Published in J Biol Chem on August 25, 1986
Microinjection of recombinant p21rho induces rapid changes in cell morphology. J Cell Biol (1990) 4.83
A role for Cdc42 in macrophage chemotaxis. J Cell Biol (1998) 3.88
Activation of both MAP kinase and phosphatidylinositide 3-kinase by Ras is required for hepatocyte growth factor/scatter factor-induced adherens junction disassembly. Mol Biol Cell (1998) 2.71
Rho- and rac-dependent assembly of focal adhesion complexes and actin filaments in permeabilized fibroblasts: an essential role for ezrin/radixin/moesin proteins. J Cell Biol (1997) 2.35
A GDP-bound of rab1 inhibits protein export from the endoplasmic reticulum and transport between Golgi compartments. J Cell Biol (1994) 2.21
Identification of a novel human Rho protein with unusual properties: GTPase deficiency and in vivo farnesylation. Mol Cell Biol (1996) 1.98
Translocation of Src kinase to the cell periphery is mediated by the actin cytoskeleton under the control of the Rho family of small G proteins. J Cell Biol (1996) 1.80
The Ras GTPase-activating-protein-related human protein IQGAP2 harbors a potential actin binding domain and interacts with calmodulin and Rho family GTPases. Mol Cell Biol (1996) 1.77
AtNOS/AtNOA1 is a functional Arabidopsis thaliana cGTPase and not a nitric-oxide synthase. J Biol Chem (2008) 1.71
Biochemical properties of the ras-related YPT protein in yeast: a mutational analysis. EMBO J (1987) 1.61
Identification of a nucleotide exchange-promoting activity for p21ras. Proc Natl Acad Sci U S A (1990) 1.60
ARF1 mediates paxillin recruitment to focal adhesions and potentiates Rho-stimulated stress fiber formation in intact and permeabilized Swiss 3T3 fibroblasts. J Cell Biol (1998) 1.55
Rem2, a new member of the Rem/Rad/Gem/Kir family of Ras-related GTPases. Biochem J (2000) 1.45
Signalling functions and biochemical properties of pertussis toxin-resistant G-proteins. Biochem J (1997) 1.42
Requirement of nucleotide exchange factor for Ypt1 GTPase mediated protein transport. J Cell Biol (1995) 1.39
Purification of a factor capable of stimulating the guanine nucleotide exchange reaction of ras proteins and its effect on ras-related small molecular mass G proteins. Proc Natl Acad Sci U S A (1990) 1.32
The oncogenic RAS2(val19) mutation locks respiration, independently of PKA, in a mode prone to generate ROS. EMBO J (2003) 1.28
The Caulobacter crescentus CgtA protein displays unusual guanine nucleotide binding and exchange properties. J Bacteriol (1999) 1.24
Hydrolysis of GTP by p21NRAS, the NRAS protooncogene product, is accompanied by a conformational change in the wild-type protein: use of a single fluorescent probe at the catalytic site. Proc Natl Acad Sci U S A (1990) 1.22
Ran's C-terminal, basic patch, and nucleotide exchange mechanisms in light of a canonical structure for Rab, Rho, Ras, and Ran GTPases. Genome Res (2003) 1.20
Characterization of a guanine nucleotide-releasing factor and a GTPase-activating protein that are specific for the ras-related protein p25rab3A. Proc Natl Acad Sci U S A (1992) 1.17
Neutralizing monoclonal antibody against ras oncogene product p21 which impairs guanine nucleotide exchange. Mol Cell Biol (1987) 1.16
Biochemical characterization of baculovirus-expressed rap1A/Krev-1 and its regulation by GTPase-activating proteins. Mol Cell Biol (1990) 1.13
The biochemistry of ras p21. Biochem J (1991) 1.08
RAC1P29S is a spontaneously activating cancer-associated GTPase. Proc Natl Acad Sci U S A (2013) 1.05
Analysis of guanine nucleotide binding and exchange kinetics of the Escherichia coli GTPase Era. J Bacteriol (2000) 1.05
Crystal structure of the YchF protein reveals binding sites for GTP and nucleic acid. J Bacteriol (2003) 1.01
Phosphorylation of the RAS2 gene product by protein kinase A inhibits the activation of yeast adenylyl cyclase. Proc Natl Acad Sci U S A (1988) 0.97
Farnesyl protein transferase inhibitors and other therapies targeting the Ras signal transduction pathway. Invest New Drugs (1999) 0.95
p190 RhoGAP, the major RasGAP-associated protein, binds GTP directly. Mol Cell Biol (1994) 0.93
Interactions of the ras-like protein p25rab3A with Mg2+ and guanine nucleotides. Biochem J (1992) 0.92
