Published in J Biol Chem on June 05, 1988
Phosphatidylserine-dependent ingestion of apoptotic cells promotes TGF-beta1 secretion and the resolution of inflammation. J Clin Invest (2002) 5.55
Transforming growth factor-beta in disease: the dark side of tissue repair. J Clin Invest (1992) 4.49
TGF-beta and the Smad signaling pathway support transcriptomic reprogramming during epithelial-mesenchymal cell transition. Mol Biol Cell (2005) 3.75
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Expression of transforming growth factor-beta 1 in specific cells and tissues of adult and neonatal mice. J Cell Biol (1989) 2.77
Autoinduction of transforming growth factor beta 1 is mediated by the AP-1 complex. Mol Cell Biol (1990) 2.73
Platelet-derived growth factor and transforming growth factor-beta enhance tissue repair activities by unique mechanisms. J Cell Biol (1989) 2.54
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Transforming growth factor-beta and the initiation of chondrogenesis and osteogenesis in the rat femur. J Cell Biol (1990) 2.19
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Transforming growth factor-beta 1 hyperexpression in African-American hypertensives: A novel mediator of hypertension and/or target organ damage. Proc Natl Acad Sci U S A (2000) 1.86
Extracellular matrix regulates expression of the TGF-beta 1 gene. J Cell Biol (1993) 1.84
Glia-dependent TGF-beta signaling, acting independently of the TH17 pathway, is critical for initiation of murine autoimmune encephalomyelitis. J Clin Invest (2007) 1.78
Complex regulation of transforming growth factor beta 1, beta 2, and beta 3 mRNA expression in mouse fibroblasts and keratinocytes by transforming growth factors beta 1 and beta 2. Mol Cell Biol (1989) 1.76
Enhanced jun gene expression is an early genomic response to transforming growth factor beta stimulation. Mol Cell Biol (1989) 1.70
Expression and secretion of gro/MGSA by stimulated human endothelial cells. EMBO J (1989) 1.70
Platelet-derived growth factor-BB and transforming growth factor beta 1 selectively modulate glycosaminoglycans, collagen, and myofibroblasts in excisional wounds. Am J Pathol (1991) 1.69
Regulation of transforming growth factor beta 1 gene expression by the product of the retinoblastoma-susceptibility gene. Proc Natl Acad Sci U S A (1991) 1.63
Evidence that furin is an authentic transforming growth factor-beta1-converting enzyme. Am J Pathol (2001) 1.60
Transforming growth factor-beta activity is potentiated by heparin via dissociation of the transforming growth factor-beta/alpha 2-macroglobulin inactive complex. J Cell Biol (1989) 1.59
Dual role for the latent transforming growth factor-beta binding protein in storage of latent TGF-beta in the extracellular matrix and as a structural matrix protein. J Cell Biol (1995) 1.58
Overexpression of transforming growth factor beta1 in arterial endothelium causes hyperplasia, apoptosis, and cartilaginous metaplasia. Proc Natl Acad Sci U S A (1998) 1.58
Characterization of the mouse transforming growth factor-beta 1 promoter and activation by the Ha-ras oncogene. Mol Cell Biol (1991) 1.55
Induction of transforming growth factor beta 1 by purified protein derivative of Mycobacterium tuberculosis. Infect Immun (1995) 1.52
Growth factor-induced acceleration of tissue repair through direct and inductive activities in a rabbit dermal ulcer model. J Clin Invest (1991) 1.48
Growth factor expression in aorta of normotensive and hypertensive rats. J Clin Invest (1989) 1.46
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Small-molecule-mediated rescue of protein function by an inducible proteolytic shunt. Proc Natl Acad Sci U S A (2007) 1.35
Enhanced expression of transforming growth factor-beta type I and type II receptors in wound granulation tissue and hypertrophic scar. Am J Pathol (1998) 1.30
Exogenous transforming growth factor-beta amplifies its own expression and induces scar formation in a model of human fetal skin repair. Ann Surg (1995) 1.30
The IE2 regulatory protein of human cytomegalovirus induces expression of the human transforming growth factor beta1 gene through an Egr-1 binding site. J Virol (1996) 1.27
On multiscale approaches to three-dimensional modelling of morphogenesis. J R Soc Interface (2005) 1.26
Transcriptional and translational regulation of TGF-beta production in response to apoptotic cells. J Immunol (2008) 1.26
Retinoic acid modulates rat Ito cell proliferation, collagen, and transforming growth factor beta production. J Clin Invest (1990) 1.24
ERK, p38, and Smad signaling pathways differentially regulate transforming growth factor-beta1 autoinduction in proximal tubular epithelial cells. Am J Pathol (2006) 1.24
