Published in Nature on February 01, 1979
New knowledge on pathogenesis of bacterial enteric infections as applied to vaccine development. Microbiol Rev (1983) 7.16
Nucleotide sequence of the bacterial transposon Tn1681 encoding a heat-stable (ST) toxin and its identification in enterotoxigenic Escherichia coli strains. Proc Natl Acad Sci U S A (1980) 5.46
Genetics of digalactoside-binding adhesin from a uropathogenic Escherichia coli strain. Infect Immun (1983) 4.03
Nucleotide sequence homology between the heat-labile enterotoxin gene of Escherichia coli and Vibrio cholerae deoxyribonucleic acid. J Bacteriol (1980) 3.89
Molecular cloning of Vibrio cholerae enterotoxin genes in Escherichia coli K-12. Proc Natl Acad Sci U S A (1982) 3.68
Properties of homogeneous heat-labile enterotoxin from Escherichia coli. Infect Immun (1980) 3.36
Synthesis of a precursor to the B subunit of heat-labile enterotoxin in Escherichia coli. J Bacteriol (1981) 2.84
Sequence homologies between A subunits of Escherichia coli and Vibrio cholerae enterotoxins. Proc Natl Acad Sci U S A (1981) 2.75
Genetic organization of the afimbrial adhesin operon and nucleotide sequence from a uropathogenic Escherichia coli gene encoding an afimbrial adhesin. J Bacteriol (1985) 2.32
In vitro formation of hybrid toxins between subunits of Escherichia coli heat-labile enterotoxin and those of cholera enterotoxin. Infect Immun (1981) 2.12
Nucleotide sequence comparison between heat-labile toxin B-subunit cistrons from Escherichia coli of human and porcine origin. Infect Immun (1985) 1.87
Cellular location of heat-labile enterotoxin in Escherichia coli. J Bacteriol (1984) 1.71
Transient entry of enterotoxin subunits into the periplasm occurs during their secretion from Vibrio cholerae. J Bacteriol (1987) 1.68
Escherichia coli heat-labile enterotoxin genes are flanked by repeated deoxyribonucleic acid sequences. J Bacteriol (1981) 1.67
Cloning and expression of a deoxyribonucleic acid fragment that encodes for the adhesive antigen K99. Infect Immun (1980) 1.55
Lincomycin increases synthetic rate and periplasmic pool size for cholera toxin. J Bacteriol (1980) 1.39
Cloning of deoxyribonucleic acid regions encoding a heat-labile and heat-stable enterotoxin originating from an enterotoxigenic Escherichia coli strain of human origin. J Bacteriol (1980) 1.34
Molecular heterogeneity of heat-labile enterotoxins from human and porcine enterotoxigenic Escherichia coli. Infect Immun (1982) 1.30
Protective effect of immunization of rats with holotoxin or B subunit of Escherichia coli heat-labile enterotoxin. Infect Immun (1981) 1.24
Molecular organization of heat-labile enterotoxin genes originating in Escherichia coli of human origin and construction of heat-labile toxoid-producing strains. J Bacteriol (1981) 1.19
Influence of route of administration on immediate and extended protection in rats immunized with Escherichia coli heart-labile enterotoxin. Infect Immun (1980) 1.15
Respective contributions to protection of primary and booster immunization with Escherichia coli heat-labile enterotoxin in rats. Infect Immun (1981) 0.97
A completely synthetic toxoid vaccine containing Escherichia coli heat-stable toxin and antigenic determinants of the heat-labile toxin B subunit. Infect Immun (1985) 0.96
Immunological relationships between cholera toxin and Escherichia coli heat-labile enterotoxin. Infect Immun (1983) 0.90
Escherichia coli heat-labile enterotoxin: DNA-directed in vitro synthesis and structure. Proc Natl Acad Sci U S A (1979) 0.83
Host response to Escherichia coli heat-labile enterotoxin via two microvillus membrane receptors in the rat intestine. Infect Immun (1989) 0.81
Construction and characterization of new cloning vehicles. II. A multipurpose cloning system. Gene (1977) 114.87
