Published in EMBO J on December 20, 1989
Structural, functional, and evolutionary relationships among extracellular solute-binding receptors of bacteria. Microbiol Rev (1993) 5.36
ABC transporters: bacterial exporters. Microbiol Rev (1993) 5.35
Split ubiquitin as a sensor of protein interactions in vivo. Proc Natl Acad Sci U S A (1994) 5.16
A novel secretory pathway for interleukin-1 beta, a protein lacking a signal sequence. EMBO J (1990) 4.43
Surface presentation of Shigella flexneri invasion plasmid antigens requires the products of the spa locus. J Bacteriol (1992) 3.91
Cis- and trans-acting functions required for endocytosis of the yeast pheromone receptors. J Cell Biol (1993) 3.85
Salmonella typhimurium mutants defective in flagellar filament regrowth and sequence similarity of FliI to F0F1, vacuolar, and archaebacterial ATPase subunits. J Bacteriol (1991) 3.45
Arabidopsis PEN3/PDR8, an ATP binding cassette transporter, contributes to nonhost resistance to inappropriate pathogens that enter by direct penetration. Plant Cell (2006) 3.20
The ABC-transporter Ste6 accumulates in the plasma membrane in a ubiquitinated form in endocytosis mutants. EMBO J (1994) 3.10
Molecular genetics of mating recognition in basidiomycete fungi. Microbiol Mol Biol Rev (1998) 2.80
Genetic analysis of an MDR-like export system: the secretion of colicin V. EMBO J (1990) 2.71
Unconventional secretion of Acb1 is mediated by autophagosomes. J Cell Biol (2010) 2.58
A presumptive helicase (MOT1 gene product) affects gene expression and is required for viability in the yeast Saccharomyces cerevisiae. Mol Cell Biol (1992) 2.56
Genetic transformation in Streptococcus pneumoniae: nucleotide sequence analysis shows comA, a gene required for competence induction, to be a member of the bacterial ATP-dependent transport protein family. J Bacteriol (1991) 2.36
Candida albicans gene encoding resistance to benomyl and methotrexate is a multidrug resistance gene. Antimicrob Agents Chemother (1994) 2.23
The Saccharomyces cerevisiae STE14 gene encodes a methyltransferase that mediates C-terminal methylation of a-factor and RAS proteins. EMBO J (1991) 2.20
Heavy metal tolerance in the fission yeast requires an ATP-binding cassette-type vacuolar membrane transporter. EMBO J (1992) 2.19
Mutational analysis of the yeast a-factor transporter STE6, a member of the ATP binding cassette (ABC) protein superfamily. EMBO J (1991) 2.18
Developmental signal transduction pathways uncovered by genetic suppressors. Proc Natl Acad Sci U S A (1996) 2.13
Pheromones trigger filamentous growth in Ustilago maydis. EMBO J (1994) 2.07
Ubiquitination of the yeast a-factor receptor. J Cell Biol (1996) 2.06
Ubiquitin-assisted dissection of protein transport across membranes. EMBO J (1994) 1.90
Metabolic instability and constitutive endocytosis of STE6, the a-factor transporter of Saccharomyces cerevisiae. Mol Biol Cell (1994) 1.88
A novel membrane-associated metalloprotease, Ste24p, is required for the first step of NH2-terminal processing of the yeast a-factor precursor. J Cell Biol (1997) 1.87
Amplification of the multidrug resistance gene pfmdr1 in Plasmodium falciparum has arisen as multiple independent events. Mol Cell Biol (1991) 1.85
Oligopeptidase B-dependent signaling mediates host cell invasion by Trypanosoma cruzi. EMBO J (1998) 1.84
Courtship in Saccharomyces cerevisiae: an early cell-cell interaction during mating. Mol Cell Biol (1990) 1.82
Genomic convergence toward diploidy in Saccharomyces cerevisiae. PLoS Genet (2006) 1.80
Cell biological mechanisms of multidrug resistance in tumors. Proc Natl Acad Sci U S A (1994) 1.75
Dual roles for Ste24p in yeast a-factor maturation: NH2-terminal proteolysis and COOH-terminal CAAX processing. J Cell Biol (1998) 1.75
Involvement of an ABC transporter in a developmental pathway regulating hypocotyl cell elongation in the light Plant Cell (1998) 1.74
Significance of C-terminal cysteine modifications to the biological activity of the Saccharomyces cerevisiae a-factor mating pheromone. Mol Cell Biol (1991) 1.70
The plasma membrane of Saccharomyces cerevisiae: structure, function, and biogenesis. Microbiol Rev (1995) 1.69
