Published in Biochemistry on October 08, 1974
Action of nicking-closing enzyme on supercoiled and nonsupercoiled closed circular DNA: formation of a Boltzmann distribution of topological isomers. Proc Natl Acad Sci U S A (1975) 6.26
Characterization of purified DNA-relaxing enzyme from human tissue culture cells. Proc Natl Acad Sci U S A (1975) 4.39
Supercoiling energy and nucleosome formation: the role of the arginine-rich histone kernel. Nucleic Acids Res (1977) 2.94
A DNA nicking-closing enzyme encapsidated in vaccinia virus: partial purification and properties. Proc Natl Acad Sci U S A (1977) 2.10
Evidence for an intermediate with a single-strand break in the reaction catalyzed by the DNA untwisting enzyme. Proc Natl Acad Sci U S A (1976) 1.89
Localization of specific topoisomerase I interactions within the transcribed region of active heat shock genes by using the inhibitor camptothecin. Mol Cell Biol (1987) 1.71
Expression of yeast DNA topoisomerase I can complement a conditional-lethal DNA topoisomerase I mutation in Escherichia coli. Proc Natl Acad Sci U S A (1987) 1.41
DNA-relaxing activity and endonuclease activity in Xenopus laevis oocytes. Proc Natl Acad Sci U S A (1976) 1.11
Purification and characterization of Xenopus laevis topoisomerase II. EMBO J (1983) 1.07
Drosophila topoisomerase I: isolation, purification and characterization. Nucleic Acids Res (1982) 1.05
Interaction of the DNA untwisting enzyme with the SV40 nucleoprotein complex. Nucleic Acids Res (1978) 1.03
Regulation of the function of eukaryotic DNA topoisomerase I: topological conditions for inactivity. Proc Natl Acad Sci U S A (1989) 1.00
Purification of a DNA nicking-closing enzyme from mouse L cells. Nucleic Acids Res (1978) 0.98
Variation in DNA swivel enzyme activity during the mammalian cell cycle. Nucleic Acids Res (1976) 0.89
Isolation and characterization of a gene encoding DNA topoisomerase I in Drosophila melanogaster. Nucleic Acids Res (1992) 0.89
DNA-relaxing enzyme from Micrococcus luteus. Nucleic Acids Res (1977) 0.83
DNA swivel enzyme activity in a nuclear membrane fraction. Nucleic Acids Res (1977) 0.82
The androgenic regulation of superhelical-DNA nicking-closing enzyme in rat ventral prostate. Biochem J (1981) 0.78
Postreplication repair in mammalian cells after ultraviolet irradiation: a model. Biophys J (1978) 0.75
Supercoiling of the DNA template during transcription. Proc Natl Acad Sci U S A (1987) 14.25
DNA topoisomerases. Annu Rev Biochem (1985) 13.01
Interaction between DNA and an Escherichia coli protein omega. J Mol Biol (1971) 11.03
Conformational fluctuations of DNA helix. Proc Natl Acad Sci U S A (1975) 8.72
Response of a protein structure to cavity-creating mutations and its relation to the hydrophobic effect. Science (1992) 6.51
DNA topoisomerase II is required at the time of mitosis in yeast. Cell (1985) 6.08
Helical repeat of DNA in solution. Proc Natl Acad Sci U S A (1979) 5.90
Transcription generates positively and negatively supercoiled domains in the template. Cell (1988) 5.73
Mutations in the gene coding for Escherichia coli DNA topoisomerase I affect transcription and transposition. Proc Natl Acad Sci U S A (1981) 5.60
The degree of unwinding of the DNA helix by ethidium. I. Titration of twisted PM2 DNA molecules in alkaline cesium chloride density gradients. J Mol Biol (1974) 5.44
Sequence dependence of the helical repeat of DNA in solution. Nature (1981) 5.21
Beta-catenin, a novel prognostic marker for breast cancer: its roles in cyclin D1 expression and cancer progression. Proc Natl Acad Sci U S A (2000) 4.71
