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W E Paul

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Top papers

Rank Title Journal Year PubWeight™‹?›
1 Interferon-gamma and B cell stimulatory factor-1 reciprocally regulate Ig isotype production. Science 1987 13.03
2 Production of a monoclonal antibody to and molecular characterization of B-cell stimulatory factor-1. Nature 1985 11.55
3 Identification of a T cell-derived b cell growth factor distinct from interleukin 2. J Exp Med 1982 9.49
4 Acquisition of lymphokine-producing phenotype by CD4+ T cells. Annu Rev Immunol 1994 8.43
5 Lymphokine control of in vivo immunoglobulin isotype selection. Annu Rev Immunol 1990 7.93
6 The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice. J Exp Med 1992 7.80
7 Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells. J Exp Med 1990 7.09
8 The IL-4 receptor: signaling mechanisms and biologic functions. Annu Rev Immunol 1999 6.19
9 Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature 1996 6.17
10 B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells. J Immunol 1986 6.16
11 Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming. Proc Natl Acad Sci U S A 1993 6.12
12 CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3. J Exp Med 1994 5.90
13 Carrier function in anti-hapten immune responses. I. Enhancement of primary and secondary anti-hapten antibody responses by carrier preimmunization. J Exp Med 1970 5.71
14 Mast cell lines produce lymphokines in response to cross-linkage of Fc epsilon RI or to calcium ionophores. Nature 1989 5.10
15 Regulation of B-cell growth and differentiation by soluble factors. Annu Rev Immunol 1983 5.09
16 T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells. Proc Natl Acad Sci U S A 2001 4.76
17 NKT cell-mediated repression of tumor immunosurveillance by IL-13 and the IL-4R-STAT6 pathway. Nat Immunol 2000 4.75
18 Suppression of in vivo polyclonal IgE responses by monoclonal antibody to the lymphokine B-cell stimulatory factor 1. Proc Natl Acad Sci U S A 1986 4.69
19 Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor. Science 1993 4.63
20 The behavior of hapten-poly-L-lysine conjugates as complete antigens in genetic responder and as haptens in nonresponder guinea pigs. J Exp Med 1966 4.58
21 Serological, biochemical, and functional identity of B cell-stimulatory factor 1 and B cell differentiation factor for IgG1. J Exp Med 1985 4.47
22 Functional specificity of thymus- dependent lymphocytes. Science 1977 4.31
23 Carrier function in anti-hapten antibody responses. 3. Stimulation of antibody synthesis and facilitation of hapten-specific secondary antibody responses by graft-versus-host reactions. J Exp Med 1971 4.29
24 Derivation of a T cell line that is highly responsive to IL-4 and IL-2 (CT.4R) and of an IL-2 hyporesponsive mutant of that line (CT.4S). J Immunol 1989 4.20
25 Colocalization of X-linked agammaglobulinemia and X-linked immunodeficiency genes. Science 1993 4.08
26 B-cell stimulatory factor-1/interleukin 4. Annu Rev Immunol 1987 4.04
27 IL-4 is required to generate and sustain in vivo IgE responses. J Immunol 1988 4.04
28 Functional heterogeneity of murine lymphoid cells. I. Responsiveness to and surface binding of concanavalin A and phytohemagglutinin. J Immunol 1972 3.96
29 Histocompatibility-linked immune response gene function in guinea pigs. Specific inhibition of antigen-induced lymphocyte proliferation by alloantisera. J Exp Med 1972 3.81
30 X-linked B-lymphocyte immune defect in CBA/HN mice. I. Studies of the function and composition of spleen cells. J Exp Med 1975 3.70
31 Interaction between antigen-presenting cells and primed T lymphocytes: an assessment of Ir gene expression in the antigen-presenting cell. Immunol Rev 1978 3.67
32 T-cell and mast cell lines respond to B-cell stimulatory factor 1. Proc Natl Acad Sci U S A 1986 3.56
33 Activation events during thymic selection. J Exp Med 1992 3.43
34 Cell-type-specific cDNA probes and the murine I region: the localization and orientation of Ad alpha. Proc Natl Acad Sci U S A 1984 3.43