Peptide size selection by the major histocompatibility complex-encoded peptide transporter. J Exp Med (1994) 1.69
A single amino acid substitution strongly modulates the activity and substrate specificity of the mouse mdr1 and mdr3 drug efflux pumps. Proc Natl Acad Sci U S A (1991) 1.68
The a-factor transporter (STE6 gene product) and cell polarity in the yeast Saccharomyces cerevisiae. J Cell Biol (1993) 1.67
Farnesyl cysteine C-terminal methyltransferase activity is dependent upon the STE14 gene product in Saccharomyces cerevisiae. Mol Cell Biol (1990) 1.67
A new pathway for protein export in Saccharomyces cerevisiae. J Cell Biol (1996) 1.66
The Candida albicans CDR3 gene codes for an opaque-phase ABC transporter. J Bacteriol (1997) 1.62
Biogenesis of the Saccharomyces cerevisiae mating pheromone a-factor. J Cell Biol (1997) 1.57
A family of small coiled-coil-forming proteins functioning at the late endosome in yeast. Mol Biol Cell (2001) 1.57
Endocytosis and vacuolar degradation of the plasma membrane-localized Pdr5 ATP-binding cassette multidrug transporter in Saccharomyces cerevisiae. Mol Cell Biol (1995) 1.56
Ste6p mutants defective in exit from the endoplasmic reticulum (ER) reveal aspects of an ER quality control pathway in Saccharomyces cerevisiae. Mol Biol Cell (1998) 1.55
Osmotic balance regulates cell fusion during mating in Saccharomyces cerevisiae. J Cell Biol (1997) 1.54
A plant plasma membrane ATP binding cassette-type transporter is involved in antifungal terpenoid secretion. Plant Cell (2001) 1.54
An ABC transporter in the mitochondrial inner membrane is required for normal growth of yeast. EMBO J (1995) 1.51
Isolation and characterization of a Saccharomyces cerevisiae peptide transport gene. Mol Cell Biol (1994) 1.49
Fungal lipopeptide mating pheromones: a model system for the study of protein prenylation. Microbiol Rev (1995) 1.48
Sexual pheromones and mating responses in fungi. Plant Cell (1993) 1.48
The interleukin-1 beta-converting enzyme (ICE) is localized on the external cell surface membranes and in the cytoplasmic ground substance of human monocytes by immuno-electron microscopy. J Exp Med (1995) 1.47
Asymmetry in sexual pheromones is not required for ascomycete mating. Curr Biol (2011) 1.46
The linker region of the ABC-transporter Ste6 mediates ubiquitination and fast turnover of the protein. EMBO J (1997) 1.45
Nucleotide sequence of the yeast STE14 gene, which encodes farnesylcysteine carboxyl methyltransferase, and demonstration of its essential role in a-factor export. Mol Cell Biol (1994) 1.43
Characterization of uptake and hydrolysis of fluorescein diacetate and carboxyfluorescein diacetate by intracellular esterases in Saccharomyces cerevisiae, which result in accumulation of fluorescent product. Appl Environ Microbiol (1995) 1.43
Biogenesis of a novel compartment for autophagosome-mediated unconventional protein secretion. J Cell Biol (2011) 1.43
RTM1: a member of a new family of telomeric repeated genes in yeast. Genetics (1995) 1.43
Role for the ubiquitin-proteasome system in the vacuolar degradation of Ste6p, the a-factor transporter in Saccharomyces cerevisiae. Mol Cell Biol (1998) 1.42
Akr1p and the type I casein kinases act prior to the ubiquitination step of yeast endocytosis: Akr1p is required for kinase localization to the plasma membrane. Mol Cell Biol (2000) 1.41
Two putative subunits of a peptide pump encoded in the human major histocompatibility complex class II region. Proc Natl Acad Sci U S A (1991) 1.40
ABC transporters in Saccharomyces cerevisiae and their interactors: new technology advances the biology of the ABCC (MRP) subfamily. Microbiol Mol Biol Rev (2009) 1.34
Magnificent seven: roles of G protein-coupled receptors in extracellular sensing in fungi. FEMS Microbiol Rev (2008) 1.33
Cloning of the cDNA for a human homologue of the Drosophila white gene and mapping to chromosome 21q22.3. Am J Hum Genet (1996) 1.32
Identification of Kel1p, a kelch domain-containing protein involved in cell fusion and morphology in Saccharomyces cerevisiae. J Cell Biol (1998) 1.32
