Published in J Exp Med on January 01, 1980
Bruton's tyrosine kinase links the B cell receptor to nuclear factor kappaB activation. J Exp Med (2000) 1.60
Lack of mature B cells in nude mice with X-linked immune deficiency. J Exp Med (1982) 1.52
Btk dosage determines sensitivity to B cell antigen receptor cross-linking. Proc Natl Acad Sci U S A (1997) 1.42
Phosphoinositide 3-kinase and Bruton's tyrosine kinase regulate overlapping sets of genes in B lymphocytes. Proc Natl Acad Sci U S A (2001) 1.06
Independent and opposing roles for Btk and lyn in B and myeloid signaling pathways. J Exp Med (1998) 1.02
Isotype profiles of anti-influenza antibodies in mice bearing the xid defect. J Virol (1985) 0.95
A sensitized genetic system for the analysis of murine B lymphocyte signal transduction pathways dependent on Bruton's tyrosine kinase. Proc Natl Acad Sci U S A (2000) 0.87
X-linked B-lymphocyte immune defect in CBA/HN mice. I. Studies of the function and composition of spleen cells. J Exp Med (1975) 3.70
Thymus-independent antigens: the preparation of covalent, hapten-ficoll conjugates. J Immunol (1975) 3.62
Surface immunoglobulin D as a functional receptor for a subclass of B lymphocytes. Immunol Rev (1977) 2.50
B-lymphocyte heterogeneity: development and characterization of an alloantiserum which distinguishes B-lymphocyte differentiation alloantigens. J Exp Med (1977) 2.44
The genetic mapping of a defective LPS response gene in C3H/HeJ mice. J Immunol (1978) 2.43
T-independent responses in B cell-defective CBA/N mice to Brucella abortus and to trinitrophenyl (TNP) conjugates of Brucella abortus. Eur J Immunol (1978) 2.13
Identification of a B-cell surface structure involved in antigen-dependent triggering: absence of this structure on B cells from CBA/N mutant mice. J Exp Med (1977) 1.95
Abnormal ratio of membrane immunoglobulin classes in mice with an X-linked B-lymphocyte defect. J Exp Med (1975) 1.82
Cellular requirements for lipopolysaccharide adjuvanticity. A role for both T lymphocytes and macrophages for in vitro responses to particulate antigens. J Exp Med (1979) 1.73
Isolation of mitogenic and adjuvant active fractions from various species of Nocardiae. Infect Immun (1975) 1.54
Lyb-7, a new B cell alloantigen controlled by genes linked to the IgCH locus. J Immunol (1979) 1.43
Defective colony formation by B lymphocytes from CBA/N and C3H/HeJ mice. J Exp Med (1977) 1.39
Development of B-lymphocyte colony-forming cells in foetal mouse tissues. Immunology (1976) 1.22
Preparation of functionalized derivatives of inulin: conjugation of erythrocytes for hemagglutination and plaque-forming cell assays. J Immunol Methods (1979) 0.96
Interferon-gamma and B cell stimulatory factor-1 reciprocally regulate Ig isotype production. Science (1987) 13.03
Production of a monoclonal antibody to and molecular characterization of B-cell stimulatory factor-1. Nature (1985) 11.55
Identification of a T cell-derived b cell growth factor distinct from interleukin 2. J Exp Med (1982) 9.49
Acquisition of lymphokine-producing phenotype by CD4+ T cells. Annu Rev Immunol (1994) 8.43
Lymphokine control of in vivo immunoglobulin isotype selection. Annu Rev Immunol (1990) 7.93
The presence of interleukin 4 during in vitro priming determines the lymphokine-producing potential of CD4+ T cells from T cell receptor transgenic mice. J Exp Med (1992) 7.80
Generation of interleukin 4 (IL-4)-producing cells in vivo and in vitro: IL-2 and IL-4 are required for in vitro generation of IL-4-producing cells. J Exp Med (1990) 7.09
The IL-4 receptor: signaling mechanisms and biologic functions. Annu Rev Immunol (1999) 6.19
Lack of IL-4-induced Th2 response and IgE class switching in mice with disrupted Stat6 gene. Nature (1996) 6.17
B cell stimulatory factor-1 enhances the IgE response of lipopolysaccharide-activated B cells. J Immunol (1986) 6.16
