Published in J Cell Biol on August 01, 1967
The mechanism of action of colchicine. Binding of colchincine-3H to cellular protein. J Cell Biol (1967) 9.66
Flagellar elongation and shortening in Chlamydomonas. The use of cycloheximide and colchicine to study the synthesis and assembly of flagellar proteins. J Cell Biol (1969) 8.72
Probing spindle assembly mechanisms with monastrol, a small molecule inhibitor of the mitotic kinesin, Eg5. J Cell Biol (2000) 5.75
Isolation of a protein subunit from microtubules. J Cell Biol (1967) 5.37
Post-translational regulation of the microtubule cytoskeleton: mechanisms and functions. Nat Rev Mol Cell Biol (2011) 3.53
Are cytoplasmic microtubules heteropolymers? Proc Natl Acad Sci U S A (1971) 3.38
Cilia regeneration in Tetrahymena and its inhibition by colchicine. J Cell Biol (1969) 2.97
Properties of the protein subunit of central-pair and outer-doublet microtubules of sea urchin flagella. J Cell Biol (1968) 2.91
Requirement for cell division for initiation of transcription of Rous sarcoma virus RNA. J Virol (1974) 2.86
A functional mitotic spindle prepared from mammalian cells in culture. Proc Natl Acad Sci U S A (1974) 2.64
Colchicine inhibition of plasma protein release from rat hepatocytes. J Cell Biol (1975) 2.56
On the role of microtubules in movement and alignment of nuclei in virus-induced syncytia. J Cell Biol (1968) 2.53
Rapid rate of tubulin dissociation from microtubules in the mitotic spindle in vivo measured by blocking polymerization with colchicine. J Cell Biol (1984) 2.42
Neuronal dynamics and axonal flow. IV. Blockage of intra-axonal enzyme transport by colchicine. Proc Natl Acad Sci U S A (1969) 2.30
The role of microtubules in the movement of pigment granules in teleost melanophores. J Cell Biol (1974) 2.21
Flagellar elongation and shortening in chlamydomonas. II. Re-utilization of flagellar proteins. J Cell Biol (1970) 2.17
Colchicine inhibition of nerve fiber formation in vitro. J Cell Biol (1972) 2.06
Motility of Mycoplasma pneumoniae. J Bacteriol (1977) 2.04
Possible role of microtubules in thyroid secretion. Proc Natl Acad Sci U S A (1970) 2.00
Dissolution of erythrocyte membranes in water and comparison of the membrane protein with other structural proteins. Proc Natl Acad Sci U S A (1968) 1.99
Histamine release from human leukocytes: studies with deuterium oxide, colchicine, and cytochalasin B. J Clin Invest (1972) 1.98
Colcemid inhibition of cell growth and the characterization of a colcemid-binding activity in Saccharomyces cerevisiae. J Cell Biol (1972) 1.89
Aster formation in eggs of Xenopus laevis. Induction by isolated basal bodies. J Cell Biol (1975) 1.73
Drugs that target dynamic microtubules: a new molecular perspective. Med Res Rev (2011) 1.70
Direct biochemical measurements of microtubule assembly and disassembly in Chinese hamster ovary cells. The effect of intercellular contact, cold, D2O, and N6,O2'-dibutyryl cyclic adenosine monophosphate. J Cell Biol (1975) 1.69
The mechanism of action of colchicine. Colchicine binding properties of sea urchin sperm tail outer doublet tubulin. J Cell Biol (1973) 1.68
Effects of colchicine and vinca alkaloids on human platelets. 3. Influence on primary internal contraction and secondary aggregation. Am J Pathol (1969) 1.63
Characterization of the colchicine binding of membrane fractions from rat and mouse liver. J Cell Biol (1974) 1.62
Exocytosis in secretory cells of rat lacrimal gland. Peroxidase release from lobules and isolated cells upon cholinergic stimulation. J Cell Biol (1976) 1.50
Serological similarity of flagellar and mitotic microtubules. J Cell Biol (1971) 1.48