35 Role of NK1.1+ T cells in a TH2 response and in immunoglobulin E production. Science 1995 3.37
36 Carrier function in anti-hapten antibody responses. IV. Experimental conditions for the induction of hapten-specific tolerance or for the stimulation of anti-hapten anamnestic responses by "nonimmunogenic" hapten-polypeptide conjugates. J Exp Med 1971 3.30
37 Frequency of B lymphocytes responsive to anti-immunoglobulin. J Exp Med 1982 3.30
38 B cell stimulatory factor-1 (interleukin 4) activates macrophages for increased tumoricidal activity and expression of Ia antigens. J Immunol 1987 3.18
39 B-cell stimulatory factor 1 activates resting B cells. Proc Natl Acad Sci U S A 1985 3.16
40 Heterogeneity of helper/inducer T lymphocytes. I. Lymphokine production and lymphokine responsiveness. J Exp Med 1987 3.12
41 Functional heterogeneity of murine lymphoid cells. 3. Differential responsiveness of T cells to phytohemagglutinin and concanavalin A as a probe for T cell subsets. J Immunol 1973 3.04
42 X-linked B-lymphocyte immune defect in CBA/N mice. II. Studies of the mechanisms underlying the immune defect. J Exp Med 1975 3.03
43 Ia antigen-bearing B cell tumor lines can present protein antigen and alloantigen in a major histocompatibility complex-restricted fashion to antigen-reactive T cells. J Exp Med 1982 3.01
44 Interleukin 4 is important in protective immunity to a gastrointestinal nematode infection in mice. Proc Natl Acad Sci U S A 1991 3.01
45 Secondary antibody responses in haptenic systems: cell population selection by antigen. J Immunol 1967 3.01
46 Antibody-dependent lymphoid cell-mediated cytotoxicity: no requirement for thymus-derived lymphocytes. Science 1972 2.98
47 Receptors for B-cell stimulatory factor-1 expressed on cells of haematopoietic lineage. Nature 1987 2.94
48 Receptors on immunocompetent cells. II. Specificity and nature of receptors on dinitrophenylated guinea pig albumin- 125 I-binding lymphocytes of normal guinea pigs. J Exp Med 1971 2.92
49 Activation of mouse lymphocytes by anti-immunoglobulin. I. Parameters of the proliferative response. J Exp Med 1978 2.86
50 Differential regulation of IgG1 and IgE synthesis by interleukin 4. J Exp Med 1988 2.84
51 Antigen presentation by resting B cells. Radiosensitivity of the antigen-presentation function and two distinct pathways of T cell activation. J Exp Med 1984 2.71
52 An interleukin 4 (IL-4)-independent pathway for CD4+ T cell IL-4 production is revealed in IL-4 receptor-deficient mice. Proc Natl Acad Sci U S A 1997 2.67
53 T lymphocyte-enriched murine peritoneal exudate cells. III. Inhibition of antigen-induced T lymphocyte Proliferation with anti-Ia antisera. J Immunol 1976 2.64
54 Magnitude of response of histocompatibility-restricted T-cell clones is a function of the product of the concentrations of antigen and Ia molecules. Proc Natl Acad Sci U S A 1983 2.57
55 Carrier function in anti-hapten immune responses. II. Specific properties of carrier cells capable of enhancing anti-hapten antibody responses. J Exp Med 1970 2.54
56 Cellular basis of regulation of expression of idiotype. I. T-suppressor cells specific for MOPC 460 idiotype regulate the expression of cells secreting anti-TNP antibodies bearing 460 idiotype. J Exp Med 1979 2.53
57 Single cell analysis reveals that IL-4 receptor/Stat6 signaling is not required for the in vivo or in vitro development of CD4+ lymphocytes with a Th2 cytokine profile. J Immunol 2000 2.52
58 T cell regulation of IgG subclass antibody production in response to T-independent antigens. J Exp Med 1981 2.50
59 Surface immunoglobulin D as a functional receptor for a subclass of B lymphocytes. Immunol Rev 1977 2.50
60 H-2-linked immune response (Ir) genes. Independent loci for Ir-IgG and Ir-IgA genes. J Exp Med 1972 2.50
61 Determination of antibody-hapten equilibrium constants by an ammonium sulfate precipitation technique. J Immunol 1969 2.49
