Published in Cell on July 01, 1977
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Characterization of a cloned ribosomal fragment from mouse which contains the 18S coding region and adjacent spacer sequences. Nucleic Acids Res (1979) 1.76
Macronuclear DNA of the hypotrichous ciliate Oxytricha fallax. Proc Natl Acad Sci U S A (1978) 1.33
Transfer RNA genes of Drosophila melanogaster. Nucleic Acids Res (1980) 1.25
Transcriptionally active and inactive gene repeats within the D. melanogaster 5S RNA gene cluster. Nucleic Acids Res (1984) 1.01
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Transmission electron microscopic method for gene mapping on polytene chromosomes by in situ hybridization. Proc Natl Acad Sci U S A (1981) 0.90
Variability in the molecular organization of the 5S RNA genes among strains of Drosophila melanogaster. Nucleic Acids Res (1980) 0.89
Propagation of restriction fragments from the mitochondrial DNA of Saccharomyces cerevisiae in E. coli by means of plasmid vectors. Nucleic Acids Res (1979) 0.86
A colony bank containing synthetic Col El hybrid plasmids representative of the entire E. coli genome. Cell (1976) 26.20
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Methylmercury as a reversible denaturing agent for agarose gel electrophoresis. Anal Biochem (1976) 21.07
Electron microscope heteroduplex studies of sequence relations among plasmids of Escherichia coli. I. Structure of F-prime factors. J Mol Biol (1972) 19.88
Rates of formation and thermal stabilities of RNA:DNA and DNA:DNA duplexes at high concentrations of formamide. Nucleic Acids Res (1977) 15.92
Mutations in the p53 gene occur in diverse human tumour types. Nature (1989) 13.62
Functional expression of cloned yeast DNA in Escherichia coli. Proc Natl Acad Sci U S A (1977) 12.89
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Electron microscope heteroduplex studies of sequence relations among plasmids of Escherichia coli. II. Structure of drug resistance (R) factors and F factors. J Mol Biol (1973) 11.40
Sequence of a yeast DNA fragment containing a chromosomal replicator and the TRP1 gene. Gene (1980) 11.03
Isolation of a yeast centromere and construction of functional small circular chromosomes. Nature (1980) 9.38
Construction and analysis of viable deletion mutants of simian virus 40. J Virol (1976) 9.11
Reducing the frequency of errors in medicine using information technology. J Am Med Inform Assoc (2001) 8.37
Enterocolitis and colon cancer in interleukin-10-deficient mice are associated with aberrant cytokine production and CD4(+) TH1-like responses. J Clin Invest (1996) 7.97
Nucleotide sequence comparisons and functional analysis of yeast centromere DNAs. Cell (1982) 7.01
A physical study by electron microscopy of the terminally reptitious, circularly permuted DNA from the coliphage particles of Escherichia coli 15. J Mol Biol (1970) 6.63
The actin genes of Drosophila: a dispersed multigene family. Cell (1980) 5.91
Yeast centromere DNA is in a unique and highly ordered structure in chromosomes and small circular minichromosomes. Cell (1982) 5.49
Transcripts of the six Drosophila actin genes accumulate in a stage- and tissue-specific manner. Cell (1983) 5.44
Electron microscope heteroduplex studies of sequence relations among bacterial plasmids: identification and mapping of the insertion sequences IS1 and IS2 in F and R plasmids. J Bacteriol (1975) 5.44
The actin genes of Drosophila: protein coding regions are highly conserved but intron positions are not. Cell (1981) 5.27
Determinants of HIV-1 shedding in the genital tract of women. Lancet (2001) 5.10
A method for the deletion of restriction sites in bacterial plasmid deoxyribonucleic acid. Mol Gen Genet (1976) 4.92
A 240 kd multisubunit protein complex, CBF3, is a major component of the budding yeast centromere. Cell (1991) 4.88
Covalently closed circular DNA of avian sarcoma virus: purification from nuclei of infected quail tumor cells and measurement by electron microscopy and gel electrophoresis. J Mol Biol (1976) 4.65
Changes in collateral channel filling immediately after controlled coronary artery occlusion by an angioplasty balloon in human subjects. J Am Coll Cardiol (1985) 4.61
