Published in Mol Cell Biol on October 01, 1985
A nuclear factor for IL-6 expression (NF-IL6) is a member of a C/EBP family. EMBO J (1990) 9.17
Dependence of liver-specific transcription on tissue organization. Mol Cell Biol (1985) 2.38
A variant nuclear protein in dedifferentiated hepatoma cells binds to the same functional sequences in the beta fibrinogen gene promoter as HNF-1. EMBO J (1988) 1.79
Expression of a human cytomegalovirus late gene is posttranscriptionally regulated by a 3'-end-processing event occurring exclusively late after infection. Mol Cell Biol (1986) 1.78
Transcriptional and posttranscriptional control of immunoglobulin mRNA production during B lymphocyte development. Nucleic Acids Res (1986) 1.77
Tissue-specific, developmental, hormonal, and dietary regulation of rat phosphoenolpyruvate carboxykinase-human growth hormone fusion genes in transgenic mice. Mol Cell Biol (1992) 1.65
Conditional enhancement of liver-specific gene transcription. Proc Natl Acad Sci U S A (1988) 1.61
Positive and negative regulatory elements in the mouse albumin enhancer. Proc Natl Acad Sci U S A (1989) 1.58
Hepatocyte dedifferentiation and extinction is accompanied by a block in the synthesis of mRNA coding for the transcription factor HNF1/LFB1. EMBO J (1990) 1.51
Expression of six mouse major urinary protein genes in the mammary, parotid, sublingual, submaxillary, and lachrymal glands and in the liver. Mol Cell Biol (1987) 1.30
Functional characterization of a complex protein-DNA-binding domain located within the human immunodeficiency virus type 1 long terminal repeat leader region. J Virol (1989) 1.19
HNF4 and HNF1 as well as a panel of hepatic functions are extinguished and reexpressed in parallel in chromosomally reduced rat hepatoma-human fibroblast hybrids. J Cell Biol (1993) 1.12
Genes encoding Pir51, Beclin 1, RbAp48 and aldolase b are up or down-regulated in human primary hepatocellular carcinoma. World J Gastroenterol (2004) 1.09
Regulation of albumin gene expression in a series of rat hepatocyte cell lines immortalized by simian virus 40 and maintained in chemically defined medium. Mol Cell Biol (1987) 1.09
Preproenkephalin promoter yields region-specific and long-term expression in adult brain after direct in vivo gene transfer via a defective herpes simplex viral vector. Proc Natl Acad Sci U S A (1994) 1.03
Hybrid cell lines constitute a potential reservoir of polarized cells: isolation and study of highly differentiated hepatoma-derived hybrid cells able to form functional bile canaliculi in vitro. J Cell Biol (1991) 1.01
Cellular promoters incorporated into the adenovirus genome: effects of viral regulatory elements on transcription rates and cell specificity of albumin and beta-globin promoters. Mol Cell Biol (1986) 0.99
The bifunctional DCOH protein binds to HNF1 independently of its 4-alpha-carbinolamine dehydratase activity. Nucleic Acids Res (1997) 0.95
Suppression of albumin enhancer activity by H-ras and AP-1 in hepatocyte cell lines. Mol Cell Biol (1994) 0.91
Hepatoma variants (C2) are defective for transcriptional and post-transcriptional actions from both endogenous and viral genomes. EMBO J (1987) 0.88
Tissue-specific gene expression in mouse hepatocytes cultured in growth-restricting medium. Mol Cell Biol (1988) 0.86
Differential effects of cell density on 5-lipoxygenase (5-LO), five-lipoxygenase-activating protein (FLAP) and interleukin-1 beta (IL-1 beta) expression in human neutrophils. Inflammation (1997) 0.84
Recognition of the CDEI motif GTCACATG by mouse nuclear proteins and interference with the early development of the mouse embryo. Nucleic Acids Res (1991) 0.84
Liver-enriched transcription factors uncoupled from expression of hepatic functions in hepatoma cell lines. Mol Cell Biol (1997) 0.83
Alteration of cellular gene expression in adenovirus transformed cells by post-transcriptional mechanisms. Nucleic Acids Res (1986) 0.77
Silybin counteracts lipid excess and oxidative stress in cultured steatotic hepatic cells. World J Gastroenterol (2016) 0.75
Multiscale cytometry and regulation of 3D cell cultures on a chip. Nat Commun (2017) 0.75
