Published in J Mol Biol on September 20, 1987
Structural analysis of substrate binding by the molecular chaperone DnaK. Science (1996) 6.13
A potent and broad neutralizing antibody recognizes and penetrates the HIV glycan shield. Science (2011) 5.44
Interactions of protein antigens with antibodies. Proc Natl Acad Sci U S A (1996) 3.53
Highly conserved protective epitopes on influenza B viruses. Science (2012) 3.47
Crystal structure of delta9 stearoyl-acyl carrier protein desaturase from castor seed and its relationship to other di-iron proteins. EMBO J (1996) 2.84
Structure of an antibody-antigen complex: crystal structure of the HyHEL-10 Fab-lysozyme complex. Proc Natl Acad Sci U S A (1989) 2.65
Dissection of the carbohydrate specificity of the broadly neutralizing anti-HIV-1 antibody 2G12. Proc Natl Acad Sci U S A (2005) 2.50
Optimization of affinity, specificity and function of designed influenza inhibitors using deep sequencing. Nat Biotechnol (2012) 2.14
CEP: a conformational epitope prediction server. Nucleic Acids Res (2005) 2.14
Retrostructural analysis of metalloproteins: application to the design of a minimal model for diiron proteins. Proc Natl Acad Sci U S A (2000) 2.01
The bHLH transcription factor POPEYE regulates response to iron deficiency in Arabidopsis roots. Plant Cell (2010) 1.98
Atomic structure of an alphabeta T cell receptor (TCR) heterodimer in complex with an anti-TCR fab fragment derived from a mitogenic antibody. EMBO J (1998) 1.74
Rigid protein motion as a model for crystallographic temperature factors. Proc Natl Acad Sci U S A (1991) 1.74
A conformational switch in human immunodeficiency virus gp41 revealed by the structures of overlapping epitopes recognized by neutralizing antibodies. J Virol (2009) 1.63
Antigen recognition by variable lymphocyte receptors. Science (2008) 1.61
Structural analysis of ligand stimulation of the histidine kinase NarX. Structure (2009) 1.59
Crystal structure of an H-2Kb-ovalbumin peptide complex reveals the interplay of primary and secondary anchor positions in the major histocompatibility complex binding groove. Proc Natl Acad Sci U S A (1995) 1.59
Structural basis for specificity and potency of a flavonoid inhibitor of human CDK2, a cell cycle kinase. Proc Natl Acad Sci U S A (1996) 1.47
A general binding mechanism for all human sulfatases by the formylglycine-generating enzyme. Proc Natl Acad Sci U S A (2005) 1.45
Structural insights into key sites of vulnerability on HIV-1 Env and influenza HA. Immunol Rev (2012) 1.44
Crystal structure of Penicillium citrinum P1 nuclease at 2.8 A resolution. EMBO J (1991) 1.44
Structure of antibody F425-B4e8 in complex with a V3 peptide reveals a new binding mode for HIV-1 neutralization. J Mol Biol (2007) 1.42
Influence of protein flexibility and peptide conformation on reactivity of monoclonal anti-peptide antibodies with a protein alpha-helix. Proc Natl Acad Sci U S A (1987) 1.34
Molecular structure of leucine aminopeptidase at 2.7-A resolution. Proc Natl Acad Sci U S A (1990) 1.33
Structure of a classical broadly neutralizing stem antibody in complex with a pandemic H2 influenza virus hemagglutinin. J Virol (2013) 1.22
26-10 Fab-digoxin complex: affinity and specificity due to surface complementarity. Proc Natl Acad Sci U S A (1993) 1.22
Getting a sense for signals: regulation of the plant iron deficiency response. Biochim Biophys Acta (2012) 1.22
Crystal structure of an idiotype-anti-idiotype Fab complex. Proc Natl Acad Sci U S A (1994) 1.21
Structural origins of efficient proton abstraction from carbon by a catalytic antibody. Proc Natl Acad Sci U S A (2005) 1.21
Influenza human monoclonal antibody 1F1 interacts with three major antigenic sites and residues mediating human receptor specificity in H1N1 viruses. PLoS Pathog (2012) 1.19