Palmitoylation and plasma membrane localization of Ras2p by a nonclassical trafficking pathway in Saccharomyces cerevisiae. Mol Cell Biol (2003) 1.29
Characteristics of peptide and major histocompatibility complex class I/beta 2-microglobulin binding to the transporters associated with antigen processing (TAP1 and TAP2). Proc Natl Acad Sci U S A (1994) 1.27
Uptake of the ATP-binding cassette (ABC) transporter Ste6 into the yeast vacuole is blocked in the doa4 Mutant. Mol Biol Cell (2001) 1.27
Functional complementation between bacterial MDR-like export systems: colicin V, alpha-hemolysin, and Erwinia protease. J Bacteriol (1991) 1.27
Small heat-shock proteins select deltaF508-CFTR for endoplasmic reticulum-associated degradation. Mol Biol Cell (2006) 1.24
Magnesium Adenosine 5[prime]-Triphosphate-Energized Transport of Glutathione-S-Conjugates by Plant Vacuolar Membrane Vesicles. Plant Physiol (1995) 1.24
Phylogenetic analysis of fungal ABC transporters. BMC Genomics (2010) 1.22
Roles of prenyl protein proteases in maturation of Saccharomyces cerevisiae a-factor. Genetics (1998) 1.22
Characterization of the ATPase activity of P-glycoprotein from multidrug-resistant Chinese hamster ovary cells. Biochem J (1995) 1.20
A mouse model for X-linked adrenoleukodystrophy. Proc Natl Acad Sci U S A (1997) 1.20
Nonlytic viral spread enhanced by autophagy components. Proc Natl Acad Sci U S A (2014) 1.19
Multiple sex pheromones and receptors of a mushroom-producing fungus elicit mating in yeast. Mol Biol Cell (1999) 1.19
Recycling of the yeast a-factor receptor. J Cell Biol (2000) 1.19
Functional expression of human mdr1 in the yeast Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1992) 1.17
Sequence of the clathrin heavy chain from Saccharomyces cerevisiae and requirement of the COOH terminus for clathrin function. J Cell Biol (1991) 1.17
Analysis of the immunoglobulin A protease gene of Streptococcus sanguis. Infect Immun (1991) 1.15
The adhesin Hwp1 and the first daughter cell localize to the a/a portion of the conjugation bridge during Candida albicans mating. Mol Biol Cell (2003) 1.14
The human genome project. Proc Natl Acad Sci U S A (1993) 1.14
Biogenesis of the Saccharomyces cerevisiae pheromone a-factor, from yeast mating to human disease. Microbiol Mol Biol Rev (2012) 1.13
AFR1 promotes polarized apical morphogenesis in Saccharomyces cerevisiae. Mol Cell Biol (1995) 1.11
Role of the ABC transporter Ste6 in cell fusion during yeast conjugation. J Cell Biol (1996) 1.09
Isolation and characterization of the Cryptococcus neoformans MATa pheromone gene. Genetics (2002) 1.09
Isolation and characterization of Drosophila multidrug resistance gene homologs. Mol Cell Biol (1991) 1.07
Dtrlp, a multidrug resistance transporter of the major facilitator superfamily, plays an essential role in spore wall maturation in Saccharomyces cerevisiae. Eukaryot Cell (2002) 1.07
Linking yeast genetics to mammalian genomes: identification and mapping of the human homolog of CDC27 via the expressed sequence tag (EST) data base. Proc Natl Acad Sci U S A (1993) 1.05
Domain interactions in the yeast ATP binding cassette transporter Ycf1p: intragenic suppressor analysis of mutations in the nucleotide binding domains. J Bacteriol (2001) 1.04
The cell adhesion molecule DdCAD-1 in Dictyostelium is targeted to the cell surface by a nonclassical transport pathway involving contractile vacuoles. J Cell Biol (1997) 1.04
AtOPT3, a member of the oligopeptide transporter family, is essential for embryo development in Arabidopsis. Plant Cell (2002) 1.04
Endoproteolytic processing of a farnesylated peptide in vitro. Proc Natl Acad Sci U S A (1992) 1.03
Mutations within the first LSGGQ motif of Ste6p cause defects in a-factor transport and mating in Saccharomyces cerevisiae. J Bacteriol (1996) 1.01
bfr1+, a novel gene of Schizosaccharomyces pombe which confers brefeldin A resistance, is structurally related to the ATP-binding cassette superfamily. J Bacteriol (1995) 1.01
Saccharomyces cerevisiae a-factor mutants reveal residues critical for processing, activity, and export. Eukaryot Cell (2006) 1.01
