Published in Proc Natl Acad Sci U S A on October 01, 1983
Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proc Natl Acad Sci U S A (1986) 12.14
Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth. J Exp Med (1986) 9.86
Type beta transforming growth factor: a bifunctional regulator of cellular growth. Proc Natl Acad Sci U S A (1985) 5.93
Specific binding to cultured cells of 125I-labeled type beta transforming growth factor from human platelets. Proc Natl Acad Sci U S A (1984) 3.01
Type beta transforming growth factor is the primary differentiation-inducing serum factor for normal human bronchial epithelial cells. Proc Natl Acad Sci U S A (1986) 2.93
Transforming growth factor-beta increases steady state levels of type I procollagen and fibronectin messenger RNAs posttranscriptionally in cultured human dermal fibroblasts. J Clin Invest (1987) 2.74
Inhibitory action of transforming growth factor beta on endothelial cells. Proc Natl Acad Sci U S A (1987) 2.50
Enhanced production and extracellular deposition of the endothelial-type plasminogen activator inhibitor in cultured human lung fibroblasts by transforming growth factor-beta. J Cell Biol (1986) 2.44
Modulation of type beta transforming growth factor activity in bone cultures by osteotropic hormones. Proc Natl Acad Sci U S A (1987) 2.29
Tumor cell autocrine motility factor. Proc Natl Acad Sci U S A (1986) 2.28
Expression of transforming growth factor-beta 1 is increased in human vascular restenosis lesions. J Clin Invest (1992) 1.82
Epidermal growth factor and transforming growth factor-alpha: differential intracellular routing and processing of ligand-receptor complexes. Cell Regul (1991) 1.73
Soluble factor requirements for the autostimulatory growth of B lymphoblasts immortalized by Epstein-Barr virus. J Exp Med (1984) 1.69
Increased secretion of type beta transforming growth factor accompanies viral transformation of cells. Mol Cell Biol (1985) 1.65
Transforming growth factor-beta: possible roles in carcinogenesis. Br J Cancer (1988) 1.51
Molecules, cancer, and the surgeon. A review of molecular biology and its implications for surgical oncology. Ann Surg (1990) 1.39
The latent transforming growth factor beta binding protein (LTBP) family. Biochem J (2000) 1.27
Potentiation of growth factor activity by exogenous c-myc expression. Proc Natl Acad Sci U S A (1986) 1.25
Activation of growth factor secretion in tumorigenic states of breast cancer induced by 17 beta-estradiol or v-Ha-ras oncogene. Proc Natl Acad Sci U S A (1987) 1.22
Transforming growth factor-beta induces skeletal muscle atrophy and fibrosis through the induction of atrogin-1 and scleraxis. Muscle Nerve (2012) 1.21
Smad signaling in skeletal development and regeneration. Cytokine Growth Factor Rev (2009) 1.17
Induction of a mitogen-responsive gene after expression of the Ha-ras oncogene in NIH 3T3 fibroblasts. Mol Cell Biol (1989) 1.15
Transforming growth factor alpha inhibits secretion of gastric acid. Proc Natl Acad Sci U S A (1986) 1.14
Stimulation of glucose uptake by transforming growth factor beta: evidence for the requirement of epidermal growth factor-receptor activation. Proc Natl Acad Sci U S A (1985) 1.07
Abnormal expression of Col X, PTHrP, TGF-beta, bFGF, and VEGF in cartilage with Kashin-Beck disease. J Bone Miner Metab (2006) 1.06
Production of TGF-alpha and TGF-beta by cultured keratinocytes, skin and oral squamous cell carcinomas--potential autocrine regulation of normal and malignant epithelial cell proliferation. Br J Cancer (1989) 1.05
High-level expression of c-H-ras1 fails to fully transform rat-1 cells. Mol Cell Biol (1988) 1.03
Expression of transforming growth factor-alpha in primary human colon and lung carcinomas. Br J Cancer (1990) 1.02
TGF-β synergizes with defects in the Hippo pathway to stimulate human malignant mesothelioma growth. J Exp Med (2012) 1.01
Epithelial-mesenchymal transition stimulates human cancer cells to extend microtubule-based invasive protrusions and suppresses cell growth in collagen gel. PLoS One (2012) 1.01
Cooperative transforming activities of ras, myc, and src viral oncogenes in nonestablished rat adrenocortical cells. J Virol (1988) 0.98
Production of transforming growth factor-beta activity by Ki-1 positive lymphoma cells and analysis of its role in the regulation of Ki-1 positive lymphoma growth. Am J Pathol (1988) 0.96
Anti-sense transforming growth factor alpha oligonucleotides inhibit autocrine stimulated proliferation of a colon carcinoma cell line. Mol Biol Cell (1992) 0.95
Transforming growth factor-beta modulates the high-affinity receptors for epidermal growth factor and transforming growth factor-alpha. J Cell Biol (1985) 0.95
Growth control in cultured 3T3 fibroblasts. V. Purification of an Mr 13,000 polypeptide responsible for growth inhibitory activity. J Cell Biol (1986) 0.92