The Nutraceutic Silybin Counteracts Excess Lipid Accumulation and Ongoing Oxidative Stress in an In Vitro Model of Non-Alcoholic Fatty Liver Disease Progression. Front Nutr (2017) 0.75
Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry (1979) 180.95
Hybridization of denatured RNA and small DNA fragments transferred to nitrocellulose. Proc Natl Acad Sci U S A (1980) 109.70
Number and evolutionary conservation of alpha- and beta-tubulin and cytoplasmic beta- and gamma-actin genes using specific cloned cDNA probes. Cell (1980) 17.55
CLONAL GROWTH OF MAMMALIAN CELLS IN A CHEMICALLY DEFINED, SYNTHETIC MEDIUM. Proc Natl Acad Sci U S A (1965) 9.53
Transcriptional control in the production of liver-specific mRNAs. Cell (1981) 9.35
A quantitative comparison of formation of spontaneous and virus-produced viable hybrids. Proc Natl Acad Sci U S A (1969) 3.89
Production of mRNA in Chinese hamster cells: relationship of the rate of synthesis to the cytoplasmic concentration of nine specific mRNA sequences. Cell (1979) 3.67
A genetic analysis of extinction: trans-dominant loci regulate expression of liver-specific traits in hepatoma hybrid cells. Cell (1984) 3.60
HEPATOMAS IN TISSUE CULTURE COMPARED WITH ADAPTING LIVER IN VIVO. Natl Cancer Inst Monogr (1964) 3.53
The evolution of alpha-fetoprotein and albumin. II. The structures of the alpha-fetoprotein and albumin genes in the mouse. J Biol Chem (1981) 3.26
Tissue-specific expression is conferred by a sequence from the 5' end of the rat albumin gene. EMBO J (1984) 3.07
Changes in liver-specific compared to common gene transcription during primary culture of mouse hepatocytes. Mol Cell Biol (1983) 3.01
Characterization of differentiated and dedifferentiated clones from a rat hepatoma. Biochimie (1974) 2.75
Dependence of liver-specific transcription on tissue organization. Mol Cell Biol (1985) 2.38
Isolation and characterization of the gene coding for cytosolic phosphoenolpyruvate carboxykinase (GTP) from the rat. Proc Natl Acad Sci U S A (1983) 1.99
Expression of differentiated functions in hepatoma cell hybrids: induction of mouse albumin production in rat hepatoma-mouse fibroblast hybrids. Proc Natl Acad Sci U S A (1972) 1.90
Undermethylation at the 5' end of the albumin gene is necessary but not sufficient for albumin production by rat hepatoma cells in culture. Cell (1982) 1.87
Posttranscriptional modulation of gene expression in cultured rat hepatocytes. Mol Cell Biol (1984) 1.75
Polysome immunoprecipitation of phenylalanine hydroxylase mRNA from rat liver and cloning of its cDNA. Proc Natl Acad Sci U S A (1982) 1.69
A transplantable bile-secreting hepatocellular carcinoma in the rat. J Natl Cancer Inst (1961) 1.64
Transcriptional and post-transcriptional control of specific messenger RNAs in adult and embryonic liver. J Mol Biol (1984) 1.63
Fine structure and evolution of the rat serum albumin gene. Mol Cell Biol (1981) 1.62
Immunofluorescence analysis of the time-course of extinction, reexpression, and activation of albumin production in rat hepatoma-mouse fibroblast heterokaryons and hybrids. J Cell Biol (1981) 1.55
Dedifferentiated variants of a rat hepatoma:reversion analysis. Cell (1980) 1.43
Expression of fetal and neonatal hepatic functions by mouse hepatoma-rat hepatoma hybrids. Somatic Cell Genet (1979) 1.43
Rat glutathione S-transferase. Cloning of double-stranded cDNA and induction of its mRNA. J Biol Chem (1982) 1.36
Expression of the albumin gene in rat hepatoma cells and their dedifferentiated variants. Cell (1981) 1.30
Gene expression during liver regeneration. J Mol Biol (1984) 1.27
A selective system for hepatoma cells producing gluconeogenic enzymes. Somatic Cell Genet (1977) 1.05
Expression of differentiated functions in hepatoma cell hybrids: selection in glucose-free media of segregated hybrid cells which reexpress gluconeogenic enzymes. Somatic Cell Genet (1977) 0.96
Dedifferentiated variants of a rat hepatoma: partial reversion induced by cell aggregation. Cell (1980) 0.95
Selective isolation of stable and unstable dedifferentiated variants from a rat hepatoma cell line. J Cell Physiol (1982) 0.83
Coordinate secretion of rat and mouse albumin by mouse hepatoma x rat hepatoma hybrid cells directly reflects the intracellular concentration of the corresponding mRNAs. J Cell Physiol (1983) 0.79