62 B-lymphocyte heterogeneity: development and characterization of an alloantiserum which distinguishes B-lymphocyte differentiation alloantigens. J Exp Med 1977 2.44
63 B cell stimulatory factor-1/interleukin-4 mRNA is expressed by normal and transformed mast cells. Cell 1987 2.44
64 Mouse splenic and bone marrow cell populations that express high-affinity Fc epsilon receptors and produce interleukin 4 are highly enriched in basophils. Proc Natl Acad Sci U S A 1991 2.41
65 DNP-Lys-ficoll: a T-independent antigen which elicits both IgM and IgG anti-DNP antibody-secreting cells. J Immunol 1975 2.40
66 IL-18, although antiallergic when administered with IL-12, stimulates IL-4 and histamine release by basophils. Proc Natl Acad Sci U S A 1999 2.35
67 Specificity of cellular immune responses. Antigen concentration dependence of stimulation of DNA synthesis in vitro by specifically sensitized cells, as an expression of the binding characteristics of cellular antibody. J Exp Med 1968 2.32
68 Antigen presentation in the murine T-lymphocyte proliferative response. I. Requirement for genetic identity at the major histocompatibility complex. J Exp Med 1977 2.30
69 Idiotype-anti-idiotype regulation. I. Immunization with a levan-binding myeloma protein leads to the appearance of auto-anti-(anti-idiotype) antibodies and to the activation of silent clones. J Exp Med 1981 2.28
70 Cultured NK1.1+ CD4+ T cells produce large amounts of IL-4 and IFN-gamma upon activation by anti-CD3 or CD1. J Immunol 1997 2.28
71 A mouse IgM allotypic determinant (Igh-6.5) recognized by a monoclonal rat antibody. J Immunol 1981 2.27
72 T-lymphocyte-enriched murine peritoneal exudate cells. II. Genetic control of antigen-induced T-lymphocyte proliferation. J Exp Med 1976 2.27
73 IFN-gamma stimulates IgG2a secretion by murine B cells stimulated with bacterial lipopolysaccharide. J Immunol 1988 2.24
74 Effect of thymus-derived lymphocytes on amount and affinity of anti-hapten antibody. J Immunol 1971 2.19
75 Cross-linking Fc receptors stimulate splenic non-B, non-T cells to secrete interleukin 4 and other lymphokines. Proc Natl Acad Sci U S A 1990 2.18
76 Inability of mice with a defect in B-lymphocyte maturation to respond to phosphorycholine on immunogenic carriers. J Exp Med 1977 2.18
77 Communications. IgD-bearing human lymphocytes. J Immunol 1972 2.17
78 Studies on the effect of the carrier molecule on antihapten antibody synthesis. I. Effect of carrier on the nature of the antibody synthesized. J Exp Med 1966 2.16
79 T-independent responses in B cell-defective CBA/N mice to Brucella abortus and to trinitrophenyl (TNP) conjugates of Brucella abortus. Eur J Immunol 1978 2.13
80 T lymphocyte-enriched murine peritoneal exudate cells. I. A reliable assay for antigen-induced T lymphocyte proliferation. J Immunol 1975 2.11
81 Receptors on immunocompetent cells. 3. Specificity and nature of receptors on dinitrophenylated guinea pig albumin- 125 I-binding cells of immunized guinea pigs. J Exp Med 1971 2.11
82 Cellular requirements for the primary in vitro antibody response to DNP-ficoll. J Exp Med 1974 2.10
83 B cell stimulatory factor 1 (interleukin 4) is a potent costimulant for normal resting T lymphocytes. J Exp Med 1987 2.09
84 Ontogeny of B lymphocytes. II. Relative rates of appearance of lymphocytes bearing surface immunoglobulin and complement receptors. J Exp Med 1974 2.03
85 Receptors on immunocompetent cells. V. Cellular correlates of the "maturation" of the immune response. J Exp Med 1972 2.03
86 IL-4 production by T cells from naive donors. IL-2 is required for IL-4 production. J Immunol 1990 2.03
87 Radioresistance of cooperative function of carrier-specific lymphocytes in antihapten antibody responses. Science 1970 2.03
88 Radioimmunoassay of thyrotropin in human serum. J Clin Endocrinol Metab 1965 2.01
89 Regulation of expression of IL-4 alleles: analysis using a chimeric GFP/IL-4 gene. Immunity 2001 1.97
90 A study of the passive transfer of delayed hypersensitivity to DNP-poly-L-lysine and DNP-GL in responder and nonresponder guinea pigs. J Exp Med 1967 1.94
