Mol Cell Biol (1993) 1.03
Pathways of transformation in Ustilago maydis determined by DNA conformation. Genetics (1990) 1.02
Homologous recombination enhancement conferred by the Z-DNA motif d(TG)30 is abrogated by simian virus 40 T antigen binding to adjacent DNA sequences. Mol Cell Biol (1990) 1.02
Evidence that retroviral transduction is mediated by DNA not by RNA. Proc Natl Acad Sci U S A (1990) 1.02
Dominant transformation by mutated human ras genes in vitro requires more than 100 times higher expression than is observed in cancers. Proc Natl Acad Sci U S A (1997) 1.01
Oncogene amplification during tumorigenesis of established rat fibroblasts reversibly transformed by activated human ras oncogenes. Mol Cell Biol (1986) 1.01
Plasmids containing mouse rDNA do not recombine with cellular ribosomal genes when introduced into cultured mouse cells. Mol Cell Biol (1984) 0.99
Nonhomologous DNA end joining in Schizosaccharomyces pombe efficiently eliminates DNA double-strand-breaks from haploid sequences. Nucleic Acids Res (1994) 0.99
Gene targeting in Penicillium chrysogenum: disruption of the lys2 gene leads to penicillin overproduction. J Bacteriol (1999) 0.96
Construction and use of a dominant, selectable marker: a Harvey sarcoma virus-dihydrofolate reductase chimera. Mol Cell Biol (1983) 0.95
High-level transgene expression by homologous recombination-mediated gene transfer. Nucleic Acids Res (2011) 0.94
Gene amplification accompanies low level increases in the activity of dihydrofolate reductase in antifolate-resistant Chinese hamster lung cells containing abnormally banding chromosomes. J Cell Biol (1982) 0.93
Template requirements for in vivo replication of adenovirus DNA. Mol Cell Biol (1986) 0.93
UV stimulation of DNA-mediated transformation of human cells. Mol Cell Biol (1985) 0.92
Inhibitory effect of interferon on the genetic and oncogenic transformation by viral and cellular genes. J Virol (1985) 0.92
Two integrated partial repeats of simian virus 40 together code for a super-T antigen. Mol Cell Biol (1985) 0.91
Transmission electron microscopic method for gene mapping on polytene chromosomes by in situ hybridization. Proc Natl Acad Sci U S A (1981) 0.90
Homologous recombination and the repair of double-strand breaks during cotransformation of Dictyostelium discoideum. Mol Cell Biol (1988) 0.90
Some property of the nucleus determines the competence of Neurospora crassa for transformation. Genetics (1995) 0.89
In vitro and in vivo interactions of DNA ligase IV with a subunit of the condensin complex. Mol Biol Cell (2003) 0.89
Genetic instability at the adenine phosphoribosyltransferase locus in mouse L cells. Mol Cell Biol (1982) 0.89
Insertional activation of a promoterless thymidine kinase gene. Mol Cell Biol (1988) 0.88
Avian proto-myc genes promoted by defective or nondefective retroviruses are single-hit transforming genes in primary cells. Proc Natl Acad Sci U S A (1989) 0.87
Deletions in the SV40 late polyadenylation region downstream of the AATAAA mediate similar effects on expression in various mammalian cell lines. Nucleic Acids Res (1988) 0.86
Unstable transformation of mouse 3T3 cells by transfection with DNA from normal human lymphocytes. EMBO J (1984) 0.86
Marker rescue from bleomycin-treated Chlamydomonas reinhardi. Genetics (1983) 0.85
Distinct mouse DNA sequences enable establishment and persistence of plasmid DNA polymers in mouse cells. Nucleic Acids Res (1989) 0.84
Transfection of mouse fibroblast cells with a promoterless herpes simplex virus thymidine kinase gene: number of integrated gene copies and structure of single and amplified gene sequences. Mol Cell Biol (1985) 0.83
Adenovirus late sequences linked to herpes simplex virus thymidine kinase may be introduced into eukaryotic cells and transcribed. Nucleic Acids Res (1981) 0.81
Overexpression of caspase-9 triggers its activation and apoptosis in vitro. Croat Med J (2006) 0.80
Adult chicken alpha-globin gene expression in transfected QT6 quail cells: evidence for a negative regulatory element in the alpha D gene region. Nucleic Acids Res (1991) 0.80