Simple agarose gel electrophoretic method for the identification and characterization of plasmid deoxyribonucleic acid. J Bacteriol (1976) 43.93
General method for the isolation of plasmid deoxyribonucleic acid. J Bacteriol (1973) 31.68
FACS-optimized mutants of the green fluorescent protein (GFP). Gene (1996) 24.12
The agent of bacillary angiomatosis. An approach to the identification of uncultured pathogens. N Engl J Med (1990) 15.92
Contribution of adhesion to bacterial persistence in the mouse urinary tract. Infect Immun (1983) 14.71
Construction and expression of recombinant plasmids encoding type 1 or D-mannose-resistant pili from a urinary tract infection Escherichia coli isolate. Infect Immun (1981) 14.05
Characterization of plasmids and plasmid-associated determinants of Yersinia enterocolitica pathogenesis. Infect Immun (1981) 13.80
Identification of the uncultured bacillus of Whipple's disease. N Engl J Med (1992) 12.33
Uniform nomenclature for bacterial plasmids: a proposal. Bacteriol Rev (1976) 12.28
Polynucleotide sequence relationships among members of Enterobacteriaceae. J Bacteriol (1969) 11.27
Specific labeling and physical characterization of R-factor deoxyribonucleic acid in Escherichia coli. J Bacteriol (1970) 11.06
Coordinate regulation and sensory transduction in the control of bacterial virulence. Science (1989) 10.59
Common themes in microbial pathogenicity revisited. Microbiol Mol Biol Rev (1997) 10.52
Identification of invasin: a protein that allows enteric bacteria to penetrate cultured mammalian cells. Cell (1987) 9.80
A single genetic locus encoded by Yersinia pseudotuberculosis permits invasion of cultured animal cells by Escherichia coli K-12. Nature (1985) 9.45
Translocation of a plasmid DNA sequence which mediates ampicillin resistance: molecular nature and specificity of insertion. Proc Natl Acad Sci U S A (1975) 9.20
The enterotoxin plasmids of Escherichia coli. J Infect Dis (1974) 9.10
The generation of a ColE1-Apr cloning vehicle which allows detection of inserted DNA. Mol Gen Genet (1975) 8.80
Origin of the TEM-beta-lactamase gene found on plasmids. J Bacteriol (1975) 8.70
Plasmid-linked ampicillin resistance in haempohilus influenza type b. Infect Immun (1975) 8.68
Tn5-induced mutations affecting virulence factors of Bordetella pertussis. Infect Immun (1983) 8.49
Molecular nature of two nonconjugative plasmids carrying drug resistance genes. J Bacteriol (1974) 8.42
Characterization of plasmid deoxyribonucleic acid from Neisseria gonorrhoeae. Infect Immun (1974) 8.30
Detection of enterotoxigenic Escherichia coli by DNA colony hybridization. J Infect Dis (1980) 8.15
Common themes in microbial pathogenicity. Microbiol Rev (1989) 7.78
Association of hemolysin production, hemagglutination of human erythrocytes, and virulence for chicken embryos of extraintestinal Escherichia coli isolates. Infect Immun (1978) 7.28
A whole-genome microarray reveals genetic diversity among Helicobacter pylori strains. Proc Natl Acad Sci U S A (2000) 6.85
Evidence for two genetic loci in Yersinia enterocolitica that can promote invasion of epithelial cells. Infect Immun (1988) 6.68
Characterization of common virulence plasmids in Yersinia species and their role in the expression of outer membrane proteins. Infect Immun (1984) 6.63
The ability of Salmonella to enter mammalian cells is affected by bacterial growth state. Proc Natl Acad Sci U S A (1990) 6.57
Altered states: involvement of phosphorylated CagA in the induction of host cellular growth changes by Helicobacter pylori. Proc Natl Acad Sci U S A (1999) 6.34
Molecular epidemiology of Vibrio cholerae in the U.S. Gulf Coast. J Clin Microbiol (1982) 6.34
Plasmid-associated enterotoxin production in a strain of Escherichia coli isolated from humans. Infect Immun (1972) 6.21
Identification of enterotoxigenic Escherichia coli by colony hybridization using three enterotoxin gene probes. J Infect Dis (1982) 6.09
