Published in Science on November 28, 1997
Identification of genes differentially regulated by interferon alpha, beta, or gamma using oligonucleotide arrays. Proc Natl Acad Sci U S A (1998) 13.39
Principles of interleukin (IL)-6-type cytokine signalling and its regulation. Biochem J (2003) 10.77
Stat proteins and oncogenesis. J Clin Invest (2002) 4.79
Interferon gamma is required for activation-induced death of T lymphocytes. J Exp Med (2002) 3.80
Sendai virus C proteins counteract the interferon-mediated induction of an antiviral state. J Virol (1999) 2.99
Suppression of epithelial apoptosis and delayed mammary gland involution in mice with a conditional knockout of Stat3. Genes Dev (1999) 2.91
Targeting the interleukin-6/Jak/stat pathway in human malignancies. J Clin Oncol (2012) 2.46
How Stat1 mediates constitutive gene expression: a complex of unphosphorylated Stat1 and IRF1 supports transcription of the LMP2 gene. EMBO J (2000) 2.33
Regulation of c-myc expression by IFN-gamma through Stat1-dependent and -independent pathways. EMBO J (2000) 2.11
Functional analysis of human herpesvirus 8-encoded viral interferon regulatory factor 1 and its association with cellular interferon regulatory factors and p300. J Virol (1999) 2.11
Acetylation of Stat1 modulates NF-kappaB activity. Genes Dev (2006) 2.10
Constitutive and IFN-gamma-induced nuclear import of STAT1 proceed through independent pathways. EMBO J (2002) 2.01
Shp-2 tyrosine phosphatase functions as a negative regulator of the interferon-stimulated Jak/STAT pathway. Mol Cell Biol (1999) 1.93
Constitutively activated Stat3 protects fibroblasts from serum withdrawal and UV-induced apoptosis and antagonizes the proapoptotic effects of activated Stat1. Proc Natl Acad Sci U S A (2001) 1.89
BRCA1 transcriptionally regulates genes involved in breast tumorigenesis. Proc Natl Acad Sci U S A (2002) 1.89
Unphosphorylated STAT1 prolongs the expression of interferon-induced immune regulatory genes. Proc Natl Acad Sci U S A (2009) 1.78
Signal transducer and activator of transcription-1 is critical for apoptosis in macrophages subjected to endoplasmic reticulum stress in vitro and in advanced atherosclerotic lesions in vivo. Circulation (2008) 1.72
TNF-induced signaling in apoptosis. J Clin Immunol (1999) 1.71
Sendai virus C proteins must interact directly with cellular components to interfere with interferon action. J Virol (2000) 1.69
Signals transducers and activators of transcription (STAT)-induced STAT inhibitor-1 (SSI-1)/suppressor of cytokine signaling-1 (SOCS-1) suppresses tumor necrosis factor alpha-induced cell death in fibroblasts. Proc Natl Acad Sci U S A (2000) 1.65
Paradigm shifts in the cell biology of STAT signaling. Semin Cell Dev Biol (2008) 1.61
Impaired development of CD4+ CD25+ regulatory T cells in the absence of STAT1: increased susceptibility to autoimmune disease. J Exp Med (2003) 1.59
Specificity of signaling by STAT1 depends on SH2 and C-terminal domains that regulate Ser727 phosphorylation, differentially affecting specific target gene expression. EMBO J (2001) 1.59
STAT1-deficient mice spontaneously develop estrogen receptor α-positive luminal mammary carcinomas. Breast Cancer Res (2012) 1.56
IRF9 and STAT1 are required for IgG autoantibody production and B cell expression of TLR7 in mice. J Clin Invest (2008) 1.55
Series introduction. JAK-STAT signaling in human disease. J Clin Invest (2002) 1.54
Naturally occurring substitutions in the P/V gene convert the noncytopathic paramyxovirus simian virus 5 into a virus that induces alpha/beta interferon synthesis and cell death. J Virol (2002) 1.50
Regulation of Stat3 nuclear export. J Clin Invest (2003) 1.46
How cells respond to interferons revisited: from early history to current complexity. Cytokine Growth Factor Rev (2007) 1.46
The SH integral membrane protein of the paramyxovirus simian virus 5 is required to block apoptosis in MDBK cells. J Virol (2001) 1.46
HOXA5-induced apoptosis in breast cancer cells is mediated by caspases 2 and 8. Mol Cell Biol (2004) 1.44
STAT-1: a novel regulator of apoptosis. Int J Exp Pathol (2003) 1.43
Recruitment of Stat1 to chromatin is required for interferon-induced serine phosphorylation of Stat1 transactivation domain. Proc Natl Acad Sci U S A (2008) 1.43
Induction of apoptosis by paramyxovirus simian virus 5 lacking a small hydrophobic gene. J Virol (2003) 1.40
