Published in J Cell Biol on September 01, 1973
Addition of colchicine--tubulin complex to microtubule ends: the mechanism of substoichiometric colchicine poisoning. Proc Natl Acad Sci U S A (1977) 2.72
Rapid rate of tubulin dissociation from microtubules in the mitotic spindle in vivo measured by blocking polymerization with colchicine. J Cell Biol (1984) 2.42
Blockage of amyloid induction by colchicine in an animal model. J Exp Med (1974) 1.96
The in vitro assembly of flagellar outer doublet tubulin. J Cell Biol (1978) 1.51
Exocytosis in secretory cells of rat lacrimal gland. Peroxidase release from lobules and isolated cells upon cholinergic stimulation. J Cell Biol (1976) 1.50
A quantitative ultrastructural study of microtubule content and secretory granule accumulation in parathyroid glands of phosphate- and colchicine-treated rats. J Clin Invest (1975) 1.35
Promotion of fluorescence upon binding of colchicine to tubulin. Proc Natl Acad Sci U S A (1974) 1.27
Properties of tubulin in unfertilized sea urchin eggs. Quantitation and characterization by the colchicine-binding reaction. J Cell Biol (1976) 1.25
Control of cell volume in the J774 macrophage by microtubule disassembly and cyclic AMP. J Cell Biol (1981) 1.09
Taxol-induced rose microtubule polymerization in vitro and its inhibition by colchicine. J Cell Biol (1984) 1.08
Molecules in mammalian brain that interact with the colchicine site on tubulin. Proc Natl Acad Sci U S A (1979) 0.94
Microtubule assembly and function in Chlamydomonas: inhibition of growth and flagellar regeneration by antitubulins and other drugs and isolation of resistant mutants. J Bacteriol (1974) 0.91
Microtubule protein during ciliogenesis in the mouse oviduct. J Cell Biol (1974) 0.90
Response of microtubules to the addition of colchicine and tubulin-colchicine: evaluation of models for the interaction of drugs with microtubules. Biochem J (1997) 0.87
Fragment based group QSAR and molecular dynamics mechanistic studies on arylthioindole derivatives targeting the α-β interfacial site of human tubulin. BMC Genomics (2014) 0.83
Extrinsic factors regulate partial agonist efficacy of strychnine-sensitive glycine receptors. BMC Pharmacol (2004) 0.78
Insulin release and the microtubular system of the islets of Langerhans. Identification and characterization of tubulin-like protein. Biochem J (1975) 0.78
Podophyllotoxin analogues active versus Trypanosoma brucei. Bioorg Med Chem Lett (2010) 0.77
Characterization of colchicine-binding activity in Dictyostelium discoideum. Biochem J (1978) 0.75
Protein measurement with the Folin phenol reagent. J Biol Chem (1951) 1743.91
Cell motility by labile association of molecules. The nature of mitotic spindle fibers and their role in chromosome movement. J Gen Physiol (1967) 13.71
The colchicine-binding protein of mammalian brain and its relation to microtubules. Biochemistry (1968) 12.96
The mechanism of action of colchicine. Binding of colchincine-3H to cellular protein. J Cell Biol (1967) 9.66
The mechanism of action of colchicine. Colchicine binding to sea urchin eggs and the mitotic apparatus. J Cell Biol (1967) 6.85
Isolation of a protein subunit from microtubules. J Cell Biol (1967) 5.37
Evidence for four classes of microtubules in individual cells. J Cell Sci (1967) 5.29
Properties of colchicine binding protein from chick embryo brain. Interactions with vinca alkaloids and podophyllotoxin. Biochemistry (1970) 4.26
Thermal fractionation of outer fiber doublet microtubules into A- and B-subfiber components. A- and B-tubulin. J Mol Biol (1970) 3.42
Are cytoplasmic microtubules heteropolymers? Proc Natl Acad Sci U S A (1971) 3.38
Cilia regeneration in Tetrahymena and its inhibition by colchicine. J Cell Biol (1969) 2.97
Properties of the protein subunit of central-pair and outer-doublet microtubules of sea urchin flagella. J Cell Biol (1968) 2.91
The biochemical events of mitosis. I. Synthesis and properties of colchicine labeled with tritium in its acetyl moiety. Biochemistry (1966) 2.74
Nucleoside transport in mammalian cells. Inhibition by colchicine. Biochemistry (1972) 2.70
The biochemical events of mitosis. II. The in vivo and in vitro binding of colchicine in grasshopper embryos and its possible relation to inhibition of mitosis. Biochemistry (1967) 2.62