Unconventional protein secretion: an evolving mechanism. EMBO J (2013) 0.98
Unconventional secretion by autophagosome exocytosis. J Cell Biol (2010) 0.98
Hsp70 targets a cytoplasmic quality control substrate to the San1p ubiquitin ligase. J Biol Chem (2013) 0.98
An Aeromonas salmonicida gene which influences a-protein expression in Escherichia coli encodes a protein containing an ATP-binding cassette and maps beside the surface array protein gene. J Bacteriol (1993) 0.97
Detection of specific sequences among DNA fragments separated by gel electrophoresis. J Mol Biol (1975) 503.08
Sequencing end-labeled DNA with base-specific chemical cleavages. Methods Enzymol (1980) 287.68
A simple method for displaying the hydropathic character of a protein. J Mol Biol (1982) 150.65
Transformation of intact yeast cells treated with alkali cations. J Bacteriol (1983) 100.26
Rapid and sensitive protein similarity searches. Science (1985) 76.83
Cloning in single-stranded bacteriophage as an aid to rapid DNA sequencing. J Mol Biol (1980) 61.16
One-step gene disruption in yeast. Methods Enzymol (1983) 52.81
Prediction of protein antigenic determinants from amino acid sequences. Proc Natl Acad Sci U S A (1981) 32.98
Fluorographic detection of radioactivity in polyacrylamide gels with the water-soluble fluor, sodium salicylate. Anal Biochem (1979) 22.03
Yeast/E. coli shuttle vectors with multiple unique restriction sites. Yeast (1986) 17.88
A subfamily of stress proteins facilitates translocation of secretory and mitochondrial precursor polypeptides. Nature (1988) 11.00
Cloning, sequence and expression of two distinct human interleukin-1 complementary DNAs. Nature (1985) 9.94
All ras proteins are polyisoprenylated but only some are palmitoylated. Cell (1989) 9.68
Internal duplication and homology with bacterial transport proteins in the mdr1 (P-glycoprotein) gene from multidrug-resistant human cells. Cell (1986) 8.53
Nucleotide sequence of an Escherichia coli chromosomal hemolysin. J Bacteriol (1985) 8.53
The biochemistry of P-glycoprotein-mediated multidrug resistance. Annu Rev Biochem (1989) 7.13
Bacterial periplasmic transport systems: structure, mechanism, and evolution. Annu Rev Biochem (1986) 6.23
The heparin-binding (fibroblast) growth factor family of proteins. Annu Rev Biochem (1989) 5.98
Mammalian multidrug resistance gene: complete cDNA sequence indicates strong homology to bacterial transport proteins. Cell (1986) 5.51
Isolation of the putative structural gene for the lysine-arginine-cleaving endopeptidase required for processing of yeast prepro-alpha-factor. Cell (1984) 5.26
Predicting the orientation of eukaryotic membrane-spanning proteins. Proc Natl Acad Sci U S A (1989) 5.15
Secretion of cyclolysin, the calmodulin-sensitive adenylate cyclase-haemolysin bifunctional protein of Bordetella pertussis. EMBO J (1988) 4.75
Complete nucleotide sequence and identification of membrane components of the histidine transport operon of S. typhimurium. Nature (1982) 4.71
Yeast alpha factor is processed from a larger precursor polypeptide: the essential role of a membrane-bound dipeptidyl aminopeptidase. Cell (1983) 4.24
Evidence the yeast STE3 gene encodes a receptor for the peptide pheromone a factor: gene sequence and implications for the structure of the presumed receptor. Proc Natl Acad Sci U S A (1986) 4.07
Enzymes required for yeast prohormone processing. Annu Rev Physiol (1988) 4.06
Homology of 54K protein of signal-recognition particle, docking protein and two E. coli proteins with putative GTP-binding domains. Nature (1989) 4.05
Genetic and pharmacological suppression of oncogenic mutations in ras genes of yeast and humans. Science (1989) 3.90
Homology between P-glycoprotein and a bacterial haemolysin transport protein suggests a model for multidrug resistance. Nature (1987) 3.79
Spectrophotometric quantitation of silver grains eluted from autoradiograms. Anal Biochem (1983) 3.73
RAM, a gene of yeast required for a functional modification of RAS proteins and for production of mating pheromone a-factor. Cell (1986) 3.57