Biochemical procedure for production of small deletions in simian virus 40 DNA. Proc Natl Acad Sci U S A (1975) 4.59
Mapping of poly(A) sequences in the electron microscope reveals unusual structure of type C oncornavirus RNA molecules. Cell (1976) 4.41
High-frequency transformation of yeast by plasmids containing the cloned yeast ARG4 gene. Proc Natl Acad Sci U S A (1979) 4.37
Biochemical construction and selection of hybrid plasmids containing specific segments of the Escherichia coli genome. Proc Natl Acad Sci U S A (1975) 4.33
IS2, a genetic element for turn-off and turn-on of gene activity in E. coli. Mol Gen Genet (1974) 4.16
Interspersion of repetitive and nonrepetitive DNA sequences in the Drosophila melanogaster genome. Cell (1975) 4.13
Hydrodynamic shear breakage of DNA. Biopolymers (1972) 4.12
Functional expression of cloned yeast DNA in Escherichia coli: specific complementation of argininosuccinate lyase (argH) mutations. J Mol Biol (1978) 3.91
On the probability of ring closure of lambda DNA. J Mol Biol (1966) 3.82
The inducible lac operator-repressor system is functional in mammalian cells. Cell (1987) 3.80
Thermodynamic and kinetic studies on the interconversion between the linear and circular forms of phage lambda DNA. J Mol Biol (1966) 3.76
Improved methods for the formation and stabilization of R-loops. Nucleic Acids Res (1979) 3.73
Drosophila has one myosin heavy-chain gene with three developmentally regulated transcripts. Cell (1983) 3.69
Topotecan versus paclitaxel for the treatment of recurrent epithelial ovarian cancer. J Clin Oncol (1997) 3.61
Expression of the mitochondrial genome in HeLa cells. VI. Size determination of mitochondrial ribosomal RNA by electron microscopy. J Mol Biol (1971) 3.57
Transcriptional activation of the Cdk inhibitor p21 by vitamin D3 leads to the induced differentiation of the myelomonocytic cell line U937. Genes Dev (1996) 3.49
A rat brain Na+ channel alpha subunit with novel gating properties. Neuron (1988) 3.48
Cuticle protein genes of Drosophila: structure, organization and evolution of four clustered genes. Cell (1982) 3.48
Interleukin-10 is a central regulator of the response to LPS in murine models of endotoxic shock and the Shwartzman reaction but not endotoxin tolerance. J Clin Invest (1995) 3.43
Electron-microscopic visualization of deletion mutations. Proc Natl Acad Sci U S A (1968) 3.35
Sequence arrangement of the rDNA of Drosophila melanogaster. Cell (1977) 3.35
Viruses as precipitants of asthmatic attacks in children. JAMA (1974) 3.30
Intercellular Communication: Renal, Urinary Bladder, Sensory, and Salivary Gland Cells. Science (1965) 3.28
The inward rectifier potassium channel family. Curr Opin Neurobiol (1995) 3.23
RD-114, baboon, and woolly monkey viral RNA's compared in size and structure. Cell (1976) 3.20
Immunoglobulin heavy chain gene organization in mice: analysis of a myeloma genomic clone containing variable and alpha constant regions. Proc Natl Acad Sci U S A (1979) 3.19
Hierarchical assembly of cell-matrix adhesion complexes. Biochem Soc Trans (2004) 3.15
Microtubule-motor activity of a yeast centromere-binding protein complex. Nature (1992) 3.11
Steady states, charge movements, and rates for a cloned GABA transporter expressed in Xenopus oocytes. Neuron (1993) 3.10
Cloning and expression of a rat brain GABA transporter. Science (1990) 3.08
An electron microscope study of Sindbis virus RNA. Cold Spring Harb Symp Quant Biol (1974) 2.99
Overlap hybridization screening: isolation and characterization of overlapping DNA fragments surrounding the leu2 gene on yeast chromosome III. Gene (1979) 2.97
A heteroduplex study of the sequence relationships between the RNAs of M-MSV and M-MLV. Cell (1977) 2.96
High-molecular-weight RNAs of AKR, NZB, and wild mouse viruses and avian reticuloendotheliosis virus all have similar dimer structures. J Virol (1978) 2.96
A new method of in situ hybridization. Chromosoma (1975) 2.94
Correlates of certification in family medicine in the billing patterns of Ontario general practitioners. CMAJ (1989) 2.91