Rat brain microtubule protein: purification and determination of covalently bound phosphate and carbohydrate. Proc Natl Acad Sci U S A (1972) 2.52
Differential effects of antimitotic agents on the stability and behavior of cytoplasmic and ciliary microtubules. Protoplasma (1968) 1.92
Heterogeneity of tubulin subunits. Proc Natl Acad Sci U S A (1971) 1.77
Definition of three classes of binding sites in isolated microtubule crystals. Biochemistry (1972) 1.57
Chemical heterogeneity of protofilaments forming the outer doublets from sea urchin flagella. Exp Cell Res (1972) 1.32
Developmental changes in microtubule protein of chick brain. Biochemistry (1973) 1.10
Opposite end assembly and disassembly of microtubules at steady state in vitro. Cell (1978) 5.16
Mechanism of mitotic block and inhibition of cell proliferation by taxol at low concentrations. Proc Natl Acad Sci U S A (1993) 5.11
Mitotic mechanism based on intrinsic microtubule behaviour. Nature (1978) 4.48
Properties of colchicine binding protein from chick embryo brain. Interactions with vinca alkaloids and podophyllotoxin. Biochemistry (1970) 4.26
Effects of vinblastine, podophyllotoxin and nocodazole on mitotic spindles. Implications for the role of microtubule dynamics in mitosis. J Cell Sci (1992) 4.00
T-cell mediated rejection of gene-modified HIV-specific cytotoxic T lymphocytes in HIV-infected patients. Nat Med (1996) 3.88
Microtubule treadmills--possible molecular machinery. Nature (1981) 3.58
Are cytoplasmic microtubules heteropolymers? Proc Natl Acad Sci U S A (1971) 3.38
Interaction of drugs with microtubule proteins. Fed Proc (1974) 3.14
Mammalian mad2 and bub1/bubR1 recognize distinct spindle-attachment and kinetochore-tension checkpoints. Proc Natl Acad Sci U S A (2001) 3.06
Occluding junctions and cytoskeletal components in a cultured transporting epithelium. J Cell Biol (1980) 3.04
Experimental modulation of occluding junctions in a cultured transporting epithelium. J Cell Biol (1980) 3.00
Mitotic block induced in HeLa cells by low concentrations of paclitaxel (Taxol) results in abnormal mitotic exit and apoptotic cell death. Cancer Res (1996) 3.00
Precipitation of proteins by vinblastine and calcium ions. Proc Natl Acad Sci U S A (1970) 3.00
Mechanism of inhibition of cell proliferation by Vinca alkaloids. Cancer Res (1991) 2.81
Substoichiometric binding of taxol suppresses microtubule dynamics. Biochemistry (1995) 2.79
The POU-specific domain of Pit-1 is essential for sequence-specific, high affinity DNA binding and DNA-dependent Pit-1-Pit-1 interactions. Cell (1990) 2.78
Microtubules and actin filaments: dynamic targets for cancer chemotherapy. Curr Opin Cell Biol (1998) 2.78
The biochemical events of mitosis. I. Synthesis and properties of colchicine labeled with tritium in its acetyl moiety. Biochemistry (1966) 2.74
Addition of colchicine--tubulin complex to microtubule ends: the mechanism of substoichiometric colchicine poisoning. Proc Natl Acad Sci U S A (1977) 2.72
Nucleoside transport in mammalian cells. Inhibition by colchicine. Biochemistry (1972) 2.70
The biochemical events of mitosis. II. The in vivo and in vitro binding of colchicine in grasshopper embryos and its possible relation to inhibition of mitosis. Biochemistry (1967) 2.62
Structural and functional membrane polarity in cultured monolayers of MDCK cells. J Membr Biol (1980) 2.50
Kinetic stabilization of microtubule dynamic instability in vitro by vinblastine. Biochemistry (1993) 2.48
Analysis of clinical decision-making in multi-disciplinary cancer teams. Ann Oncol (2005) 2.31
Microtubule dynamics in vitro are regulated by the tubulin isotype composition. Proc Natl Acad Sci U S A (1994) 2.17
A low pH-inducible, PhoPQ-dependent acid tolerance response protects Salmonella typhimurium against inorganic acid stress. J Bacteriol (1998) 2.15
Mitotic block in HeLa cells by vinblastine: ultrastructural changes in kinetochore-microtubule attachment and in centrosomes. J Cell Sci (1993) 2.10
Inhibition of the transport of several hexoses in mammalian cells by cytochalasin B. J Biol Chem (1972) 2.05
Resistance to Taxol in lung cancer cells associated with increased microtubule dynamics. Proc Natl Acad Sci U S A (2001) 2.00