Dynamical mechanisms for skeletal pattern formation in the vertebrate limb. Proc Biol Sci (2004) 1.22
A phorbol ester-regulated ribonuclease system controlling transforming growth factor beta 1 gene expression in hematopoietic cells. Mol Cell Biol (1990) 1.17
Transforming growth factor-(beta)s and mammary gland involution; functional roles and implications for cancer progression. J Mammary Gland Biol Neoplasia (2009) 1.15
MicroRNA-326 regulates profibrotic functions of transforming growth factor-β in pulmonary fibrosis. Am J Respir Cell Mol Biol (2014) 1.14
How does TGF-β mediate tubulointerstitial fibrosis? Semin Nephrol (2012) 1.14
Tenascin-C expression by fibroblasts is elevated in stressed collagen gels. J Cell Biol (1994) 1.14
Transforming growth factor beta mediates the progesterone suppression of an epithelial metalloproteinase by adjacent stroma in the human endometrium. Proc Natl Acad Sci U S A (1995) 1.13
TGFbeta1 regulates gene expression of its own converting enzyme furin. J Clin Invest (1997) 1.13
Molecular aspects of regulation of collagen gene expression in fibrosis. J Clin Immunol (2005) 1.13
Transcriptional regulation of the transforming growth factor beta 1 promoter by v-src gene products is mediated through the AP-1 complex. Mol Cell Biol (1990) 1.11
The protein tyrosine phosphatase Pez regulates TGFbeta, epithelial-mesenchymal transition, and organ development. J Cell Biol (2007) 1.11
Transforming growth factors beta 1 and 2 transcriptionally regulate human papillomavirus (HPV) type 16 early gene expression in HPV-immortalized human genital epithelial cells. J Virol (1990) 1.11
Fra-2 mediates oxygen-sensitive induction of transforming growth factor beta in cardiac fibroblasts. Cardiovasc Res (2010) 1.06
Regulation of transforming growth factor-beta 1 gene expression by glucocorticoids in normal human T lymphocytes. J Clin Invest (1991) 1.04
Smad3 regulates Rho signaling via NET1 in the transforming growth factor-beta-induced epithelial-mesenchymal transition of human retinal pigment epithelial cells. J Biol Chem (2010) 1.04
A major advance in the use of growth factors to enhance wound healing. J Clin Invest (1993) 1.03
Human gamma interferon strongly upregulates its own gene expression in peripheral blood lymphocytes. J Exp Med (1989) 1.02
Elevated D-glucose concentrations modulate TGF-beta 1 synthesis by human cultured renal proximal tubular cells. The permissive role of platelet-derived growth factor. Am J Pathol (1995) 1.02
Activin A is an autocrine activator of rat pancreatic stellate cells: potential therapeutic role of follistatin for pancreatic fibrosis. Gut (2003) 1.01
Localization of TGF-beta type II receptor and ED-A fibronectin in normal conjunctiva and failed filtering blebs. Mol Vis (2008) 1.01
High glucose concentration induces the overexpression of transforming growth factor-beta through the activation of a platelet-derived growth factor loop in human mesangial cells. Am J Pathol (1996) 1.00
Characterization of the TGF-β1 signaling abnormalities in the Gata1low mouse model of myelofibrosis. Blood (2013) 0.99
Urokinase-receptor biosynthesis, mRNA level and gene transcription are increased by transforming growth factor beta 1 in human A549 lung carcinoma cells. EMBO J (1991) 0.99
Cyclic AMP induces transforming growth factor beta 2 gene expression and growth arrest in the human androgen-independent prostate carcinoma cell line PC-3. Proc Natl Acad Sci U S A (1992) 0.98
Genetic variants of Tgfb1 act as context-dependent modifiers of mouse skin tumor susceptibility. Proc Natl Acad Sci U S A (2006) 0.97
Tissue stretch decreases soluble TGF-beta1 and type-1 procollagen in mouse subcutaneous connective tissue: evidence from ex vivo and in vivo models. J Cell Physiol (2008) 0.96
TGF-beta suppresses the upregulation of MMP-2 by vascular smooth muscle cells in response to PDGF-BB. Am J Physiol Cell Physiol (2009) 0.95
C-peptide reverses TGF-beta1-induced changes in renal proximal tubular cells: implications for treatment of diabetic nephropathy. Am J Physiol Renal Physiol (2008) 0.95
Neovascularization in aged mice: delayed angiogenesis is coincident with decreased levels of transforming growth factor beta1 and type I collagen. Am J Pathol (1998) 0.92
A 60-kD protein mediates the binding of transforming growth factor-beta to cell surface and extracellular matrix proteoglycans. J Cell Biol (1993) 0.90
Fibroblast growth factor enhances type beta 1 transforming growth factor gene expression in osteoblast-like cells. J Cell Biol (1989) 0.89
Autoinduction of activin genes in early Xenopus embryos. Biochem J (1994) 0.89