Interleukin 12 acts directly on CD4+ T cells to enhance priming for interferon gamma production and diminishes interleukin 4 inhibition of such priming. Proc Natl Acad Sci U S A (1993) 6.12
CD4pos, NK1.1pos T cells promptly produce interleukin 4 in response to in vivo challenge with anti-CD3. J Exp Med (1994) 5.90
Carrier function in anti-hapten immune responses. I. Enhancement of primary and secondary anti-hapten antibody responses by carrier preimmunization. J Exp Med (1970) 5.71
Mast cell lines produce lymphokines in response to cross-linkage of Fc epsilon RI or to calcium ionophores. Nature (1989) 5.10
Regulation of B-cell growth and differentiation by soluble factors. Annu Rev Immunol (1983) 5.09
T-bet is rapidly induced by interferon-gamma in lymphoid and myeloid cells. Proc Natl Acad Sci U S A (2001) 4.76
NKT cell-mediated repression of tumor immunosurveillance by IL-13 and the IL-4R-STAT6 pathway. Nat Immunol (2000) 4.75
Suppression of in vivo polyclonal IgE responses by monoclonal antibody to the lymphokine B-cell stimulatory factor 1. Proc Natl Acad Sci U S A (1986) 4.69
Interleukin-2 receptor gamma chain: a functional component of the interleukin-4 receptor. Science (1993) 4.63
The behavior of hapten-poly-L-lysine conjugates as complete antigens in genetic responder and as haptens in nonresponder guinea pigs. J Exp Med (1966) 4.58
Serological, biochemical, and functional identity of B cell-stimulatory factor 1 and B cell differentiation factor for IgG1. J Exp Med (1985) 4.47
Functional specificity of thymus- dependent lymphocytes. Science (1977) 4.31
Carrier function in anti-hapten antibody responses. 3. Stimulation of antibody synthesis and facilitation of hapten-specific secondary antibody responses by graft-versus-host reactions. J Exp Med (1971) 4.29
Derivation of a T cell line that is highly responsive to IL-4 and IL-2 (CT.4R) and of an IL-2 hyporesponsive mutant of that line (CT.4S). J Immunol (1989) 4.20
Colocalization of X-linked agammaglobulinemia and X-linked immunodeficiency genes. Science (1993) 4.08
Oligomeric structure of gp41, the transmembrane protein of human immunodeficiency virus type 1. J Virol (1989) 4.07
B-cell stimulatory factor-1/interleukin 4. Annu Rev Immunol (1987) 4.04
IL-4 is required to generate and sustain in vivo IgE responses. J Immunol (1988) 4.04
Functional heterogeneity of murine lymphoid cells. I. Responsiveness to and surface binding of concanavalin A and phytohemagglutinin. J Immunol (1972) 3.96
Defining criteria for autoimmune diseases (Witebsky's postulates revisited) Immunol Today (1993) 3.81
Histocompatibility-linked immune response gene function in guinea pigs. Specific inhibition of antigen-induced lymphocyte proliferation by alloantisera. J Exp Med (1972) 3.81
X-linked B-lymphocyte immune defect in CBA/HN mice. I. Studies of the function and composition of spleen cells. J Exp Med (1975) 3.70
Interaction between antigen-presenting cells and primed T lymphocytes: an assessment of Ir gene expression in the antigen-presenting cell. Immunol Rev (1978) 3.67
Anti-immunoglobulin stimulation of B lymphocytes activates src-related protein-tyrosine kinases. Proc Natl Acad Sci U S A (1991) 3.57
T-cell and mast cell lines respond to B-cell stimulatory factor 1. Proc Natl Acad Sci U S A (1986) 3.56
Cell-type-specific cDNA probes and the murine I region: the localization and orientation of Ad alpha. Proc Natl Acad Sci U S A (1984) 3.43
Activation events during thymic selection. J Exp Med (1992) 3.43
Role of NK1.1+ T cells in a TH2 response and in immunoglobulin E production. Science (1995) 3.37
Frequency of B lymphocytes responsive to anti-immunoglobulin. J Exp Med (1982) 3.30
B cell stimulatory factor-1 (interleukin 4) activates macrophages for increased tumoricidal activity and expression of Ia antigens. J Immunol (1987) 3.18