Cytokines, inflammation and colon cancer. Curr Cancer Drug Targets (2011) 1.38
Stat1 as a component of tumor necrosis factor alpha receptor 1-TRADD signaling complex to inhibit NF-kappaB activation. Mol Cell Biol (2000) 1.33
Longer and shorter forms of Sendai virus C proteins play different roles in modulating the cellular antiviral response. J Virol (2001) 1.32
Toll-like receptor 9 signaling by CpG-B oligodeoxynucleotides induces an apoptotic pathway in human chronic lymphocytic leukemia B cells. Blood (2010) 1.31
p38 MAPK enhances STAT1-dependent transcription independently of Ser-727 phosphorylation. Proc Natl Acad Sci U S A (2002) 1.30
Signal transducers and activators of transcription as regulators of growth, apoptosis and breast development. Breast Cancer Res (2000) 1.30
Role of signal transducer and activator of transcription 3 in neuronal survival and regeneration. Rev Neurosci (2008) 1.28
Activation of the STAT1 pathway in rheumatoid arthritis. Ann Rheum Dis (2004) 1.26
Distinct roles of the NH2- and COOH-terminal domains of the protein inhibitor of activated signal transducer and activator of transcription (STAT) 1 (PIAS1) in cytokine-induced PIAS1-Stat1 interaction. Proc Natl Acad Sci U S A (2000) 1.12
Design of conditionally active STATs: insights into STAT activation and gene regulatory function. Mol Cell Biol (1999) 1.11
STAT signaling in the pathogenesis and treatment of cancer. Mol Med (1999) 1.11
A STAT3-decoy oligonucleotide induces cell death in a human colorectal carcinoma cell line by blocking nuclear transfer of STAT3 and STAT3-bound NF-κB. BMC Cell Biol (2011) 1.07
Thioredoxin reductase mediates cell death effects of the combination of beta interferon and retinoic acid. Mol Cell Biol (1998) 1.06
Virus-activated interferon regulatory factor 7 upregulates expression of the interferon-regulated BST2 gene independently of interferon signaling. J Virol (2012) 1.05
Susceptibility of signal transducer and activator of transcription-1-deficient mice to pulmonary fibrogenesis. Am J Pathol (2005) 1.03
Stat1-dependent, p53-independent expression of p21(waf1) modulates oxysterol-induced apoptosis. Mol Cell Biol (2002) 1.03
STAT3 deletion sensitizes cells to oxidative stress. Biochem Biophys Res Commun (2009) 1.02
The Epstein-Barr virus SM protein induces STAT1 and interferon-stimulated gene expression. J Virol (2003) 1.02
DIO-1 is a gene involved in onset of apoptosis in vitro, whose misexpression disrupts limb development. Proc Natl Acad Sci U S A (1999) 1.02
Murine gammaherpesvirus 68 has evolved gamma interferon and stat1-repressible promoters for the lytic switch gene 50. J Virol (2010) 1.01
The tumor suppressor function of STAT1 in breast cancer. JAKSTAT (2013) 1.00
Regulation of Stat1 protein expression by phenylalanine 172 in the coiled-coil domain. Biochem Biophys Res Commun (2006) 0.98
Essential role of STAT1 in caspase-independent cell death of activated macrophages through the p38 mitogen-activated protein kinase/STAT1/reactive oxygen species pathway. Mol Cell Biol (2005) 0.96
Caspase-1 is a direct target gene of ETS1 and plays a role in ETS1-induced apoptosis. Cancer Res (2005) 0.96
Apigenin and luteolin modulate microglial activation via inhibition of STAT1-induced CD40 expression. J Neuroinflammation (2008) 0.95
Interferon-resistant Daudi cell line with a Stat2 defect is resistant to apoptosis induced by chemotherapeutic agents. J Biol Chem (2009) 0.95
A novel role for Stat1 in phagosome acidification and natural host resistance to intracellular infection by Leishmania major. PLoS Pathog (2009) 0.95
EGCG mitigates neurotoxicity mediated by HIV-1 proteins gp120 and Tat in the presence of IFN-gamma: role of JAK/STAT1 signaling and implications for HIV-associated dementia. Brain Res (2006) 0.95
Stat1 phosphorylation determines Ras oncogenicity by regulating p27 kip1. PLoS One (2008) 0.95
Hypoxia/re-oxygenation-induced, redox-dependent activation of STAT1 (signal transducer and activator of transcription 1) confers resistance to apoptotic cell death via hsp70 induction. Biochem J (2004) 0.94
STAT3 inhibitors for cancer therapy: Have all roads been explored? JAKSTAT (2013) 0.94
Phosphorylation of IRF8 in a pre-associated complex with Spi-1/PU.1 and non-phosphorylated Stat1 is critical for LPS induction of the IL1B gene. Mol Immunol (2007) 0.94
The role of gene expression profiling in early-stage non-small cell lung cancer. J Thorac Dis (2010) 0.93