Reduced expression of TGF beta is associated with advanced disease in transitional cell carcinoma. Br J Cancer (1993) 0.87
Human cytomegalovirus induces TGF-β1 activation in renal tubular epithelial cells after epithelial-to-mesenchymal transition. PLoS Pathog (2010) 0.87
Fibulin-2 deficiency attenuates angiotensin II-induced cardiac hypertrophy by reducing transforming growth factor-β signalling. Clin Sci (Lond) (2014) 0.87
Accumulation of exogenous activated TGF-β in the superficial zone of articular cartilage. Biophys J (2013) 0.86
Heterogeneous engineered cartilage growth results from gradients of media-supplemented active TGF-β and is ameliorated by the alternative supplementation of latent TGF-β. Biomaterials (2015) 0.85
Rapamycin-conditioned donor dendritic cells differentiate CD4CD25Foxp3 T cells in vitro with TGF-beta1 for islet transplantation. Am J Transplant (2010) 0.84
Retracted Deficiency of cardiomyocyte-specific microRNA-378 contributes to the development of cardiac fibrosis involving a transforming growth factor β (TGFβ1)-dependent paracrine mechanism. J Biol Chem (2014) 0.84
Overexpression of transforming growth factor-beta in transgenic mice carrying the human T-cell lymphotropic virus type I tax gene. Mol Cell Biol (1991) 0.84
Effect of TGF-β1 Stimulation on the Secretome of Human Adipose-Derived Mesenchymal Stromal Cells. Stem Cells Transl Med (2015) 0.82
Tumour cell-derived Wnt7a recruits and activates fibroblasts to promote tumour aggressiveness. Nat Commun (2016) 0.82
Activin Receptor-Like Kinase Receptors ALK5 and ALK1 Are Both Required for TGFβ-Induced Chondrogenic Differentiation of Human Bone Marrow-Derived Mesenchymal Stem Cells. PLoS One (2015) 0.81
Nitric oxide inhibits glomerular TGF-beta signaling via SMOC-1. J Am Soc Nephrol (2009) 0.81
The TGFβ receptor-interacting protein km23-1/DYNLRB1 plays an adaptor role in TGFβ1 autoinduction via its association with Ras. J Biol Chem (2012) 0.80
Expression and autoregulation of transforming growth factor beta receptor mRNA in small-cell lung cancer cell lines. Br J Cancer (1996) 0.80
Modulation of transforming growth factor-beta 1 antiproliferative effects on endothelial cells by cysteine, cystine, and N-acetylcysteine. J Clin Invest (1992) 0.79
Development of a retroviral vector for inducible expression of transforming growth factor beta 1. J Virol (1990) 0.78
Increased expression of stress inducible protein 1 in glioma-associated microglia/macrophages. J Neuroimmunol (2014) 0.77
Effect of transforming growth factor beta on experimental Salmonella typhimurium infection in mice. Infect Immun (1999) 0.77
Immunohistochemical localization of transforming growth factor β-1 and its relationship with collagen expression in advanced liver fibrosis due to biliary atresia. Clin Exp Gastroenterol (2010) 0.77
The Role of TGF-β in the Association Between Primary Graft Dysfunction and Bronchiolitis Obliterans Syndrome. Am J Transplant (2015) 0.76
The IL-8/IL-8R Axis: A Double Agent in Tumor Immune Resistance. Vaccines (Basel) (2016) 0.76
Lipopolysaccharide and hypoxia significantly alters interleukin-8 and macrophage chemoattractant protein-1 production by human fibroblasts but not fibrosis related factors. Hippokratia (2011) 0.75
Inhibition of the TGFβ Pathway Enhances Retinal Regeneration in Adult Zebrafish. PLoS One (2016) 0.75
Down-regulation of cellular platelet-derived growth factor receptors induced by an activated neu receptor tyrosine kinase. Cell Regul (1991) 0.75
Re-epithelialization resulted from prostate basal cells in canine prostatic urethra may represent the ideal healing method after two-micron laser resection of the prostate. Asian J Androl (2015) 0.75
Comparative functional analysis of rat TGF-beta1 and Xenopus laevis TGF-beta5 promoters suggest differential regulations. J Mol Evol (2003) 0.75
Regulating the availability of transforming growth factor ß1 in B104 neuroblastoma cells. Exp Neurol (2010) 0.75
Age-Related Macular Degeneration and Intracrine Biology: An Hypothesis. Ochsner J (2016) 0.75
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Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death. Proc Natl Acad Sci U S A (1993) 10.82
Human transforming growth factor-beta complementary DNA sequence and expression in normal and transformed cells. Nature (1985) 10.13
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Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response. Nat Cell Biol (1999) 5.58
Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta. EMBO J (1999) 5.49
Human transforming growth factor-alpha: precursor structure and expression in E. coli. Cell (1984) 5.39