B-cell stimulatory factor 1 activates resting B cells. Proc Natl Acad Sci U S A (1985) 3.16
Heterogeneity of helper/inducer T lymphocytes. I. Lymphokine production and lymphokine responsiveness. J Exp Med (1987) 3.12
Functional heterogeneity of murine lymphoid cells. 3. Differential responsiveness of T cells to phytohemagglutinin and concanavalin A as a probe for T cell subsets. J Immunol (1973) 3.04
X-linked B-lymphocyte immune defect in CBA/N mice. II. Studies of the mechanisms underlying the immune defect. J Exp Med (1975) 3.03
Ia antigen-bearing B cell tumor lines can present protein antigen and alloantigen in a major histocompatibility complex-restricted fashion to antigen-reactive T cells. J Exp Med (1982) 3.01
Interleukin 4 is important in protective immunity to a gastrointestinal nematode infection in mice. Proc Natl Acad Sci U S A (1991) 3.01
Secondary antibody responses in haptenic systems: cell population selection by antigen. J Immunol (1967) 3.01
Antibody-dependent lymphoid cell-mediated cytotoxicity: no requirement for thymus-derived lymphocytes. Science (1972) 2.98
Receptors for B-cell stimulatory factor-1 expressed on cells of haematopoietic lineage. Nature (1987) 2.94
Receptors on immunocompetent cells. II. Specificity and nature of receptors on dinitrophenylated guinea pig albumin- 125 I-binding lymphocytes of normal guinea pigs. J Exp Med (1971) 2.92
Persistent calcium elevation correlates with the induction of surface immunoglobulin-mediated B cell DNA synthesis. J Exp Med (1993) 2.88
Activation of mouse lymphocytes by anti-immunoglobulin. I. Parameters of the proliferative response. J Exp Med (1978) 2.86
Differential regulation of IgG1 and IgE synthesis by interleukin 4. J Exp Med (1988) 2.84
Antigen presentation by resting B cells. Radiosensitivity of the antigen-presentation function and two distinct pathways of T cell activation. J Exp Med (1984) 2.71
An interleukin 4 (IL-4)-independent pathway for CD4+ T cell IL-4 production is revealed in IL-4 receptor-deficient mice. Proc Natl Acad Sci U S A (1997) 2.67
T lymphocyte-enriched murine peritoneal exudate cells. III. Inhibition of antigen-induced T lymphocyte Proliferation with anti-Ia antisera. J Immunol (1976) 2.64
Magnitude of response of histocompatibility-restricted T-cell clones is a function of the product of the concentrations of antigen and Ia molecules. Proc Natl Acad Sci U S A (1983) 2.57
Carrier function in anti-hapten immune responses. II. Specific properties of carrier cells capable of enhancing anti-hapten antibody responses. J Exp Med (1970) 2.54
Cellular basis of regulation of expression of idiotype. I. T-suppressor cells specific for MOPC 460 idiotype regulate the expression of cells secreting anti-TNP antibodies bearing 460 idiotype. J Exp Med (1979) 2.53
Single cell analysis reveals that IL-4 receptor/Stat6 signaling is not required for the in vivo or in vitro development of CD4+ lymphocytes with a Th2 cytokine profile. J Immunol (2000) 2.52
T cell regulation of IgG subclass antibody production in response to T-independent antigens. J Exp Med (1981) 2.50
Surface immunoglobulin D as a functional receptor for a subclass of B lymphocytes. Immunol Rev (1977) 2.50
H-2-linked immune response (Ir) genes. Independent loci for Ir-IgG and Ir-IgA genes. J Exp Med (1972) 2.50
Determination of antibody-hapten equilibrium constants by an ammonium sulfate precipitation technique. J Immunol (1969) 2.49
Induction of IgG3 secretion by interferon gamma: a model for T cell-independent class switching in response to T cell-independent type 2 antigens. J Exp Med (1992) 2.47
B-lymphocyte heterogeneity: development and characterization of an alloantiserum which distinguishes B-lymphocyte differentiation alloantigens. J Exp Med (1977) 2.44