Mapping the active site tyrosine of Escherichia coli DNA gyrase. J Biol Chem (1987) 4.68
Cloning and sequencing of the Escherichia coli gyrA gene coding for the A subunit of DNA gyrase. J Mol Biol (1987) 4.66
Structure and mechanism of DNA topoisomerase II. Nature (1996) 4.56
Micrococcus luteus DNA gyrase: active components and a model for its supercoiling of DNA. Proc Natl Acad Sci U S A (1978) 4.54
Variation of the average rotation angle of the DNA helix and the superhelical turns of covalently closed cyclic lambda DNA. J Mol Biol (1969) 4.48
Interactions between twisted DNAs and enzymes: the effects of superhelical turns. J Mol Biol (1974) 4.43
Identification of primitive human hematopoietic cells capable of repopulating NOD/SCID mouse bone marrow: implications for gene therapy. Nat Med (1996) 4.42
Flipping of cloned d(pCpG)n.d(pCpG)n DNA sequences from right- to left-handed helical structure by salt, Co(III), or negative supercoiling. Proc Natl Acad Sci U S A (1982) 4.35
Thermodynamic properties of superhelical DNAs. Biochemistry (1975) 4.20
Torsional rigidity of DNA and length dependence of the free energy of DNA supercoiling. J Mol Biol (1984) 4.03
Purification of primitive human hematopoietic cells capable of repopulating immune-deficient mice. Proc Natl Acad Sci U S A (1997) 3.84
On the probability of ring closure of lambda DNA. J Mol Biol (1966) 3.82
Negatively supercoiled plasmids contain left-handed Z-DNA segments as detected by specific antibody binding. Cell (1982) 3.80
Thermodynamic and kinetic studies on the interconversion between the linear and circular forms of phage lambda DNA. J Mol Biol (1966) 3.76
Energetics of B-to-Z transition in DNA. Proc Natl Acad Sci U S A (1983) 3.66
A relationship between protein stability and protein function. Proc Natl Acad Sci U S A (1995) 3.44
Interaction between DNA and Escherichia coli protein omega. Formation of a complex between single-stranded DNA and omega protein. J Biol Chem (1978) 3.35
Covalent bonds between protein and DNA. Formation of phosphotyrosine linkage between certain DNA topoisomerases and DNA. J Biol Chem (1980) 3.31
DNA supercoiling and its effects on DNA structure and function. Cold Spring Harb Symp Quant Biol (1983) 3.29
DNA topoisomerase-targeting antitumor drugs can be studied in yeast. Proc Natl Acad Sci U S A (1988) 3.10
Yeast DNA topoisomerase II is encoded by a single-copy, essential gene. Cell (1984) 2.80
Angular alteration of the DNA helix by E. coli RNA polymerase. Nat New Biol (1972) 2.75
Supercoiling of intracellular DNA can occur in eukaryotic cells. Cell (1988) 2.69
Cruciform formation in a negatively supercoiled DNA may be kinetically forbidden under physiological conditions. Cell (1983) 2.69
Drosophila DNA topoisomerase I is associated with transcriptionally active regions of the genome. Proc Natl Acad Sci U S A (1984) 2.69
Binding specificity determines polarity of DNA unwinding by the Sgs1 protein of S. cerevisiae. J Mol Biol (1999) 2.66
Recent studies of DNA topoisomerases. Biochim Biophys Acta (1987) 2.65
Topoisomerase I interacts with transcribed regions in Drosophila cells. Cell (1986) 2.65
DNA-DNA gyrase complex: the wrapping of the DNA duplex outside the enzyme. Cell (1978) 2.60
Deoxyribonucleic acid gyrase-deoxyribonucleic acid complex containing 140 base pairs of deoxyribonucleic acid and an alpha 2 beta 2 protein core. Biochemistry (1980) 2.59
On the sequence determinants and flexibility of the kinetoplast DNA fragment with abnormal gel electrophoretic mobilities. J Mol Biol (1985) 2.57