Gene transfer of truncated NGF receptor clones leads to cell surface expression in mouse fibroblasts. Nucleic Acids Res (1989) 0.80
Multiple insertions and tandem repeats of origin-minus simian virus 40 DNA in transformed rat and mouse cells. J Virol (1988) 0.79
The rat albumin gene promoter is appropriately regulated in transient but not in stable transfections. Nucleic Acids Res (1988) 0.79
Satellite DNA induces unstable expression of the adjacent herpes simplex virus tk gene cotransfected in mouse cells. Mol Cell Biol (1988) 0.79
Integration of a vector containing rodent repetitive elements in the rat genome. Nucleic Acids Res (1987) 0.78
Differential expression of porcine major histocompatibility DNA sequences introduced into mouse L cells. Mol Cell Biol (1983) 0.78
Efficient expression of an Epstein-Barr nuclear antigen in Drosophila cells transfected with Epstein-Barr virus DNA. EMBO J (1985) 0.78
Amplification and expression of heterologous ornithine decarboxylase in Chinese hamster cells. Mol Cell Biol (1988) 0.77
Regulatory Elements in Vectors for Efficient Generation of Cell Lines Producing Target Proteins. Acta Naturae (2015) 0.77
Use of single stranded targeting DNA or negative selection does not further increase the efficiency of a GGTA1 promoter trap. J Mol Cloning Genet Recomb (2013) 0.75
Differential expression of mouse beta/goat beta c, mouse beta/goat beta F, and mouse beta/goat epsilon II hybrid globin genes in murine erythroleukemia cells. Mol Cell Biol (1986) 0.75
The T4 gene encodes the AIDS virus receptor and is expressed in the immune system and the brain. Cell (1986) 22.26
DNA-mediated transfer of the adenine phosphoribosyltransferase locus into mammalian cells. Proc Natl Acad Sci U S A (1979) 21.22
Transformation of mammalian cells with genes from procaryotes and eucaryotes. Cell (1979) 21.15
Biochemical transfer of single-copy eucaryotic genes using total cellular DNA as donor. Cell (1978) 19.44
Transfer of purified herpes virus thymidine kinase gene to cultured mouse cells. Cell (1977) 18.95
A novel multigene family may encode odorant receptors: a molecular basis for odor recognition. Cell (1991) 18.19
Analysis of transcriptional regulatory signals of the HSV thymidine kinase gene: identification of an upstream control region. Cell (1981) 12.73
Intragenic DNA spacers interrupt the ovalbumin gene. Proc Natl Acad Sci U S A (1978) 11.03
Visualizing an olfactory sensory map. Cell (1996) 8.79
The isolation and nucleotide sequence of a cDNA encoding the T cell surface protein T4: a new member of the immunoglobulin gene family. Cell (1985) 7.16
A spatial map of olfactory receptor expression in the Drosophila antenna. Cell (1999) 6.42
A soluble form of CD4 (T4) protein inhibits AIDS virus infection. Nature (1988) 6.39
The transfer and stable integration of the HSV thymidine kinase gene into mouse cells. Cell (1978) 6.38
The prevalence of dementia: a quantitative integration of the literature. Acta Psychiatr Scand (1987) 6.19
Allelic inactivation regulates olfactory receptor gene expression. Cell (1994) 5.93
A novel ras-related gene family. Cell (1985) 5.81
An olfactory sensory map in the fly brain. Cell (2000) 5.29
Selective digestion of transcriptionally active ovalbumin genes from oviduct nuclei. Proc Natl Acad Sci U S A (1976) 5.27
Differences in human alpha- and beta-globin gene expression in mouse erythroleukemia cells: the role of intragenic sequences. Cell (1984) 5.12
A novel family of genes encoding putative pheromone receptors in mammals. Cell (1995) 4.88
Crystal structure of an HIV-binding recombinant fragment of human CD4. Nature (1990) 4.81
Topographic organization of sensory projections to the olfactory bulb. Cell (1994) 4.74
A chemosensory gene family encoding candidate gustatory and olfactory receptors in Drosophila. Cell (2001) 4.64
Location of ribosomal DNA in the human chromosome complement. Proc Natl Acad Sci U S A (1972) 4.10
Synthesis of globin ribonucleic acid from duck-reticulocyte chromatin in vitro. Proc Natl Acad Sci U S A (1973) 3.93