Fine structural changes in neurons and nerve fibers associated with colchicine inhibition of nerve fiber formation in vitro. J Cell Biol (1973) 1.45
Evidence for a role of the microtubular system in the secretion of newly synthesized albumin and other proteins by the liver. J Clin Invest (1974) 1.44
Identification of direct protein targets of small molecules. ACS Chem Biol (2010) 1.44
The movement of optically detectable organelles in myelinated axons of Xenopus laevis. J Physiol (1974) 1.43
Colchicine-binding protein and the secretion of thyroid hormone. J Cell Biol (1972) 1.40
Reversal by light of the action of N-methyl N-desacetyl colchicine on mitosis. J Cell Biol (1970) 1.37
Promotion of fluorescence upon binding of colchicine to tubulin. Proc Natl Acad Sci U S A (1974) 1.27
Properties of tubulin in unfertilized sea urchin eggs. Quantitation and characterization by the colchicine-binding reaction. J Cell Biol (1976) 1.25
Virus replication, cytopathology, and lysosomal enzyme response of mitotic and interphase Hep-2 cells infected with poliovirus. J Virol (1973) 1.19
The melanocyte model. Colchicine-like effects of other antimitotic agents. J Cell Biol (1971) 1.17
Nuclear membrane fusion in fertilized Lytechinus variegatus eggs. J Cell Biol (1973) 1.11
Purification of intact microtubules from brain. J Cell Biol (1970) 1.11
Is cytoskeleton involved in vesicular stomatitis virus reproduction? J Virol (1980) 1.07
Synthesis and some properties of an actin-like nuclear protein in the slime mold Physarum polycephalum. J Bacteriol (1971) 1.06
Organic synthesis toward small-molecule probes and drugs. Proc Natl Acad Sci U S A (2011) 1.02
Microtubule protein synthesis during oogenesis and early embryogenesis in Xenopus laevis. Biochem J (1975) 1.01
Velocity distributions of the streaming protoplasm in Nitella flexilis. Biophys J (1977) 1.00
Immunochemical studies of 22S protein from isolated mitotic apparatus. J Cell Biol (1969) 0.99
Mitotic force generators and chromosome segregation. Cell Mol Life Sci (2010) 0.98
Cell elongation in the cultured embryonic chick lens epithelium with and without protein synthesis. Involvement of microtubules. J Cell Biol (1972) 0.97
Plant-derived anti-inflammatory compounds: hopes and disappointments regarding the translation of preclinical knowledge into clinical progress. Mediators Inflamm (2014) 0.96
Selective extraction of isolated mitotic apparatus. Evidence that typical microtubule protein is extracted by organic mercurial. J Cell Biol (1971) 0.95
Phosphorylation of myosin light chain during capping of mouse T-lymphoma cells. J Cell Biol (1981) 0.95
Antitumor agents. 284. New desmosdumotin B analogues with bicyclic B-ring as cytotoxic and antitubulin agents. J Med Chem (2011) 0.94
Action of vinblastine on the spontaneous release of acetylcholine at the frog neuromuscular junction. J Physiol (1976) 0.93
Sister Chromatid Segregation during Mitosis in Polyploid Wheat. Genetics (1969) 0.89
Relationship between dibutyryl cyclic AMP and microtubule organization in contracting heart muscle cells. Proc Natl Acad Sci U S A (1978) 0.88
Plant microtubule studies: past and present. J Plant Res (2007) 0.86
Independent expression of avian sarcoma virus in doubly infected chicken embryo fibroblasts. J Virol (1981) 0.86
Effective killing of the human pathogen Candida albicans by a specific inhibitor of non-essential mitotic kinesin Kip1p. Mol Microbiol (2007) 0.85
Completion of the first meiotic division after fertilization in Urechis caupo eggs despite inhibition of protein synthesis. J Cell Biol (1968) 0.84