Simian immunodeficiency virus infection in the brain and lung leads to differential type I IFN signaling during acute infection. J Immunol (2011) 0.91
The p42 variant of ETS1 protein rescues defective Fas-induced apoptosis in colon carcinoma cells. Proc Natl Acad Sci U S A (1999) 0.90
Interferon-gamma regulates nucleoside transport systems in macrophages through signal transduction and activator of transduction factor 1 (STAT1)-dependent and -independent signalling pathways. Biochem J (2003) 0.90
Critical role for protein tyrosine phosphatase SHP-1 in controlling infection of central nervous system glia and demyelination by Theiler's murine encephalomyelitis virus. J Virol (2002) 0.90
Unphosphorylated STAT1 promotes sarcoma development through repressing expression of Fas and bad and conferring apoptotic resistance. Cancer Res (2012) 0.90
Hydrogen sulfide postconditioning protects isolated rat hearts against ischemia and reperfusion injury mediated by the JAK2/STAT3 survival pathway. Braz J Med Biol Res (2012) 0.90
A STAT3-inhibitory hairpin decoy oligodeoxynucleotide discriminates between STAT1 and STAT3 and induces death in a human colon carcinoma cell line. Mol Cancer (2012) 0.89
Increased activity of caspase 3 and caspase 8 in anti-Fas-induced apoptosis in lymphocytes from ageing humans. Clin Exp Immunol (1999) 0.87
Janus kinases and signal transducers and activators of transcription: their roles in cytokine signaling, development and immunoregulation. Arthritis Res (1999) 0.87
Proapoptotic and antiapoptotic actions of Stat1 versus Stat3 underlie neuroprotective and immunoregulatory functions of IL-11. J Immunol (2011) 0.86
A novel role for brain interleukin-6: facilitation of cognitive flexibility in rat orbitofrontal cortex. J Neurosci (2014) 0.86
Regulation of karyopherin α1 and nuclear import by mammalian target of rapamycin. J Biol Chem (2012) 0.86
Stat1 activation attenuates IL-6 induced Stat3 activity but does not alter apoptosis sensitivity in multiple myeloma. BMC Cancer (2012) 0.85
Procaspase 8 and Bax are up-regulated by distinct pathways in Streptococcal pyrogenic exotoxin B-induced apoptosis. J Biol Chem (2009) 0.85
Preclinical studies on targeted delivery of multiple IFNα2b to HLA-DR in diverse hematologic cancers. Blood (2011) 0.84
Innate immunity in pluripotent human cells: attenuated response to interferon-β. J Biol Chem (2013) 0.84
Signal transducer and activator of transcription 1 negatively regulates constitutive gamma interferon-inducible lysosomal thiol reductase expression. Immunology (2010) 0.84
The differential interferon responses of two strains of Stat1-deficient mice do not alter susceptibility to HSV-1 and VSV in vivo. Virology (2014) 0.84
JAK-STAT in heterochromatin and genome stability. JAKSTAT (2013) 0.83
STAT1-caspase 3 pathway in the apoptotic process associated with steroid-induced necrosis of the femoral head. J Mol Histol (2014) 0.83
A new player in cell death. Science (1997) 0.81
Response to interferons and antibacterial innate immunity in the absence of tyrosine-phosphorylated STAT1. EMBO Rep (2016) 0.81
cDNA cloning and promoter analysis of rat caspase-9. Biochem J (2001) 0.81
STAT2 phosphorylation and signaling. JAKSTAT (2013) 0.81
Induction of high STAT1 expression in transgenic mice with LQTS and heart failure. Biochem Biophys Res Commun (2007) 0.81
PKC-δ mediates interferon-α-induced apoptosis through c-Jun NH₂-terminal kinase activation. BMC Cell Biol (2012) 0.81
Pretreatment with Fucoidan from Fucus vesiculosus Protected against ConA-Induced Acute Liver Injury by Inhibiting Both Intrinsic and Extrinsic Apoptosis. PLoS One (2016) 0.80
Neuronal c-Abl activation leads to induction of cell cycle and interferon signaling pathways. J Neuroinflammation (2012) 0.80
Activation of IFN/STAT1 signalling predicts response to chemotherapy in oestrogen receptor-negative breast cancer. Br J Cancer (2015) 0.80
The Signal Transducer and Activator of Transcription 1 (STAT1) Inhibits Mitochondrial Biogenesis in Liver and Fatty Acid Oxidation in Adipocytes. PLoS One (2015) 0.79
Macrophage-specific up-regulation of apolipoprotein E gene expression by STAT1 is achieved via long range genomic interactions. J Biol Chem (2011) 0.79
JAK kinases are required for the bacterial RNA and poly I:C induced tyrosine phosphorylation of PKR. Int J Clin Exp Med (2012) 0.79
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