Stat3 as an oncogene. Cell (1999) 17.39
Stats: transcriptional control and biological impact. Nat Rev Mol Cell Biol (2002) 15.33
POLYRIBOSOMES IN NORMAL AND POLIOVIRUS-INFECTED HELA CELLS AND THEIR RELATIONSHIP TO MESSENGER-RNA. Proc Natl Acad Sci U S A (1963) 12.17
Evidence for virus-specific noncapsid proteins in poliovirus-infected HeLa cells. Proc Natl Acad Sci U S A (1965) 11.84
Stat3: a STAT family member activated by tyrosine phosphorylation in response to epidermal growth factor and interleukin-6. Science (1994) 11.33
Intragenic DNA spacers interrupt the ovalbumin gene. Proc Natl Acad Sci U S A (1978) 11.03
An adenylic acid-rich sequence in messenger RNA of HeLa cells and its possible relationship to reiterated sites in DNA. Proc Natl Acad Sci U S A (1971) 11.01
Polyadenylic acid sequences: role in conversion of nuclear RNA into messenger RNA. Science (1971) 10.54
Maximal activation of transcription by Stat1 and Stat3 requires both tyrosine and serine phosphorylation. Cell (1995) 10.16
Variety in the level of gene control in eukaryotic cells. Nature (1982) 9.61
Transcriptional control in the production of liver-specific mRNAs. Cell (1981) 9.35
An early haematopoietic defect in mice lacking the transcription factor GATA-2. Nature (1994) 8.60
Transcriptional responses to polypeptide ligands: the JAK-STAT pathway. Annu Rev Biochem (1995) 8.52
A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma. Science (1993) 6.44
The role of STATs in transcriptional control and their impact on cellular function. Oncogene (2000) 6.42
Steps in the processing of Ad2 mRNA: poly(A)+ nuclear sequences are conserved and poly(A) addition precedes splicing. Cell (1978) 6.36
Liver-enriched transcription factor HNF-4 is a novel member of the steroid hormone receptor superfamily. Genes Dev (1990) 6.33
Ribonucleic acids from animal cells. Bacteriol Rev (1968) 6.13
Interferon-dependent tyrosine phosphorylation of a latent cytoplasmic transcription factor. Science (1992) 6.09
Interferon-induced nuclear factors that bind a shared promoter element correlate with positive and negative transcriptional control. Genes Dev (1988) 6.08
Aspects of the synthesis of poliovirus RNA and the formation of virus particles. Virology (1966) 5.85
Stabilization of alpha-synuclein secondary structure upon binding to synthetic membranes. J Biol Chem (1998) 5.81
Interferon activation of the transcription factor Stat91 involves dimerization through SH2-phosphotyrosyl peptide interactions. Cell (1994) 5.79
The primary transcription unit of the mouse beta-major globin gene. Cell (1981) 5.75
Activation of transcription by IFN-gamma: tyrosine phosphorylation of a 91-kD DNA binding protein. Science (1992) 5.71
Proteins of transcription factor ISGF-3: one gene encodes the 91-and 84-kDa ISGF-3 proteins that are activated by interferon alpha. Proc Natl Acad Sci U S A (1992) 5.50
Cytoplasmic activation of ISGF3, the positive regulator of interferon-alpha-stimulated transcription, reconstituted in vitro. Genes Dev (1989) 5.09
Choice of STATs and other substrates specified by modular tyrosine-based motifs in cytokine receptors. Science (1995) 4.90
Leptin activation of Stat3 in the hypothalamus of wild-type and ob/ob mice but not db/db mice. Nat Genet (1996) 4.84
Transcriptional induction of two genes in human cells by beta interferon. Proc Natl Acad Sci U S A (1984) 4.84
Rapidly labeled HeLa cell nuclear RNA. I. Identification by zone sedimentation of a heterogeneous fraction separate from ribosomal precursor RNA. J Mol Biol (1966) 4.83
The initiation sites for RNA transcription in Ad2 DNA. Cell (1977) 4.76
A common nuclear signal transduction pathway activated by growth factor and cytokine receptors. Science (1993) 4.65
Interferon-induced transcription of a gene encoding a 15-kDa protein depends on an upstream enhancer element. Proc Natl Acad Sci U S A (1987) 4.61
Identification of the membrane protein and "core" protein of Sindbis virus. Proc Natl Acad Sci U S A (1968) 4.52
Addition of polyadenylate sequences to virus-specific RNA during adenovirus replication. Proc Natl Acad Sci U S A (1971) 4.48
Multiple hepatocyte-enriched nuclear factors function in the regulation of transthyretin and alpha 1-antitrypsin genes. Mol Cell Biol (1989) 4.47