91 Studies on the effect of the carrier molecule on antihapten antibody synthesis. II. Carrier specificity of anti-2,4-dinitrophenyl-poly-l-lysine antibodies. J Exp Med 1966 1.94
92 Defective IgE production by SJL mice is linked to the absence of CD4+, NK1.1+ T cells that promptly produce interleukin 4. Proc Natl Acad Sci U S A 1995 1.94
93 Long-term culture of normal mouse B lymphocytes. Proc Natl Acad Sci U S A 1981 1.94
94 Stat6 is necessary and sufficient for IL-4's role in Th2 differentiation and cell expansion. J Immunol 2001 1.93
95 Functional specificity of antigen-binding receptors of lymphocytes. Transplant Rev 1970 1.92
96 CD8+ T cells can be primed in vitro to produce IL-4. J Immunol 1992 1.91
97 Multichain immune recognition receptors: similarities in structure and signaling pathways. Immunol Today 1992 1.90
98 An IL-4 receptor region containing an insulin receptor motif is important for IL-4-mediated IRS-1 phosphorylation and cell growth. Cell 1994 1.89
99 T cell regulation of immunoglobulin class expression in the antibody response to trinitrophenyl-ficoll. Evidence for T cell enhancement of the immunoglobulin class switch. J Exp Med 1982 1.88
100 Quantitation of immunoglobulin mu-gamma 1 heavy chain switch region recombination by a digestion-circularization polymerase chain reaction method. Proc Natl Acad Sci U S A 1992 1.86
101 IL-18 induction of IgE: dependence on CD4+ T cells, IL-4 and STAT6. Nat Immunol 2000 1.86
102 In vitro responses of CBA/N mice: spleen cells of mice with an X-linked defect that precludes immune responses to several thymus-independent antigens can respond to TNP-lipopolysaccharide. J Immunol 1976 1.86
103 Ongoing HIV dissemination during HAART. Nat Med 1999 1.85
104 X-linked B-lymphocyte defect in CBA/N mice. III. Abnormal development of B-lymphocyte populations defined by their density of surface immunoglobulin. J Exp Med 1976 1.84
105 Adaptive cellular interactions in the immune system: the tunable activation threshold and the significance of subthreshold responses. Proc Natl Acad Sci U S A 1992 1.83
106 A study of the 'termination' of tolerance to BSA with DNP-BSA in rabbits: relative affinities of the antibodies for the immunizing and the paralysing antigens. Immunology 1967 1.82
107 Abnormal ratio of membrane immunoglobulin classes in mice with an X-linked B-lymphocyte defect. J Exp Med 1975 1.82
108 Partial purification of murine B cell stimulatory factor (BSF)-1. J Immunol 1985 1.81
109 The requirement for two complementing Ir-GLphi immune response genes in the T-lymphocyte proliferative response to poly-(Glu53Lys36Phe11). J Exp Med 1976 1.81
110 Regulation of IgG1 and IgE production by interleukin 4. Immunol Rev 1988 1.80
111 Multiple modes of cellular activation and virus transmission in HIV infection: a role for chronically and latently infected cells in sustaining viral replication. Proc Natl Acad Sci U S A 1998 1.80
112 Schistosome-infected IL-4 receptor knockout (KO) mice, in contrast to IL-4 KO mice, fail to develop granulomatous pathology while maintaining the same lymphokine expression profile. J Immunol 1999 1.78
113 Polyclonal stimulation of resting B lymphocytes by antigen-specific T lymphocytes. J Exp Med 1984 1.76
114 Cellular basis of regulation of expression of idiotype. II. Immunity to anti-MOPC-460 idiotype antibodies increases the level of anti-trinitrophenyl antibodies bearing 460 idiotypes. J Exp Med 1979 1.76
115 IA mutant functional antigen-presenting cell lines. J Immunol 1983 1.76
116 CD28-mediated costimulation of interleukin 2 (IL-2) production plays a critical role in T cell priming for IL-4 and interferon gamma production. J Exp Med 1994 1.76
117 Biochemical and physicochemical characterization of mouse B cell growth factor: a lymphokine distinct from interleukin 2. J Immunol 1983 1.73
118 B-lymphocyte heterogeneity: ontogenetic development and organ distribution of B-lymphocyte populations defined by their density of surface immunoglobulin. J Exp Med 1976 1.72