Post-translational processing of p21ras is two-step and involves carboxyl-methylation and carboxy-terminal proteolysis. EMBO J (1989) 3.51
Protein localization and membrane traffic in yeast. Annu Rev Cell Biol (1985) 3.51
Conjugation in Saccharomyces cerevisiae. Annu Rev Cell Biol (1988) 3.47
Structure of Saccharomyces cerevisiae mating hormone a-factor. Identification of S-farnesyl cysteine as a structural component. J Biol Chem (1988) 3.42
Physiological characterization of Saccharomyces cerevisiae mutants supersensitive to G1 arrest by a factor and alpha factor pheromones. Mol Cell Biol (1982) 3.37
The export of the DNA replication inhibitor Microcin B17 provides immunity for the host cell. EMBO J (1988) 3.25
Amplification of a gene related to mammalian mdr genes in drug-resistant Plasmodium falciparum. Science (1989) 3.25
The yeast STE12 protein binds to the DNA sequence mediating pheromone induction. Proc Natl Acad Sci U S A (1989) 3.01
Molecular characterization of the oligopeptide permease of Salmonella typhimurium. J Mol Biol (1987) 3.00
The synthesis and function of proteases in Saccharomyces: genetic approaches. Annu Rev Genet (1984) 2.97
Nucleotide binding by membrane components of bacterial periplasmic binding protein-dependent transport systems. EMBO J (1985) 2.49
Negative regulation of STE6 gene expression by the alpha 2 product of Saccharomyces cerevisiae. Mol Cell Biol (1984) 2.34
ATP synthase (H+-ATPase): results by combined biochemical and molecular biological approaches. Annu Rev Biochem (1989) 2.31
ATP-binding sites in the membrane components of histidine permease, a periplasmic transport system. Proc Natl Acad Sci U S A (1984) 1.97
Purification of the 170- to 180-kilodalton membrane glycoprotein associated with multidrug resistance. 170- to 180-kilodalton membrane glycoprotein is an ATPase. J Biol Chem (1988) 1.85
The mdr1 gene, responsible for multidrug-resistance, codes for P-glycoprotein. Biochem Biophys Res Commun (1986) 1.71
Amino acid sequences of a-factor mating peptides from Saccharomyces cerevisiae. J Biol Chem (1987) 1.56
ATP-binding properties of P glycoprotein from multidrug-resistant KB cells. FASEB J (1987) 1.50
Extracellular suppression allows mating by pheromone-deficient sterile mutants of Saccharomyces cerevisiae. J Bacteriol (1983) 1.46
Reconstitution of a bacterial periplasmic permease in proteoliposomes and demonstration of ATP hydrolysis concomitant with transport. Proc Natl Acad Sci U S A (1989) 1.46
The human mdr3 gene encodes a novel P-glycoprotein homologue and gives rise to alternatively spliced mRNAs in liver. EMBO J (1987) 1.42
Sequences upstream of the STE6 gene required for its expression and regulation by the mating type locus in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1986) 1.39
Identification and localization of the membrane-associated, ATP-binding subunit of the oligopeptide permease of Salmonella typhimurium. Eur J Biochem (1989) 1.12
Active transport of maltose in membrane vesicles obtained from Escherichia coli cells producing tethered maltose-binding protein. J Bacteriol (1989) 1.12
Model systems for the study of seven-transmembrane-segment receptors. Annu Rev Biochem (1991) 5.70
Glycosylation and processing of prepro-alpha-factor through the yeast secretory pathway. Cell (1984) 5.53
Isolation of the putative structural gene for the lysine-arginine-cleaving endopeptidase required for processing of yeast prepro-alpha-factor. Cell (1984) 5.26
Yeast alpha factor is processed from a larger precursor polypeptide: the essential role of a membrane-bound dipeptidyl aminopeptidase. Cell (1983) 4.24
Enzymes required for yeast prohormone processing. Annu Rev Physiol (1988) 4.06
A putative protein kinase overcomes pheromone-induced arrest of cell cycling in S. cerevisiae. Cell (1989) 3.99
An MF alpha 1-SUC2 (alpha-factor-invertase) gene fusion for study of protein localization and gene expression in yeast. Proc Natl Acad Sci U S A (1983) 3.95
Genetic and pharmacological suppression of oncogenic mutations in ras genes of yeast and humans. Science (1989) 3.90
A candidate protein kinase C gene, PKC1, is required for the S. cerevisiae cell cycle. Cell (1990) 3.87