Clobetasone butyrate, a new topical corticosteroid: clinical activity and effects on pituitary-adrenal axis function and model of epidermal atrophy. Br Med J (1975) 1.87
POU-domain proteins Pit-1 and Oct-1 interact to form a heteromeric complex and can cooperate to induce expression of the prolactin promoter. Genes Dev (1991) 1.84
Effectiveness of physician-based interventions with problem drinkers: a review. CMAJ (1995) 1.83
Functional interactions between the proline-rich and repeat regions of tau enhance microtubule binding and assembly. Mol Biol Cell (1997) 1.81
Cation-selective ion channels formed by p7 of hepatitis C virus are blocked by hexamethylene amiloride. FEBS Lett (2004) 1.79
Occluding junctions in cultured epithelial monolayers. Am J Physiol (1981) 1.76
Modulation of CENP-E organization at kinetochores by spindle microtubule attachment. Cell Motil Cytoskeleton (1996) 1.71
Increase in interleukin (IL)-1 beta and IL-6 in bronchoalveolar lavage fluid obtained from infants with chronic lung disease of prematurity. Pediatr Res (1996) 1.71
Kinesin is associated with a nonmicrotubule component of sea urchin mitotic spindles. Proc Natl Acad Sci U S A (1987) 1.67
Taxol differentially modulates the dynamics of microtubules assembled from unfractionated and purified beta-tubulin isotypes. Biochemistry (1997) 1.66
Vinblastine suppresses dynamics of individual microtubules in living interphase cells. Mol Biol Cell (1995) 1.66
Role of GTP hydrolysis in microtubule polymerization: evidence for a coupled hydrolysis mechanism. Biochemistry (1990) 1.66
A pituitary POU domain protein, Pit-1, activates both growth hormone and prolactin promoters transcriptionally. Genes Dev (1989) 1.62
Uptake and intracellular survival of Bordetella pertussis in human macrophages. Infect Immun (1992) 1.56
Purification and biochemical characterization of tubulin from the budding yeast Saccharomyces cerevisiae. Biochemistry (1993) 1.56
Occluding junctions in MDCK cells: modulation of transepithelial permeability by the cytoskeleton. J Cell Biochem (1982) 1.55
Microtubules as drug receptors: pharmacological properties of microtubule protein. Ann N Y Acad Sci (1975) 1.54
The phosphorylcholine epitope undergoes phase variation on a 43-kilodalton protein in Pseudomonas aeruginosa and on pili of Neisseria meningitidis and Neisseria gonorrhoeae. Infect Immun (1998) 1.53
Structure of the tubulin dimer. J Biol Chem (1977) 1.50
National practice patterns of sentinel lymph node dissection for breast carcinoma. J Am Coll Surg (2001) 1.48
Assisted reproductive therapies and imprinting disorders--a preliminary British survey. Hum Reprod (2005) 1.48
Management of invasive meningococcal disease in children and young people: summary of SIGN guidelines. BMJ (2008) 1.48
C. elegans unc-4 gene encodes a homeodomain protein that determines the pattern of synaptic input to specific motor neurons. Nature (1992) 1.47
Cold-stable microtubules from brain. Biochemistry (1980) 1.46
Three cases of impulse control disorder in Parkinson's disease patients receiving dopamine replacement therapy. Ir Med J (2013) 1.46
A Ca-activated ATPase in the mitotic apparatus of the sea urchin egg (isolated by a new method). Exp Cell Res (1972) 1.45
Kinetic stabilization of microtubule dynamics at steady state by tau and microtubule-binding domains of tau. Biochemistry (1995) 1.43
Characterization of an immuno-dominant variable surface antigen from pathogenic and nonpathogenic Entamoeba histolytica. J Exp Med (1990) 1.42
Autoregulation of pit-1 gene expression mediated by two cis-active promoter elements. Nature (1990) 1.41
Regulation of the microtubule steady state in vitro by ATP. Cell (1979) 1.36
Action of drugs on microtubules. Life Sci (1975) 1.35
Kinetic analysis of tubulin exchange at microtubule ends at low vinblastine concentrations. Biochemistry (1990) 1.35
Human T-cell leukemia virus (HTLV-I) antibodies in Africa. Science (1984) 1.35
Tempol, a stable free radical, is a novel murine radiation protector. Cancer Res (1992) 1.34
Isolation of bovine brain microtubule protein without glycerol: polymerization kinetics change during purification cycles. Anal Biochem (1979) 1.34
Two different monoclonal antibodies to alpha-tubulin inhibit the bending of reactivated sea urchin spermatozoa. Cell Motil (1982) 1.33