Evidence for distinct mechanisms of transition state stabilization of GTPases by fluoride. Proc Natl Acad Sci U S A (1998) 0.92
The SpoIIAA protein of Bacillus subtilis has GTP-binding properties. J Bacteriol (1996) 0.92
Spontaneous nucleotide exchange in low molecular weight GTPases by fluorescently labeled gamma-phosphate-linked GTP analogs. Proc Natl Acad Sci U S A (2004) 0.88
Interaction of GTPase-activating protein with p21ras, measured using a continuous assay for inorganic phosphate release. Biochem J (1992) 0.86
Guanine nucleotide binding properties of rap1 purified from human neutrophils. Biochem J (1990) 0.84
The Ras G Domain Lacks the Intrinsic Propensity to Form Dimers. Biophys J (2015) 0.82
Kinetic characterization of guanine-nucleotide-induced exocytosis from permeabilized rat mast cells. Biochem J (1993) 0.82
Fluoroaluminate treatment of rat liver microsomes inhibits GTP-dependent vesicle fusion. Biochem J (1991) 0.79
A Homogenous Bioluminescent System for Measuring GTPase, GTPase Activating Protein, and Guanine Nucleotide Exchange Factor Activities. Assay Drug Dev Technol (2015) 0.78
Kinetic mechanisms of mutation-dependent Harvey Ras activation and their relevance for the development of Costello syndrome. Biochemistry (2013) 0.76
Involvement of GTP in cell-free activation of neutrophil NADPH oxidase. Studies with GTP analogues. Biochem J (1992) 0.75
The small GTP-binding protein rho regulates the assembly of focal adhesions and actin stress fibers in response to growth factors. Cell (1992) 30.02
The small GTP-binding protein rac regulates growth factor-induced membrane ruffling. Cell (1992) 28.36
Rho, rac, and cdc42 GTPases regulate the assembly of multimolecular focal complexes associated with actin stress fibers, lamellipodia, and filopodia. Cell (1995) 24.99
Psychological outcomes of different treatment policies in women with early breast cancer outside a clinical trial. BMJ (1990) 10.93
Rho GTPases and their effector proteins. Biochem J (2000) 8.89
Rho GTPases control polarity, protrusion, and adhesion during cell movement. J Cell Biol (1999) 8.66
Integrin-mediated activation of Cdc42 controls cell polarity in migrating astrocytes through PKCzeta. Cell (2001) 7.07
An essential role for Rho, Rac, and Cdc42 GTPases in cell cycle progression through G1. Science (1995) 6.03
Rac and Cdc42 induce actin polymerization and G1 cell cycle progression independently of p65PAK and the JNK/SAPK MAP kinase cascade. Cell (1996) 5.34
Interplay between Rac and Rho in the control of substrate contact dynamics. Curr Biol (1999) 5.29
Activation of the NADPH oxidase involves the small GTP-binding protein p21rac1. Nature (1991) 5.16
The small GTPases Rho and Rac are required for the establishment of cadherin-dependent cell-cell contacts. J Cell Biol (1997) 5.15
Identification of two distinct mechanisms of phagocytosis controlled by different Rho GTPases. Science (1998) 4.92
Microinjection of recombinant p21rho induces rapid changes in cell morphology. J Cell Biol (1990) 4.83
Rho, Rac and Cdc42 GTPases regulate the organization of the actin cytoskeleton. Curr Opin Cell Biol (1997) 4.72
A conserved binding motif defines numerous candidate target proteins for both Cdc42 and Rac GTPases. J Biol Chem (1995) 4.62
Regulation of scatter factor/hepatocyte growth factor responses by Ras, Rac, and Rho in MDCK cells. Mol Cell Biol (1995) 4.60
The cytoplasmic protein GAP is implicated as the target for regulation by the ras gene product. Nature (1988) 4.33
Ras and Rho GTPases: a family reunion. Cell (2000) 4.21
Identification of transforming gene in two human sarcoma cell lines as a new member of the ras gene family located on chromosome 1. Nature (1983) 3.86
Synthesis in E. coli of a polypeptide with human leukocyte interferon activity. Nature (1980) 3.78
Phosphatidylinositol 4,5-bisphosphate induces actin-based movement of raft-enriched vesicles through WASP-Arp2/3. Curr Biol (2000) 3.75
Psychological effects of being offered choice of surgery for breast cancer. BMJ (1994) 3.48
Normal p21N-ras couples bombesin and other growth factor receptors to inositol phosphate production. Nature (1986) 3.41
