Published in J Clin Invest on July 01, 1979
Detection of an unusually stable fibrinolytic inhibitor produced by bovine endothelial cells. Proc Natl Acad Sci U S A (1983) 2.20
Cultured bovine endothelial cells produce both urokinase and tissue-type plasminogen activators. J Cell Biol (1982) 1.77
Natural anticoagulant mechanisms. J Clin Invest (1984) 1.75
Thrombin induction of plasminogen activator-inhibitor in cultured human endothelial cells. J Clin Invest (1986) 1.60
Detection and partial characterization of an inhibitor of plasminogen activator in human platelets. J Clin Invest (1984) 1.50
Alpha-thrombin induces release of platelet-derived growth factor-like molecule(s) by cultured human endothelial cells. J Cell Biol (1986) 1.29
Activated protein C stimulates the fibrinolytic activity of cultured endothelial cells and decreases antiactivator activity. Proc Natl Acad Sci U S A (1985) 1.27
Thrombin stimulates tissue plasminogen activator release from cultured human endothelial cells. J Clin Invest (1984) 1.21
Binding of thrombin to subendothelial extracellular matrix. Protection and expression of functional properties. J Clin Invest (1989) 1.06
Differing polarity of the constitutive and regulated secretory pathways for von Willebrand factor in endothelial cells. J Cell Biol (1989) 1.00
Human tissue-type plasminogen activator releases fibrinopeptides A and B from fibrinogen. J Clin Invest (1988) 0.91
Interaction of plasmin with endothelial cells. Biochem J (1984) 0.91
Effect of cell density on thrombin binding to a specific site on bovine vascular endothelial cells. J Cell Biol (1981) 0.83
Bradykinin and thrombin effects on polyphosphoinositide hydrolysis and prostacyclin production in endothelial cells. Biochem J (1989) 0.81
A rapid and sensitive method for the quantitation of microgram quantities of protein utilizing the principle of protein-dye binding. Anal Biochem (1976) 903.81
Plasminogen: purification from human plasma by affinity chromatography. Science (1970) 11.72
Stimulation of endothelial cell prostacyclin production by thrombin, trypsin, and the ionophore A 23187. J Clin Invest (1978) 4.35
Culture of arterial endothelial cells: characterization and growth of bovine aortic cells. Thromb Diath Haemorrh (1975) 3.68
Mitogenic activity of blood components. I. Thrombin and prothrombin. Proc Natl Acad Sci U S A (1975) 3.20
Synthesis of a fibrinolytic activator and inhibitor by endothelial cells. Proc Natl Acad Sci U S A (1977) 2.83
The role of serine proteases in the blood coagulation cascade. Adv Enzymol Relat Areas Mol Biol (1979) 2.21
The selectivity of the thrombin-induced platelet release reaction: subcellular localization of released and retained constituents. J Lab Clin Med (1970) 2.13
Control of proliferation of human vascular endothelial cells. Characterization of the response of human umbilical vein endothelial cells to fibroblast growth factor, epidermal growth factor, and thrombin. J Cell Biol (1978) 2.06
Stimulation of growth and calcium influx in cultured, bovine, aortic endothelial cells by platelets and vasoactive substances. J Cell Physiol (1977) 1.50
Thrombin stimulates the production and release of a major surface-associated glycoprotein (fibronectin) in cultures of human fibroblasts. Exp Cell Res (1978) 1.31
Cell surface action of thrombin is sufficient to initiate division of chick cells. Cell (1978) 1.25
An assay for transforming growth factor-beta using cells transfected with a plasminogen activator inhibitor-1 promoter-luciferase construct. Anal Biochem (1994) 6.31
Bacterial lipopolysaccharide and inflammatory mediators augment IL-6 secretion by human endothelial cells. J Immunol (1989) 3.01
Synthesis of a fibrinolytic activator and inhibitor by endothelial cells. Proc Natl Acad Sci U S A (1977) 2.83
Identification of regulatory sequences in the type 1 plasminogen activator inhibitor gene responsive to transforming growth factor beta. J Biol Chem (1991) 2.52
Endothelial cells produce a latent inhibitor of plasminogen activators that can be activated by denaturants. J Biol Chem (1985) 2.23
Purification of an inhibitor of plasminogen activator (antiactivator) synthesized by endothelial cells. J Biol Chem (1984) 2.22