Structural evaluation of potent NKT cell agonists: implications for design of novel stimulatory ligands. J Mol Biol (2009) 1.13
Antibody recognition of the pandemic H1N1 Influenza virus hemagglutinin receptor binding site. J Virol (2013) 1.12
Predicting the helix packing of globular proteins by self-correcting distance geometry. Protein Sci (1995) 1.10
Anomalous diffraction in crystallographic phase evaluation. Q Rev Biophys (2014) 1.08
Structure determination of an anti-HIV-1 Fab 447-52D-peptide complex from an epitaxially twinned data set. Acta Crystallogr D Biol Crystallogr (2008) 1.03
An algorithm to generate low-resolution protein tertiary structures from knowledge of secondary structure. Proc Natl Acad Sci U S A (1994) 0.99
Receptor mimicry by antibody F045-092 facilitates universal binding to the H3 subtype of influenza virus. Nat Commun (2014) 0.99
Brownian dynamics simulations of protein folding: access to milliseconds time scale and beyond. Proc Natl Acad Sci U S A (1998) 0.99
A novel dimerization motif in the C-terminal domain of the Thermus thermophilus DEAD box helicase Hera confers substantial flexibility. Nucleic Acids Res (2008) 0.98
Crystal structure of a human rhinovirus neutralizing antibody complexed with a peptide derived from viral capsid protein VP2. EMBO J (1994) 0.97
Identification, characterization, and structure analysis of the cyclic di-AMP-binding PII-like signal transduction protein DarA. J Biol Chem (2014) 0.95
Modulation of antibody affinity by a non-contact residue. Protein Sci (1993) 0.95
A variable light domain fluorogen activating protein homodimerizes to activate dimethylindole red. Biochemistry (2012) 0.95
Structural and functional analysis of the globular head domain of p115 provides insight into membrane tethering. J Mol Biol (2009) 0.94
Structure and mechanism of the Propionibacterium acnes polyunsaturated fatty acid isomerase. Proc Natl Acad Sci U S A (2006) 0.93
Alternative recognition of the conserved stem epitope in influenza A virus hemagglutinin by a VH3-30-encoded heterosubtypic antibody. J Virol (2014) 0.93
Altering the antigenicity of proteins. Proc Natl Acad Sci U S A (1992) 0.91
Crystal structure of Taq DNA polymerase in complex with an inhibitory Fab: the Fab is directed against an intermediate in the helix-coil dynamics of the enzyme. Proc Natl Acad Sci U S A (1998) 0.90
Protein degradation and iron homeostasis. Biochim Biophys Acta (2012) 0.90
Crystal structures of a quorum-quenching antibody. J Mol Biol (2007) 0.89
Alternate protein frameworks for molecular recognition. Proc Natl Acad Sci U S A (1995) 0.88
Structure-based design of a protein immunogen that displays an HIV-1 gp41 neutralizing epitope. J Mol Biol (2011) 0.87
A peptide inhibitor of HIV-1 neutralizing antibody 2G12 is not a structural mimic of the natural carbohydrate epitope on gp120. FASEB J (2008) 0.86
Metal substitutions at the diiron sites of hemerythrin and myohemerythrin: contributions of divalent metals to stability of a four-helix bundle protein. Proc Natl Acad Sci U S A (1992) 0.85
Ligand binding by antibody IgE Lb4: assessment of binding site preferences using microcalorimetry, docking, and free energy simulations. Biophys J (1999) 0.82
Folding kinetics of designer proteins. Application of the diffusion-collision model to a de novo designed four-helix bundle. Biophys J (1992) 0.82
Structural and biochemical analysis of the essential diadenylate cyclase CdaA from Listeria monocytogenes. J Biol Chem (2015) 0.80
Molecular insights into γδ T cell costimulation by an anti-JAML antibody. Structure (2011) 0.78
The structure of the death receptor 4-TNF-related apoptosis-inducing ligand (DR4-TRAIL) complex. Acta Crystallogr F Struct Biol Commun (2015) 0.78
