Published in Nature on November 27, 1987
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Two distinct estrogen-regulated promoters generate transcripts encoding the two functionally different human progesterone receptor forms A and B. EMBO J (1990) 5.05
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Regulated expression of foreign genes in mammalian cells under the control of coliphage T3 RNA polymerase and lac repressor. Proc Natl Acad Sci U S A (1989) 3.70
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A 13 bp palindrome is a functional estrogen responsive element and interacts specifically with estrogen receptor. Nucleic Acids Res (1988) 2.67
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Estrogen-responsive element of the human pS2 gene is an imperfectly palindromic sequence. Proc Natl Acad Sci U S A (1989) 2.60
Cyclic AMP and phorbol ester-stimulated transcription mediated by similar DNA elements that bind distinct proteins. Proc Natl Acad Sci U S A (1988) 2.40
Sequence elements in the human osteocalcin gene confer basal activation and inducible response to hormonal vitamin D3. Proc Natl Acad Sci U S A (1989) 2.31
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Characterization of response elements for androgens, glucocorticoids and progestins in mouse mammary tumour virus. Nucleic Acids Res (1988) 2.28
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Progesterone and glucocorticoid response elements occur in the long control regions of several human papillomaviruses involved in anogenital neoplasia. J Virol (1989) 1.83
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Estrogen receptor selectively binds the "coding strand" of an estrogen responsive element. Proc Natl Acad Sci U S A (1989) 1.20
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Tissue-specific and steroid-dependent interaction of transcription factors with the oestrogen-inducible apoVLDL II promoter in vivo. EMBO J (1988) 1.17
Two remote glucocorticoid responsive units interact cooperatively to promote glucocorticoid induction of rat tyrosine aminotransferase gene expression. Nucleic Acids Res (1989) 1.17
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A nuclear factor I-like activity and a liver-specific repressor govern estrogen-regulated in vitro transcription from the Xenopus laevis vitellogenin B1 promoter. Mol Cell Biol (1989) 1.13
Concentration dependence of transcriptional transactivation in inducible E1A-containing human cells. Mol Cell Biol (1988) 1.12
A progesterone responsive element maps to the far upstream steroid dependent DNase hypersensitive site of chicken lysozyme chromatin. EMBO J (1988) 1.08
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Functional interaction of hybrid response elements with wild-type and mutant steroid hormone receptors. Mol Cell Biol (1991) 1.03
Structural differences between the hormone and antihormone estrogen receptor complexes bound to the hormone response element. Proc Natl Acad Sci U S A (1991) 1.01
Distinguishable promoter elements are involved in transcriptional activation by E1a and cyclic AMP. Mol Cell Biol (1989) 0.99
A common ancestor DNA motif for invertebrate and vertebrate hormone response elements. EMBO J (1991) 0.98
Glucocorticoid activation of chromogranin A gene expression. Identification and characterization of a novel glucocorticoid response element. J Clin Invest (1994) 0.97
Metal replacement in "zinc finger" and its effect on DNA binding. Environ Health Perspect (1994) 0.94
Estrogen and progesterone receptor-binding sites on the chicken vitellogenin II gene: synergism of steroid hormone action. Mol Cell Biol (1988) 0.94
Interaction of glucocorticoid receptor (GR) with estrogen receptor (ER) α and activator protein 1 (AP1) in dexamethasone-mediated interference of ERα activity. J Biol Chem (2013) 0.93
A steroid hormone response unit in the late leader of the noncoding control region of the human polyomavirus BK confers enhanced host cell permissivity. J Virol (1994) 0.91
Synergistic action of glucocorticoid and estradiol responsive elements. Proc Natl Acad Sci U S A (1988) 0.89
Norgestrel and gestodene stimulate breast cancer cell growth through an oestrogen receptor mediated mechanism. Br J Cancer (1993) 0.88
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Transcriptional regulation of the human P450 oxidoreductase gene: hormonal regulation and influence of promoter polymorphisms. Mol Endocrinol (2011) 0.88
In vivo footprinting of the estrogen-inducible vitellogenin II gene from chicken. Nucleic Acids Res (1988) 0.88
Localization of androgen receptors and estrogen receptors in the same cells of the songbird brain. Proc Natl Acad Sci U S A (1990) 0.86
Novel DNA motif binding activity observed in vivo with an estrogen receptor α mutant mouse. Mol Endocrinol (2014) 0.86