Is plasminogen activator inhibitor-1 the molecular switch that governs urokinase receptor-mediated cell adhesion and release? J Cell Biol (1996) 2.21
Detection of an unusually stable fibrinolytic inhibitor produced by bovine endothelial cells. Proc Natl Acad Sci U S A (1983) 2.20
Cytokine activation of vascular endothelium. Effects on tissue-type plasminogen activator and type 1 plasminogen activator inhibitor. J Biol Chem (1988) 2.04
Regulation of mRNAs for type-1 plasminogen activator inhibitor, fibronectin, and type I procollagen by transforming growth factor-beta. Divergent responses in lung fibroblasts and carcinoma cells. J Biol Chem (1988) 1.93
Regulation of type 1 plasminogen activator inhibitor gene expression in cultured bovine aortic endothelial cells. Induction by transforming growth factor-beta, lipopolysaccharide, and tumor necrosis factor-alpha. J Biol Chem (1989) 1.92
Elevated expression of transforming growth factor-beta in adipose tissue from obese mice. Mol Med (1997) 1.92
Regulation of the fibrinolytic system of cultured human vascular endothelium by interleukin 1. J Clin Invest (1986) 1.89
Cloning and sequence of a cDNA coding for the human beta-migrating endothelial-cell-type plasminogen activator inhibitor. Proc Natl Acad Sci U S A (1986) 1.85
Regulation of murine type 1 plasminogen activator inhibitor gene expression in vivo. Tissue specificity and induction by lipopolysaccharide, tumor necrosis factor-alpha, and transforming growth factor-beta. J Clin Invest (1991) 1.85
Cultured bovine endothelial cells produce both urokinase and tissue-type plasminogen activators. J Cell Biol (1982) 1.77
Increased type 1 plasminogen activator inhibitor gene expression in atherosclerotic human arteries. Proc Natl Acad Sci U S A (1992) 1.76
Distribution and regulation of plasminogen activator inhibitor-1 in murine adipose tissue in vivo. Induction by tumor necrosis factor-alpha and lipopolysaccharide. J Clin Invest (1996) 1.65
Type 1 plasminogen activator inhibitor gene: functional analysis and glucocorticoid regulation of its promoter. Proc Natl Acad Sci U S A (1988) 1.64
Reverse fibrin autography: a method to detect and partially characterize protease inhibitors after sodium dodecyl sulfate--polyacrylamide gel electrophoresis. Anal Biochem (1984) 1.59
Activation of rabbit Hageman factor by homogenates of cultured rabbit endothelial cells. J Clin Invest (1980) 1.53
Cellular localization of type 1 plasminogen activator inhibitor messenger RNA and protein in murine renal tissue. Am J Pathol (1993) 1.52
Changes in procoagulant and fibrinolytic gene expression during bleomycin-induced lung injury in the mouse. J Clin Invest (1995) 1.52
Detection and partial characterization of an inhibitor of plasminogen activator in human platelets. J Clin Invest (1984) 1.50
Type 1 plasminogen activator inhibitor. Prog Hemost Thromb (1989) 1.49
Murine CD14 gene expression in vivo: extramyeloid synthesis and regulation by lipopolysaccharide. J Exp Med (1995) 1.46
The primary plasminogen-activator inhibitors in endothelial cells, platelets, serum, and plasma are immunologically related. Proc Natl Acad Sci U S A (1985) 1.46
Murine tissue factor gene expression in vivo. Tissue and cell specificity and regulation by lipopolysaccharide. Am J Pathol (1993) 1.45
Tissue factor gene expression in the adipose tissues of obese mice. Proc Natl Acad Sci U S A (1998) 1.44
Leptin-dependent platelet aggregation and arterial thrombosis suggests a mechanism for atherothrombotic disease in obesity. J Clin Invest (2001) 1.41
Plasminogen activator inhibitor-1 and its cofactor vitronectin stabilize arterial thrombi after vascular injury in mice. Circulation (2001) 1.39
Structural and functional analysis of the plasminogen activator inhibitor-1 binding motif in the somatomedin B domain of vitronectin. J Biol Chem (1996) 1.31
Fibrin deposition in tissues from endotoxin-treated mice correlates with decreases in the expression of urokinase-type but not tissue-type plasminogen activator. J Clin Invest (1996) 1.29
Tissue distribution and regulation of murine von Willebrand factor gene expression in vivo. Blood (1998) 1.29
Distinct antithrombotic consequences of platelet glycoprotein Ibalpha and VI deficiency in a mouse model of arterial thrombosis. J Thromb Haemost (2006) 1.28
