Published in Cancer Res on April 15, 1987
Hydroethidine- and MitoSOX-derived red fluorescence is not a reliable indicator of intracellular superoxide formation: another inconvenient truth. Free Radic Biol Med (2010) 2.32
Inhibition of growth, transformation, and expression of human papillomavirus type 16 E7 in human keratinocytes by alpha interferons. J Virol (1993) 0.86
Clinical and immune modulatory effects of alternative weekly interleukin-2 and interferon alfa-2a in patients with advanced renal cell carcinoma and melanoma. Br J Cancer (1991) 0.82
Immunomodulation during prolonged treatment with combined interleukin-2 and interferon-alpha in patients with advanced malignancy. Br J Cancer (1993) 0.81
In vivo treatment with interferon causes augmentation of IL-2 induced lymphokine-activated killer cells in the organs of mice. Clin Exp Immunol (1991) 0.75
Metastasis results from preexisting variant cells within a malignant tumor. Science (1977) 6.47
The pathogenesis of cancer metastasis. Nature (1980) 5.74
Selection of successive tumour lines for metastasis. Nat New Biol (1973) 5.03
Metastasis: quantitative analysis of distribution and fate of tumor emboli labeled with 125 I-5-iodo-2'-deoxyuridine. J Natl Cancer Inst (1970) 4.88
Biological diversity in metastatic neoplasms: origins and implications. Science (1982) 3.95
Biological behavior of malignant melanoma cells correlated to their survival in vivo. Cancer Res (1975) 3.59
Tumor heterogeneity and the biology of cancer invasion and metastasis. Cancer Res (1978) 3.54
Correlation of patterns of anchorage-independent growth with in vivo behavior of cells from a murine fibrosarcoma. Proc Natl Acad Sci U S A (1980) 3.38
Interferon induces a unique protein in mouse cells bearing a gene for resistance to influenza virus. Proc Natl Acad Sci U S A (1983) 3.17
The biology of cancer invasion and metastasis. Adv Cancer Res (1978) 2.94
Orthotopic models are necessary to predict therapy of transplantable tumors in mice. Cancer Metastasis Rev (1999) 2.83
Blockade of NF-kappaB activity in human prostate cancer cells is associated with suppression of angiogenesis, invasion, and metastasis. Oncogene (2001) 2.71
In vivo selection and characterization of metastatic variants from human pancreatic adenocarcinoma by using orthotopic implantation in nude mice. Neoplasia (1999) 2.71
Influence of organ environment on the growth, selection, and metastasis of human colon carcinoma cells in nude mice. Cancer Res (1988) 2.67
Selection of highly metastatic variants of different human prostatic carcinomas using orthotopic implantation in nude mice. Clin Cancer Res (1996) 2.59
The relationship of embolic homogeneity, number, size and viability to the incidence of experimental metastasis. Eur J Cancer (1973) 2.54
Blockade of the epidermal growth factor receptor signaling by a novel tyrosine kinase inhibitor leads to apoptosis of endothelial cells and therapy of human pancreatic carcinoma. Cancer Res (2000) 2.43
Rationale and methods for the use of nude mice to study the biology and therapy of human cancer metastasis. Cancer Metastasis Rev (1986) 2.42
In vitro selection of murine B16 melanoma variants with enhanced tissue-invasive properties. Cancer Res (1980) 2.40
Interferon-alpha-mediated down-regulation of angiogenesis-related genes and therapy of bladder cancer are dependent on optimization of biological dose and schedule. Clin Cancer Res (1999) 2.39
Elevated expression of phosphatidylserine in the outer membrane leaflet of human tumor cells and recognition by activated human blood monocytes. Cancer Res (1991) 2.37
In vivo selection of highly metastatic cells from surgical specimens of different primary human colon carcinomas implanted into nude mice. Cancer Res (1988) 2.36
Expression of angiogenesis-related genes and progression of human ovarian carcinomas in nude mice. J Natl Cancer Inst (1998) 2.36
Growth and metastasis of tumor cells isolated from a human renal cell carcinoma implanted into different organs of nude mice. Cancer Res (1986) 2.30
Expression of interleukin 8 correlates with the metastatic potential of human melanoma cells in nude mice. Cancer Res (1994) 2.28
Metastatic heterogeneity of cells from an ultraviolet light-induced murine fibrosarcoma of recent origin. Cancer Res (1978) 2.28
Macrophage-derived metalloelastase is responsible for the generation of angiostatin in Lewis lung carcinoma. Cell (1997) 2.16
Metastatic behavior of human tumor cell lines grown in the nude mouse. Cancer Res (1984) 2.13
Organ selectivity for implantation survival and growth of B16 melanoma variant tumor lines. J Natl Cancer Inst (1976) 2.09
A human melanoma line heterogeneous with respect to metastatic capacity in athymic nude mice. J Natl Cancer Inst (1984) 2.08
