Published in EMBO J on September 01, 1984
Chromatin accessibility pre-determines glucocorticoid receptor binding patterns. Nat Genet (2011) 6.98
Synergistic action of the glucocorticoid receptor with transcription factors. EMBO J (1988) 3.34
Acceptor sites for retroviral integrations map near DNase I-hypersensitive sites in chromatin. J Virol (1986) 3.21
Depletion of histone H4 and nucleosomes activates the PHO5 gene in Saccharomyces cerevisiae. EMBO J (1988) 2.67
Specific glucocorticoid receptor binding to DNA reconstituted in a nucleosome. EMBO J (1988) 2.66
Carcinogenic nickel silences gene expression by chromatin condensation and DNA methylation: a new model for epigenetic carcinogens. Mol Cell Biol (1995) 2.14
Hormone induces binding of receptors and transcription factors to a rearranged nucleosome on the MMTV promoter in vivo. EMBO J (1995) 2.09
Transcription factor access to chromatin. Nucleic Acids Res (1997) 2.02
A T cell-specific enhancer is located in a DNase I-hypersensitive area at the 3' end of the CD3-delta gene. EMBO J (1988) 1.90
Cell-type specific activity of two glucocorticoid responsive units of rat tyrosine aminotransferase gene is associated with multiple binding sites for C/EBP and a novel liver-specific nuclear factor. Nucleic Acids Res (1991) 1.66
Regulation of expression of the human interferon gamma gene. Proc Natl Acad Sci U S A (1985) 1.51
A simpler and better method to cleave chromatin with DNase 1 for hypersensitive site analyses. Nucleic Acids Res (1991) 1.48
Chromatin structures of the rat tyrosine aminotransferase gene relate to the function of its cis-acting elements. Mol Cell Biol (1990) 1.46
Deletions near the albino locus on chromosome 7 of the mouse affect the level of tyrosine aminotransferase mRNA. Proc Natl Acad Sci U S A (1985) 1.30
Ligand-specific dynamics of the androgen receptor at its response element in living cells. Mol Cell Biol (2006) 1.28
Analysis of CpG methylation and genomic footprinting at the tyrosine aminotransferase gene: DNA methylation alone is not sufficient to prevent protein binding in vivo. EMBO J (1991) 1.23
Distinct H-2-linked regulation of T-cell responses to the pre-S and S regions of the same hepatitis B surface antigen polypeptide allows circumvention of nonresponsiveness to the S region. Proc Natl Acad Sci U S A (1985) 1.21
Partial overlapping of binding sequences for steroid hormone receptors and DNaseI hypersensitive sites in the rabbit uteroglobin gene region. Nucleic Acids Res (1987) 1.19
Two remote glucocorticoid responsive units interact cooperatively to promote glucocorticoid induction of rat tyrosine aminotransferase gene expression. Nucleic Acids Res (1989) 1.17
Expression of glutathione S-transferase during rat liver development. Biochem J (1992) 1.14
Differentiation-dependent chromatin rearrangement coincides with activation of human papillomavirus type 31 late gene expression. J Virol (2001) 1.13
Participation of Ets transcription factors in the glucocorticoid response of the rat tyrosine aminotransferase gene. Mol Cell Biol (1994) 1.11
Glucocorticoids: mechanisms of action and anti-inflammatory potential in asthma. Mediators Inflamm (1998) 1.10
A progesterone responsive element maps to the far upstream steroid dependent DNase hypersensitive site of chicken lysozyme chromatin. EMBO J (1988) 1.08
Ligand-dependent occupancy of the retinoic acid receptor beta 2 promoter in vivo. Mol Cell Biol (1994) 1.08
Developmental regulation of constitutive and inducible expression of hepatocyte-specific genes in the mouse. Proc Natl Acad Sci U S A (1988) 1.07
Steroid hormone dependence of four DNase I-hypersensitive regions located within the 7000-bp 5'-flanking segment of the ovalbumin gene. EMBO J (1986) 1.06
Nuclease-hypersensitive sites in chromatin of the estrogen-inducible apoVLDL II gene of chicken. Nucleic Acids Res (1985) 1.06
Retinoid-induced chromatin structure alterations in the retinoic acid receptor beta2 promoter. Mol Cell Biol (1997) 1.03
