Published in J Biol Chem on September 10, 1979
Rac1b and reactive oxygen species mediate MMP-3-induced EMT and genomic instability. Nature (2005) 7.24
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Non-immortalizing P3J-HR-1 Epstein-Barr virus: a deletion mutant of its transforming parent, Jijoye. J Virol (1982) 4.65
The JAK-STAT pathway at twenty. Immunity (2012) 4.41
Tandem gene amplification mediates copper resistance in yeast. Proc Natl Acad Sci U S A (1982) 3.84
Identification of a rare Epstein-Barr virus variant that enhances early antigen expression in Raji cells. Proc Natl Acad Sci U S A (1983) 3.71
Epstein-Barr virus with heterogeneous DNA disrupts latency. J Virol (1984) 3.51
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Amplification of the metallothionein-I gene in cadmium-resistant mouse cells. Proc Natl Acad Sci U S A (1981) 3.11
Molecular cloning and expression of the mouse ornithine decarboxylase gene. Proc Natl Acad Sci U S A (1984) 2.83
Comparison between a Stable NaCl-Selected Nicotiana Cell Line and the Wild Type : K, Na, and Proline Pools as a Function of Salinity. Plant Physiol (1983) 2.80
Isolation of amplified DNA sequences from IMR-32 human neuroblastoma cells: facilitation by fluorescence-activated flow sorting of metaphase chromosomes. Proc Natl Acad Sci U S A (1983) 2.72
Two Epstein-Barr viral nuclear neoantigens distinguished by gene transfer, serology, and chromosome binding. Proc Natl Acad Sci U S A (1983) 2.68
Enhancement of methotrexate resistance and dihydrofolate reductase gene amplification by treatment of mouse 3T6 cells with hydroxyurea. Mol Cell Biol (1983) 2.68
COT1, a gene involved in cobalt accumulation in Saccharomyces cerevisiae. Mol Cell Biol (1992) 2.62
Myc versus USF: discrimination at the cad gene is determined by core promoter elements. Mol Cell Biol (1997) 2.62
Single-copy and amplified CAD genes in Syrian hamster chromosomes localized by a highly sensitive method for in situ hybridization. Mol Cell Biol (1982) 2.21
Structure of amplified DNA in different Syrian hamster cell lines resistant to N-(phosphonacetyl)-L-aspartate. Mol Cell Biol (1983) 2.20
Deletion and amplification of the HGPRT locus in Chinese hamster cells. Mol Cell Biol (1983) 2.10
Inherited amplification of an active gene in the cytochrome P450 CYP2D locus as a cause of ultrarapid metabolism of debrisoquine. Proc Natl Acad Sci U S A (1993) 2.08
Differences in the rates of gene amplification in nontumorigenic and tumorigenic cell lines as measured by Luria-Delbrück fluctuation analysis. Proc Natl Acad Sci U S A (1989) 2.01
Messenger RNA levels of XPAC and ERCC1 in ovarian cancer tissue correlate with response to platinum-based chemotherapy. J Clin Invest (1994) 1.97
Industrial yeasts display tandem gene iteration at the CUP1 region. Mol Cell Biol (1983) 1.84
Intervening sequences in a Dictyostelium gene that encodes a low abundance class mRNA. Nucleic Acids Res (1980) 1.82
Cloning of cDNA sequences of human adenosine deaminase. Proc Natl Acad Sci U S A (1983) 1.81
General method for cloning amplified DNA by differential screening with genomic probes. Mol Cell Biol (1982) 1.78
P3HR-1 Epstein-Barr virus with heterogeneous DNA is an independent replicon maintained by cell-to-cell spread. J Virol (1985) 1.73
Cloning of abundant mRNA species present during conjugation of Tetrahymena thermophila: identification of mRNA species present exclusively during meiosis. Mol Cell Biol (1983) 1.73
Carcinogen-mediated amplification of viral DNA sequences in simian virus 40-transformed Chinese hamster embryo cells. Proc Natl Acad Sci U S A (1981) 1.72
The frequency of Epstein-Barr virus infection and associated lymphoproliferative syndrome after transplantation and its manifestations in children. Transplantation (1988) 1.72
Molecular evidence that insecticide resistance in peach-potato aphids (Myzus persicae Sulz.) results from amplification of an esterase gene. Biochem J (1988) 1.68
Isolation of a cDNA clone for the human HLA-DR antigen alpha chain by using a synthetic oligonucleotide as a hybridization probe. Proc Natl Acad Sci U S A (1982) 1.64
Molecular cloning and cell cycle-specific regulation of a functional human thymidine kinase gene. Proc Natl Acad Sci U S A (1983) 1.62