Purification and mass spectrometry identification of microtubule-binding proteins from Xenopus egg extracts. Methods Mol Med (2007) 0.84
Tyrosyltubulin ligase and colchicine binding activity in synchronized Chinese hamster cells. J Cell Biol (1978) 0.83
Chemotactic factor receptor modulation and cytoskeletal structures. Infect Immun (1981) 0.82
Microtubules and axoplasmic transport. Inhibition of transport by podophyllotoxin: an interaction with microtubule protein. J Cell Biol (1975) 0.82
The effects of colchicine on spermatogenesis in Nitella. J Cell Biol (1970) 0.81
Tubulin-dynein system in flagellar and ciliary movement. Proc Jpn Acad Ser B Phys Biol Sci (2012) 0.81
Functional characterization of toposomes from sea urchin blastula embryos by a morphogenetic cell aggregation assay. EMBO J (1986) 0.81
Recalling an aversive experience by day-old chicks is not dependent on somatic protein synthesis. Learn Mem (2005) 0.80
Interaction of Mycobacterium leprae with human airway epithelial cells: adherence, entry, survival, and identification of potential adhesins by surface proteome analysis. Infect Immun (2013) 0.80
Extracellular microtubules. The origin, structure, and attachment of flagellar hairs in Fucus and Ascophyllum antherozoids. J Cell Biol (1969) 0.79
Insulin release and the microtubular system of the islets of Langerhans. Identification and characterization of tubulin-like protein. Biochem J (1975) 0.78
Plant-derived immunomodulators: an insight on their preclinical evaluation and clinical trials. Front Plant Sci (2015) 0.78
Electrophoresis of isolated secretory granules from guinea-pig submaxillary gland. Br J Pharmacol (1974) 0.76
Chemical genetics: reshaping biology through chemistry. HFSP J (2007) 0.75
Microtubules: 50 years on from the discovery of tubulin. Nat Rev Mol Cell Biol (2016) 0.75
Electron microscope studies on puromycin-induced changes in nerve cells of the medulla oblongata. J Cell Biol (1974) 0.75
Some properties of colchicine-binding protein(s) ('microtubule protein') in soluble and particulate preparations of mammalian brain. Biochem J (1972) 0.75
Design, Synthesis and Cytotoxicity Evaluationof New 1,2-diaryl-4, 5, 6, 7-Tetrahydro-1H-benzo[d] Imidazolesas Tubulin Inhibitors. Iran J Pharm Res (2015) 0.75
The small organic compound HMN-176 delays satisfaction of the spindle assembly checkpoint by inhibiting centrosome-dependent microtubule nucleation. Mol Cancer Ther (2009) 0.75
A microtubule dynamics reconstitutional convention. J Cell Biol (2016) 0.75
Anaesthesia and cell division. Ann R Coll Surg Engl (1971) 0.75
Protein measurement with the Folin phenol reagent. J Biol Chem (1951) 1743.91
The mechanism of action of colchicine. Binding of colchincine-3H to cellular protein. J Cell Biol (1967) 9.66
STUDIES ON THE PROTEIN COMPONENTS OF CILIA FROM TETRAHYMENA PYRIFORMIS. Proc Natl Acad Sci U S A (1963) 6.67
Isolation of a protein subunit from microtubules. J Cell Biol (1967) 5.37
THE MECHANISM OF COLCHICINE INHIBITION OF MITOSIS. I. KINETICS OF INHIBITION AND THE BINDING OF H3-COLCHICINE. J Cell Biol (1965) 4.48
Studies on sulfhydryl groups during cell division of sea-urchin eggs. 8. Some properties of mitotic apparatus proteins. Biochim Biophys Acta (1966) 3.37
Adenosine triphosphatase in the mitotic apparatus. Proc Natl Acad Sci U S A (1961) 2.92
Studies on the mitotic apparatus of the sea urchin by means of antigen-antibody reactions in agar. J Biophys Biochem Cytol (1959) 2.39
THE MITOTIC APPARATUS. PHYSICAL-CHEMICAL FACTORS CONTROLLING STABILITY. J Cell Biol (1965) 2.25
The mitotic apparatus. Structural changes after isolation. J Cell Biol (1965) 2.12