Structure of Hepatitis C Virus Envelope Glycoprotein E1 Antigenic Site 314-324 in Complex with Antibody IGH526. J Mol Biol (2015) 0.78
Molecular Evolution of the Oxygen-Binding Hemerythrin Domain. PLoS One (2016) 0.76
Investigation of specificity determinants in bacterial tRNA-guanine transglycosylase reveals queuine, the substrate of its eucaryotic counterpart, as inhibitor. PLoS One (2013) 0.76
H7N9 influenza virus neutralizing antibodies that possess few somatic mutations. J Clin Invest (2016) 0.76
Crystal structure of the HIV neutralizing antibody 2G12 in complex with a bacterial oligosaccharide analog of mammalian oligomannose. Glycobiology (2014) 0.75
Structure of an HIV gp120 envelope glycoprotein in complex with the CD4 receptor and a neutralizing human antibody. Nature (1998) 24.69
The antigenic structure of the HIV gp120 envelope glycoprotein. Nature (1998) 12.44
The mass and oxygen capacity of the blood in man. J Physiol (1900) 10.55
A conserved HIV gp120 glycoprotein structure involved in chemokine receptor binding. Science (1998) 8.36
Structural basis of cell-cell adhesion by cadherins. Nature (1995) 6.56
Crystal structure of the tyrosine kinase domain of the human insulin receptor. Nature (1995) 6.16
Structural analysis of substrate binding by the molecular chaperone DnaK. Science (1996) 6.13
Distinct dendritic cell subsets differentially regulate the class of immune response in vivo. Proc Natl Acad Sci U S A (1999) 5.66
Crystal structure of core streptavidin determined from multiwavelength anomalous diffraction of synchrotron radiation. Proc Natl Acad Sci U S A (1989) 5.57
Structures of HIV-1 gp120 envelope glycoproteins from laboratory-adapted and primary isolates. Structure (2000) 5.57
Stereochemically restrained refinement of macromolecular structures. Methods Enzymol (1985) 4.93
The Absorption of Oxygen by the Lungs. J Physiol (1897) 4.50
Energetics of the HIV gp120-CD4 binding reaction. Proc Natl Acad Sci U S A (2000) 4.44
The reactivity of anti-peptide antibodies is a function of the atomic mobility of sites in a protein. Nature (1984) 4.05
Structure of ribonuclease H phased at 2 A resolution by MAD analysis of the selenomethionyl protein. Science (1990) 3.77
A prospective study of advance directives for life-sustaining care. N Engl J Med (1991) 3.72
Structure of a fibronectin type III domain from tenascin phased by MAD analysis of the selenomethionyl protein. Science (1992) 3.66
Phenotypic and functional characterization of mice that lack the type I receptor for IL-1. J Immunol (1997) 3.56
Oligomeric modeling and electrostatic analysis of the gp120 envelope glycoprotein of human immunodeficiency virus. J Virol (2000) 3.52
The Oxygen Tension of Arterial Blood. J Physiol (1896) 3.40
oskar mRNA is localized to the posterior pole of the Drosophila oocyte. Cell (1991) 3.39
The course of patients after variceal hemorrhage. Gastroenterology (1981) 3.33
A protein catalytic framework with an N-terminal nucleophile is capable of self-activation. Nature (1995) 3.30
The pathological effects due to increase of oxygen tension in the air breathed. J Physiol (1899) 3.28
Stages in the nuclear association of the herpes simplex virus transcriptional activator protein ICP4. J Virol (1987) 3.24
Hepatitis B infection in physicians. Results of a nationwide seroepidemiologic survey. JAMA (1978) 3.24
Structure of a C-type mannose-binding protein complexed with an oligosaccharide. Nature (1992) 3.19
Structural basis for activation of human lymphocyte kinase Lck upon tyrosine phosphorylation. Nature (1996) 2.94
Probability analysis of variational crystallization and its application to gp120, the exterior envelope glycoprotein of type 1 human immunodeficiency virus (HIV-1). J Biol Chem (1999) 2.85
A structural superfamily of growth factors containing a cystine knot motif. Cell (1993) 2.71