The isolation and sequence of the gene encoding T8: a molecule defining functional classes of T lymphocytes. Cell (1985) 3.91
Altering genotype and phenotype by DNA-mediated gene transfer. Science (1980) 3.82
Integration, transcription, and control of a Drosophila heat shock gene in mouse cells. Proc Natl Acad Sci U S A (1981) 3.70
Introduction and expression of a rabbit beta-globin gene in mouse fibroblasts. Proc Natl Acad Sci U S A (1979) 3.53
Spatial segregation of odorant receptor expression in the mammalian olfactory epithelium. Cell (1993) 3.53
Characterization of two members of the rho gene family from the yeast Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1987) 3.50
Transformation of mammalian cells with an amplifiable dominant-acting gene. Proc Natl Acad Sci U S A (1980) 3.39
Specific sites of interaction between histones and DNA in chromatin. Proc Natl Acad Sci U S A (1974) 3.25
Cleavage of DNA in nuclei and chromatin with staphylococcal nuclease. Biochemistry (1975) 3.20
Analysis of DNA of isolated chromatin subunits. Proc Natl Acad Sci U S A (1975) 3.17
Molecular characterization of a functional cDNA encoding the serotonin 1c receptor. Science (1988) 3.02
Mice deficient in G(olf) are anosmic. Neuron (1998) 3.00
Functional interaction between human T-cell protein CD4 and the major histocompatibility complex HLA-DR antigen. Nature (1987) 2.89
HIV infection does not require endocytosis of its receptor, CD4. Cell (1988) 2.88
The regulated expression of beta-globin genes introduced into mouse erythroleukemia cells. Cell (1983) 2.75
Isolation of transforming DNA: cloning the hamster aprt gene. Cell (1980) 2.73
Chromosome site for Epstein-Barr virus DNA in a Burkitt tumor cell line and in lymphocytes growth-transformed in vitro. Proc Natl Acad Sci U S A (1983) 2.61
Odorant receptors govern the formation of a precise topographic map. Cell (1998) 2.60
Regulated expression of human growth hormone genes in mouse cells. Cell (1982) 2.58
Gene amplification and gene correction in somatic cells. Cell (1982) 2.46
An activated Notch suppresses neurogenesis and myogenesis but not gliogenesis in mammalian cells. Development (1994) 2.46
Conservation of sequence and structure flanking the mouse and human beta-globin loci: the beta-globin genes are embedded within an array of odorant receptor genes. Proc Natl Acad Sci U S A (1999) 2.39
Health, cognitive, and psychosocial factors as predictors of mortality in an elderly community sample. J Epidemiol Community Health (1999) 2.39
Genes expressed in neurons of adult male Drosophila. Cell (1997) 2.31
Presence in human breast cancer of RNA homologous to mouse mammary tumour virus RNA. Nature (1972) 2.31
Molecular cloning and nucleotide sequence of the streptavidin gene. Nucleic Acids Res (1986) 2.30
Genes transcribed at diverse rates have a similar conformation in chromatin. Proc Natl Acad Sci U S A (1977) 2.17
A family of glutamate receptor genes: evidence for the formation of heteromultimeric receptors with distinct channel properties. Neuron (1990) 2.10
The gene encoding the T-cell surface protein T4 is located on human chromosome 12. Proc Natl Acad Sci U S A (1986) 2.08
Molecular cloning and single-channel properties of the cyclic nucleotide-gated channel from catfish olfactory neurons. Neuron (1992) 2.04
Dementia and depression among the elderly living in the Hobart community: the effect of the diagnostic criteria on the prevalence rates. Psychol Med (1985) 2.02
The family of genes encoding odorant receptors in the channel catfish. Cell (1993) 2.02
The structure of the globin genes in chromatin. Biochemistry (1975) 2.02
Particles containing RNA-instructed DNA polymerase and virus-related RNA in human breast cancers. Proc Natl Acad Sci U S A (1972) 2.02
Isolation and sequence of a cDNA encoding the major structural protein of peripheral myelin. Cell (1985) 1.99
A case-control study of Alzheimer's disease in Australia. Neurology (1990) 1.98
Ectopic expression of the serotonin 1c receptor and the triggering of malignant transformation. Science (1989) 1.97