Activated protein C stimulates the fibrinolytic activity of cultured endothelial cells and decreases antiactivator activity. Proc Natl Acad Sci U S A (1985) 1.27
Human melanoma cells derived from lymphatic metastases use integrin alpha v beta 3 to adhere to lymph node vitronectin. J Clin Invest (1992) 1.26
The fibrinolytic system of the vascular wall. Clin Haematol (1985) 1.25
Tissue distribution of factor VIII gene expression in vivo--a closer look. Thromb Haemost (2001) 1.24
Plasminogen activator inhibitor-1 regulates cell adhesion by binding to the somatomedin B domain of vitronectin. J Cell Physiol (2001) 1.23
Tumor necrosis factor alpha is a key component in the obesity-linked elevation of plasminogen activator inhibitor 1. Proc Natl Acad Sci U S A (1999) 1.23
Comparative studies of the fibrinolytic activity of cultured vascular cells. Thromb Res (1979) 1.22
Evidence that type 1 plasminogen activator inhibitor binds to the somatomedin B domain of vitronectin. J Biol Chem (1991) 1.21
Coordinated induction of plasminogen activator inhibitor-1 (PAI-1) and inhibition of plasminogen activator gene expression by hypoxia promotes pulmonary vascular fibrin deposition. J Clin Invest (1998) 1.20
Purification of a protein from bovine plasma that binds to type 1 plasminogen activator inhibitor and prevents its interaction with extracellular matrix. Evidence that the protein is vitronectin. J Biol Chem (1989) 1.20
Extracellular matrix of cultured bovine aortic endothelial cells contains functionally active type 1 plasminogen activator inhibitor. Blood (1987) 1.20
Tissue factor expression during human and mouse development. Am J Pathol (1996) 1.19
The somatomedin B domain of vitronectin. Structural requirements for the binding and stabilization of active type 1 plasminogen activator inhibitor. J Biol Chem (1994) 1.18
Mechanism of protein C-dependent clot lysis: role of plasminogen activator inhibitor. Blood (1986) 1.15
Human endothelial cells produce IL-6. Lack of responses to exogenous IL-6. Ann N Y Acad Sci (1989) 1.12
Replication of dengue and junin viruses in cultured rabbit and human endothelial cells. Infect Immun (1978) 1.12
Gene expression during the development of Bacillus subtilis bacteriophage phi29. II. Resolution of viral-specific ribonucleic acid molecules. J Virol (1973) 1.12
Serum-mediated suppression of cell-associated plasminogen activator activity in cultured endothelial cells. Cell (1980) 1.11
Tissue distribution and regulation of plasminogen activator inhibitor-1 in obese mice. Mol Med (1996) 1.10
Immunoradiometric assay to measure the binding of a specific inhibitor to tissue-type plasminogen activator. J Lab Clin Med (1985) 1.09
Detection of vitronectin mRNA in tissues and cells of the mouse. Proc Natl Acad Sci U S A (1991) 1.09
Insulin continues to induce plasminogen activator inhibitor 1 gene expression in insulin-resistant mice and adipocytes. Mol Med (2000) 1.08
Kinetic analysis of the interactions between plasminogen activator inhibitor 1 and both urokinase and tissue plasminogen activator. Arch Biochem Biophys (1988) 1.08
Effects of acidified fetal bovine serum on the fibrinolytic activity and growth of cells in culture. J Cell Physiol (1978) 1.06
Inactivation of plasminogen activator inhibitor by oxidants. Biochemistry (1986) 1.04
Astrocytes are the primary source of tissue factor in the murine central nervous system. A role for astrocytes in cerebral hemostasis. J Clin Invest (1993) 1.04
Expression of type 1 plasminogen activator inhibitor in chronic pulmonary thromboemboli. Circulation (1994) 1.04
SPARC induces the expression of type 1 plasminogen activator inhibitor in cultured bovine aortic endothelial cells. J Biol Chem (1991) 1.02
Binding of type 1 plasminogen activator inhibitor to the extracellular matrix of cultured bovine endothelial cells. J Biol Chem (1989) 1.01
An inhibitor of plasminogen activator in rabbit endothelial cells. J Biol Chem (1981) 1.01
Expression of fibrinolytic genes in atherosclerotic abdominal aortic aneurysm wall. A possible mechanism for aneurysm expansion. J Clin Invest (1995) 1.00
Kinetic analysis of the interaction between type 1 plasminogen activator inhibitor and vitronectin and evidence that the bovine inhibitor binds to a thrombin-derived amino-terminal fragment of bovine vitronectin. Biochim Biophys Acta (1991) 1.00