Similar hydrophobic replacements of Leu99 and Phe153 within the core of T4 lysozyme have different structural and thermodynamic consequences. J Mol Biol (1993) 2.50
Three-dimensional structure of the 67K N-terminal fragment of E. coli DNA topoisomerase I. Nature (1994) 2.48
The capture of a DNA double helix by an ATP-dependent protein clamp: a key step in DNA transport by type II DNA topoisomerases. Cell (1992) 2.48
Knotting of a DNA chain during ring closure. Science (1993) 2.45
Use of light for footprinting DNA in vivo. Nature (1984) 2.42
Bacterial DNA topoisomerase I can relax positively supercoiled DNA containing a single-stranded loop. J Mol Biol (1985) 2.42
Mapping of single-stranded regions in duplex DNA at the sequence level: single-strand-specific cytosine methylation in RNA polymerase-promoter complexes. Proc Natl Acad Sci U S A (1983) 2.41
A subthreshold level of DNA topoisomerases leads to the excision of yeast rDNA as extrachromosomal rings. Cell (1989) 2.37
Mapping the topography of DNA wrapped around gyrase by nucleolytic and chemical probing of complexes of unique DNA sequences. Cell (1981) 2.36
Inducible overexpression, purification, and active site mapping of DNA topoisomerase II from the yeast Saccharomyces cerevisiae. J Biol Chem (1989) 2.33
Structural and thermodynamic consequences of burying a charged residue within the hydrophobic core of T4 lysozyme. Biochemistry (1991) 2.31
Involvement of DNA topoisomerase I in transcription of human ribosomal RNA genes. Proc Natl Acad Sci U S A (1988) 2.29
Cloning and sequencing of cDNA encoding human DNA topoisomerase II and localization of the gene to chromosome region 17q21-22. Proc Natl Acad Sci U S A (1988) 2.26
On the degree of unwinding of the DNA helix by ethidium. II. Studies by electron microscopy. Biochim Biophys Acta (1975) 2.25
Solid-state synthesis and mechanical unfolding of polymers of T4 lysozyme. Proc Natl Acad Sci U S A (2000) 2.25
Cloning of yeast TOP1, the gene encoding DNA topoisomerase I, and construction of mutants defective in both DNA topoisomerase I and DNA topoisomerase II. Proc Natl Acad Sci U S A (1985) 2.21
Purification and characterization of the Sgs1 DNA helicase activity of Saccharomyces cerevisiae. J Biol Chem (1998) 2.20
Nonhistone proteins HMG1 and HMG2 change the DNA helical structure. Science (1978) 2.20
Interaction between yeast sgs1 helicase and DNA topoisomerase III. J Biol Chem (2000) 2.19
DNA topoisomerase IIbeta and neural development. Science (2000) 2.14
Effect of circularity and superhelicity on transcription from bacteriophagelambda DNA. Proc Natl Acad Sci U S A (1973) 2.13
A cavity-containing mutant of T4 lysozyme is stabilized by buried benzene. Nature (1992) 2.10
Yeast DNA topoisomerase II. An ATP-dependent type II topoisomerase that catalyzes the catenation, decatenation, unknotting, and relaxation of double-stranded DNA rings. J Biol Chem (1982) 2.09
Role of Bacillus subtilis SpoIIIE in DNA transport across the mother cell-prespore division septum. Science (2000) 2.08
Degree of superhelicity of covalently closed cyclic DNA's from Escherichia coli. J Mol Biol (1969) 2.08
Physiochemical studies on interactions between DNA and RNA polymerase. Unwinding of the DNA helix by Escherichia coli RNA polymerase. Nucleic Acids Res (1977) 2.07
Knotted single-stranded DNA rings: a novel topological isomer of circular single-stranded DNA formed by treatment with Escherichia coli omega protein. J Mol Biol (1976) 2.05
ADH1B is associated with alcohol dependence and alcohol consumption in populations of European and African ancestry. Mol Psychiatry (2011) 2.05