Amino acid sequence homology between cholera toxin and Escherichia coli heat-labile toxin. Nature (1980) 6.04
Polynucleotide sequence relationships among plasmids of the I compatibility complex. J Gen Microbiol (1974) 5.91
Haemolysin contributes to virulence of extra-intestinal E. coli infections. Nature (1981) 5.83
Organization and expression of genes responsible for type 1 piliation in Escherichia coli. J Bacteriol (1984) 5.83
Salmonella typhimurium initiates murine infection by penetrating and destroying the specialized epithelial M cells of the Peyer's patches. J Exp Med (1994) 5.78
Nature of R-factor replication in the presence of chloramphenicol. Proc Natl Acad Sci U S A (1975) 5.64
Deletions affecting the transposition of an antibiotic resistance gene. Proc Natl Acad Sci U S A (1977) 5.48
Cistrons encoding Escherichia coli heat-labile toxin. J Bacteriol (1979) 5.43
The problems of drug-resistant pathogenic bacteria. The replication of R-factor DNA in Escherichia coli K-12 following conjugation. Ann N Y Acad Sci (1971) 5.42
Macrophage-dependent induction of the Salmonella pathogenicity island 2 type III secretion system and its role in intracellular survival. Mol Microbiol (1998) 5.25
Use of a single-strand specific nuclease for analysis of bacterial and plasmid deoxyribonucleic acid homo- and heteroduplexes. J Bacteriol (1973) 5.23
The Salmonella invasin SipB induces macrophage apoptosis by binding to caspase-1. Proc Natl Acad Sci U S A (1999) 5.17
Virulence-associated plasmids from Yersinia enterocolitica and Yersinia pestis. J Bacteriol (1981) 5.11
Salmonella typhimurium invasion induces apoptosis in infected macrophages. Proc Natl Acad Sci U S A (1996) 5.03
Genetic analysis of phase change in Bordetella pertussis. Infect Immun (1984) 5.03
Yeast-enhanced green fluorescent protein (yEGFP): a reporter of gene expression in Candida albicans. Microbiology (1997) 5.00
Fluorescence-based isolation of bacterial genes expressed within host cells. Science (1997) 4.98
Polynucleotide sequence divergence among strains of Escherichia coli and closely related organisms. J Bacteriol (1972) 4.87
Filamentous hemagglutinin of Bordetella pertussis: nucleotide sequence and crucial role in adherence. Proc Natl Acad Sci U S A (1989) 4.87
Sequences required for expression of Bordetella pertussis virulence factors share homology with prokaryotic signal transduction proteins. Proc Natl Acad Sci U S A (1989) 4.78
Tyrosine phosphate hydrolysis of host proteins by an essential Yersinia virulence determinant. Proc Natl Acad Sci U S A (1991) 4.57
Bacterial genetics by flow cytometry: rapid isolation of Salmonella typhimurium acid-inducible promoters by differential fluorescence induction. Mol Microbiol (1996) 4.51
Recognition of a bacterial adhesion by an integrin: macrophage CR3 (alpha M beta 2, CD11b/CD18) binds filamentous hemagglutinin of Bordetella pertussis. Cell (1990) 4.47
Molecular characterization of environmental and nontoxigenic strains of Vibrio cholerae. Infect Immun (1981) 4.45
Penetration of Salmonella through a polarized Madin-Darby canine kidney epithelial cell monolayer. J Cell Biol (1988) 4.44
Molecular relationships among the Salmonelleae. J Bacteriol (1973) 4.35
The meaning and impact of the human genome sequence for microbiology. Trends Microbiol (2001) 4.30
Ruffles induced by Salmonella and other stimuli direct macropinocytosis of bacteria. Nature (1993) 4.30
Extraintestinal dissemination of Salmonella by CD18-expressing phagocytes. Nature (1999) 4.14
Isolation and nucleotide sequence determination of a gene encoding a heat-stable enterotoxin of Escherichia coli. Infect Immun (1983) 4.14
Transposition of a plasmid deoxyribonucleic acid sequence that mediates ampicillin resistance: independence from host rec functions and orientation of insertion. J Bacteriol (1976) 4.13