Homing of a DNA endonuclease gene by meiotic gene conversion in Saccharomyces cerevisiae. Nature (1992) 3.77
Intracellular targeting and structural conservation of a prohormone-processing endoprotease. Science (1989) 3.61
Yeast prohormone processing enzyme (KEX2 gene product) is a Ca2+-dependent serine protease. Proc Natl Acad Sci U S A (1989) 3.49
Mot1, a global repressor of RNA polymerase II transcription, inhibits TBP binding to DNA by an ATP-dependent mechanism. Genes Dev (1994) 3.45
The carboxy-terminal segment of the yeast alpha-factor receptor is a regulatory domain. Cell (1988) 3.42
Recovery of S. cerevisiae a cells from G1 arrest by alpha factor pheromone requires endopeptidase action. Cell (1979) 3.23
Isolation of the yeast calmodulin gene: calmodulin is an essential protein. Cell (1986) 3.17
Human fur gene encodes a yeast KEX2-like endoprotease that cleaves pro-beta-NGF in vivo. J Cell Biol (1990) 3.03
Yeast has homologs (CNA1 and CNA2 gene products) of mammalian calcineurin, a calmodulin-regulated phosphoprotein phosphatase. Proc Natl Acad Sci U S A (1991) 3.02
Cell interactions and regulation of cell type in the yeast Saccharomyces cerevisiae. Annu Rev Microbiol (1983) 3.00
Protein splicing elements: inteins and exteins--a definition of terms and recommended nomenclature. Nucleic Acids Res (1994) 2.97
Inhibitory and activating functions for MAPK Kss1 in the S. cerevisiae filamentous-growth signalling pathway. Nature (1997) 2.85
RGS proteins and signaling by heterotrimeric G proteins. J Biol Chem (1997) 2.82
Regulatory subunit (CNB1 gene product) of yeast Ca2+/calmodulin-dependent phosphoprotein phosphatases is required for adaptation to pheromone. Mol Cell Biol (1992) 2.80
Cell-cell recognition in Saccharomyces cerevisiae: regulation of mating-specific adhesion. J Bacteriol (1978) 2.76
Direct involvement of phosphatidylinositol 4-phosphate in secretion in the yeast Saccharomyces cerevisiae. J Biol Chem (1999) 2.72
Signaling in the yeast pheromone response pathway: specific and high-affinity interaction of the mitogen-activated protein (MAP) kinases Kss1 and Fus3 with the upstream MAP kinase kinase Ste7. Mol Cell Biol (1996) 2.57
Functional counterparts of mammalian protein kinases PDK1 and SGK in budding yeast. Curr Biol (1999) 2.56
A presumptive helicase (MOT1 gene product) affects gene expression and is required for viability in the yeast Saccharomyces cerevisiae. Mol Cell Biol (1992) 2.56
Hsl7 localizes to a septin ring and serves as an adapter in a regulatory pathway that relieves tyrosine phosphorylation of Cdc28 protein kinase in Saccharomyces cerevisiae. Mol Cell Biol (1999) 2.54
Two novel targets of the MAP kinase Kss1 are negative regulators of invasive growth in the yeast Saccharomyces cerevisiae. Genes Dev (1996) 2.49
The yeast ARD1 gene product is required for repression of cryptic mating-type information at the HML locus. Mol Cell Biol (1987) 2.30
Signal propagation and regulation in the mating pheromone response pathway of the yeast Saccharomyces cerevisiae. Dev Biol (1994) 2.30
Sst2, a negative regulator of pheromone signaling in the yeast Saccharomyces cerevisiae: expression, localization, and genetic interaction and physical association with Gpa1 (the G-protein alpha subunit). Mol Cell Biol (1996) 2.20
A conserved docking site in MEKs mediates high-affinity binding to MAP kinases and cooperates with a scaffold protein to enhance signal transmission. J Biol Chem (2000) 1.96
Yeast homologue of neuronal frequenin is a regulator of phosphatidylinositol-4-OH kinase. Nat Cell Biol (1999) 1.94
Novel yeast protein kinase (YPK1 gene product) is a 40-kilodalton phosphotyrosyl protein associated with protein-tyrosine kinase activity. Mol Cell Biol (1990) 1.93
The STE2 gene product is the ligand-binding component of the alpha-factor receptor of Saccharomyces cerevisiae. J Biol Chem (1988) 1.92
Repression of yeast Ste12 transcription factor by direct binding of unphosphorylated Kss1 MAPK and its regulation by the Ste7 MEK. Genes Dev (1998) 1.92