Towards a comprehensive view of immunoglobulin class switching. Immunol Today (1993) 2.44
B cell stimulatory factor-1/interleukin-4 mRNA is expressed by normal and transformed mast cells. Cell (1987) 2.44
Mouse splenic and bone marrow cell populations that express high-affinity Fc epsilon receptors and produce interleukin 4 are highly enriched in basophils. Proc Natl Acad Sci U S A (1991) 2.41
DNP-Lys-ficoll: a T-independent antigen which elicits both IgM and IgG anti-DNP antibody-secreting cells. J Immunol (1975) 2.40
IL-18, although antiallergic when administered with IL-12, stimulates IL-4 and histamine release by basophils. Proc Natl Acad Sci U S A (1999) 2.35
Antigen presentation in the murine T-lymphocyte proliferative response. I. Requirement for genetic identity at the major histocompatibility complex. J Exp Med (1977) 2.30
Idiotype-anti-idiotype regulation. I. Immunization with a levan-binding myeloma protein leads to the appearance of auto-anti-(anti-idiotype) antibodies and to the activation of silent clones. J Exp Med (1981) 2.28
Cultured NK1.1+ CD4+ T cells produce large amounts of IL-4 and IFN-gamma upon activation by anti-CD3 or CD1. J Immunol (1997) 2.28
Absence of the Lyt-2-,L3T4+ lineage of T cells in mice treated neonatally with anti-I-A correlates with absence of intrathymic I-A-bearing antigen-presenting cell function. J Exp Med (1985) 2.27
A mouse IgM allotypic determinant (Igh-6.5) recognized by a monoclonal rat antibody. J Immunol (1981) 2.27
T-lymphocyte-enriched murine peritoneal exudate cells. II. Genetic control of antigen-induced T-lymphocyte proliferation. J Exp Med (1976) 2.27
Increased expression of I-region-associated antigen (Ia) on B cells after cross-linking of surface immunoglobulin. J Immunol (1981) 2.26
IFN-gamma stimulates IgG2a secretion by murine B cells stimulated with bacterial lipopolysaccharide. J Immunol (1988) 2.24
Effect of thymus-derived lymphocytes on amount and affinity of anti-hapten antibody. J Immunol (1971) 2.19
Cross-linking Fc receptors stimulate splenic non-B, non-T cells to secrete interleukin 4 and other lymphokines. Proc Natl Acad Sci U S A (1990) 2.18
Inability of mice with a defect in B-lymphocyte maturation to respond to phosphorycholine on immunogenic carriers. J Exp Med (1977) 2.18
Communications. IgD-bearing human lymphocytes. J Immunol (1972) 2.17
B-cell activation by T-cell-independent type 2 antigens as an integral part of the humoral immune response to pathogenic microorganisms. Immunol Rev (2000) 2.17
Studies on the effect of the carrier molecule on antihapten antibody synthesis. I. Effect of carrier on the nature of the antibody synthesized. J Exp Med (1966) 2.16
Mitogenic effect of bacterial peptidoglycans possessing adjuvant activity. J Immunol (1975) 2.15
T-independent responses in B cell-defective CBA/N mice to Brucella abortus and to trinitrophenyl (TNP) conjugates of Brucella abortus. Eur J Immunol (1978) 2.13
T lymphocyte-enriched murine peritoneal exudate cells. I. A reliable assay for antigen-induced T lymphocyte proliferation. J Immunol (1975) 2.11
Receptors on immunocompetent cells. 3. Specificity and nature of receptors on dinitrophenylated guinea pig albumin- 125 I-binding cells of immunized guinea pigs. J Exp Med (1971) 2.11
Cellular requirements for the primary in vitro antibody response to DNP-ficoll. J Exp Med (1974) 2.10
B cell stimulatory factor 1 (interleukin 4) is a potent costimulant for normal resting T lymphocytes. J Exp Med (1987) 2.09
Ontogeny of B lymphocytes. II. Relative rates of appearance of lymphocytes bearing surface immunoglobulin and complement receptors. J Exp Med (1974) 2.03
Receptors on immunocompetent cells. V. Cellular correlates of the "maturation" of the immune response. J Exp Med (1972) 2.03
IL-4 production by T cells from naive donors. IL-2 is required for IL-4 production. J Immunol (1990) 2.03