119 Interleukin 4 suppresses interleukin 2 and interferon gamma production by naive T cells stimulated by accessory cell-dependent receptor engagement. Proc Natl Acad Sci U S A 1993 1.71
120 Interleukin 2 induces antigen-reactive T cell lines to secrete BCGF-I. J Exp Med 1983 1.71
121 Receptors on immunocompetent cells. I. Receptor specificity of cells participating in a cellular immune response. Cell Immunol 1970 1.70
122 Genetic restriction in T-lymphocyte activation by antigen-pulse peritoneal exudate cells. Cold Spring Harb Symp Quant Biol 1977 1.70
123 Role of interleukin 1 in anti-immunoglobulin-induced B cell proliferation. J Exp Med 1983 1.69
124 Activity of migration inhibitory factor in the absence of antigen. J Immunol 1972 1.68
125 IL-4 induces co-expression of intrinsic membrane IgG1 and IgE by murine B cells stimulated with lipopolysaccharide. J Immunol 1988 1.66
126 Role of T lymphocytes in the response to TNP-AECM-Ficoll. J Immunol 1980 1.66
127 B cell stimulatory factor-1 (interleukin 4) prepares resting murine B cells to secrete IgG1 upon subsequent stimulation with bacterial lipopolysaccharide. J Immunol 1987 1.66
128 Hapten carrier relationships in the DNP-PLL foreign albumin complex system: induction of tolerance and stimulation of cells in vitro. J Exp Med 1968 1.63
129 Carrier function in anti-hapten antibody responses. V. Analysis of cellular events in the enhancement of antibody responses by the "allogeneic effect" in DNP-OVA-primed guinea pigs challenged with a heterologous DNP-conjugate. J Immunol 1971 1.63
130 The effect of antigen dose and time after immunization on the amount and affinity of anti-hapten antibody. J Immunol 1968 1.61
131 B cell growth and differentiation factors. Immunol Rev 1984 1.61
132 Functional heterogeneity of murine lymphoid cells. II. Acquisition of mitogen responsiveness and of theta antigen during the ontogeny of thymocytes and "T" lymphocytes. Cell Immunol 1972 1.61
133 Regulation of growth and proliferation in B cell subpopulations. Immunol Rev 1982 1.59
134 T helper type 2 inflammatory disease in the absence of interleukin 4 and transcription factor STAT6. Proc Natl Acad Sci U S A 1998 1.58
135 Immune response to levan. I. Kinetics and ontogeny of anti-levan and anti-inulin antibody response and of expression of cross-reactive idiotype. J Immunol 1978 1.57
136 Effects of B cell stimulatory factor-1/interleukin 4 on hematopoietic progenitor cells. Blood 1987 1.56
137 Inhibition of dual Ir gene-controlled T-lymphocyte proliferative response to poly (Glu56Lys35Phe9)n with anti-Ia antisera directed against products of either I-A or I-C subregion. Proc Natl Acad Sci U S A 1978 1.55
138 Immunoglobulin subclass-specific immunodeficiency in mice with an X-linked B-lymphocyte defect. J Exp Med 1979 1.54
139 Both interleukin 2 and a second T cell-derived factor in EL-4 supernatant have activity as differentiation factors in IgM synthesis. J Exp Med 1984 1.51
140 I region-restricted antigen presentation by B cell-B lymphoma hybridomas. Nature 1982 1.48
141 Functional heterogeneity of murine lymphoid cells. IV. Allogeneic mixed lymphocyte reactivity and cytolytic activity as functions of distinct T cell subsets. J Immunol 1973 1.47
142 Production of BSF-1 during an in vivo, T-dependent immune response. J Immunol 1986 1.47
143 Anti-IL-4 diminishes in vivo priming for antigen-specific IL-4 production by T cells. J Immunol 1993 1.46
144 The role of surface IgD in the response to thymic-independent antigens. J Exp Med 1977 1.46
145 Soluble factors involved in B cell differentiation: identification of two distinct T cell-replacing factors (TRF). J Immunol 1983 1.46
146 Role of T lymphocytes in the humoral immune response. I. Proliferation of B lymphocytes in thymus-deprived mice. J Immunol 1974 1.46
147 Gene complementation in the T-lymphocyte proliferative response to poly (Glu55Lys36Phe9)n. A demonstration that both immune response gene products must be expressed in the same antigen-presenting cell. J Exp Med 1979 1.45