Cell-mediated co-action of transforming growth factors: incubation of type beta with normal rat kidney cells produces a soluble activity that prolongs the ruffling response to type alpha. J Cell Biol (1986) 0.92
Substitution of lysine for arginine at position 42 of human transforming growth factor-alpha eliminates biological activity without changing internal disulfide bonds. Mol Cell Biol (1989) 0.90
Transcriptional activation of the CEF-4/9E3 cytokine gene by pp60v-src. Mol Cell Biol (1992) 0.89
Transforming growth factor-alpha: characterization of the BamHI, RsaI, and TaqI polymorphic regions. Am J Hum Genet (1993) 0.89
Sequence-specific 1H-NMR assignments and identification of two small antiparallel beta-sheets in the solution structure of recombinant human transforming growth factor alpha. Proc Natl Acad Sci U S A (1989) 0.89
Transforming growth factor alpha: mutation of aspartic acid 47 and leucine 48 results in different biological activities. Mol Cell Biol (1988) 0.88
Malignant transformation of murine fibroblasts by a human c-Ha-ras-1 oncogene does not require a functional epidermal growth factor receptor. Mol Cell Biol (1986) 0.88
Transforming growth factor alpha: an aromatic side chain at position 38 is essential for biological activity. Mol Cell Biol (1989) 0.85
The proliferative and morphologic responses of a colon carcinoma cell line (LIM 1215) require the production of two autocrine factors. Mol Cell Biol (1991) 0.84
Convergent signaling in the regulation of connective tissue growth factor in malignant mesothelioma: TGFβ signaling and defects in the Hippo signaling cascade. Cell Cycle (2012) 0.84
Growth regulation of skin cells by epidermal cell-derived factors: implications for wound healing. Proc Natl Acad Sci U S A (1988) 0.83
Serum independence of transcription from the promoter of an avian retrovirus in v-src-transformed cells is a primary, intracellular effect of increased tyrosine phosphorylation. Proc Natl Acad Sci U S A (1990) 0.82
Epidermal and transforming growth factor alpha in patients with breast tumours. Br J Cancer (1989) 0.81
v-src inhibits differentiation via an extracellular intermediate(s). Mol Cell Biol (1985) 0.80
Transforming growth factor alpha in epithelial proliferative diseases of the breast. J Clin Pathol (1992) 0.80
Different roles of TGF-β in the multi-lineage differentiation of stem cells. World J Stem Cells (2012) 0.79
Development of antisense oligonucleotide (ASO) technology against Tgf-β signaling to prevent scarring during flexor tendon repair. J Orthop Res (2015) 0.79
Development of a retroviral vector for inducible expression of transforming growth factor beta 1. J Virol (1990) 0.78
Notch signaling activation suppresses v-Src-induced transformation of neural cells by restoring TGF-β-mediated differentiation. PLoS One (2010) 0.78
Transforming growth factor-Beta and urokinase-type plasminogen activator: dangerous partners in tumorigenesis-implications in skin cancer. ISRN Dermatol (2013) 0.77
Loss of epidermal growth factor receptors and release of transforming growth factors do not correlate with sarcoma virus-transformation in clonally-related NIH/3T3-derived cell lines. Biochem J (1985) 0.76
Mathematical model of TGF-βsignalling: feedback coupling is consistent with signal switching. BMC Syst Biol (2017) 0.75
Characterization of a comparative model of the extracellular domain of the epidermal growth factor receptor. Protein Sci (2000) 0.75
Structure-function analysis of human transforming growth factor-alpha by site-directed mutagenesis. Biochem J (1992) 0.75
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem (1976) 903.81
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Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization. J Biol Chem (1983) 9.32
Growth factors from murine sarcoma virus-transformed cells. Proc Natl Acad Sci U S A (1978) 8.01
Transforming growth factors produced by certain human tumor cells: polypeptides that interact with epidermal growth factor receptors. Proc Natl Acad Sci U S A (1980) 6.32
New class of transforming growth factors potentiated by epidermal growth factor: isolation from non-neoplastic tissues. Proc Natl Acad Sci U S A (1981) 5.89
Serum contains a platelet-derived transforming growth factor. Proc Natl Acad Sci U S A (1982) 3.88
Purification and initial characterization of a type beta transforming growth factor from human placenta. Proc Natl Acad Sci U S A (1983) 3.52
Transforming growth factors: isolation of polypeptides from virally and chemically transformed cells by acid/ethanol extraction. Proc Natl Acad Sci U S A (1980) 3.45
Transforming growth factor production by chemically transformed cells. Cancer Res (1981) 3.36