DNA transport by a type II DNA topoisomerase: evidence in favor of a two-gate mechanism. Cell (1994) 2.04
Quantitative analysis reveals expansion of human hematopoietic repopulating cells after short-term ex vivo culture. J Exp Med (1997) 2.03
The response of T4 lysozyme to large-to-small substitutions within the core and its relation to the hydrophobic effect. Protein Sci (1998) 2.02
Transcriptional block caused by a negative supercoiling induced structural change in an alternating CG sequence. Cell (1985) 2.00
Measurements of unwinding of lac operator by repressor. Nature (1974) 1.98
Identification of the yeast TOP3 gene product as a single strand-specific DNA topoisomerase. J Biol Chem (1992) 1.97
Determination of alpha-helix propensity within the context of a folded protein. Sites 44 and 131 in bacteriophage T4 lysozyme. J Mol Biol (1994) 1.95
Characterization of four novel epithelial ovarian cancer cell lines. In Vitro Cell Dev Biol Anim (2000) 1.91
Antitumor bisdioxopiperazines inhibit yeast DNA topoisomerase II by trapping the enzyme in the form of a closed protein clamp. Proc Natl Acad Sci U S A (1994) 1.84
Low lipid concentrations in critical illness: implications for preventing and treating endotoxemia. Crit Care Med (1996) 1.82
Intracellular S-adenosylhomocysteine concentrations predict global DNA hypomethylation in tissues of methyl-deficient cystathionine beta-synthase heterozygous mice. J Nutr (2001) 1.79
DNA transport by a type II topoisomerase: direct evidence for a two-gate mechanism. Proc Natl Acad Sci U S A (1996) 1.77
Low-temperature unfolding of a mutant of phage T4 lysozyme. 2. Kinetic investigations. Biochemistry (1989) 1.76
Mammalian DNA topoisomerase IIIalpha is essential in early embryogenesis. Proc Natl Acad Sci U S A (1998) 1.76
Complete nucleotide sequence of the topA gene encoding Escherichia coli DNA topoisomerase I. J Mol Biol (1986) 1.76
Energetic origins of specificity of ligand binding in an interior nonpolar cavity of T4 lysozyme. Biochemistry (1995) 1.75
Assay of human stem cells by repopulation of NOD/SCID mice. Stem Cells (1997) 1.74
Expression of human DNA topoisomerase I in yeast cells lacking yeast DNA topoisomerase I: restoration of sensitivity of the cells to the antitumor drug camptothecin. Cancer Res (1989) 1.73
Design and structural analysis of alternative hydrophobic core packing arrangements in bacteriophage T4 lysozyme. J Mol Biol (1992) 1.73
THE MEASUREMENT OF THE IODINE-ACCUMULATING FUNCTION OF THE HUMAN THYROID GLAND. J Clin Invest (1949) 1.72
The purification and characterization of DNA topoisomerases I and II of the yeast Saccharomyces cerevisiae. J Biol Chem (1984) 1.72
Hepatic nuclear factor 3- and hormone-regulated expression of the phosphoenolpyruvate carboxykinase and insulin-like growth factor-binding protein 1 genes. Mol Cell Biol (1995) 1.70
Enhancement of protein stability by the combination of point mutations in T4 lysozyme is additive. Protein Eng (1995) 1.68
Circular dichroism and DNA secondary structure. Nucleic Acids Res (1979) 1.67
Function of DNA topoisomerases as replication swivels in Saccharomyces cerevisiae. J Mol Biol (1989) 1.65
SopB protein-mediated silencing of genes linked to the sopC locus of Escherichia coli F plasmid. Proc Natl Acad Sci U S A (1995) 1.64
Search for supersymmetry using final states with one lepton, jets, and missing transverse momentum with the ATLAS detector in √s=7 TeV pp collisions. Phys Rev Lett (2011) 1.60
Knotted DNA from bacteriophage capsids. Proc Natl Acad Sci U S A (1981) 1.59