Influence of organ environment on extracellular matrix degradative activity and metastasis of human colon carcinoma cells. J Natl Cancer Inst (1990) 2.00
Metastatic model for human prostate cancer using orthotopic implantation in nude mice. J Natl Cancer Inst (1992) 2.00
Specificity of arrest, survival, and growth of selected metastatic variant cell lines. Cancer Res (1978) 1.99
Blockade of nuclear factor-kappaB signaling inhibits angiogenesis and tumorigenicity of human ovarian cancer cells by suppressing expression of vascular endothelial growth factor and interleukin 8. Cancer Res (2000) 1.98
Role of organ selectivity in the determination of metastatic patterns of B16 melanoma. Cancer Res (1980) 1.97
Relative malignant potential of human breast carcinoma cell lines established from pleural effusions and a brain metastasis. Invasion Metastasis (1991) 1.95
Mekk3 is essential for early embryonic cardiovascular development. Nat Genet (2000) 1.95
A simple quantitative assay for studying the invasive potential of high and low human metastatic variants. Cancer Lett (1987) 1.94
Thermodynamic stability and point mutations of bacteriophage T4 lysozyme. J Mol Biol (1984) 1.91
Interferons alpha and beta down-regulate the expression of basic fibroblast growth factor in human carcinomas. Proc Natl Acad Sci U S A (1995) 1.87
Interactions among clonal subpopulations affect stability of the metastatic phenotype in polyclonal populations of B16 melanoma cells. Proc Natl Acad Sci U S A (1981) 1.87
Inhibitory effect of tumor metastasis in mice by saponins, ginsenoside-Rb2, 20(R)- and 20(S)-ginsenoside-Rg3, of red ginseng. Biol Pharm Bull (1995) 1.85
Differential regulation of Th1 and Th2 functions of NKT cells by CD28 and CD40 costimulatory pathways. J Immunol (2001) 1.85
Isolation and characterization of metastatic variants from human transitional cell carcinoma passaged by orthotopic implantation in athymic nude mice. J Urol (1995) 1.82
CD44 variants but not CD44s cooperate with beta1-containing integrins to permit cells to bind to osteopontin independently of arginine-glycine-aspartic acid, thereby stimulating cell motility and chemotaxis. Cancer Res (1999) 1.82
Expression of interleukin-8 correlates with vascularity in human gastric carcinomas. Am J Pathol (1998) 1.75
Angiogenesis and metastasis. Eur J Cancer (1996) 1.72
The large P proteins of influenza A viruses are composed of one acidic and two basic polypeptides. Virology (1980) 1.71
Mx-dependent resistance to influenza viruses is induced by mouse interferons alpha and beta but not gamma. Virology (1984) 1.71
Level and function of epidermal growth factor receptor predict the metastatic potential of human colon carcinoma cells. Clin Cancer Res (1995) 1.71
Inhibition of murine melanoma experimental metastasis by recombinant desulfatohirudin, a highly specific thrombin inhibitor. Cancer Res (1991) 1.70
The effect of human recombinant macrophage colony-stimulating factor (CSF-1) on the murine mononuclear phagocyte system in vivo. J Immunol (1988) 1.63
In vivo selection of human renal cell carcinoma cells with high metastatic potential in nude mice. Clin Exp Metastasis (1989) 1.62
Critical contribution of IFN-gamma and NK cells, but not perforin-mediated cytotoxicity, to anti-metastatic effect of alpha-galactosylceramide. Eur J Immunol (2001) 1.56
Destruction of bystander cells by tumor cells transfected with inducible nitric oxide (NO) synthase gene. J Natl Cancer Inst (1997) 1.55
Angiogenesis and breast cancer metastasis. Lancet (1995) 1.55
Combined action of mouse alpha and beta interferons in influenza virus-infected macrophages carrying the resistance gene Mx. J Virol (1984) 1.52
Expression of interleukin-8 correlates with angiogenesis, tumorigenicity, and metastasis of human prostate cancer cells implanted orthotopically in nude mice. Neoplasia (2001) 1.52
Evidence for the clonal origin of spontaneous metastases. Science (1982) 1.52
Orthotopic and ectopic organ environments differentially influence the sensitivity of murine colon carcinoma cells to doxorubicin and 5-fluorouracil. Int J Cancer (1992) 1.50
Role of natural killer cells in the destruction of circulating tumor emboli. J Natl Cancer Inst (1980) 1.49
Nuclear factor-kappaB activity correlates with growth, angiogenesis, and metastasis of human melanoma cells in nude mice. Clin Cancer Res (2000) 1.48
An intestinal bacterial metabolite of ginseng protopanaxadiol saponins has the ability to induce apoptosis in tumor cells. Biochem Biophys Res Commun (1998) 1.47
Acidic pH-induced elevation in interleukin 8 expression by human ovarian carcinoma cells. Cancer Res (2000) 1.47
Metastatic behavior of tumor cells isolated from primary and metastatic human colorectal carcinomas implanted into different sites in nude mice. Cancer Res (1986) 1.47