Transforming growth factors from neoplastic and nonneoplastic tissues. Fed Proc (1983) 3.31
Synergistic interaction of two classes of transforming growth factors from murine sarcoma cells. Cancer Res (1982) 2.70
Kirsten murine sarcoma virus transformed cell lines and a spontaneously transformed rat cell-line produce transforming factors. J Cell Physiol (1980) 2.48
Growth factors produced by sarcoma virus-transformed cells. Cancer Res (1978) 1.85
Human transforming growth factor. Production by a melanoma cell line, purification, and initial characterization. J Biol Chem (1982) 1.78
Transformation induced by Abelson murine leukemia virus involves production of a polypeptide growth factor. Science (1982) 1.66
Mouse embryonic transforming growth factors related to those isolated from tumor cells. Cancer Res (1982) 1.61
Sarcoma growth factor (SGF): specific binding to epidermal growth factor (EGF) membrane receptors. J Cell Physiol (1980) 1.54
Antibodies to the epidermal growth factor receptor block the biological activities of sarcoma growth factor. Proc Natl Acad Sci U S A (1983) 1.48
Affinity labeling of a transforming growth factor receptor that does not interact with epidermal growth factor. Proc Natl Acad Sci U S A (1982) 1.44
Mouse embryos contain polypeptide growth factor(s) capable of inducing a reversible neoplastic phenotype in nontransformed cells in culture. J Cell Physiol (1982) 1.43
Properties of a sarcoma-growth-factor-like peptide from cells transformed by a temperature-sensitive sarcoma virus. J Cell Physiol (1981) 1.30
High-performance liquid chromatography and picomole-level detection of peptides and proteins. Methods Enzymol (1981) 1.30
Transforming growth factors in the urine of normal, pregnant, and tumor-bearing humans. J Natl Cancer Inst (1982) 1.19
Purification by reverse-phase high-performance liquid chromatography of an epidermal growth factor-dependent transforming growth factor. Anal Biochem (1982) 1.07
Cells transformed by Rous sarcoma virus release transforming growth factors. J Cell Physiol (1982) 0.93
Identification of an epidermal growth factor-related transforming growth factor from rat fetuses. Biochem Biophys Res Commun (1982) 0.89
Anchorage-independent growth-conferring factor production by rat mammary tumor cells. Cancer Res (1982) 0.88
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Transforming growth factor type beta: rapid induction of fibrosis and angiogenesis in vivo and stimulation of collagen formation in vitro. Proc Natl Acad Sci U S A (1986) 12.14
Transforming growth factor beta 1 null mutation in mice causes excessive inflammatory response and early death. Proc Natl Acad Sci U S A (1993) 10.82
Human transforming growth factor-beta complementary DNA sequence and expression in normal and transformed cells. Nature (1985) 10.13
Production of transforming growth factor beta by human T lymphocytes and its potential role in the regulation of T cell growth. J Exp Med (1986) 9.86
Transforming growth factor-beta in human platelets. Identification of a major storage site, purification, and characterization. J Biol Chem (1983) 9.32
Control of a mucosal challenge and prevention of AIDS by a multiprotein DNA/MVA vaccine. Science (2001) 9.09
Free recombination within Helicobacter pylori. Proc Natl Acad Sci U S A (1998) 8.06
Regulation of immune responses by TGF-beta. Annu Rev Immunol (1998) 8.01
Autocrine secretion and malignant transformation of cells. N Engl J Med (1980) 7.49
MRC image processing programs. J Struct Biol (1996) 6.91
Expression and secretion of type beta transforming growth factor by activated human macrophages. Proc Natl Acad Sci U S A (1987) 6.76
Nerve growth factor receptors on human melanoma cells in culture. Proc Natl Acad Sci U S A (1977) 6.62
Transforming growth factor type beta induces monocyte chemotaxis and growth factor production. Proc Natl Acad Sci U S A (1987) 6.43
Transforming growth factors produced by certain human tumor cells: polypeptides that interact with epidermal growth factor receptors. Proc Natl Acad Sci U S A (1980) 6.32
Autocrine growth factors and cancer. Nature (1985) 5.97
Type beta transforming growth factor: a bifunctional regulator of cellular growth. Proc Natl Acad Sci U S A (1985) 5.93
New class of transforming growth factors potentiated by epidermal growth factor: isolation from non-neoplastic tissues. Proc Natl Acad Sci U S A (1981) 5.89
Horizontal transfer of penicillin-binding protein genes in penicillin-resistant clinical isolates of Streptococcus pneumoniae. Proc Natl Acad Sci U S A (1989) 5.65
Mice lacking Smad3 show accelerated wound healing and an impaired local inflammatory response. Nat Cell Biol (1999) 5.58
Antimicrobial susceptibility patterns of Nocardia asteroides. Antimicrob Agents Chemother (1988) 5.56