The isolation and preliminary characterization of a major soluble protein of the sea urchin egg. Exp Cell Res (1959) 1.98
A crystalline protein of high molecular weight from cytoplasmic granules in sea urchin eggs and embryos. Dev Biol (1965) 1.46
Counteraction of the anti-mitotic effects of D20 in the dividing eggs of Argacia punctulata: a temperature-pressure analysis. Exp Cell Res (1966) 1.46
The colchicine-binding protein of mammalian brain and its relation to microtubules. Biochemistry (1968) 12.96
Mechanism of adenosine triphosphate hydrolysis by actomyosin. Biochemistry (1971) 9.73
The mechanism of action of colchicine. Binding of colchincine-3H to cellular protein. J Cell Biol (1967) 9.66
Arp2/3 complex and actin depolymerizing factor/cofilin in dendritic organization and treadmilling of actin filament array in lamellipodia. J Cell Biol (1999) 8.24
A structural change in the kinesin motor protein that drives motility. Nature (1999) 6.92
Microtubules. Annu Rev Biochem (1973) 6.75
Analysis of the actin-myosin II system in fish epidermal keratocytes: mechanism of cell body translocation. J Cell Biol (1997) 6.67
Association of high-molecular-weight proteins with microtubules and their role in microtubule assembly in vitro. Proc Natl Acad Sci U S A (1975) 6.35
Nucleated assembly of microtubules in porcine brain extracts. Science (1972) 6.22
Head-to-tail polymerization of microtubules in vitro. Electron microscope analysis of seeded assembly. J Cell Biol (1980) 5.64
Isolation of a protein subunit from microtubules. J Cell Biol (1967) 5.37
Purification of tubulin and associated high molecular weight proteins from porcine brain and characterization of microtubule assembly in vitro. Ann N Y Acad Sci (1975) 5.26
Structural polarity and directional growth of microtubules of Chlamydomonas flagella. J Mol Biol (1974) 4.80
Chromosomes move poleward in anaphase along stationary microtubules that coordinately disassemble from their kinetochore ends. J Cell Biol (1987) 4.52
The pericentriolar material in Chinese hamster ovary cells nucleates microtubule formation. J Cell Biol (1977) 4.41
Functional coordination of microtubule-based and actin-based motility in melanophores. Curr Biol (1998) 4.03
Energetics and mechanism of actomyosin adenosine triphosphatase. Biochemistry (1976) 3.97
Self-polarization and directional motility of cytoplasm. Curr Biol (1999) 3.93
Kinetochore microtubule dynamics and the metaphase-anaphase transition. J Cell Biol (1995) 3.86
Mechanism of actomyosin ATPase and the problem of muscle contraction. CRC Crit Rev Biochem (1979) 3.83
Microtubule assembly in vitro. Fed Proc (1974) 3.82
Myosin II filament assemblies in the active lamella of fibroblasts: their morphogenesis and role in the formation of actin filament bundles. J Cell Biol (1995) 3.55
Direct observation of microtubule dynamics in living cells. Nature (1988) 3.47
Cytoplasmic filaments and tubules. Fed Proc (1968) 3.22
Centriole cycle in Chinese hamster ovary cells as determined by whole-mount electron microscopy. J Cell Biol (1981) 3.17
Kinetic analysis of microtubule self-assembly in vitro. J Mol Biol (1977) 3.15
Microtubule release from the centrosome. Proc Natl Acad Sci U S A (1997) 2.97
High throughput protein fold identification by using experimental constraints derived from intramolecular cross-links and mass spectrometry. Proc Natl Acad Sci U S A (2000) 2.96
Properties of the protein subunit of central-pair and outer-doublet microtubules of sea urchin flagella. J Cell Biol (1968) 2.91
Isolated flagellar apparatus of Chlamydomonas: characterization of forward swimming and alteration of waveform and reversal of motion by calcium ions in vitro. J Cell Sci (1978) 2.91