Different regions of the estrogen receptor are required for synergistic action with the glucocorticoid and progesterone receptors. Mol Cell Biol (1989) 0.85
Analysis of the human guanylin gene and the processing and cellular localization of the peptide. Proc Natl Acad Sci U S A (1995) 0.83
Cooperative interaction of oestrogen receptor 'zinc finger' domain polypeptides on DNA binding. Biochem J (1995) 0.82
Characterization of a glucocorticoid responsive element and identification of an AT-rich element that regulate the link protein gene. Nucleic Acids Res (1995) 0.81
Dual transcriptional control by Ear3/COUP: negative regulation through the DR1 direct repeat and positive regulation through a sequence downstream of the transcriptional start site of the mouse mammary tumor virus promoter. Proc Natl Acad Sci U S A (1995) 0.81
Artificial steroid hormone response element generated by dam-methylation. Nucleic Acids Res (1992) 0.80
Chromatin immunoprecipitation: advancing analysis of nuclear hormone signaling. J Mol Endocrinol (2012) 0.80
Methylation of an alpha-foetoprotein gene intragenic site modulates gene activity. Nucleic Acids Res (1992) 0.80
A review of the serotonin transporter and prenatal cortisol in the development of autism spectrum disorders. Mol Autism (2013) 0.78
Estrogen-inducible binding of a nuclear factor to the vitellogenin upstream region. Mol Cell Biol (1988) 0.78
Rational design of an estrogen receptor mutant with altered DNA-binding specificity. Nucleic Acids Res (2007) 0.78
Detection of an oestrogen receptor-like protein in human meningiomas by band shift assay using a synthetic oestrogen responsive element (ERE). Br J Cancer (1993) 0.75
The nuclear receptor superfamily: the second decade. Cell (1995) 24.99
CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements. Nucleic Acids Res (1987) 15.65
Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety. Nat Genet (1999) 11.79
5'-Terminal sequences of eucaryotic mRNA can be cloned with high efficiency. Nucleic Acids Res (1981) 8.10
Steroid hormone receptors: many actors in search of a plot. Cell (1995) 7.22
Resetting of circadian time in peripheral tissues by glucocorticoid signaling. Science (2000) 6.55
DNA binding of the glucocorticoid receptor is not essential for survival. Cell (1998) 6.40
Cooperativity of glucocorticoid response elements located far upstream of the tyrosine aminotransferase gene. Cell (1987) 6.12
Genomic footprinting reveals cell type-specific DNA binding of ubiquitous factors. Cell (1987) 4.91
The hormone regulatory element of mouse mammary tumour virus mediates progesterone induction. EMBO J (1986) 4.04
Exons encode functional and structural units of chicken lysozyme. Proc Natl Acad Sci U S A (1980) 4.01
Glucocorticoid and progesterone receptors bind to the same sites in two hormonally regulated promoters. Nature (1985) 3.45
Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation. Genes Dev (1995) 3.41
In vivo protein-DNA interactions in a glucocorticoid response element require the presence of the hormone. Nature (1987) 3.39
Synergistic action of the glucocorticoid receptor with transcription factors. EMBO J (1988) 3.34
Glucocorticoid responsiveness of the transcriptional enhancer of Moloney murine sarcoma virus. Cell (1986) 3.31
Postimplantation expression patterns indicate a role for the mouse forkhead/HNF-3 alpha, beta and gamma genes in determination of the definitive endoderm, chordamesoderm and neuroectoderm. Development (1993) 3.25
A DNA sequence of 15 base pairs is sufficient to mediate both glucocorticoid and progesterone induction of gene expression. Proc Natl Acad Sci U S A (1987) 3.07
Sequences in the promoter region of the chicken lysozyme gene required for steroid regulation and receptor binding. Cell (1984) 3.01
Severe impairment of spermatogenesis in mice lacking the CREM gene. Nature (1996) 2.63
Functional analysis of alternatively spliced tyrosinase gene transcripts. EMBO J (1988) 2.60
Nucleotide sequence of cloned cDNA encoding bovine arginine vasopressin-neurophysin II precursor. Nature (1982) 2.54
Hepatocyte-specific expression of Cre recombinase. Genesis (2000) 2.52
Multiple mRNAs are generated from the chicken lysozyme gene. Cell (1981) 2.46
Magnetic vortex core reversal by excitation with short bursts of an alternating field. Nature (2006) 2.45
Tissue-specific DNaseI hypersensitive sites in the 5'-flanking sequences of the tryptophan oxygenase and the tyrosine aminotransferase genes. EMBO J (1984) 2.42
Repression of inflammatory responses in the absence of DNA binding by the glucocorticoid receptor. EMBO J (2001) 2.34
Recent gene conversion involving bovine vasopressin and oxytocin precursor genes suggested by nucleotide sequence. Nature (1984) 2.34
Glucocorticoid hormones inhibit food-induced phase-shifting of peripheral circadian oscillators. EMBO J (2001) 2.24
Targeted mutation of the CREB gene: compensation within the CREB/ATF family of transcription factors. Proc Natl Acad Sci U S A (1994) 2.24