Characterization of a new low molecular weight RNA in HeLa cell ribosomes. J Mol Biol (1968) 4.44
Sindbis virus infection of chick and hamster cells: synthesis of virus-specific proteins. Virology (1969) 4.38
Complementation of a mutant cell line: central role of the 91 kDa polypeptide of ISGF3 in the interferon-alpha and -gamma signal transduction pathways. EMBO J (1993) 4.35
The definition of a large viral transcription unit late in Ad2 infection of HeLa cells: mapping by effects of ultraviolet irradiation. Cell (1977) 4.13
ISGF3, the transcriptional activator induced by interferon alpha, consists of multiple interacting polypeptide chains. Proc Natl Acad Sci U S A (1990) 4.11
A STAT protein domain that determines DNA sequence recognition suggests a novel DNA-binding domain. Genes Dev (1995) 4.11
Stat3 activation is required for cellular transformation by v-src. Mol Cell Biol (1998) 4.09
A transcriptional hierarchy involved in mammalian cell-type specification. Nature (1992) 4.08
Biogenesis of mRNA: genetic regulation in mammalian cells. Science (1973) 4.01
Hepatocyte nuclear factor 3 alpha belongs to a gene family in mammals that is homologous to the Drosophila homeotic gene fork head. Genes Dev (1991) 4.01
Evidence that all messenger RNA molecules (except histone messenger RNA) contain Poly (A) sequences and that the Poly(A) has a nuclear function. J Mol Biol (1972) 3.93
Subunit of an alpha-interferon-responsive transcription factor is related to interferon regulatory factor and Myb families of DNA-binding proteins. Mol Cell Biol (1992) 3.90
Song presentation induces gene expression in the songbird forebrain. Proc Natl Acad Sci U S A (1992) 3.82
Crystal structure of a tyrosine phosphorylated STAT-1 dimer bound to DNA. Cell (1998) 3.79
Disruption of the HNF-4 gene, expressed in visceral endoderm, leads to cell death in embryonic ectoderm and impaired gastrulation of mouse embryos. Genes Dev (1994) 3.76
The proteins of ISGF-3, the interferon alpha-induced transcriptional activator, define a gene family involved in signal transduction. Proc Natl Acad Sci U S A (1992) 3.74
Polypeptide signalling to the nucleus through tyrosine phosphorylation of Jak and Stat proteins. Nature (1993) 3.73
The winged-helix transcription factor HNF-3 beta is required for notochord development in the mouse embryo. Cell (1994) 3.71
Production of mRNA in Chinese hamster cells: relationship of the rate of synthesis to the cytoplasmic concentration of nine specific mRNA sequences. Cell (1979) 3.67
Transcriptional induction by interferon. New protein(s) determine the extent and length of the induction. J Biol Chem (1986) 3.63
Transcriptionally active Stat1 is required for the antiproliferative effects of both interferon alpha and interferon gamma. Proc Natl Acad Sci U S A (1996) 3.62
HNF-3A, a hepatocyte-enriched transcription factor of novel structure is regulated transcriptionally. Genes Dev (1990) 3.50
Structural difference between the 5' termini of viral and cellular mRNA in poliovirus-infected cells: possible basis for the inhibition of host protein synthesis. J Virol (1976) 3.46
The decrease in size and synthetic activity of poliovirus polysomes late in the infectious cycle. Virology (1967) 3.41
Competition hybridization by "pre-saturation" of HeLa cell DNA. J Mol Biol (1969) 3.40
Implications of RNA-RNA splicing in evolution of eukaryotic cells. Science (1978) 3.39
The turnover of nuclear DNA-like RNA in HeLa cells. J Cell Biol (1968) 3.39
A poly(A) addition site and a downstream termination region are required for efficient cessation of transcription by RNA polymerase II in the mouse beta maj-globin gene. Proc Natl Acad Sci U S A (1987) 3.38
Characterization of a novel protein regulated during the critical period for song learning in the zebra finch. Neuron (1995) 3.37
Interleukin 12 signaling in T helper type 1 (Th1) cells involves tyrosine phosphorylation of signal transducer and activator of transcription (Stat)3 and Stat4. J Exp Med (1995) 3.37
The definition of a large viral transcription unit late in Ad2 infection of HeLa cells: mapping of nascent RNA molecules labeled in isolated nuclei. Cell (1977) 3.32