Phosphoproteins are components of mitotic microtubule organizing centers. Proc Natl Acad Sci U S A (1984) 2.84
Polarity of microtubules nucleated by centrosomes and chromosomes of Chinese hamster ovary cells in vitro. J Cell Biol (1980) 2.75
Kinetic studies of the cooperative binding of subfragment 1 to regulated actin. Proc Natl Acad Sci U S A (1980) 2.74
Polymerization of tubulin in vivo: direct evidence for assembly onto microtubule ends and from centrosomes. J Cell Biol (1985) 2.72
Characterization of microtubule assembly in porcine brain extracts by viscometry. Biochemistry (1973) 2.68
On the mechanisms of cytokinesis in animal cells. J Theor Biol (1983) 2.63
Correlative light and electron microscopy of the cytoskeleton of cultured cells. Methods Enzymol (1998) 2.59
Interacting head mechanism of microtubule-kinesin ATPase. J Biol Chem (1997) 2.57
Microtubule dynamics in vivo: a test of mechanisms of turnover. J Cell Biol (1987) 2.56
Injection of anticentromere antibodies in interphase disrupts events required for chromosome movement at mitosis. J Cell Biol (1990) 2.46
Comparison of the myosin and actomyosin ATPase mechanisms of the four types of vertebrate muscles. J Mol Biol (1980) 2.46
Microtubule-nucleating activity of centrosomes in Chinese hamster ovary cells is independent of the centriole cycle but coupled to the mitotic cycle. J Cell Biol (1981) 2.43
Dendritic organization of actin comet tails. Curr Biol (2001) 2.43
Ionic and nucleotide requirements for microtubule polymerization in vitro. Biochemistry (1975) 2.43
Role of tubulin-associated proteins in microtubule nucleation and elongation. J Mol Biol (1977) 2.38
The non-tubulin component of microtubule protein oligomers. Effect on self-association and hydrodynamic properties. J Biol Chem (1978) 2.36
Intermediate states of subfragment 1 and actosubfragment 1 ATPase: reevaluation of the mechanism. Biochemistry (1978) 2.35
Plectin sidearms mediate interaction of intermediate filaments with microtubules and other components of the cytoskeleton. J Cell Biol (1996) 2.35
Microtubule dynamics and chromosome motion visualized in living anaphase cells. J Cell Biol (1988) 2.31
Microtuble assembly: some possible regulatory mechanisms. J Supramol Struct (1974) 2.21
Differential turnover of tyrosinated and detyrosinated microtubules. Proc Natl Acad Sci U S A (1987) 2.15
Transient state phosphate production in the hydrolysis of nucleoside triphosphates by myosin. Biochemistry (1970) 2.11
Non-sarcomeric mode of myosin II organization in the fibroblast lamellum. J Cell Biol (1993) 2.10
Mode of centriole duplication and distribution. J Cell Biol (1990) 2.07
Identity and polymerization-stimulatory activity of the nontubulin proteins associated with microtubules. Biochemistry (1977) 2.07
Proposed definitions for the audit of postoperative infection: a discussion paper. Surgical Infection Study Group. Ann R Coll Surg Engl (1991) 2.06
Microtubule treadmilling in vivo. Science (1997) 2.05
Polarity of microtubules of the mitotic spindle. J Mol Biol (1978) 2.02
Self-assembly of microtubules in extracts of cultured HeLa cells and the identification of HeLa microtubule-associated proteins. Proc Natl Acad Sci U S A (1979) 1.99
Further purification and characterization of slime mold myosin and slime mold actin. Biochemistry (1969) 1.96
Management of abdominal aortic aneurysm. Br J Surg (1978) 1.95
Improved procedures for electron microscopic visualization of the cytoskeleton of cultured cells. J Struct Biol (1996) 1.93
Survey of operating theatres in Great Britain and Ireland. J Hosp Infect (1995) 1.92