148 Membrane-associated immunoglobulin of rabbit peripheral blood lymphocytes: allelic exclusion at the b locus. Proc Natl Acad Sci U S A 1971 1.45
149 Alloantiserum-induced inhibition of immune response gene product function. II. Genetic analysis of target antigens. J Exp Med 1974 1.45
150 IL-4- and IL-4 receptor-deficient BALB/c mice reveal differences in susceptibility to Leishmania major parasite substrains. J Immunol 1999 1.45
151 Guinea-pig Ia antigens: functional significance and chemical characterization. Transplant Rev 1976 1.44
152 Lyb-7, a new B cell alloantigen controlled by genes linked to the IgCH locus. J Immunol 1979 1.43
153 Infection with Nippostrongylus brasiliensis or injection of anti-IgD antibodies markedly enhances Fc-receptor-mediated interleukin 4 production by non-B, non-T cells. J Exp Med 1990 1.43
154 Resistance of guinea pigs to leukemia following transfer of immunocompetent allogeneic lymphoid cells. Cancer Res 1972 1.42
155 Impaired interleukin 4 signaling in T helper type 1 cells. J Exp Med 1998 1.41
156 T-lymphocyte-enriched murine peritoneal exudate cells. IV. Genetic control of cross-stimulation at the T-cell level. J Exp Med 1977 1.40
157 Genetic control of the specificity of anti-DNP antibodies. II. Differences in the specificity of anti-DNP antibody produced by several inbred strains of mice. J Immunol 1970 1.40
158 Long-term culture and cloning of nontransformed human B lymphocytes. J Exp Med 1981 1.39
159 Lymphocyte classes in New Zealand mice. II. Decreased frequency of immunoglobulin-bearing lymphocytes and increased frequency of lymphocytes lacking detectable theta or immunoglobulin determinants. J Immunol 1972 1.39
160 Receptors on immunocompetent cells. IV. Direct measurement of avidity of cell receptors and cooperative binding of multivalent ligands. J Exp Med 1972 1.38
161 Hapten-specific augmentation of the anti-idiotype antibody response to hapten-myeloma protein conjugates in mice. Eur J Immunol 1973 1.37
162 Activation of mouse lymphocytes by anti-immunoglobulin. II. A thymus-independent response by a mature subset of B lymphocytes. J Exp Med 1978 1.37
163 Genetic control of the immune response of inbred guinea pigs to 2,4-dinitrophenyl guinea pig albumin. Frequency of antigen-binding lymphocytes and avidity of antibodies secreted by plaque-forming cells. J Immunol 1972 1.36
164 Serologic and functional characterization of a panel of antigen-presenting cell lines expressing mutant I-A class II molecules. J Exp Med 1983 1.35
165 Stimulus-response in the mixed lymphocyte reaction. J Exp Med 1973 1.35
166 Membrane IgM, IgD, and IgG act as signal transmission molecules in a series of B lymphomas. J Immunol 1986 1.34
167 Immune response to levan. III. The capacity to produce anti-inulin antibodies and cross-reactive idiotypes appears late in ontogeny. J Immunol 1979 1.34
168 Genetic control of immunological responsiveness in guinea pigs to 2,4-dinitrophenyl conjugates of poly-L-arginine, protamine, and poly-L-ornithine. Proc Natl Acad Sci U S A 1969 1.34
169 Long-term growth and cloning of non-transformed lymphocytes. Nature 1981 1.33
170 Antigen-macrophage interaction. II. Relative roles of cytophilic antibody and other membrane sites. J Immunol 1973 1.32
171 Interferon-gamma inhibits the action of B cell stimulatory factor (BSF)-1 on resting B cells. J Immunol 1986 1.32
172 Role of the thymus in directing the development of a subset of B lymphocytes. J Exp Med 1982 1.32
173 Autoreactivity, dynamic tuning and selectivity. Curr Opin Immunol 2001 1.32
174 FRIP, a hematopoietic cell-specific rasGAP-interacting protein phosphorylated in response to cytokine stimulation. Immunity 1998 1.31
175 Up-regulation of interleukin 4/B-cell stimulatory factor 1 receptor expression. Proc Natl Acad Sci U S A 1988 1.31
176 Hapten-specific tolerance. Preferential depression of the high affinity antibody response. J Exp Med 1972 1.31