Purification and cloning of interferon-stimulated gene factor 2 (ISGF2): ISGF2 (IRF-1) can bind to the promoters of both beta interferon- and interferon-stimulated genes but is not a primary transcriptional activator of either. Mol Cell Biol (1990) 3.31
Cytoplasmic activation of GAF, an IFN-gamma-regulated DNA-binding factor. EMBO J (1991) 3.28
Two contact regions between Stat1 and CBP/p300 in interferon gamma signaling. Proc Natl Acad Sci U S A (1996) 3.26
Effect of adenovirus on metabolism of specific host mRNAs: transport control and specific translational discrimination. Mol Cell Biol (1983) 3.25
Rapidly labeled HeLa cell nuclear RNA. II. Base composition and cellular localization of a heterogeneous RNA fraction. J Mol Biol (1966) 3.22
Double-stranded regions in heterogeneous nuclear RNA from Hela cells. Proc Natl Acad Sci U S A (1972) 3.21
Biogenesis and characterization of histone messenger RNA in HeLa cells. J Mol Biol (1972) 3.14
Angiographic progression of coronary artery disease and the development of myocardial infarction. J Am Coll Cardiol (1988) 3.10
Polyadenylic acid segment in mRNA becomes shorter with age. Nat New Biol (1973) 3.09
Early Ad-2 transcription units: only promoter-proximal RNA continues to be made in the presence of DRB. Virology (1979) 3.06
SV40-specific RNA in the nucleus and polyribosomes of transformed cells. Proc Natl Acad Sci U S A (1970) 3.05
Adenovirus E1B proteins are required for accumulation of late viral mRNA and for effects on cellular mRNA translation and transport. Mol Cell Biol (1985) 3.04
Methylated, blocked 5 termini in HeLa cell mRNA. Proc Natl Acad Sci U S A (1975) 3.02
Changes in liver-specific compared to common gene transcription during primary culture of mouse hepatocytes. Mol Cell Biol (1983) 3.01
The "retinoic acid syndrome" in acute promyelocytic leukemia. Ann Intern Med (1992) 2.99
PaxDb, a database of protein abundance averages across all three domains of life. Mol Cell Proteomics (2012) 2.93
Regulation of the primary expression of the early adenovirus transcription units. J Virol (1979) 2.92
Interferon-stimulated transcription: isolation of an inducible gene and identification of its regulatory region. Proc Natl Acad Sci U S A (1986) 2.92
Spacing of palindromic half sites as a determinant of selective STAT (signal transducers and activators of transcription) DNA binding and transcriptional activity. Proc Natl Acad Sci U S A (1995) 2.92
Identification of a Stat gene that functions in Drosophila development. Cell (1996) 2.90
Wiskott-Aldrich syndrome protein regulates podosomes in primary human macrophages. Proc Natl Acad Sci U S A (1999) 2.89
Expression of transcription factor HNF-4 in the extraembryonic endoderm, gut, and nephrogenic tissue of the developing mouse embryo: HNF-4 is a marker for primary endoderm in the implanting blastocyst. Proc Natl Acad Sci U S A (1994) 2.85
Stat3 and Stat4: members of the family of signal transducers and activators of transcription. Proc Natl Acad Sci U S A (1994) 2.81
Synergistic interaction between interferon-alpha and interferon-gamma through induced synthesis of one subunit of the transcription factor ISGF3. EMBO J (1990) 2.75
Globin RNA transcription: a possible termination site and demonstration of transcriptional control correlated with altered chromatin structure. Cell (1982) 2.72
Antagonism between apolipoprotein AI regulatory protein 1, Ear3/COUP-TF, and hepatocyte nuclear factor 4 modulates apolipoprotein CIII gene expression in liver and intestinal cells. Mol Cell Biol (1992) 2.72
Overlapping elements in the guanylate-binding protein gene promoter mediate transcriptional induction by alpha and gamma interferons. Mol Cell Biol (1991) 2.71
Processing of adenovirus specific nuclear RNA during virus replication. Virology (1972) 2.71
A liver-specific DNA-binding protein recognizes multiple nucleotide sites in regulatory regions of transthyretin, alpha 1-antitrypsin, albumin, and simian virus 40 genes. Proc Natl Acad Sci U S A (1988) 2.71
The effects of methionine deprivation on ribosome synthesis in HeLa cells. Proc Natl Acad Sci U S A (1967) 2.66
Further evidence on the nuclear origin and transfer to the cytoplasm of polyadenylic acid sequences in mammalian cell RNA. J Mol Biol (1973) 2.61