Some recent advances in the chemistry and biology of transforming growth factor-beta. J Cell Biol (1987) 5.25
Transforming growth factor beta is an important immunomodulatory protein for human B lymphocytes. J Immunol (1986) 5.19
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Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor beta after antigen-specific triggering. Proc Natl Acad Sci U S A (1992) 4.94
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Characterization of a membrane receptor for transforming growth factor-beta in normal rat kidney fibroblasts. J Biol Chem (1984) 4.20
Randomized trial of fenretinide to prevent second breast malignancy in women with early breast cancer. J Natl Cancer Inst (1999) 4.04
Accelerated healing of incisional wounds in rats induced by transforming growth factor-beta. Science (1987) 4.03
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Type beta transforming growth factor in human platelets: release during platelet degranulation and action on vascular smooth muscle cells. J Cell Biol (1986) 3.77
A nuclear factor 1 binding site mediates the transcriptional activation of a type I collagen promoter by transforming growth factor-beta. Cell (1988) 3.72
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Immunodetection and quantitation of the two forms of transforming growth factor-beta (TGF-beta 1 and TGF-beta 2) secreted by cells in culture. J Cell Physiol (1989) 3.58
Transforming growth factor-beta 1: histochemical localization with antibodies to different epitopes. J Cell Biol (1989) 3.55
Purification and initial characterization of a type beta transforming growth factor from human placenta. Proc Natl Acad Sci U S A (1983) 3.52
Polypeptide transforming growth factors isolated from bovine sources and used for wound healing in vivo. Science (1983) 3.51
Purification and properties of a type beta transforming growth factor from bovine kidney. Biochemistry (1983) 3.49
Role of transforming growth factor-beta in the development of the mouse embryo. J Cell Biol (1987) 3.48
Evidence that transforming growth factor-beta is a hormonally regulated negative growth factor in human breast cancer cells. Cell (1987) 3.45
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Transforming growth factors from neoplastic and nonneoplastic tissues. Fed Proc (1983) 3.31
Effects of transforming growth factor beta on the functions of natural killer cells: depressed cytolytic activity and blunting of interferon responsiveness. J Immunol (1986) 3.29
Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions. Proc Natl Acad Sci U S A (1995) 3.25
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Sarcoma growth factor from conditioned medium of virally transformed cells is composed of both type alpha and type beta transforming growth factors. Proc Natl Acad Sci U S A (1983) 3.02
Type beta transforming growth factor is the primary differentiation-inducing serum factor for normal human bronchial epithelial cells. Proc Natl Acad Sci U S A (1986) 2.93
Increased production and immunohistochemical localization of transforming growth factor-beta in idiopathic pulmonary fibrosis. Am J Respir Cell Mol Biol (1991) 2.89
Distribution and modulation of the cellular receptor for transforming growth factor-beta. J Cell Biol (1987) 2.87
Functional characterization of transforming growth factor beta signaling in Smad2- and Smad3-deficient fibroblasts. J Biol Chem (2001) 2.85
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Role of retinoids in differentiation and carcinogenesis. Cancer Res (1983) 2.74
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Peptide growth factors are multifunctional. Nature (1988) 2.71
Synergistic interaction of two classes of transforming growth factors from murine sarcoma cells. Cancer Res (1982) 2.70
Transforming growth factor-beta is a potent immunosuppressive agent that inhibits IL-1-dependent lymphocyte proliferation. J Immunol (1988) 2.70
Mesoderm induction in amphibians: the role of TGF-beta 2-like factors. Science (1988) 2.68
Cellular transformation by coordinated action of three peptide growth factors from human platelets. Nature (1984) 2.66
Tumor suppressor activity of the TGF-beta pathway in human cancers. Cytokine Growth Factor Rev (1996) 2.57
Successful treatment of experimental allergic encephalomyelitis with transforming growth factor-beta 1. J Immunol (1991) 2.52
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Identification of multiple active growth factors in basement membrane Matrigel suggests caution in interpretation of cellular activity related to extracellular matrix components. Exp Cell Res (1992) 2.38