On the possibility of metabolic control of replicon "misfiring": relationship to emergence of malignant phenotypes in mammalian cell lineages. Proc Natl Acad Sci U S A (1981) 1.61
Structure of adenosine deaminase mRNAs from normal and adenosine deaminase-deficient human cell lines. Mol Cell Biol (1984) 1.60
Molecular structure of the human argininosuccinate synthetase gene: occurrence of alternative mRNA splicing. Mol Cell Biol (1984) 1.58
Expression in COS-1 cells of Epstein-Barr virus nuclear antigen from a complete gene and a deleted gene. J Virol (1984) 1.57
Molecular mechanisms of drug resistance. Biochem J (1990) 1.56
Hepatitis B virus transcript produced by RNA splicing. J Virol (1989) 1.52
Structure of the gene for CAD, the multifunctional protein that initiates UMP synthesis in Syrian hamster cells. Mol Cell Biol (1982) 1.46
Adenosine deaminase messenger RNAs in lymphoblast cell lines derived from leukemic patients and patients with hereditary adenosine deaminase deficiency. J Clin Invest (1983) 1.44
Loss and stabilization of amplified dihydrofolate reductase genes in mouse sarcoma S-180 cell lines. Mol Cell Biol (1981) 1.42
Structural similarity of bovine lung prostaglandin F synthase to lens epsilon-crystallin of the European common frog. Proc Natl Acad Sci U S A (1988) 1.39
Identification and expression of a nuclear antigen from the genomic region of the Jijoye strain of Epstein-Barr virus that is missing in its nonimmortalizing deletion mutant, P3HR-1. Proc Natl Acad Sci U S A (1985) 1.38
Amplification of integrated viral DNA sequences in polyoma virus-transformed cells. Proc Natl Acad Sci U S A (1980) 1.38
Evolution of chromosomal regions containing transfected and amplified dihydrofolate reductase sequences. Mol Cell Biol (1983) 1.35
Co-amplification of double minute chromosomes, multiple drug resistance, and cell surface P-glycoprotein in DNA-mediated transformants of mouse cells. Mol Cell Biol (1984) 1.34
Properties of single-step mutants of Syrian hamster cell lines resistant to N-(phosphonacetyl)-L-aspartate. Mol Cell Biol (1983) 1.32
Overproduction of the free radical of ribonucleotide reductase in hydroxyurea-resistant mouse fibroblast 3T6 cells. Proc Natl Acad Sci U S A (1981) 1.31
Abundant nuclear ribonucleoprotein form of CAD RNA. Mol Cell Biol (1985) 1.30
Expression of several amplified genes in an adenylate-deaminase overproducing variant of Chinese hamster fibroblasts. EMBO J (1984) 1.30
Rapid spontaneous dihydrofolate reductase gene amplification shown by fluorescence-activated cell sorting. Proc Natl Acad Sci U S A (1983) 1.30
Structure of DNA formed in the first step of CAD gene amplification. EMBO J (1986) 1.29
Correlation of double-minute chromosomes with unstable multidrug cross-resistance in uptake mutants of neuroblastoma cells. Proc Natl Acad Sci U S A (1981) 1.28
Gene-amplification model of carcinogenesis. Proc Natl Acad Sci U S A (1981) 1.25
Temporal order of gene replication in Chinese hamster ovary cells. Mol Cell Biol (1989) 1.25
Formation of an inverted duplication can be an initial step in gene amplification. Mol Cell Biol (1988) 1.24
Isolation and visualization of large compact ribonucleoprotein particles of specific nuclear RNAs. Proc Natl Acad Sci U S A (1989) 1.23
Coordinate amplification of metallothionein I and II genes in cadmium-resistant Chinese hamster cells: implications for mechanisms regulating metallothionein gene expression. Mol Cell Biol (1985) 1.23
Amplification and cloning of the Chinese hamster glutamine synthetase gene. EMBO J (1984) 1.16
Thymidylate synthetase overproduction in 5-fluorodeoxyuridine-resistant mouse fibroblasts. Mol Cell Biol (1982) 1.16
DNA polymerase alpha mutants from a Drosophila melanogaster cell line. Proc Natl Acad Sci U S A (1980) 1.16
Characterization of rat calcitonin mRNA. Proc Natl Acad Sci U S A (1980) 1.15
A nuclear matrix attachment region organizes the Epstein-Barr viral plasmid in Raji cells into a single DNA domain. EMBO J (1992) 1.15
Genetic deletion of caspase-2 accelerates MMTV/c-neu-driven mammary carcinogenesis in mice. Cell Death Differ (2013) 1.13
