Published in Cell on September 25, 1987
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Camptothecin, a specific inhibitor of type I DNA topoisomerase, induces DNA breakage at replication forks. Mol Cell Biol (1988) 2.05
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Sequence dependent modulating effect of camptothecin on the DNA-cleaving activity of the calf thymus type I topoisomerase. Nucleic Acids Res (1990) 0.84
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Activation of cAMP-dependent protein kinase alters the chromatin structure of the urokinase-type plasminogen activator gene promoter. Nucleic Acids Res (1994) 0.75
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High-efficiency deleter mice show that FLPe is an alternative to Cre-loxP. Nat Genet (2000) 11.80
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The PHD finger: implications for chromatin-mediated transcriptional regulation. Trends Biochem Sci (1995) 6.97
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Cooperativity of glucocorticoid response elements located far upstream of the tyrosine aminotransferase gene. Cell (1987) 6.12
The Saccharomyces cerevisiae Set1 complex includes an Ash2 homologue and methylates histone 3 lysine 4. EMBO J (2001) 5.34
Genomic footprinting reveals cell type-specific DNA binding of ubiquitous factors. Cell (1987) 4.91
DNA cloning by homologous recombination in Escherichia coli. Nat Biotechnol (2000) 4.75
Improved properties of FLP recombinase evolved by cycling mutagenesis. Nat Biotechnol (1998) 4.14
The hormone regulatory element of mouse mammary tumour virus mediates progesterone induction. EMBO J (1986) 4.04
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Oestrogen and glucocorticoid responsive elements are closely related but distinct. Nature (1987) 3.95
The SANT domain: a putative DNA-binding domain in the SWI-SNF and ADA complexes, the transcriptional co-repressor N-CoR and TFIIIB. Trends Biochem Sci (1996) 3.55
Glucocorticoid and progesterone receptors bind to the same sites in two hormonally regulated promoters. Nature (1985) 3.45
Targeted disruption of the glucocorticoid receptor gene blocks adrenergic chromaffin cell development and severely retards lung maturation. Genes Dev (1995) 3.41
In vivo protein-DNA interactions in a glucocorticoid response element require the presence of the hormone. Nature (1987) 3.39
Synergistic action of the glucocorticoid receptor with transcription factors. EMBO J (1988) 3.34
Glucocorticoid responsiveness of the transcriptional enhancer of Moloney murine sarcoma virus. Cell (1986) 3.31
Postimplantation expression patterns indicate a role for the mouse forkhead/HNF-3 alpha, beta and gamma genes in determination of the definitive endoderm, chordamesoderm and neuroectoderm. Development (1993) 3.25
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A DNA sequence of 15 base pairs is sufficient to mediate both glucocorticoid and progesterone induction of gene expression. Proc Natl Acad Sci U S A (1987) 3.07
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Codon-improved Cre recombinase (iCre) expression in the mouse. Genesis (2002) 2.92
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The S. cerevisiae SET3 complex includes two histone deacetylases, Hos2 and Hst1, and is a meiotic-specific repressor of the sporulation gene program. Genes Dev (2001) 2.76
Severe impairment of spermatogenesis in mice lacking the CREM gene. Nature (1996) 2.63
Functional analysis of alternatively spliced tyrosinase gene transcripts. EMBO J (1988) 2.60
The chromo shadow domain, a second chromo domain in heterochromatin-binding protein 1, HP1. Nucleic Acids Res (1995) 2.59
Nucleotide sequence of cloned cDNA encoding bovine arginine vasopressin-neurophysin II precursor. Nature (1982) 2.54
Hepatocyte-specific expression of Cre recombinase. Genesis (2000) 2.52
Multiple mRNAs are generated from the chicken lysozyme gene. Cell (1981) 2.46
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Tissue-specific DNaseI hypersensitive sites in the 5'-flanking sequences of the tryptophan oxygenase and the tyrosine aminotransferase genes. EMBO J (1984) 2.42
RecE/RecT and Redalpha/Redbeta initiate double-stranded break repair by specifically interacting with their respective partners. Genes Dev (2000) 2.39
Repression of inflammatory responses in the absence of DNA binding by the glucocorticoid receptor. EMBO J (2001) 2.34
Recent gene conversion involving bovine vasopressin and oxytocin precursor genes suggested by nucleotide sequence. Nature (1984) 2.34
Efficient and precise engineering of a 200 kb beta-globin human/bacterial artificial chromosome in E. coli DH10B using an inducible homologous recombination system. Gene Ther (1999) 2.32
Identification of a novel 17,000-dalton parathyroid hormone-like adenylate cyclase-stimulating protein from a tumor associated with humoral hypercalcemia of malignancy. J Biol Chem (1987) 2.30
Glucose stimulates human beta cell replication in vivo in islets transplanted into NOD-severe combined immunodeficiency (SCID) mice. Diabetologia (2010) 2.26
Glucocorticoid hormones inhibit food-induced phase-shifting of peripheral circadian oscillators. EMBO J (2001) 2.24