177 Increased frequency of interleukin 4-producing T cells as a result of polyclonal priming. Use of a single-cell assay to detect interleukin 4-producing cells. Eur J Immunol 1991 1.31
178 IL-4 activates a distinct signal transduction cascade from IL-3 in factor-dependent myeloid cells. EMBO J 1992 1.31
179 In differentiated CD4+ T cells, interleukin 4 production is cytokine-autonomous, whereas interferon gamma production is cytokine-dependent. Proc Natl Acad Sci U S A 1997 1.31
180 Conventional, naive CD4+ T cells provide an initial source of IL-4 during Th2 differentiation. J Immunol 2000 1.31
181 Separate control of B lymphocyte early activation and proliferation in response to anti-IgM antibodies. J Immunol 1985 1.30
182 Mechanisms involved in the antileukemic effect of immunocompetent allogeneic lymphoid cell transfer. Cancer Res 1972 1.30
183 NK1.1+ CD4+ T cells lose NK1.1 expression upon in vitro activation. J Immunol 1997 1.28
184 B cell stimulatory factor 1 (BSF-1) prepares resting B cells to enter S phase in response to anti-IgM and lipopolysaccharide. J Exp Med 1986 1.27
185 Augmented anti-S 3 antibody responses to an S 3 -protein conjugate. J Immunol 1971 1.27
186 The specificity of cellular immune responses in guinea pigs. I. T cells specific for 2,4-dinitrophenyl-o-tyrosyl residues. J Exp Med 1975 1.26
187 Interleukin 4 receptor: signaling mechanisms. Immunol Today 1994 1.25
188 Purified Fc epsilon R+ bone marrow and splenic non-B, non-T cells are highly enriched in the capacity to produce IL-4 in response to immobilized IgE, IgG2a, or ionomycin. J Immunol 1991 1.24
189 Production of interleukin-4 and other cytokines following stimulation of mast cell lines and in vivo mast cells/basophils. Int Arch Allergy Appl Immunol 1991 1.23
190 Cell-cell interactions in the T cell proliferative response. I. Analysis of the cell types involved and evidence for nonspecific T cell recruitment. J Immunol 1980 1.23
191 IL-3 promotes production of IL-4 by splenic non-B, non-T cells in response to Fc receptor cross-linkage. J Immunol 1990 1.23
192 The effect of dose in tolerance induction on the subsequent response to a cross-reactive antigen. Immunology 1969 1.23
193 Expression of IFN regulatory factor family proteins in lymphocytes. Induction of Stat-1 and IFN consensus sequence binding protein expression by T cell activation. J Immunol 1996 1.22
194 Three distinct signals can induce class II gene expression in a murine pre-B-cell line. Proc Natl Acad Sci U S A 1986 1.22
195 Cell division is not a "clock" measuring acquisition of competence to produce IFN-gamma or IL-4. J Immunol 2001 1.22
196 NIH conference. Asthma. Ann Intern Med 1994 1.22
197 Functional heterogeneity of murine lymphoid cells. V. Lymphocytes lacking detectable surface theta or immunoglobulin determinants. J Exp Med 1973 1.22
198 The specificity of cellular immune responses in guinea pigs. III. The precision of antigen recognition by T lymphocytes. J Exp Med 1976 1.22
199 T help requirements for the generation of an in vivo IgE response: a late acting form of T cell help other than IL-4 is required for IgE but not for IgG1 production. J Immunol 1989 1.21
200 Carrier function in anti-hapten antibody responses. VI. Establishment of experimental conditions for either inhibitory or enhancing influences of carrier-specific cells on antibody production. J Immunol 1973 1.21
201 Role of a nonimmunoglobulin cell surface determinant in the activation of B lymphocytes by thymus-independent antigens. J Exp Med 1979 1.19
202 BSF-1 action on resting B cells does not require elevation of inositol phospholipid metabolism or increased [Ca2+]i. J Immunol 1986 1.19
203 Structural control of immunogenicity. II. Antibody synthesis and cellular immunity in response to immunization with mono-epsilon-oligo-L-lysines. Immunology 1971 1.19
204 Isolation of a cDNA clone corresponding to an X-linked gene family (XLR) closely linked to the murine immunodeficiency disorder xid. Nature 1985 1.18
205 Cell membrane IgD: demonstration of IgD on human lymphocytes by enzyme-catalyzed iodination and comparison with cell surface Ig of mouse, guinea pig, and rabbit. J Immunol 1976 1.18