Variceal hemorrhage: a critical evaluation of survival analysis. Gastroenterology (1982) 2.60
Structures of an MHC class II molecule with covalently bound single peptides. Science (1996) 2.58
Structure-function analysis of cell adhesion by neural (N-) cadherin. Neuron (1998) 2.57
Conferring RNA polymerase activity to a DNA polymerase: a single residue in reverse transcriptase controls substrate selection. Proc Natl Acad Sci U S A (1997) 2.54
Immunologic tolerance to renal allografts after bone marrow transplants from the same donors. Ann Intern Med (1991) 2.46
Generation of murine dendritic cells from flt3-ligand-supplemented bone marrow cultures. Blood (2000) 2.45
Structure of the calcium-dependent lectin domain from a rat mannose-binding protein determined by MAD phasing. Science (1991) 2.44
Paracentric inversions in humans: a review of 446 paracentric inversions with presentation of 120 new cases. Am J Med Genet (1995) 2.39
Dimeric association and segmental variability in the structure of human CD4. Nature (1997) 2.35
Spirochetes in the aqueous humor in seronegative ocular syphilis. Persistence after penicillin therapy. Arch Ophthalmol (1967) 2.30
Structure-based analysis of catalysis and substrate definition in the HIT protein family. Science (1997) 2.27
Crystal structure of the extracellular domain from P0, the major structural protein of peripheral nerve myelin. Neuron (1996) 2.25
Mechanistic implications from the structure of a catalytic fragment of Moloney murine leukemia virus reverse transcriptase. Structure (1995) 2.20
Motility in Pseudomonas fluorescens with special reference to survival advantage and negative chemotaxis. Life Sci (1968) 2.17
ON A CASE OF SEPTICAEMIA TREATED BY INTRAVENOUS INJECTION OF EUSOL. Br Med J (1915) 2.16
Spontaneous regression of primary malignant melanomas with regional metastases. Cancer (1965) 2.15
Structure of a dehydratase-isomerase from the bacterial pathway for biosynthesis of unsaturated fatty acids: two catalytic activities in one active site. Structure (1996) 2.14
Alteplase versus heparin in acute pulmonary embolism: randomised trial assessing right-ventricular function and pulmonary perfusion. Lancet (1993) 2.12
The crystal structure of GMP synthetase reveals a novel catalytic triad and is a structural paradigm for two enzyme families. Nat Struct Biol (1996) 2.11
A new modification of the Krajian silver stain for Treponema pallidum. Br J Vener Dis (1969) 2.09
Characterization and crystallization of core streptavidin. J Biol Chem (1987) 2.09
Using the Internet for psychological research: personality testing on the World Wide Web. Br J Psychol (1999) 2.06
Gastroduodenal mucosa and dyspeptic symptoms in arthritic patients during chronic nonsteroidal anti-inflammatory drug use. Am J Gastroenterol (1987) 2.05
Direct phase determination based on anomalous scattering. Methods Enzymol (1985) 2.02
Hereditary aspects of malignant melanoma. JAMA (1967) 1.98
Iatrogenic Campylobacter pylori infection is a cause of epidemic achlorhydria. Am J Gastroenterol (1988) 1.97
Gastric adaptation. Studies in humans during continuous aspirin administration. Gastroenterology (1988) 1.97
Incidence of reactive VDRL tests in the normal rabbit. Br J Vener Dis (1967) 1.94
T and B lymphocytes and Reed-Sternberg cells in Hodgkin's disease lymph nodes and spleens. Clin Exp Immunol (1976) 1.91
Experimental Observations ON THE ANTISEPTIC ACTION OF HYPOCHLOROUS ACID AND ITS APPLICATION TO WOUND TREATMENT. Br Med J (1915) 1.87
Structure of human chorionic gonadotropin at 2.6 A resolution from MAD analysis of the selenomethionyl protein. Structure (1994) 1.87
B- and T-lymphocyte markers on transformed lymphocytes from mitogen-stimulated cultures of normal and CLL lymphocytes and on tonsil blasts. Clin Exp Immunol (1974) 1.86