Variable content of double minute chromosomes is not correlated with degree of phenotype instability in methotrexate-resistant human cell lines. Mol Cell Biol (1982) 1.13
Co-amplification of rRNA genes with CAD genes in N-(phosphonacetyl)-L-aspartate-resistant Syrian hamster cells. Mol Cell Biol (1983) 1.11
RNA-dependent DNA polymerase activity in cauliflower mosaic virus-infected plant leaves. EMBO J (1984) 1.11
Properties of dispersed, highly repeated DNA within and near the hamster CAD gene. Mol Cell Biol (1982) 1.11
Identification of an origin of bidirectional DNA replication in the ubiquitously expressed mammalian CAD gene. Mol Cell Biol (1995) 1.09
High-frequency mutation at the adenine phosphoribosyltransferase locus in Chinese hamster ovary cells due to deletion of the gene. Proc Natl Acad Sci U S A (1983) 1.09
High-frequency structural gene deletion as the basis for functional hemizygosity of the adenine phosphoribosyltransferase locus in Chinese hamster ovary cells. Proc Natl Acad Sci U S A (1983) 1.09
Chromosome-mediated gene transfer of multidrug resistance. Mol Cell Biol (1986) 1.08
Lessons from a decade of integrating cancer copy number alterations with gene expression profiles. Brief Bioinform (2011) 1.08
Mapping of the genes encoding the HLA-DR alpha chain and the HLA-related antigens to a chromosome 6 deletion by using genomic blotting. Proc Natl Acad Sci U S A (1983) 1.06
Direct demonstration of genetic alterations at the dihydrofolate reductase locus after gamma irradiation. Mol Cell Biol (1982) 1.06
Evolution and stability of chromosomal DNA coamplified with the CAD gene. Mol Cell Biol (1989) 1.05
Specific DNA sequence amplification in human neuroblastoma cells. Proc Natl Acad Sci U S A (1983) 1.05
Purification and Characterization of the Bifunctional Enzyme Lysine-Ketoglutarate Reductase-Saccharopine Dehydrogenase from Maize. Plant Physiol (1996) 1.05
Selective amplification of polymorphic dihydrofolate reductase gene loci in Chinese hamster lung cells. Proc Natl Acad Sci U S A (1982) 1.03
Amplification and hormone-regulated expression of a mouse mammary tumor virus-Eco gpt fusion plasmid in mouse 3T6 cells. Mol Cell Biol (1983) 1.03
A new determinant of glucocorticoid sensitivity in lymphoid cell lines. J Cell Biol (1983) 1.02
Construction of a cDNA to the hamster CAD gene and its application toward defining the domain for aspartate transcarbamylase. Mol Cell Biol (1985) 1.02
Primary structures of bovine liver low molecular weight kininogen precursors and their two mRNAs. Proc Natl Acad Sci U S A (1983) 1.02
Recombination in the Vicinity of Insertions of Transposon Tn 5 in MYXOCOCCUS XANTHUS. Genetics (1983) 1.01
Stepwise isolation and properties of unstable Chinese hamster cell variants that overproduce adenylate deaminase. Mol Cell Biol (1982) 1.00
U1, U2, and U6 small nuclear ribonucleoproteins (snRNPs) are associated with large nuclear RNP particles containing transcripts of an amplified gene in vivo. Proc Natl Acad Sci U S A (1986) 1.00
Gene for OTC: characterisation and linkage to Duchenne muscular dystrophy. Nucleic Acids Res (1985) 0.99
Moderate-level gene amplification in methotrexate-resistant Chinese hamster ovary cells is accompanied by chromosomal translocations at or near the site of the amplified DHFR gene. Mol Cell Biol (1984) 0.97
Molecular analysis of argininosuccinate synthetase deficiency in human fibroblasts. J Clin Invest (1982) 0.97
Correlation of unstable multidrug cross resistance in Chinese hamster ovary cells with a homogeneously staining region on chromosome 1. Mol Cell Biol (1983) 0.97
Chromosomal alterations associated with overproduction of asparagine synthetase in albizziin-resistant Chinese hamster ovary cells. Mol Cell Biol (1983) 0.97
In vivo titration of mitomycin C action by four Escherichia coli genomic regions on multicopy plasmids. J Bacteriol (2001) 0.95
DNA methylation patterns associated with asparagine synthetase expression in asparagine-overproducing and -auxotrophic cells. Mol Cell Biol (1989) 0.95
Neoplastic transformation of human small airway epithelial cells induced by arsenic. Mol Med (2008) 0.95
A detailed comparison of the 5'-end of the ovalbumin gene cloned from chicken oviduct and erythrocyte DNA. Nucleic Acids Res (1980) 0.95