2,3,7,8-Tetrachlorodibenzo-p-dioxin-inducible aryl hydrocarbon receptor-mediated change in CYP1A1 chromatin structure occurs independently of transcription. Mol Cell Biol (1989) 1.00
Glucocorticoid receptor DNA-binding specificity is increased by the organization of DNA in nucleosomes. Proc Natl Acad Sci U S A (1992) 1.00
Developmental acquisition of DNase I sensitivity of the phosphoenolpyruvate carboxykinase (GTP) gene in rat liver. Proc Natl Acad Sci U S A (1987) 0.96
Glucocorticoids and protein kinase A coordinately modulate transcription factor recruitment at a glucocorticoid-responsive unit. Mol Cell Biol (1995) 0.92
Hepatocyte differentiation in vitro: initiation of tyrosine aminotransferase expression in cultured fetal rat hepatocytes. J Cell Biol (1989) 0.91
In vivo footprinting of the estrogen-inducible vitellogenin II gene from chicken. Nucleic Acids Res (1988) 0.88
In vivo analysis of DNase I hypersensitive sites in the human CFTR gene. Mol Med (1999) 0.86
Expression from the tyrosine aminotransferase promoter (nt -350 to +1) is liver-specific and dependent on the binding of both liver-enriched and ubiquitous trans-acting factors. Nucleic Acids Res (1994) 0.82
Selective loss of a DNase I hypersensitive site upstream of the tyrosine aminotransferase gene in mice homozygous for lethal albino deletions. Proc Natl Acad Sci U S A (1992) 0.81
Structure of active chromatin: isolation and characterization of transcriptionally active chromatin from rat liver. Biochem J (1997) 0.80
Nutritional regulation of nucleosomal structure at the chicken malic enzyme promoter in liver. Nucleic Acids Res (1992) 0.79
Regulation of tyrosine aminotransferase gene expression by glucocorticoids in quiescent and regenerating liver. Biochem J (1996) 0.77
Applications of recombinant DNA technology to studies of metabolic regulation. Biochem J (1987) 0.76
Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate. Proc Natl Acad Sci U S A (1979) 72.18
Chromosomal subunits in active genes have an altered conformation. Science (1976) 14.63
Characterization of DNA sequences through which cadmium and glucocorticoid hormones induce human metallothionein-IIA gene. Nature (1984) 7.57
A 200 base pair region at the 5' end of the chicken adult beta-globin gene is accessible to nuclease digestion. Cell (1981) 6.43
Sequence-specific binding of glucocorticoid receptor to MTV DNA at sites within and upstream of the transcribed region. Cell (1983) 6.01
The glucocorticoid receptor binds to defined nucleotide sequences near the promoter of mouse mammary tumour virus. Nature (1983) 5.76
Active chromatin. Nature (1982) 5.13
DNAase I-hypersensitive sites of chromatin. Cell (1981) 5.06
Specific factor conferring nuclease hypersensitivity at the 5' end of the chicken adult beta-globin gene. Proc Natl Acad Sci U S A (1984) 4.03
Chromatin. Annu Rev Biochem (1982) 4.00
Temporal order of chromatin structural changes associated with activation of the major chicken vitellogenin gene. Cell (1983) 3.62
Genetic control of morphogenetic and biochemical differentiation: lethal albino deletions in the mouse. Cell (1979) 3.50
Subfragments of the large terminal repeat cause glucocorticoid-responsive expression of mouse mammary tumor virus and of an adjacent gene. Proc Natl Acad Sci U S A (1983) 3.42
Non-random cleavage of SV40 DNA in the compact minichromosome and free in solution by micrococcal nuclease. Biochem Biophys Res Commun (1980) 3.05
Sequences in the promoter region of the chicken lysozyme gene required for steroid regulation and receptor binding. Cell (1984) 3.01
Nuclease-hypersensitive sites in the chromatin domain of the chicken lysozyme gene. Nucleic Acids Res (1983) 2.48
Further evidence for posttranscriptional control of inducible tyrosine aminotransferase synthesis in cultured hepatoma cells. Nat New Biol (1972) 2.15
Isolation and characterization of the rat tyrosine aminotransferase gene. Proc Natl Acad Sci U S A (1984) 1.77
A 5'-flanking sequence essential for progesterone regulation of an ovalbumin fusion gene. Nature (1983) 1.70
Isolation of cDNA clones coding for rat tyrosine aminotransferase. Proc Natl Acad Sci U S A (1982) 1.65