Constitutive and inducible interleukin 8 expression by hypoxia and acidosis renders human pancreatic cancer cells more tumorigenic and metastatic. Clin Cancer Res (1999) 1.45
Increasing metastatic potential is associated with increasing genetic instability of clones isolated from murine neoplasms. Proc Natl Acad Sci U S A (1981) 1.44
Characterization in vivo and in vitro of tumor cells selected for resistance to syngeneic lymphocyte-mediated cytotoxicity. Cancer Res (1976) 1.44
Tyrosine phosphorylation of mitogen-activated protein kinases is necessary for activation of murine macrophages by natural and synthetic bacterial products. J Exp Med (1993) 1.44
Macrophages and metastasis--a biological approach to cancer therapy. Cancer Res (1985) 1.43
MxA-dependent inhibition of measles virus glycoprotein synthesis in a stably transfected human monocytic cell line. J Virol (1993) 1.43
A recombinant human interferon-alpha B/D hybrid with a broad host-range. J Gen Virol (1987) 1.42
Specific chromosomal defects associated with metastatic potential in K-1735 melanoma clones. Involvement of chromosomes 4 and 14. Cancer Genet Cytogenet (1991) 1.41
Fluorescent methylation-specific polymerase chain reaction for DNA-based detection of prostate cancer in bodily fluids. Cancer Res (2000) 1.40
Involvement of macrophages in the eradication of established metastases following intravenous injection of liposomes containing macrophage activators. Cancer Res (1982) 1.40
Experimental nude mouse model of human colorectal cancer liver metastases. J Natl Cancer Inst (1986) 1.38
Constituents of the Vietnamese medicinal plant Orthosiphon stamineus. Chem Pharm Bull (Tokyo) (2000) 1.38
Organ-specific modulation of steady-state mdr gene expression and drug resistance in murine colon cancer cells. J Natl Cancer Inst (1994) 1.37
Transfection with the inducible nitric oxide synthase gene suppresses tumorigenicity and abrogates metastasis by K-1735 murine melanoma cells. J Exp Med (1995) 1.37
Demonstration of multiple phenotypic diversity in a murine melanoma of recent origin. J Natl Cancer Inst (1981) 1.37
Expression of vascular endothelial growth factor is necessary but not sufficient for production and growth of brain metastasis. Cancer Res (2000) 1.36
Eradication of spontaneous metastases and activation of alveolar macrophages by intravenous injection of liposomes containing muramyl dipeptide. Proc Natl Acad Sci U S A (1981) 1.34
Evidence that intravenously derived murine pulmonary melanoma metastases can originate from the expansion of a single tumor cell. Cancer Res (1986) 1.33
Relationship of host immune status to tumor cell arrest, distribution, and survival in experimental metastasis. Cancer (1977) 1.33
Interleukin 8: an autocrine growth factor for human ovarian cancer. Oncol Res (2000) 1.33
Correlation of growth capacity of human tumor cells in hard agarose with their in vivo proliferative capacity at specific metastatic sites. J Natl Cancer Inst (1989) 1.32
Analysis of the fate of systemically administered liposomes and implications for their use in drug delivery. Cancer Res (1982) 1.32
Differential permeability of the blood-brain barrier in experimental brain metastases produced by human neoplasms implanted into nude mice. Am J Pathol (1992) 1.31
Inhibition of pulmonary metastasis by intravenous injection of specifically activated macrophages. Cancer Res (1974) 1.30
Angiogenic molecules and cancer metastasis. In Vivo (1998) 1.30
Structural and immunochemical studies of teichoic acid of Listeria monocytogenes. J Biochem (1983) 1.29
MxA gene expression after live virus vaccination: a sensitive marker for endogenous type I interferon. J Infect Dis (1994) 1.29
Inhibition of malignant ascites and growth of human ovarian carcinoma by oral administration of a potent inhibitor of the vascular endothelial growth factor receptor tyrosine kinases. Int J Oncol (2000) 1.28
Angiogenic heterogeneity: regulation of neoplastic angiogenesis by the organ microenvironment. J Natl Cancer Inst (2001) 1.28
Therapy of spontaneous metastases by intravenous injection of liposomes containing lymphokines. Science (1980) 1.28
Natural and recombinant human interleukin 1-beta is cytotoxic for human melanoma cells. J Immunol (1986) 1.27
Modulation of the invasive phenotype of human colon carcinoma cells by organ specific fibroblasts of nude mice. Differentiation (1992) 1.26
Transfection of interleukin-8 increases angiogenesis and tumorigenesis of human gastric carcinoma cells in nude mice. Br J Cancer (1999) 1.26
Production of experimental malignant pleural effusions is dependent on invasion of the pleura and expression of vascular endothelial growth factor/vascular permeability factor by human lung cancer cells. Am J Pathol (2000) 1.26
Inhibition of tumor angiogenesis and metastasis by a saponin of Panax ginseng, ginsenoside-Rb2. Biol Pharm Bull (1994) 1.26