Multiple RNA regulatory elements mediate distinct steps in localization of oskar mRNA. Development (1993) 1.86
Optic nerve sheath decompression for relief of chronic monocular choked disc. Am J Ophthalmol (1969) 1.84
Microbiology of the frankfurter process: salmonella and natural aerobic flora. Appl Microbiol (1974) 1.83
Muscle fibre type populations of human leg muscles. Histochem J (1975) 1.83
Characterisation of malignant mediastinal lymphoid neoplasm (Sternberg sarcoma) as thymic in origin. Lancet (1973) 1.78
Aspirin and the stomach. Ann Intern Med (1986) 1.77
Structural interactions of fibroblast growth factor receptor with its ligands. Proc Natl Acad Sci U S A (2000) 1.76
RNA regulatory element BLE1 directs the early steps of bicoid mRNA localization. Development (1993) 1.76
Whence pseudotumor cerebri? J Clin Neuroophthalmol (1985) 1.76
Recovery of Treponema pallidum from aqueous humor removed at cataract surgery in man by passive transfer to rabbit testis. Am J Ophthalmol (1968) 1.76
A mutant herpesvirus protein leads to a block in nuclear localization of other viral proteins. Mol Cell Biol (1986) 1.75
Immunological reason for chronic ill health after infectious mononucleosis. Br Med J (Clin Res Ed) (1983) 1.74
Locally critical quantum phase transitions in strongly correlated metals. Nature (2001) 1.74
Crystal structure of a functional unit from Octopus hemocyanin. J Mol Biol (1998) 1.71
Structure of a heparin-linked biologically active dimer of fibroblast growth factor. Nature (1998) 1.71
Studies on negative chemotaxis and the survival value of motility in Pseudomonas fluorescens. J Gen Microbiol (1969) 1.71
Non-tumor causes of the Foster Kennedy syndrome. J Neurosurg (1967) 1.71
Coupled formation of an amidotransferase interdomain ammonia channel and a phosphoribosyltransferase active site. Biochemistry (1997) 1.70
Crystal structure of a soluble form of the human T cell coreceptor CD8 at 2.6 A resolution. Cell (1992) 1.70
The current status of treponema cuniculi. Review of the literature. Br J Vener Dis (1967) 1.69
Painful ophthalmoplegia. The Tolosa-Hunt syndrome. Am J Ophthalmol (1966) 1.68
Structural and mutational analysis of the PhoQ histidine kinase catalytic domain. Insight into the reaction mechanism. J Biol Chem (2001) 1.67
Enzymes utilizing glutamine as an amide donor. Adv Enzymol Relat Areas Mol Biol (1998) 1.67
Structure of the UmuD' protein and its regulation in response to DNA damage. Nature (1996) 1.66
Crystallographic structure analysis of lamprey hemoglobin from anomalous dispersion of synchrotron radiation. Proteins (1988) 1.64
Mechanisms of neurulation: traditional viewpoint and recent advances. Development (1990) 1.64
Protein structure refinement: Streptomyces griseus serine protease A at 1.8 A resolution. J Mol Biol (1979) 1.60
Effect of incorporation of cidofovir into DNA by human cytomegalovirus DNA polymerase on DNA elongation. Antimicrob Agents Chemother (1997) 1.60
The fluorescent antibody tissue stain for Treponema pallidum in the eye. Am J Ophthalmol (1967) 1.59
Crystal structure of I-Ak in complex with a dominant epitope of lysozyme. Immunity (1998) 1.58
Experimental seronegative syphilis. Am J Ophthalmol (1965) 1.56
Mutational analysis of the interaction between CD4 and class II MHC: class II antigens contact CD4 on a surface opposite the gp120-binding site. Cell (1991) 1.53
Radiation damage in protein crystallography. J Mol Biol (1976) 1.52
Skin involvement in Hodgkin's disease. Cancer (1980) 1.51
Defective insulin signaling pathway and increased glycogen synthase kinase-3 activity in the brain of diabetic mice: parallels with Alzheimer's disease and correction by insulin. J Neurosci Res (2008) 1.50
Ischemic optic neuropathy. Am J Ophthalmol (1966) 1.49