Transcriptional regulation of the tryptophan oxygenase gene in rat liver by glucocorticoids. J Biol Chem (1983) 1.48
Regulation of tyrosine alpha-ketoglutarate transaminase in rat liver. VI. Induction by pancreatic hormones. J Biol Chem (1967) 1.47
Regulation of the synthesis of tyrosine aminotransferase: the relationship to mRNATAT. Mol Cell Biochem (1983) 1.34
Isolation and characterization of the rat tryptophan oxygenase gene. EMBO J (1982) 1.26
Organ specificity of glucocorticoid-sensitive tyrosine aminotransferase. Separation from aspartate aminotransferase isoenzymes. J Biol Chem (1984) 0.90
Pretranslational control of tryptophan oxygenase levels in Morris hepatoma and host liver. Cancer Res (1976) 0.89
The nuclear receptor superfamily: the second decade. Cell (1995) 24.99
CAT constructions with multiple unique restriction sites for the functional analysis of eukaryotic promoters and regulatory elements. Nucleic Acids Res (1987) 15.65
Conditional gene targeting in macrophages and granulocytes using LysMcre mice. Transgenic Res (1999) 12.83
Disruption of the glucocorticoid receptor gene in the nervous system results in reduced anxiety. Nat Genet (1999) 11.79
5'-Terminal sequences of eucaryotic mRNA can be cloned with high efficiency. Nucleic Acids Res (1981) 8.10
Self-organization of microtubules into bipolar spindles around artificial chromosomes in Xenopus egg extracts. Nature (1996) 7.94
Steroid hormone receptors: many actors in search of a plot. Cell (1995) 7.22
CTCF is a uniquely versatile transcription regulator linked to epigenetics and disease. Trends Genet (2001) 6.80
Resetting of circadian time in peripheral tissues by glucocorticoid signaling. Science (2000) 6.55
DNA binding of the glucocorticoid receptor is not essential for survival. Cell (1998) 6.40
Cooperativity of glucocorticoid response elements located far upstream of the tyrosine aminotransferase gene. Cell (1987) 6.12
Genomic footprinting reveals cell type-specific DNA binding of ubiquitous factors. Cell (1987) 4.91
Modular structure of a chicken lysozyme silencer: involvement of an unusual thyroid hormone receptor binding site. Cell (1990) 4.13
The hormone regulatory element of mouse mammary tumour virus mediates progesterone induction. EMBO J (1986) 4.04
Exons encode functional and structural units of chicken lysozyme. Proc Natl Acad Sci U S A (1980) 4.01
Oestrogen and glucocorticoid responsive elements are closely related but distinct. Nature (1987) 3.95
Cooperativity of the glucocorticoid receptor and the CACCC-box binding factor. Nature (1988) 3.69
Many transcription factors interact synergistically with steroid receptors. Science (1988) 3.49
Glucocorticoid and progesterone receptors bind to the same sites in two hormonally regulated promoters. Nature (1985) 3.45
Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation. Genes Dev (1995) 3.41
In vivo protein-DNA interactions in a glucocorticoid response element require the presence of the hormone. Nature (1987) 3.39
Synergistic action of the glucocorticoid receptor with transcription factors. EMBO J (1988) 3.34
Glucocorticoid responsiveness of the transcriptional enhancer of Moloney murine sarcoma virus. Cell (1986) 3.31
Postimplantation expression patterns indicate a role for the mouse forkhead/HNF-3 alpha, beta and gamma genes in determination of the definitive endoderm, chordamesoderm and neuroectoderm. Development (1993) 3.25
A DNA sequence of 15 base pairs is sufficient to mediate both glucocorticoid and progesterone induction of gene expression. Proc Natl Acad Sci U S A (1987) 3.07
Sequences in the promoter region of the chicken lysozyme gene required for steroid regulation and receptor binding. Cell (1984) 3.01
A transferable silencing domain is present in the thyroid hormone receptor, in the v-erbA oncogene product and in the retinoic acid receptor. EMBO J (1992) 2.93
Mouse lysozyme M gene: isolation, characterization, and expression studies. Proc Natl Acad Sci U S A (1988) 2.84
Quantum information storage for over 180 s using donor spins in a 28Si "semiconductor vacuum". Science (2012) 2.65