Thymidine 5'-monophosphate-requiring mutants of Saccharomyces cerevisiae are deficient in thymidylate synthetase. J Bacteriol (1977) 1.90
The yeast repeated element sigma contains a hormone-inducible promoter. Mol Cell Biol (1987) 1.88
Ste5 RING-H2 domain: role in Ste4-promoted oligomerization for yeast pheromone signaling. Science (1997) 1.88
Phosphatidylinositol 4-kinase: gene structure and requirement for yeast cell viability. Science (1993) 1.86
Genetic manipulation of Saccharomyces cerevisiae by use of the LYS2 gene. Mol Cell Biol (1986) 1.84
Differential regulation of transcription: repression by unactivated mitogen-activated protein kinase Kss1 requires the Dig1 and Dig2 proteins. Proc Natl Acad Sci U S A (1998) 1.73
Genetic and biochemical characterization of a phosphatidylinositol-specific phospholipase C in Saccharomyces cerevisiae. Mol Cell Biol (1993) 1.71
Protein-tyrosine kinase activity in Saccharomyces cerevisiae. Science (1986) 1.68
The a-factor transporter (STE6 gene product) and cell polarity in the yeast Saccharomyces cerevisiae. J Cell Biol (1993) 1.67
Solid phase peptide synthesis of alpha-factor, a yeast mating pheromone. Biochem Biophys Res Commun (1977) 1.66
Yeast KEX2 endopeptidase correctly cleaves a neuroendocrine prohormone in mammalian cells. Science (1988) 1.64
Molecular cloning of hormone-responsive genes from the yeast Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1984) 1.59
Identification of tubulin from the yeast Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1978) 1.57
Yeast mating pheromone alpha factor inhibits adenylate cyclase. Proc Natl Acad Sci U S A (1980) 1.57
Expression and purification of the Saccharomyces cerevisiae alpha-factor receptor (Ste2p), a 7-transmembrane-segment G protein-coupled receptor. J Biol Chem (1997) 1.56
Putting it on and taking it off: phosphoprotein phosphatase involvement in cell cycle regulation. Cell (1989) 1.55
A conserved motif at the amino termini of MEKs might mediate high-affinity interaction with the cognate MAPKs. Trends Biochem Sci (1996) 1.54
Identification and characterization of an essential family of inositol polyphosphate 5-phosphatases (INP51, INP52 and INP53 gene products) in the yeast Saccharomyces cerevisiae. Genetics (1998) 1.52
Dynamic localization of the Swe1 regulator Hsl7 during the Saccharomyces cerevisiae cell cycle. Mol Biol Cell (2001) 1.49
Extracellular suppression allows mating by pheromone-deficient sterile mutants of Saccharomyces cerevisiae. J Bacteriol (1983) 1.46
Mutational activation of the STE5 gene product bypasses the requirement for G protein beta and gamma subunits in the yeast pheromone response pathway. Mol Cell Biol (1994) 1.46
Beta and gamma subunits of a yeast guanine nucleotide-binding protein are not essential for membrane association of the alpha subunit but are required for receptor coupling. Proc Natl Acad Sci U S A (1990) 1.46
A functional prepro-alpha-factor gene in Saccharomyces yeasts can contain three, four, or five repeats of the mature pheromone sequence. Mol Cell Biol (1983) 1.45
Multiple Ca2+/calmodulin-dependent protein kinase genes in a unicellular eukaryote. EMBO J (1991) 1.43
Nucleotidylation, not phosphorylation, is the major source of the phosphotyrosine detected in enteric bacteria. J Bacteriol (1989) 1.42
Mutational analysis of STE5 in the yeast Saccharomyces cerevisiae: application of a differential interaction trap assay for examining protein-protein interactions. Genetics (1997) 1.38
Phosphorylation and localization of Kss1, a MAP kinase of the Saccharomyces cerevisiae pheromone response pathway. Mol Biol Cell (1995) 1.36
G1 cyclin degradation: the PEST motif of yeast Cln2 is necessary, but not sufficient, for rapid protein turnover. Mol Cell Biol (1994) 1.36
Structure and calcium-binding properties of Frq1, a novel calcium sensor in the yeast Saccharomyces cerevisiae. Biochemistry (2000) 1.32
Vertebrate and yeast calmodulin, despite significant sequence divergence, are functionally interchangeable. Proc Natl Acad Sci U S A (1989) 1.29
Purification and characterization of VDE, a site-specific endonuclease from the yeast Saccharomyces cerevisiae. J Biol Chem (1993) 1.29