Chemical heterogeneity of protofilaments forming the outer doublets from sea urchin flagella. Exp Cell Res (1972) 1.32
Mechanism of inhibition of microtubule polymerization by colchicine: inhibitory potencies of unliganded colchicine and tubulin-colchicine complexes. Biochemistry (1992) 1.30
Genomic and cDNA actin sequences from a virulent strain of Entamoeba histolytica. Proc Natl Acad Sci U S A (1987) 1.30
Use of drugs to study role of microtubule assembly dynamics in living cells. Methods Enzymol (1998) 1.29
Pattern span: a tool for unwelding visuo-spatial memory. Neuropsychologia (1999) 1.29
The clinical evaluation of a new topical corticosteroid, clobetasol propionate. An international controlled trial. Br J Dermatol (1974) 1.28
The coronavirus infectious bronchitis virus nucleoprotein localizes to the nucleolus. J Virol (2001) 1.28
Microtubule-associated proteins (MAPs): a monoclonal antibody to MAP 1 decorates microtubules in vitro but stains stress fibers and not microtubules in vivo. Proc Natl Acad Sci U S A (1985) 1.28
Mitotic HeLa cells contain a CENP-E-associated minus end-directed microtubule motor. EMBO J (1995) 1.27
Properties of tubulin in unfertilized sea urchin eggs. Quantitation and characterization by the colchicine-binding reaction. J Cell Biol (1976) 1.25
Multiplex PCR for detection and typing of porcine circoviruses. J Clin Microbiol (1999) 1.24
A randomized, controlled trial of the influence of prenatal parenting education on postpartum anxiety and marital adjustment. Fam Med (1995) 1.22
A mutation in the RIEG1 gene associated with Peters' anomaly. J Med Genet (1999) 1.22
Taxol stabilization of microtubules in vitro: dynamics of tubulin addition and loss at opposite microtubule ends. Biochemistry (1985) 1.21
A latent activity dynein-like cytoplasmic magnesium adenosine triphosphatase. J Biol Chem (1985) 1.21
Phase dynamics at microtubule ends: the coexistence of microtubule length changes and treadmilling. J Cell Biol (1987) 1.21
Low potency of taxol at microtubule minus ends: implications for its antimitotic and therapeutic mechanism. Cancer Res (1998) 1.20
The use and action of drugs in analyzing mitosis. Methods Cell Biol (1999) 1.17
Mechanism of mitotic block and inhibition of cell proliferation by the semisynthetic Vinca alkaloids vinorelbine and its newer derivative vinflunine. Mol Pharmacol (2001) 1.16
Anxiety and its determinants in patients undergoing magnetic resonance imaging. J Behav Ther Exp Psychiatry (1994) 1.16
Interaction of vinblastine with steady-state microtubules in vitro. J Mol Biol (1982) 1.15
Kinetic stabilization of microtubule dynamics at steady state in vitro by substoichiometric concentrations of tubulin-colchicine complex. Biochemistry (1995) 1.15
Medical screening in the workplace: proposed principles. J Occup Med (1986) 1.15
Sedimentation analysis of novel DNA structures formed by homo-oligonucleotides. Biophys J (2001) 1.14
Maternal behavior, social support, and economic conditions as predictors of distress in children. New Dir Child Dev (1990) 1.13
The relationship between nonorganic signs and centralization of symptoms in the prediction of return to work for patients with low back pain. Phys Ther (1997) 1.12
Isolation of a conserved sequence deleted in Duchenne muscular dystrophy patients. Nucleic Acids Res (1987) 1.12
The effect on plasma corticosteroid levels of the short term topical application of clobetasol propionate. Br J Dermatol (1974) 1.11
Isolation and partial characterization of human platelet vinculin. J Cell Biol (1985) 1.10
Identification of a distinct class of vinblastine binding sites on microtubules. J Mol Biol (1986) 1.10
Developmental changes in microtubule protein of chick brain. Biochemistry (1973) 1.10
Detection of porcine reproductive and respiratory syndrome virus and efficient differentiation between Canadian and European strains by reverse transcription and PCR amplification. J Clin Microbiol (1994) 1.10
Novel mechanism of resistance to paclitaxel (Taxol) in human K562 leukemia cells by combined selection with PSC 833. Oncol Res (1995) 1.09
Mechanism of colchicine-dimer addition to microtubule ends: implications for the microtubule polymerization mechanism. Biochemistry (1980) 1.09