Severe impairment of spermatogenesis in mice lacking the CREM gene. Nature (1996) 2.63
Functional analysis of alternatively spliced tyrosinase gene transcripts. EMBO J (1988) 2.60
Nucleotide sequence of cloned cDNA encoding bovine arginine vasopressin-neurophysin II precursor. Nature (1982) 2.54
Hepatocyte-specific expression of Cre recombinase. Genesis (2000) 2.52
Multiple mRNAs are generated from the chicken lysozyme gene. Cell (1981) 2.46
Magnetic vortex core reversal by excitation with short bursts of an alternating field. Nature (2006) 2.45
Negative protein 1, which is required for function of the chicken lysozyme gene silencer in conjunction with hormone receptors, is identical to the multivalent zinc finger repressor CTCF. Mol Cell Biol (1997) 2.37
Repression of inflammatory responses in the absence of DNA binding by the glucocorticoid receptor. EMBO J (2001) 2.34
Recent gene conversion involving bovine vasopressin and oxytocin precursor genes suggested by nucleotide sequence. Nature (1984) 2.34
Glucocorticoid hormones inhibit food-induced phase-shifting of peripheral circadian oscillators. EMBO J (2001) 2.24
Targeted mutation of the CREB gene: compensation within the CREB/ATF family of transcription factors. Proc Natl Acad Sci U S A (1994) 2.24
Phosphorylation of CREB affects its binding to high and low affinity sites: implications for cAMP induced gene transcription. EMBO J (1992) 2.23
CD4+ lymphocyte count in African patients co-infected with HIV and tuberculosis. J Acquir Immune Defic Syndr Hum Retrovirol (1995) 2.23
The effect of pulsed 900-MHz GSM mobile phone radiation on the acrosome reaction, head morphometry and zona binding of human spermatozoa. Int J Androl (2011) 2.16
A CamKIIalpha iCre BAC allows brain-specific gene inactivation. Genesis (2001) 2.08
Spaced training induces normal long-term memory in CREB mutant mice. Curr Biol (1997) 2.07
Activity of two different silencer elements of the chicken lysozyme gene can be compensated by enhancer elements. EMBO J (1987) 2.07
A yeast artificial chromosome covering the tyrosinase gene confers copy number-dependent expression in transgenic mice. Nature (1993) 2.06
Defective limbic system in mice lacking the tailless gene. Nature (1997) 2.05
Reporter constructs with low background activity utilizing the cat gene. Gene (1992) 2.02
Impaired fetal T cell development and perinatal lethality in mice lacking the cAMP response element binding protein. Proc Natl Acad Sci U S A (1998) 2.02
Reduction of morphine abstinence in mice with a mutation in the gene encoding CREB. Science (1996) 2.01
New cosmid vectors developed for eukaryotic DNA cloning. Gene (1984) 1.97
Characterization of the mouse HNF-4 gene and its expression during mouse embryogenesis. Mech Dev (1994) 1.96
The glucocorticoid receptor is required for stress erythropoiesis. Genes Dev (1999) 1.92
Rescue of the albino phenotype by introduction of a functional tyrosinase gene into mice. EMBO J (1990) 1.91
Regulation of Cre recombinase activity by the synthetic steroid RU 486. Nucleic Acids Res (1996) 1.91
mRNA complexity and egg white protein mRNA content in mature and hormone-withdrawn oviduct. Cell (1977) 1.91
Mineralocorticoid receptor knockout mice: pathophysiology of Na+ metabolism. Proc Natl Acad Sci U S A (1998) 1.90
Camptothecin-induced in vivo topoisomerase I cleavages in the transcriptionally active tyrosine aminotransferase gene. Cell (1987) 1.90
Glucocorticoid induction of the rat tryptophan oxygenase gene is mediated by two widely separated glucocorticoid-responsive elements. EMBO J (1987) 1.87
Processing and quality control of DNA array hybridization data. Bioinformatics (2000) 1.86
Inactivation of the winged helix transcription factor HNF3alpha affects glucose homeostasis and islet glucagon gene expression in vivo. Genes Dev (1999) 1.86
Gene shuttling: moving of cloned DNA into and out of eukaryotic cells. Nucleic Acids Res (1982) 1.85
Multiple transcripts of the mouse tyrosinase gene are generated by alternative splicing. EMBO J (1988) 1.82