Control of yeast mating signal transduction by a mammalian beta 2-adrenergic receptor and Gs alpha subunit. Science (1990) 1.28
Mutational analysis suggests that activation of the yeast pheromone response mitogen-activated protein kinase pathway involves conformational changes in the Ste5 scaffold protein. Mol Biol Cell (2000) 1.25
Glutactin, a novel Drosophila basement membrane-related glycoprotein with sequence similarity to serine esterases. EMBO J (1990) 1.23
Secretion of peptides and proteins lacking hydrophobic signal sequences: the role of adenosine triphosphate-driven membrane translocators. Endocr Rev (1992) 1.20
VDE endonuclease cleaves Saccharomyces cerevisiae genomic DNA at a single site: physical mapping of the VMA1 gene. Nucleic Acids Res (1992) 1.19
A novel FK506- and rapamycin-binding protein (FPR3 gene product) in the yeast Saccharomyces cerevisiae is a proline rotamase localized to the nucleolus. J Cell Biol (1994) 1.19
Functional expression of human mdr1 in the yeast Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1992) 1.17
Casein kinase II catalyzes tyrosine phosphorylation of the yeast nucleolar immunophilin Fpr3. J Biol Chem (1997) 1.15
Overexpression of the yeast MCK1 protein kinase suppresses conditional mutations in centromere-binding protein genes CBF2 and CBF5. Mol Gen Genet (1995) 1.15
Purification and characterization of a soluble phosphatidylinositol 4-kinase from the yeast Saccharomyces cerevisiae. J Biol Chem (1992) 1.12
Saccharomyces cerevisiae STE14 gene is required for COOH-terminal methylation of a-factor mating pheromone. J Biol Chem (1990) 1.10
Mutations in the pho80 gene confer permeability to 5'-mononucleotides in Saccharomyces cerevisiae. Genetics (1982) 1.08
High-throughput screening for drug discovery. Nature (1996) 1.08
An essential function of a phosphoinositide-specific phospholipase C is relieved by inhibition of a cyclin-dependent protein kinase in the yeast Saccharomyces cerevisiae. Genetics (1998) 1.08
Isolation of the yeast calmodulin gene using synthetic oligonucleotide probes. Methods Enzymol (1987) 1.05
Identification and characterization of the CLK1 gene product, a novel CaM kinase-like protein kinase from the yeast Saccharomyces cerevisiae. J Biol Chem (1996) 1.03
Yeast MCK1 protein kinase autophosphorylates at tyrosine and serine but phosphorylates exogenous substrates at serine and threonine. J Biol Chem (1993) 1.03
High affinity interaction of yeast transcriptional regulator, Mot1, with TATA box-binding protein (TBP). J Biol Chem (2001) 1.03
Pheromone action regulates G-protein alpha-subunit myristoylation in the yeast Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1993) 1.03
Purification and enzymic properties of Mot1 ATPase, a regulator of basal transcription in the yeast Saccharomyces cerevisiae. J Biol Chem (2000) 1.02
Complete nucleotide sequence of the gene encoding the regulatory subunit of 3',5'-cyclic AMP-dependent protein kinase from the yeast Saccharomyces cerevisiae. Nucleic Acids Res (1987) 0.98
An essential role for cyclic AMP in growth control: the case for yeast. Cell (1982) 0.96
The PAL1 gene product is a peroxisomal ATP-binding cassette transporter in the yeast Saccharomyces cerevisiae. J Cell Biol (1996) 0.96
Thymidylate synthetase from Saccharomyces cerevisiae. Purification and enzymic properties. J Biol Chem (1981) 0.96
Receptor-G protein signaling in yeast. Annu Rev Physiol (1991) 0.95
The MF alpha 1 gene of Saccharomyces cerevisiae: genetic mapping and mutational analysis of promoter elements. Genetics (1989) 0.93
Aberrant protein phosphorylation at tyrosine is responsible for the growth-inhibitory action of pp60v-src expressed in the yeast Saccharomyces cerevisiae. Mol Biol Cell (1994) 0.92
Yeast mating pheromone activates mammalian gonadotrophs: evolutionary conservation of a reproductive hormone? Science (1982) 0.91
Exogenous dTMP utilization by a novel tup mutant of Saccharomyces cerevisiae. J Bacteriol (1982) 0.90
Dedicated transporters for peptide export and intercompartmental traffic in the yeast Saccharomyces cerevisiae. Cold Spring Harb Symp Quant Biol (1992) 0.90