Targeted disruption of SMAD3 results in impaired mucosal immunity and diminished T cell responsiveness to TGF-beta. EMBO J (1999) 5.49
Human transforming growth factor-alpha: precursor structure and expression in E. coli. Cell (1984) 5.39
Some recent advances in the chemistry and biology of transforming growth factor-beta. J Cell Biol (1987) 5.25
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Transforming growth factor beta is an important immunomodulatory protein for human B lymphocytes. J Immunol (1986) 5.19
Transforming growth factor-beta: biological function and chemical structure. Science (1986) 5.08
Evolution of genetic redundancy. Nature (1997) 4.95
Suppressor T cells generated by oral tolerization to myelin basic protein suppress both in vitro and in vivo immune responses by the release of transforming growth factor beta after antigen-specific triggering. Proc Natl Acad Sci U S A (1992) 4.94
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Biologically active phorbol esters specifically alter affinity of epidermal growth factor membrane receptors. Nature (1979) 4.72
Suppression of experimental glomerulonephritis by antiserum against transforming growth factor beta 1. Nature (1990) 4.64
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The changing prevalence of asthma in school children. Clin Allergy (1971) 4.60
Can dietary beta-carotene materially reduce human cancer rates? Nature (1981) 4.43
Characterization of a membrane receptor for transforming growth factor-beta in normal rat kidney fibroblasts. J Biol Chem (1984) 4.20
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Randomized trial of fenretinide to prevent second breast malignancy in women with early breast cancer. J Natl Cancer Inst (1999) 4.04
Accelerated healing of incisional wounds in rats induced by transforming growth factor-beta. Science (1987) 4.03
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Latent transforming growth factor-beta from human platelets. A high molecular weight complex containing precursor sequences. J Biol Chem (1988) 3.91
Type beta transforming growth factor in human platelets: release during platelet degranulation and action on vascular smooth muscle cells. J Cell Biol (1986) 3.77
A nuclear factor 1 binding site mediates the transcriptional activation of a type I collagen promoter by transforming growth factor-beta. Cell (1988) 3.72
Role of transforming growth factor-beta signaling in cancer. J Natl Cancer Inst (2000) 3.63
Immunodetection and quantitation of the two forms of transforming growth factor-beta (TGF-beta 1 and TGF-beta 2) secreted by cells in culture. J Cell Physiol (1989) 3.58
Transformation by murine and feline sarcoma viruses specifically blocks binding of epidermal growth factor to cells. Nature (1976) 3.56
Transforming growth factor-beta 1: histochemical localization with antibodies to different epitopes. J Cell Biol (1989) 3.55
Purification and initial characterization of a type beta transforming growth factor from human placenta. Proc Natl Acad Sci U S A (1983) 3.52
Polypeptide transforming growth factors isolated from bovine sources and used for wound healing in vivo. Science (1983) 3.51
Purification and properties of a type beta transforming growth factor from bovine kidney. Biochemistry (1983) 3.49
Role of transforming growth factor-beta in the development of the mouse embryo. J Cell Biol (1987) 3.48
Transforming growth factors: isolation of polypeptides from virally and chemically transformed cells by acid/ethanol extraction. Proc Natl Acad Sci U S A (1980) 3.45
Retracted A link between virulence and ecological abundance in natural populations of Staphylococcus aureus. Science (2001) 3.44
Role of interspecies transfer of chromosomal genes in the evolution of penicillin resistance in pathogenic and commensal Neisseria species. J Mol Evol (1992) 3.44
Physiological actions and clinical applications of transforming growth factor-beta (TGF-beta). Growth Factors (1993) 3.43
Transforming growth factors from neoplastic and nonneoplastic tissues. Fed Proc (1983) 3.31
Effects of transforming growth factor beta on the functions of natural killer cells: depressed cytolytic activity and blunting of interferon responsiveness. J Immunol (1986) 3.29
Hepatic expression of mature transforming growth factor beta 1 in transgenic mice results in multiple tissue lesions. Proc Natl Acad Sci U S A (1995) 3.25
Transforming growth factors produced by retrovirus-transformed rodent fibroblasts and human melanoma cells: amino acid sequence homology with epidermal growth factor. Proc Natl Acad Sci U S A (1983) 3.21
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Type beta transforming growth factor is the primary differentiation-inducing serum factor for normal human bronchial epithelial cells. Proc Natl Acad Sci U S A (1986) 2.93