Targeted mutation of the CREB gene: compensation within the CREB/ATF family of transcription factors. Proc Natl Acad Sci U S A (1994) 2.24
Phosphorylation of CREB affects its binding to high and low affinity sites: implications for cAMP induced gene transcription. EMBO J (1992) 2.23
Identification of a cDNA encoding a parathyroid hormone-like peptide from a human tumor associated with humoral hypercalcemia of malignancy. Proc Natl Acad Sci U S A (1988) 2.20
Heterodimerization of the Drosophila ecdysone receptor with retinoid X receptor and ultraspiracle. Nature (1993) 2.15
Ligand-regulated site-specific recombination. Proc Natl Acad Sci U S A (1995) 2.14
A CamKIIalpha iCre BAC allows brain-specific gene inactivation. Genesis (2001) 2.08
Spaced training induces normal long-term memory in CREB mutant mice. Curr Biol (1997) 2.07
A yeast artificial chromosome covering the tyrosinase gene confers copy number-dependent expression in transgenic mice. Nature (1993) 2.06
Defective limbic system in mice lacking the tailless gene. Nature (1997) 2.05
Reporter constructs with low background activity utilizing the cat gene. Gene (1992) 2.02
Impaired fetal T cell development and perinatal lethality in mice lacking the cAMP response element binding protein. Proc Natl Acad Sci U S A (1998) 2.02
Reduction of morphine abstinence in mice with a mutation in the gene encoding CREB. Science (1996) 2.01
New cosmid vectors developed for eukaryotic DNA cloning. Gene (1984) 1.97
Characterization of the mouse HNF-4 gene and its expression during mouse embryogenesis. Mech Dev (1994) 1.96
Efficient FLP recombination in mouse ES cells and oocytes. Genesis (2001) 1.94
The glucocorticoid receptor is required for stress erythropoiesis. Genes Dev (1999) 1.92
Alteration of Cre recombinase site specificity by substrate-linked protein evolution. Nat Biotechnol (2001) 1.92
Rescue of the albino phenotype by introduction of a functional tyrosinase gene into mice. EMBO J (1990) 1.91
Regulation of Cre recombinase activity by the synthetic steroid RU 486. Nucleic Acids Res (1996) 1.91
Defining the roles of parathyroid hormone-related protein in normal physiology. Physiol Rev (1996) 1.91
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Mineralocorticoid receptor knockout mice: pathophysiology of Na+ metabolism. Proc Natl Acad Sci U S A (1998) 1.90
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Glucocorticoid induction of the rat tryptophan oxygenase gene is mediated by two widely separated glucocorticoid-responsive elements. EMBO J (1987) 1.87
Different thermostabilities of FLP and Cre recombinases: implications for applied site-specific recombination. Nucleic Acids Res (1996) 1.86
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Factors associated with humoral hypercalcemia of malignancy stimulate adenylate cyclase in osteoblastic cells. J Clin Invest (1983) 1.84
Sensing X chromosome pairs before X inactivation via a novel X-pairing region of the Xic. Science (2007) 1.83
Humoral hypercalcemia of cancer. Identification of a novel parathyroid hormone-like peptide. N Engl J Med (1988) 1.82
Multiple transcripts of the mouse tyrosinase gene are generated by alternative splicing. EMBO J (1988) 1.82
Targeted expression of placental lactogen in the beta cells of transgenic mice results in beta cell proliferation, islet mass augmentation, and hypoglycemia. J Biol Chem (2000) 1.82
Quantitative comparison of DNA looping in vitro and in vivo: chromatin increases effective DNA flexibility at short distances. EMBO J (1999) 1.80
Cloning of chicken lysozyme structural gene sequences synthesized in vitro. Nucleic Acids Res (1978) 1.80
Simplified generation of targeting constructs using ET recombination. Nucleic Acids Res (1999) 1.79
A simple assay to determine the functionality of Cre or FLP recombination targets in genomic manipulation constructs. Nucleic Acids Res (1996) 1.78
Isolation and characterization of the rat tyrosine aminotransferase gene. Proc Natl Acad Sci U S A (1984) 1.77
Identification of adenylate cyclase-stimulating activity and cytochemical glucose-6-phosphate dehydrogenase-stimulating activity in extracts of tumors from patients with humoral hypercalcemia of malignancy. Proc Natl Acad Sci U S A (1983) 1.75
The HNF-3 gene family of transcription factors in mice: gene structure, cDNA sequence, and mRNA distribution. Genomics (1994) 1.74
Breast cancer incidence highest in the range of one species of house mouse, Mus domesticus. Br J Cancer (2000) 1.73
Calcium homeostasis in immobilization: an example of resorptive hypercalciuria. N Engl J Med (1982) 1.71
Quantitative bone histomorphometry in humoral hypercalcemia of malignancy: uncoupling of bone cell activity. J Clin Endocrinol Metab (1982) 1.68
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A cyclic AMP response element mediates repression of tyrosine aminotransferase gene transcription by the tissue-specific extinguisher locus Tse-1. Cell (1990) 1.67
Multiple mRNA isoforms of the transcription activator protein CREB: generation by alternative splicing and specific expression in primary spermatocytes. EMBO J (1992) 1.66
Isolation of cDNA clones coding for rat tyrosine aminotransferase. Proc Natl Acad Sci U S A (1982) 1.65