Cloning of chicken lysozyme structural gene sequences synthesized in vitro. Nucleic Acids Res (1978) 1.80
Isolation and characterization of the rat tyrosine aminotransferase gene. Proc Natl Acad Sci U S A (1984) 1.77
Transcriptional repression by the insulator protein CTCF involves histone deacetylases. Nucleic Acids Res (2000) 1.74
The HNF-3 gene family of transcription factors in mice: gene structure, cDNA sequence, and mRNA distribution. Genomics (1994) 1.74
Lipopolysaccharide and ceramide docking to CD14 provokes ligand-specific receptor clustering in rafts. Eur J Immunol (2001) 1.68
A cyclic AMP response element mediates repression of tyrosine aminotransferase gene transcription by the tissue-specific extinguisher locus Tse-1. Cell (1990) 1.67
Multiple mRNA isoforms of the transcription activator protein CREB: generation by alternative splicing and specific expression in primary spermatocytes. EMBO J (1992) 1.66
Isolation of cDNA clones coding for rat tyrosine aminotransferase. Proc Natl Acad Sci U S A (1982) 1.65
Temporomandibular joint morphology following post-traumatic ankylosis in 26 patients. Int J Oral Maxillofac Surg (2005) 1.63
The mesenchymal winged helix transcription factor Fkh6 is required for the control of gastrointestinal proliferation and differentiation. Genes Dev (1997) 1.62
Negative transcriptional regulation mediated by thyroid hormone response element 144 requires binding of the multivalent factor CTCF to a novel target DNA sequence. J Biol Chem (1999) 1.62
Glucocorticoid receptor binds cooperatively to adjacent recognition sites. EMBO J (1989) 1.61
The tissue-specific extinguisher locus TSE1 encodes a regulatory subunit of cAMP-dependent protein kinase. Cell (1991) 1.59
Six members of the mouse forkhead gene family are developmentally regulated. Proc Natl Acad Sci U S A (1993) 1.56
Targeted disruption of the gene encoding hepatocyte nuclear factor 3gamma results in reduced transcription of hepatocyte-specific genes. Mol Cell Biol (1998) 1.56
Lysozyme gene activity in chicken macrophages is controlled by positive and negative regulatory elements. Nucleic Acids Res (1987) 1.54
Mice with an increased glucocorticoid receptor gene dosage show enhanced resistance to stress and endotoxic shock. Mol Cell Biol (2000) 1.54
Control of cellular content of chicken egg white protein specific RNA during estrogen administration and withdrawal. Biochemistry (1979) 1.53
Arrangement of coding and intervening sequences of chicken lysozyme gene. Proc Natl Acad Sci U S A (1979) 1.53
Microtubule disassembly increases endothelial cell barrier dysfunction: role of MLC phosphorylation. Am J Physiol Lung Cell Mol Physiol (2001) 1.52
Activation of the tyrosine aminotransferase gene is dependent on synergy between liver-specific and hormone-responsive elements. Proc Natl Acad Sci U S A (1993) 1.51
Genetic dissection of glucocorticoid receptor function in mice. Curr Opin Genet Dev (1998) 1.50
The mouse homolog of the orphan nuclear receptor tailless is expressed in the developing forebrain. Development (1995) 1.49
The DNA binding-independent function of the glucocorticoid receptor mediates repression of AP-1-dependent genes in skin. J Cell Biol (1999) 1.48
Transcriptional regulation of the tryptophan oxygenase gene in rat liver by glucocorticoids. J Biol Chem (1983) 1.48
A simpler and better method to cleave chromatin with DNase 1 for hypersensitive site analyses. Nucleic Acids Res (1991) 1.48
Deficiency of an enzyme of tyrosine metabolism underlies altered gene expression in newborn liver of lethal albino mice. Genes Dev (1992) 1.47
Chromatin structures of the rat tyrosine aminotransferase gene relate to the function of its cis-acting elements. Mol Cell Biol (1990) 1.46
Synthesis of ds-cDNA involving addition of dCMP tails to allow cloning of 5'-terminal m RNA sequences. Methods Enzymol (1983) 1.46
Deficits in memory tasks of mice with CREB mutations depend on gene dosage. Learn Mem (1999) 1.45
Hormonal control of egg white protein messenger RNA synthesis in the chicken oviduct. Cold Spring Harb Symp Quant Biol (1978) 1.45