The structure and function of yeast centromeres. Annu Rev Genet (1985) 2.84
Analysis of centromeric DNA in the fission yeast Schizosaccharomyces pombe. Proc Natl Acad Sci U S A (1986) 2.82
Electron microscope heteroduplex study of sequence relations of T2, T4, and T6 bacteriophage DNAs. Virology (1974) 2.82
Phase III, multicenter, double-blind, randomized study of letrozole, an aromatase inhibitor, for advanced breast cancer versus megestrol acetate. J Clin Oncol (2001) 2.81
Heteroduplex analysis of the sequence relations between the RNAs of mink cell focus-inducing and murine leukemia viruses. J Virol (1978) 2.79
Retention of women enrolled in a prospective study of human immunodeficiency virus infection: impact of race, unstable housing, and use of human immunodeficiency virus therapy. Am J Epidemiol (2001) 2.77
Sequence variation in dispersed repetitive sequences in Saccharomyces cerevisiae. J Mol Biol (1981) 2.76
Genomic substitutions of centromeres in Saccharomyces cerevisiae. Nature (1983) 2.76
Isolation and characterization of the yeast 3-phosphoglycerokinase gene (PGK) by an immunological screening technique. J Biol Chem (1980) 2.75
Delta sequences and double symmetry in a yeast chromosomal replicator region. J Mol Biol (1982) 2.73
Replication in Saccharomyces cerevisiae of plasmid pBR313 carrying DNA from the yeast trpl region. Gene (1979) 2.73
Isolation and characterization of a gene (CBF2) specifying a protein component of the budding yeast kinetochore. J Cell Biol (1993) 2.72
Electron microscope heteroduplex study of the heterogeneity of Mu phage and prophage DNA. Virology (1974) 2.72
Frameshift suppression: a nucleotide addition in the anticodon of a glycine transfer RNA. Nat New Biol (1973) 2.67
Structure, subunit composition, and molecular weight of RD-114 RNA. J Virol (1975) 2.66
Selective dissociation of histones from calf thymus nucleoprotein. J Mol Biol (1967) 2.65
Efficacy of zoledronic acid in postmenopausal women with early breast cancer receiving adjuvant letrozole: 36-month results of the ZO-FAST Study. Ann Oncol (2010) 2.64
Electron microscopic heteroduplex studies of sequence relations among plasmids of Escherichia coli: structure of F13 and related F-primes. J Bacteriol (1975) 2.60
Point mutations in yeast CBF5 can abolish in vivo pseudouridylation of rRNA. Mol Cell Biol (1999) 2.59
Heteroduplex analysis of avian RNA tumor viruses. Proc Natl Acad Sci U S A (1977) 2.59
The use of SI units in reporting results obtained in hospital laboratories. J Clin Pathol (1974) 2.55
Population health and health care use: an information system for policy makers. Milbank Q (1996) 2.54
Differential methylation of hypoxanthine phosphoribosyltransferase genes on active and inactive human X chromosomes. Proc Natl Acad Sci U S A (1984) 2.52
Heteroduplex structures of bacteriophage Mu DNA. Virology (1973) 2.52
Identification of the class I genes of the mouse major histocompatibility complex by DNA-mediated gene transfer. Nature (1982) 2.48
Direct selection procedure for the isolation of functional centromeric DNA. Proc Natl Acad Sci U S A (1981) 2.45
Mutational analysis of meiotic and mitotic centromere function in Saccharomyces cerevisiae. Genetics (1987) 2.43
RGS proteins reconstitute the rapid gating kinetics of gbetagamma-activated inwardly rectifying K+ channels. Proc Natl Acad Sci U S A (1997) 2.43
An essential yeast protein, CBF5p, binds in vitro to centromeres and microtubules. Mol Cell Biol (1993) 2.43
Isolation and subcloning analysis of functional centromere DNA (CEN11) from Saccharomyces cerevisiae chromosome XI. Mol Cell Biol (1982) 2.43
Sensitivity and specificity of QTc dispersion for identification of risk of cardiac death in patients with peripheral vascular disease. BMJ (1996) 2.43
Effect of DNA length on the free energy of binding of an unwinding ligand to a supercoiled DNA. J Mol Biol (1972) 2.40
Toxic effects of excess cloned centromeres. Mol Cell Biol (1986) 2.40
Mutational and in vitro protein-binding studies on centromere DNA from Saccharomyces cerevisiae. Mol Cell Biol (1987) 2.40
Role of plasmid-coded RNA and ribonuclease III in plasmid DNA replication. Cell (1979) 2.39