Rho GTPases. J Biol Chem (1998) 3.35
The assembly of integrin adhesion complexes requires both extracellular matrix and intracellular rho/rac GTPases. J Cell Biol (1995) 3.33
Signal transduction pathways regulating Rho-mediated stress fibre formation: requirement for a tyrosine kinase. EMBO J (1994) 3.26
Intracellular localization of the P21rho proteins. J Cell Biol (1992) 3.21
The development of a multi-disciplinary approach to the assessment and management of child sexual abuse in an inner city Health District. Health Trends (1988) 3.21
Two GTPases, Cdc42 and Rac, bind directly to a protein implicated in the immunodeficiency disorder Wiskott-Aldrich syndrome. Curr Biol (1996) 3.13
Cdc42 controls secretory and endocytic transport to the basolateral plasma membrane of MDCK cells. Nat Cell Biol (1999) 3.12
Role of actin polymerization and adhesion to extracellular matrix in Rac- and Rho-induced cytoskeletal reorganization. J Cell Biol (1997) 3.12
Regulation of myc gene expression in HL-60 leukaemia cells by a vitamin D metabolite. Nature (1984) 3.06
The ELF3 zeitnehmer regulates light signalling to the circadian clock. Nature (2000) 3.05
Dynamic fatty acylation of p21N-ras. EMBO J (1987) 2.99
Directed selective pressure on a beta-lactamase to analyse molecular changes involved in development of enzyme function. Nature (1977) 2.93
Attendance of general practitioners at child protection case conferences. BMJ (1991) 2.90
Bcr encodes a GTPase-activating protein for p21rac. Nature (1991) 2.90
The TSC1 tumour suppressor hamartin regulates cell adhesion through ERM proteins and the GTPase Rho. Nat Cell Biol (2000) 2.89
Activation of the small GTP-binding proteins rho and rac by growth factor receptors. J Cell Sci (1995) 2.80
The oral examination: a study of academic and non-academic factors. Med Educ (1993) 2.65
Interaction of Rac with p67phox and regulation of phagocytic NADPH oxidase activity. Science (1994) 2.65
Cdc42 induces filopodia by promoting the formation of an IRSp53:Mena complex. Curr Biol (2001) 2.54
A requirement for Rho and Cdc42 during cytokinesis in Xenopus embryos. Curr Biol (1997) 2.53
Rho, rac and cdc42 GTPases: regulators of actin structures, cell adhesion and motility. Biochem Soc Trans (1995) 2.43
Human N-ras: cDNA cloning and gene structure. Nucleic Acids Res (1985) 2.41
Induction of monocytic differentiation and bone resorption by 1,25-dihydroxyvitamin D3. Proc Natl Acad Sci U S A (1983) 2.38
A new member of the Rho family, Rnd1, promotes disassembly of actin filament structures and loss of cell adhesion. J Cell Biol (1998) 2.36
Faciogenital dysplasia protein (FGD1) and Vav, two related proteins required for normal embryonic development, are upstream regulators of Rho GTPases. Curr Biol (1996) 2.36
Rho- and rac-dependent assembly of focal adhesion complexes and actin filaments in permeabilized fibroblasts: an essential role for ezrin/radixin/moesin proteins. J Cell Biol (1997) 2.35
Teaching senior oncologists communication skills: results from phase I of a comprehensive longitudinal program in the United Kingdom. J Clin Oncol (1998) 2.34
rho family GTPase activating proteins p190, bcr and rhoGAP show distinct specificities in vitro and in vivo. EMBO J (1993) 2.31
Involvement of the Arp2/3 complex in phagocytosis mediated by FcgammaR or CR3. Nat Cell Biol (2000) 2.29
Purification of recombinant Rho/Rac/G25K from Escherichia coli. Methods Enzymol (1995) 2.23
The rho gene product expressed in E. coli is a substrate of botulinum ADP-ribosyltransferase C3. Biochem Biophys Res Commun (1989) 2.23
Increasing cataract surgery to meet Vision 2020 targets; experience from two rural programmes in east Africa. Br J Ophthalmol (2005) 2.22
IpaC induces actin polymerization and filopodia formation during Shigella entry into epithelial cells. EMBO J (1999) 2.20
Signaling to Rho GTPases. Exp Cell Res (1999) 2.19
Post-translational modifications of p21rho proteins. J Biol Chem (1992) 2.17
Identification of distinct cytoplasmic targets for ras/R-ras and rho regulatory proteins. J Biol Chem (1989) 2.15
Rho: a connection between membrane receptor signalling and the cytoskeleton. Trends Cell Biol (1996) 2.13