Early return to work after repair of a unilateral inguinal hernia. Br J Surg (1983) 1.89
Colcemid inhibition of cell growth and the characterization of a colcemid-binding activity in Saccharomyces cerevisiae. J Cell Biol (1972) 1.89
Microtubule dynamics at the G2/M transition: abrupt breakdown of cytoplasmic microtubules at nuclear envelope breakdown and implications for spindle morphogenesis. J Cell Biol (1996) 1.88
Origin of kinetochore microtubules in Chinese hamster ovary cells. Chromosoma (1980) 1.87
Immunofluorescence localization of HeLa cell microtubule-associated proteins on microtubules in vitro and in vivo. J Cell Biol (1980) 1.87
Isolation of an actomyosin-like protein complex from slime mold plasmodium and the separation of the complex into actin- and myosin-like fractions. Biochemistry (1969) 1.86
Microtubules are acetylated in domains that turn over slowly. J Cell Sci (1989) 1.86
Growth and lability of Chaetopterus oocyte mitotic spindles isolated in the presence of porcine brain tubulin. J Cell Biol (1974) 1.85
Centriole distribution during tripolar mitosis in Chinese hamster ovary cells. J Cell Biol (1984) 1.83
Kinetic mechanism of a monomeric kinesin construct. J Biol Chem (1997) 1.81
Immunostructural evidence for the template mechanism of microtubule nucleation. Nat Cell Biol (2000) 1.81
Transient kinetics of adenosine 5'-diphosphate and adenosine 5'-(beta, gamma-imidotriphosphate) binding to subfragment 1 and actosubfragment 1. Biochemistry (1982) 1.77
Widespread distribution of a 210,000 mol wt microtubule-associated protein in cells and tissues of primates. J Cell Biol (1980) 1.74
The ATPase mechanism of skeletal and smooth muscle acto-subfragment 1. J Biol Chem (1984) 1.71
A rapid method for quantitative determination of microtubule protein using DEAE-cellulose filters. Anal Biochem (1972) 1.70
Removal of the projections from cytoplasmic microtubules in vitro by digestion with trypsin. J Biol Chem (1977) 1.65
Centrosomal and non-centrosomal microtubules. Biol Cell (1999) 1.64
Microtubules of the kinetochore fiber turn over in metaphase but not in anaphase. J Cell Biol (1989) 1.64
Structure of kinetochore fibers: microtubule continuity and inter-microtubule bridges. Chromosoma (1981) 1.64
The attachment of kinetochores to the pro-metaphase spindle in PtK1 cells. Recovery from low temperature treatment. Chromosoma (1981) 1.64
Two components of actin-based retrograde flow in sea urchin coelomocytes. Mol Biol Cell (1999) 1.63
Studies on the kinetics of formation and dissociation of the actomyosin complex. Biochemistry (1969) 1.60
Transient phase of adenosine triphosphate hydrolysis by myosin, heavy meromyosin, and subfragment 1. Biochemistry (1977) 1.60
Speckle microscopic evaluation of microtubule transport in growing nerve processes. Nat Cell Biol (1999) 1.60
Self-organization of a propulsive actin network as an evolutionary process. Proc Natl Acad Sci U S A (2001) 1.60
Chemistry of muscle contraction. Annu Rev Biochem (1972) 1.59
Steady state dynamics of intermediate filament networks. J Cell Biol (1992) 1.59
Proteins of the mammalian mitotic spindle: phosphorylation/dephosphorylation of MAP-4 during mitosis. J Cell Sci (1991) 1.58
Quantitative determination of the proportion of microtubule polymer present during the mitosis-interphase transition. J Cell Sci (1994) 1.57
Kinetic studies of calcium binding to regulatory complexes from skeletal muscle. J Biol Chem (1985) 1.57
Cadherin-mediated regulation of microtubule dynamics. Nat Cell Biol (2000) 1.56
Mechanism of microtubule kinesin ATPase. Biochemistry (1995) 1.55
Assembly and turnover of detyrosinated tubulin in vivo. J Cell Biol (1987) 1.55