Phosphorylation of CREB affects its binding to high and low affinity sites: implications for cAMP induced gene transcription. EMBO J (1992) 2.23
A CamKIIalpha iCre BAC allows brain-specific gene inactivation. Genesis (2001) 2.08
Sonic hedgehog is not required for the induction of medial floor plate cells in the zebrafish. Development (1998) 2.08
Spaced training induces normal long-term memory in CREB mutant mice. Curr Biol (1997) 2.07
A yeast artificial chromosome covering the tyrosinase gene confers copy number-dependent expression in transgenic mice. Nature (1993) 2.06
Defective limbic system in mice lacking the tailless gene. Nature (1997) 2.05
Reporter constructs with low background activity utilizing the cat gene. Gene (1992) 2.02
Impaired fetal T cell development and perinatal lethality in mice lacking the cAMP response element binding protein. Proc Natl Acad Sci U S A (1998) 2.02
Reduction of morphine abstinence in mice with a mutation in the gene encoding CREB. Science (1996) 2.01
New cosmid vectors developed for eukaryotic DNA cloning. Gene (1984) 1.97
Characterization of the mouse HNF-4 gene and its expression during mouse embryogenesis. Mech Dev (1994) 1.96
The glucocorticoid receptor is required for stress erythropoiesis. Genes Dev (1999) 1.92
Rescue of the albino phenotype by introduction of a functional tyrosinase gene into mice. EMBO J (1990) 1.91
Regulation of Cre recombinase activity by the synthetic steroid RU 486. Nucleic Acids Res (1996) 1.91
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mRNA complexity and egg white protein mRNA content in mature and hormone-withdrawn oviduct. Cell (1977) 1.91
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Glucocorticoid induction of the rat tryptophan oxygenase gene is mediated by two widely separated glucocorticoid-responsive elements. EMBO J (1987) 1.87
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Multiple transcripts of the mouse tyrosinase gene are generated by alternative splicing. EMBO J (1988) 1.82
Cloning of chicken lysozyme structural gene sequences synthesized in vitro. Nucleic Acids Res (1978) 1.80
Isolation and characterization of the rat tyrosine aminotransferase gene. Proc Natl Acad Sci U S A (1984) 1.77
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A cyclic AMP response element mediates repression of tyrosine aminotransferase gene transcription by the tissue-specific extinguisher locus Tse-1. Cell (1990) 1.67
Multiple mRNA isoforms of the transcription activator protein CREB: generation by alternative splicing and specific expression in primary spermatocytes. EMBO J (1992) 1.66
Isolation of cDNA clones coding for rat tyrosine aminotransferase. Proc Natl Acad Sci U S A (1982) 1.65
The mesenchymal winged helix transcription factor Fkh6 is required for the control of gastrointestinal proliferation and differentiation. Genes Dev (1997) 1.62
Glucocorticoid receptor binds cooperatively to adjacent recognition sites. EMBO J (1989) 1.61
The tissue-specific extinguisher locus TSE1 encodes a regulatory subunit of cAMP-dependent protein kinase. Cell (1991) 1.59
Six members of the mouse forkhead gene family are developmentally regulated. Proc Natl Acad Sci U S A (1993) 1.56
Targeted disruption of the gene encoding hepatocyte nuclear factor 3gamma results in reduced transcription of hepatocyte-specific genes. Mol Cell Biol (1998) 1.56
Mice with an increased glucocorticoid receptor gene dosage show enhanced resistance to stress and endotoxic shock. Mol Cell Biol (2000) 1.54
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Transcriptional regulation of the tryptophan oxygenase gene in rat liver by glucocorticoids. J Biol Chem (1983) 1.48
A simpler and better method to cleave chromatin with DNase 1 for hypersensitive site analyses. Nucleic Acids Res (1991) 1.48
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Chromatin structures of the rat tyrosine aminotransferase gene relate to the function of its cis-acting elements. Mol Cell Biol (1990) 1.46
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A method for the generation of YAC transgenic mice by pronuclear microinjection. Nucleic Acids Res (1993) 1.40
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Ethanol impairs migration of the prechordal plate in the zebrafish embryo. Dev Biol (1998) 1.38
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A bovine papilloma virus vector with a dominant resistance marker replicates extrachromosomally in mouse and E. coli cells. EMBO J (1983) 1.33
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Two genetically defined trans-acting loci coordinately regulate overlapping sets of liver-specific genes. Cell (1990) 1.30
Deletions near the albino locus on chromosome 7 of the mouse affect the level of tyrosine aminotransferase mRNA. Proc Natl Acad Sci U S A (1985) 1.30