Cardiopulmonary exercise testing as a screening test for perioperative management of major surgery in the elderly. Chest (1999) 2.11
The MAP kinase kinase kinase MLK2 co-localizes with activated JNK along microtubules and associates with kinesin superfamily motor KIF3. EMBO J (1998) 2.10
GAPs for rho-related GTPases. Trends Genet (1994) 2.09
Value of microscopy in the diagnosis of dysentery associated with invasive Entamoeba histolytica. J Clin Pathol (1994) 2.03
Circadian clock-regulated expression of phytochrome and cryptochrome genes in Arabidopsis. Plant Physiol (2001) 2.03
Activation of platelet phosphatidylinositide 3-kinase requires the small GTP-binding protein Rho. J Biol Chem (1993) 2.02
Heavy schistosomiasis associated with poor short-term memory and slower reaction times in Tanzanian schoolchildren. Trop Med Int Health (2002) 2.02
How many people with heart failure are appropriate for biventricular resynchronization? Eur Heart J (2000) 2.00
The C. elegans PH domain protein CED-12 regulates cytoskeletal reorganization via a Rho/Rac GTPase signaling pathway. Dev Cell (2001) 1.96
Long-term efficacy of continuing hepatitis B vaccination in infancy in two Gambian villages. Lancet (1995) 1.95
Rac/Cdc42 and p65PAK regulate the microtubule-destabilizing protein stathmin through phosphorylation at serine 16. J Biol Chem (2000) 1.90
Phosphatidylinositol 3-kinase signals activate a selective subset of Rac/Rho-dependent effector pathways. Curr Biol (1996) 1.90
Target cell specificity of two species of human interferon-alpha produced in Escherichia coli and of hybrid molecules derived from them. Proc Natl Acad Sci U S A (1981) 1.89
Predicting the distribution of urinary schistosomiasis in Tanzania using satellite sensor data. Trop Med Int Health (2001) 1.89
Role of guanine nucleotide-binding proteins--ras-family or trimeric proteins or both--in Ca2+ sensitization of smooth muscle. Proc Natl Acad Sci U S A (1996) 1.87
BRCA2 is a moderate penetrance gene contributing to young-onset prostate cancer: implications for genetic testing in prostate cancer patients. Br J Cancer (2011) 1.86
The GTPase Rap1 controls functional activation of macrophage integrin alphaMbeta2 by LPS and other inflammatory mediators. Curr Biol (2000) 1.86
Rac mediates growth factor-induced arachidonic acid release. Cell (1995) 1.83
Activation of RhoA by lysophosphatidic acid and Galpha12/13 subunits in neuronal cells: induction of neurite retraction. Mol Biol Cell (1999) 1.76
A novel role for RhoGDI as an inhibitor of GAP proteins. EMBO J (1993) 1.74
A new rac target POSH is an SH3-containing scaffold protein involved in the JNK and NF-kappaB signalling pathways. EMBO J (1998) 1.72
Regulation and function of the Rho subfamily of small GTPases. Curr Opin Genet Dev (1994) 1.71
Evidence for an association between hookworm infection and cognitive function in Indonesian school children. Trop Med Int Health (1999) 1.71
p190-B, a new member of the Rho GAP family, and Rho are induced to cluster after integrin cross-linking. J Biol Chem (1995) 1.70
Rac mediates cytoskeletal rearrangements and increased cell motility induced by urokinase-type plasminogen activator receptor binding to vitronectin. J Cell Biol (2001) 1.68
Hepatitis B vaccination policy in drug treatment services. BMJ (1995) 1.68
Rate of reinfection with intestinal nematodes after treatment of children with mebendazole or albendazole in a highly endemic area. Trans R Soc Trop Med Hyg (1996) 1.67
A transforming gene present in human sarcoma cell lines. Nature (1982) 1.67
Functional independence of circadian clocks that regulate plant gene expression. Curr Biol (2000) 1.66
Biochemical and biological properties of the human N-ras p21 protein. Mol Cell Biol (1987) 1.65
Salmonella typhimurium induces membrane ruffling by a growth factor-receptor-independent mechanism. Proc Natl Acad Sci U S A (1993) 1.62
Measurement of intrinsic nucleotide exchange and GTP hydrolysis rates. Methods Enzymol (1995) 1.61
Hox-1.6: a mouse homeo-box-containing gene member of the Hox-1 complex. EMBO J (1987) 1.61
Direct involvement of the small GTP-binding protein Rho in lbc oncogene function. J Biol Chem (1995) 1.60