Amplification of the gene for histidyl-tRNA synthetase in histidinol-resistant Chinese hamster ovary cells. Mol Cell Biol (1985) 0.95
Selection of tunicamycin-resistant Chinese hamster ovary cells with increased N-acetylglucosaminyltransferase activity. J Cell Biol (1982) 0.95
Selective expression of alternative lck mRNAs in human malignant cell lines. Mol Cell Biol (1989) 0.95
Resistance to chemotherapeutic antimetabolites: a function of salvage pathway involvement and cellular response to DNA damage. Br J Cancer (1997) 0.95
Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate. Proc Natl Acad Sci U S A (1979) 72.18
Method for detection of specific RNAs in agarose gels by transfer to diazobenzyloxymethyl-paper and hybridization with DNA probes. Proc Natl Acad Sci U S A (1977) 40.24
Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science (1994) 26.02
Detection of specific RNAs or specific fragments of DNA by fractionation in gels and transfer to diazobenzyloxymethyl paper. Methods Enzymol (1979) 18.24
Regulation of simian virus 40 transcription: sensitive analysis of the RNA species present early in infections by virus or viral DNA. J Virol (1979) 15.69
Splicing of messenger RNA precursors. Annu Rev Biochem (1986) 14.41
Transfer of small DNA fragments from polyacrylamide gels to diazobenzyloxymethyl-paper and detection by hybridization with DNA probes. Biochem Biophys Res Commun (1978) 12.71
Rapid DNA isolations for enzymatic and hybridization analysis. Methods Enzymol (1980) 11.28
Nucleic acid hybridization using DNA covalently coupled to cellulose. Cell (1975) 11.26
Recognition of cap structure in splicing in vitro of mRNA precursors. Cell (1984) 8.67
Transcriptional and posttranscriptional regulation of interferon-induced gene expression in human cells. Cell (1984) 8.32
Histone-GFP fusion protein enables sensitive analysis of chromosome dynamics in living mammalian cells. Curr Biol (1998) 8.12
Use of dimethyl suberimidate, a cross-linking reagent, in studying the subunit structure of oligomeric proteins. Proc Natl Acad Sci U S A (1970) 7.37
Regulation of the G2/M transition by p53. Oncogene (2001) 7.02
Transfer of proteins from gels to diazobenzyloxymethyl-paper and detection with antisera: a method for studying antibody specificity and antigen structure. Proc Natl Acad Sci U S A (1979) 6.93
Recombinase-mediated gene activation and site-specific integration in mammalian cells. Science (1991) 6.51
A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma. Science (1993) 6.44
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Quantitative analysis of specific labelled RNA'S using DNA covalently linked to diazobenzyloxymethyl-paper. Nucleic Acids Res (1979) 5.66
alpha-Interferon-induced transcription of HLA and metallothionein genes containing homologous upstream sequences. Nature (1985) 5.30
T antigen binds to simian virus 40 DNA at the origin of replication. Proc Natl Acad Sci U S A (1975) 5.22
Lariat RNA's as intermediates and products in the splicing of messenger RNA precursors. Science (1984) 5.11
A protein tyrosine kinase in the interferon alpha/beta signaling pathway. Cell (1992) 4.96
Splicing of adenovirus RNA in a cell-free transcription system. Proc Natl Acad Sci U S A (1983) 4.69
A leucine-rich nuclear export signal in the p53 tetramerization domain: regulation of subcellular localization and p53 activity by NES masking. EMBO J (1999) 4.68
DNA damage triggers a prolonged p53-dependent G1 arrest and long-term induction of Cip1 in normal human fibroblasts. Genes Dev (1994) 4.64
Splicing of messenger RNA precursors is inhibited by antisera to small nuclear ribonucleoprotein. Cell (1983) 4.42
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Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-gamma signal transduction pathway. Nature (1993) 4.20
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N-(Phosphonacetyl)-L-aspartate-resistant hamster cells overaccumulate a single mRNA coding for the multifunctional protein that catalyzes the first steps of UMP synthesis. J Biol Chem (1979) 1.95
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