206 Fig1, an interleukin 4-induced mouse B cell gene isolated by cDNA representational difference analysis. Proc Natl Acad Sci U S A 1997 1.18
207 The immune response to an isomaltohexosyl-protein conjugate, a thymus-dependent analogue of alpha(1 replaced by 6) dextran. J Immunol 1982 1.18
208 IL-4 requirements for the generation of secondary in vivo IgE responses. J Immunol 1991 1.18
209 Antigen-specific T cell clones restricted to unique F1 major histocompatibility complex determinants. Inhibition of proliferation with monoclonal anti-Ia antibody. J Exp Med 1981 1.16
210 Guinea pig immune response-related histocompatibility antigens. Partial characterization and distribution. J Exp Med 1975 1.16
211 Transient inhibition of interleukin 4 signaling by T cell receptor ligation. J Exp Med 2000 1.16
212 In vitro selection and extended culture of antigen-specific T lymphocytes. II. Mechanisms of selection. J Immunol 1975 1.16
213 Self-tolerance: context dependent tuning of T cell antigen recognition. Semin Immunol 2000 1.15
214 Growth and gene expression are predominantly controlled by distinct regions of the human IL-4 receptor. Immunity 1996 1.15
215 T lymphocyte-dependent B lymphocyte proliferative response to antigen. I Genetic restriction of the stimulation of B lymphocyte proliferation. J Exp Med 1981 1.15
216 Mapping of the X-linked immune deficiency mutation (xid) of CBA/N mice. J Immunol 1980 1.14
217 High-efficiency purification and chemical characterization of B cell stimulatory factor-1/interleukin 4. J Immunol 1987 1.14
218 Regulation of the anti-inulin antibody response by a nonallotype-linked gene. J Exp Med 1980 1.14
219 Alternative splicing, gene localization, and binding of SH2-B to the insulin receptor kinase domain. Mamm Genome 1999 1.14
220 Lamin B is rapidly phosphorylated in lymphocytes after activation of protein kinase C. Proc Natl Acad Sci U S A 1988 1.13
221 Signaling via IL-2 and IL-4 in JAK3-deficient severe combined immunodeficiency lymphocytes: JAK3-dependent and independent pathways. Immunity 1996 1.13
222 Lack of skin fibrosis in tight skin (TSK) mice with targeted mutation in the interleukin-4R alpha and transforming growth factor-beta genes. J Invest Dermatol 2001 1.13
223 Effects of interleukin-3 with or without the c-kit ligand, stem cell factor, on the survival and cytoplasmic granule formation of mouse basophils and mast cells in vitro. Am J Pathol 1994 1.13
224 Interferon gamma stabilizes the T helper cell type 1 phenotype. J Exp Med 2001 1.12
225 Antigen-binding receptors on lymphocytes. Contemp Top Immunobiol 1974 1.10
226 Genetic and cellular regulation of the expression of specific antibody idiotypes in the anti-polyfructosan immune response. Ann Immunol (Paris) 1979 1.10
227 Antigen presentation in the murine T lymphocyte proliferative response. II. Ir-GAT-controlled T lymphocyte responses require antigen-presenting cells from a high responder donor. Eur J Immunol 1978 1.10
228 Analysis of B cell activation requirements with TNP-conjugated polyacrylamide beads. J Immunol 1979 1.10
229 Phorbol myristate acetate inhibits anti-IgM-mediated signaling in resting B cells. Proc Natl Acad Sci U S A 1986 1.09
230 The impact of HIV on naïve T-cell homeostasis. Nat Med 2000 1.08
231 Anti-immunoglobulin antibodies. I. Expression of cross-reactive idiotypes and Ir gene control of the response to IgG2a of the b allotype. J Exp Med 1980 1.08
232 Sequence analysis and expression of an X-linked, lymphocyte-regulated gene family (XLR). J Exp Med 1987 1.07
233 T cell dependence and factor reconstitution of in vitro antibody responses to TNP-B. Abortus and TNP-Ficoll: restoration of depleted responses with chromatographed fractions of a T cell-derived factor. J Immunol 1983 1.07
234 Heterogeneity of Ia expression on normal B cells, neonatal B cells, and on cells from B cell-defective CBA/N mice. J Immunol 1980 1.06
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