Analysis of the complexity and diversity of mRNA from chicken liver and oviduct. Cell (1976) 1.92
The NH2-terminal sequence of the avian oncovirus gag precursor polyprotein (Pr76gag). Virology (1978) 1.90
An ancient provirus has imposed androgen regulation on the adjacent mouse sex-limited protein gene. Cell (1988) 1.90
A structure for amplified DNA. Cell (1983) 1.88
Structure and expression of the human and mouse T4 genes. Proc Natl Acad Sci U S A (1987) 1.77
Glucocorticoids enhance stability of human growth hormone mRNA. Mol Cell Biol (1987) 1.77
A receptor guanylyl cyclase expressed specifically in olfactory sensory neurons. Proc Natl Acad Sci U S A (1995) 1.77
Evidence for translation of viral-specific RNA in cells of a mouse mammary carcinoma. Proc Natl Acad Sci U S A (1972) 1.76
An olfactory sensory map develops in the absence of normal projection neurons or GABAergic interneurons. Neuron (1998) 1.76
A single gene encodes multiple neuropeptides mediating a stereotyped behavior. Cell (1983) 1.75
Genetic covariation between neuroticism and the symptoms of anxiety and depression. Genet Epidemiol (1984) 1.73
Detection of RNA-instructed DNA polymerase and high molecular weight RNA in malignant tissue. Proc Natl Acad Sci U S A (1972) 1.73
Nucleosomes are phased along the mouse beta-major globin gene in erythroid and nonerythroid cells. Cell (1986) 1.70
Crystal structure of a soluble form of the human T cell coreceptor CD8 at 2.6 A resolution. Cell (1992) 1.70
Design, synthesis, and pharmacological characterization of 4-[4, 4-dimethyl-3-(4-hydroxybutyl)-5-oxo-2-thioxo-1-imidazolidinyl]- 2-iodobenzonitrile as a high-affinity nonsteroidal androgen receptor ligand. J Med Chem (2000) 1.69
Editing of glutamate receptor subunit B pre-mRNA in vitro by site-specific deamination of adenosine. Nature (1995) 1.68
Odorant receptors on axon termini in the brain. Science (2004) 1.67
Memory complaints as a precursor of memory impairment in older people: a longitudinal analysis over 7-8 years. Psychol Med (2001) 1.65
CD4: collaborator in immune recognition and HIV infection. Cell (1990) 1.59
Introduction of a viral thymidine kinase gene and the human beta-globin gene into developmentally multipotential mouse teratocarcinoma cells. Proc Natl Acad Sci U S A (1980) 1.58
The 5HT2 receptor defines a family of structurally distinct but functionally conserved serotonin receptors. Proc Natl Acad Sci U S A (1990) 1.58
Hsp90 regulates androgen receptor hormone binding affinity in vivo. J Biol Chem (1996) 1.56
Thymic selection in CD8 transgenic mice supports an instructive model for commitment to a CD4 or CD8 lineage. Cell (1991) 1.54
Molecular probes for the development and plasticity of neural crest derivatives. Cell (1985) 1.53
A bipotential neuroendocrine precursor whose choice of cell fate is determined by NGF and glucocorticoids. Cell (1986) 1.53
The level of CD8 expression can determine the outcome of thymic selection. Cell (1992) 1.53
Formation of precise connections in the olfactory bulb occurs in the absence of odorant-evoked neuronal activity. Neuron (2000) 1.52
The epidemiology of Alzheimer's disease. Br Med Bull (1986) 1.51
Coding of olfactory information: topography of odorant receptor expression in the catfish olfactory epithelium. Cell (1993) 1.49
An analysis of diversity in the cognitive performance of elderly community dwellers: individual differences in change scores as a function of age. Psychol Aging (1999) 1.49
The neglect of prevention in psychiatry. Aust N Z J Psychiatry (1992) 1.45
A map of pheromone receptor activation in the mammalian brain. Cell (1999) 1.43
Psychological immunisation. A proposal for preventive psychiatry. Lancet (1972) 1.41
5-HT1c receptor is a prominent serotonin receptor subtype in the central nervous system. Proc Natl Acad Sci U S A (1989) 1.39
Genomic analysis of orthologous mouse and human olfactory receptor loci. Proc Natl Acad Sci U S A (2001) 1.39
Virus-related RNA in human and mouse mammary tumors. J Natl Cancer Inst (1972) 1.34
Genetic ablation and restoration of the olfactory topographic map. Cell (2000) 1.34