Salmonella interactions with polarized human intestinal Caco-2 epithelial cells. J Infect Dis (1990) 4.09
Granuloma-specific expression of Mycobacterium virulence proteins from the glycine-rich PE-PGRS family. Science (2000) 4.08
Helicobacter pylori genetic diversity within the gastric niche of a single human host. Proc Natl Acad Sci U S A (2001) 4.05
Genetics of digalactoside-binding adhesin from a uropathogenic Escherichia coli strain. Infect Immun (1983) 4.03
Plasmid-mediated beta-lactamase production in Neisseria gonorrhoeae. Antimicrob Agents Chemother (1977) 4.02
The construction of a cloning vector designed for gene replacement in Bordetella pertussis. Gene (1986) 4.01
Nucleotide sequence homology between the heat-labile enterotoxin gene of Escherichia coli and Vibrio cholerae deoxyribonucleic acid. J Bacteriol (1980) 3.89
Polynucleotide sequence relationships among Ent plasmids and the relationship between Ent and other plasmids. J Bacteriol (1975) 3.88
The molecular nature of R-factors. J Mol Biol (1966) 3.88
Comparison of the ability of enteroinvasive Escherichia coli, Salmonella typhimurium, Yersinia pseudotuberculosis, and Yersinia enterocolitica to enter and replicate within HEp-2 cells. Infect Immun (1987) 3.81
Identification of a Salmonella typhimurium invasion locus by selection for hyperinvasive mutants. Proc Natl Acad Sci U S A (1992) 3.79
Molecular characterization of two beta-lactamase-specifying plasmids isolated from Neisseria gonorrhoeae. J Bacteriol (1977) 3.76
The ail locus is found uniquely in Yersinia enterocolitica serotypes commonly associated with disease. Infect Immun (1989) 3.75
Cloning and expression of an afimbrial adhesin (AFA-I) responsible for P blood group-independent, mannose-resistant hemagglutination from a pyelonephritic Escherichia coli strain. Infect Immun (1984) 3.75
Nucleotide sequence of the papA gene encoding the Pap pilus subunit of human uropathogenic Escherichia coli. J Bacteriol (1984) 3.73
Conjugal transfer of R plasmids in Neisseria gonorrhoeae. Nature (1977) 3.71
Analysis of sequences transposed by complementation of two classes of transposition-deficient mutants of Tn3. J Bacteriol (1978) 3.69
Detection of Shigella in feces using DNA amplification. J Infect Dis (1990) 3.61
Identification and characterization of TnphoA mutants of Salmonella that are unable to pass through a polarized MDCK epithelial cell monolayer. Mol Microbiol (1988) 3.59
Epithelial cell surfaces induce Salmonella proteins required for bacterial adherence and invasion. Science (1989) 3.55
Evidence for plasmid contribution to the virulence of fish pathogen Vibrio anguillarum. Infect Immun (1977) 3.49
Pertussis toxin and extracytoplasmic adenylate cyclase as virulence factors of Bordetella pertussis. J Infect Dis (1984) 3.48
Phase variation in Bordetella pertussis by frameshift mutation in a gene for a novel two-component system. Nature (1989) 3.48
Genetics of the Enterobacteriaceae. C. Molecular relationships among members of the Enterobacteriaceae. Adv Genet (1971) 3.43
Yersinia signals macrophages to undergo apoptosis and YopJ is necessary for this cell death. Proc Natl Acad Sci U S A (1997) 3.43
Salmonellosis: host immune responses and bacterial virulence determinants. Annu Rev Immunol (1996) 3.41
Signal transduction in the mammalian cell during bacterial attachment and entry. Cell (1993) 3.41
Polynucleotide sequence relationships among some bacterial plasmids. J Bacteriol (1971) 3.38
Attaching and effacing locus of a Citrobacter freundii biotype that causes transmissible murine colonic hyperplasia. Infect Immun (1993) 3.34
Molecular cloning and physical characterization of a chromosomal hemolysin from Escherichia coli. Infect Immun (1983) 3.30
Characterization of an Escherichia coli plasmid encoding for synthesis of heat-labile toxin: molecular cloning of the toxin determinant. Infect Immun (1978) 3.28