Disruption of the plasminogen activator inhibitor 1 gene reduces the adiposity and improves the metabolic profile of genetically obese and diabetic ob/ob mice. FASEB J (2001) 0.99
Cultured granulosa cells produce two plasminogen activators and an antiactivator, each regulated differently by gonadotropins. Endocrinology (1985) 0.99
Induction of plasminogen activator inhibitor 1 gene expression in murine liver by lipopolysaccharide. Cellular localization and role of endogenous tumor necrosis factor-alpha. Am J Pathol (1997) 0.99
Fibrinolytic system of vascular endothelial cells. Role of plasminogen activator inhibitors. Haemostasis (1988) 0.99
The majority of type 1 plasminogen activator inhibitor associated with cultured human endothelial cells is located under the cells and is accessible to solution-phase tissue-type plasminogen activator. J Cell Biol (1990) 0.98
Characterization of two monoclonal antibodies against human tissue-type plasminogen activator. Thromb Haemost (1985) 0.96
Distribution of vitronectin mRNA during murine development. Dev Dyn (1995) 0.95
Altered expression of plasminogen activator inhibitor type 1 in placentas from pregnant women with preeclampsia and/or intrauterine fetal growth retardation. Blood (1994) 0.94
Dysfunction of glomerular fibrinolysis in experimental antiglomerular basement membrane antibody glomerulonephritis. J Am Soc Nephrol (1993) 0.93
The dexamethasone-induced inhibitor of plasminogen activator in hepatoma cells is antigenically-related to an inhibitor produced by bovine aortic endothelial cells. Thromb Haemost (1986) 0.92
Messenger RNA for plasminogen activator inhibitor. Thromb Res (1986) 0.92
Abnormal expression of type 1 plasminogen activator inhibitor and tissue factor in severe preeclampsia. Thromb Haemost (1998) 0.91
Interactions between type 1 plasminogen activator inhibitor, extracellular matrix and vitronectin. Cell Differ Dev (1990) 0.91
Endotoxin stimulates expression of the murine urokinase receptor gene in vivo. Am J Pathol (1995) 0.91
Role of tumor necrosis factor alpha in induction of murine CD14 gene expression by lipopolysaccharide. Infect Immun (1997) 0.91
Regulation of tissue factor gene expression in obesity. Blood (2001) 0.90
Changes in the plasma levels of type 1 and type 2 plasminogen activator inhibitors in normal pregnancy and in patients with severe preeclampsia. Blood (1989) 0.89
Intracellular plasminogen activator activity in growing and quiescent cells. J Cell Physiol (1978) 0.89
The kidneys of mice with autoimmune disease acquire a hypofibrinolytic/procoagulant state that correlates with the development of glomerulonephritis and tissue microthrombosis. Am J Pathol (1997) 0.89
Serum-derived vitronectin influences the pericellular distribution of type 1 plasminogen activator inhibitor. J Cell Biol (1990) 0.89
The leptin receptor system of human platelets. J Thromb Haemost (2005) 0.88
Expression of transforming growth factor-beta and tumor necrosis factor-alpha in the plasma and tissues of mice with lupus nephritis. Lab Invest (2000) 0.88
Type 1 plasminogen activator inhibitor induces multimerization of plasma vitronectin. A suggested mechanism for the generation of the tissue form of vitronectin in vivo. J Biol Chem (1996) 0.87
Localization of vitronectin in the normal and atherosclerotic human vessel wall. Histochem Cell Biol (1997) 0.87
Interactions between fibrin and the plasminogen activators produced by cultured endothelial cells. Blood (1983) 0.87
Protein C inhibitor is expressed in tubular cells of human kidney. J Clin Invest (1994) 0.86
Extrahepatic expression and regulation of protein C in the mouse. Am J Pathol (1998) 0.86
Fibrinolytic pathways and the endothelium. Semin Thromb Hemost (1987) 0.86
Expression and cellular localization of messenger RNA for plasminogen activator inhibitor type 1 in human astrocytomas in vivo. Cancer Res (1994) 0.85
Vitronectin gene expression in vivo. Evidence for extrahepatic synthesis and acute phase regulation. J Biol Chem (1994) 0.85
The PAI-1/vitronectin interaction: two cats in a bag? Thromb Haemost (1995) 0.85
Platelets stimulate endothelial cells to synthesize type 1 plasminogen activator inhibitor. Evaluation of the role of transforming growth factor beta. Blood (1991) 0.85