Published in Science on July 04, 1968
Ribosomal resistance to streptomycin and spectinomycin in Neisseria gonorrhoeae. J Bacteriol (1974) 1.96
Cryptopleurine resistance: genetic locus for a 40S ribosomal component in Saccharomyces cerevisiae. J Bacteriol (1974) 1.85
Ribosomal RNA and protein mutants resistant to spectinomycin. EMBO J (1990) 1.75
Independent in vitro assembly of a ribonucleoprotein particle containing the 3' domain of 16S rRNA. Proc Natl Acad Sci U S A (1994) 1.43
Spectinomycin interacts specifically with the residues G1064 and C1192 in 16S rRNA, thereby potentially freezing this molecule into an inactive conformation. Nucleic Acids Res (1994) 1.36
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Sucrose-dependent spectinomycin-resistant mutants of Escherichia coli. J Bacteriol (1976) 1.27
Analysis of ribosomes from viomycin-sensitive and -resistant strains of Mycobacterium smegmatis. J Bacteriol (1972) 1.20
Elongation factor G-induced structural change in helix 34 of 16S rRNA related to translocation on the ribosome. RNA (2001) 1.02
Ribosome-thylakoid association in peas: influence of anoxia. Plant Physiol (1979) 0.94
Coordinated alterations in ribosomes and cytoplasmic membrane in sucrose-dependent, spectinomycin-resistant mutants of Escherichia coli. J Bacteriol (1976) 0.94
Requirement of proteins S5 and S9 from 30S subunits for the ribosome-dependent GTPase activity of elongation factor G. Proc Natl Acad Sci U S A (1973) 0.87
Derivatives of 4-dihydro-4-deoxy-4(R)-amino spectinomycin and their activity against susceptible and resistant Escherichia coli strains. Antimicrob Agents Chemother (1982) 0.83
Analysis for antigenic similarities among the 30S ribosomal proteins of Escherichia coli. J Bacteriol (1971) 0.75
Suppression of spectinomycin resistance in a mutant of Escherichia coli K-12. J Bacteriol (1975) 0.75
The polypeptide encoded by the cDNA for human cell surface antigen Fas can mediate apoptosis. Cell (1991) 10.96
Transposition of R factor genes to bacteriophage lambda. Proc Natl Acad Sci U S A (1975) 9.28
Plasmid-determined resistance to antimicrobial agents. Annu Rev Microbiol (1978) 8.35
Mechanisms of antibiotic resistance in bacteria. Annu Rev Biochem (1973) 7.08
Insulin-IGF2 region on chromosome 11p encodes a gene implicated in HLA-DR4-dependent diabetes susceptibility. Nature (1991) 6.17
Assembly mapping of 30S ribosomal proteins from E. coli. Nature (1970) 6.00
The problems of drug-resistant pathogenic bacteria. R factors: biochemical mechanisms of resistance to aminoglycoside antibiotics. Ann N Y Acad Sci (1971) 5.52
Effects of heating in dodecyl sulfate solution on the conformation and electrophoretic mobility of isolated major outer membrane proteins from Escherichia coli K-12. J Biochem (1976) 5.52
Correlation of 30S ribosomal proteins of Escherichia coli isolated in different laboratories. Mol Gen Genet (1971) 5.49
Identification and functional characterization of the protein controlled by the streptomycin-resistant locus in E. coli. Nature (1969) 5.47
Aminoglycoside antibiotic-inactivating enzymes in actinomycetes similar to those present in clinical isolates of antibiotic-resistant bacteria. Proc Natl Acad Sci U S A (1973) 5.20
Enzymatic acetylation of aminoglycoside antibiotics by Escherichia coli carrying an R factor. Biochemistry (1971) 5.01
"Infectious" transplantation tolerance. Science (1993) 4.98
Transposition of an antibiotic resistance element in mycobacteria. Nature (1990) 4.85
The DNA sequence and analysis of human chromosome 6. Nature (2003) 4.75
Expression of a transposable antibiotic resistance element in Saccharomyces. Nature (1980) 4.66
Influence of molecular size and osmolarity of sugars and dextrans on the synthesis of outer membrane proteins O-8 and O-9 of Escherichia coli K-12. J Bacteriol (1979) 4.58
Antibiotic inhibitors of the bacterial ribosome. Bacteriol Rev (1968) 4.56
Misreading of RNA codewords induced by aminoglycoside antibiotics. Mol Pharmacol (1965) 4.45
Detection of an unstable fragment of DNA specific to individuals with myotonic dystrophy. Nature (1992) 4.44
Single vs weekly courses of antenatal corticosteroids for women at risk of preterm delivery: A randomized controlled trial. JAMA (2001) 4.30
Distribution of thiols in microorganisms: mycothiol is a major thiol in most actinomycetes. J Bacteriol (1996) 3.98
Assembly mapping of 30 S ribosomal proteins from Escherichia coli. Further studies. J Biol Chem (1974) 3.93
A distinctive class of integron in the Vibrio cholerae genome. Science (1998) 3.86
Gentamicin resistance in strains of Pseudomonas aeruginosa mediated by enzymatic N-acetylation of the deoxystreptamine moiety. Biochemistry (1972) 3.56
Aminoglycoside antibiotics: inactivation by phosphorylation in Escherichia coli carrying R factors. J Bacteriol (1969) 3.52
On the evolution of Tn21-like multiresistance transposons: sequence analysis of the gene (aacC1) for gentamicin acetyltransferase-3-I(AAC(3)-I), another member of the Tn21-based expression cassette. Mol Gen Genet (1989) 3.46
Structure and function of ribosomes and their molecular components. Cold Spring Harb Symp Quant Biol (1969) 3.34
The isolation and partial characterization of a new restriction endonuclease from Providencia stuartii. Nucleic Acids Res (1976) 3.30
R-factor mediated gentamicin resistance: A new enzyme which modifies aminoglycoside antibiotics. FEBS Lett (1971) 3.28
Horizontal gene transfer and the origin of species: lessons from bacteria. Trends Microbiol (2000) 3.24
Primary structure of the ompF gene that codes for a major outer membrane protein of Escherichia coli K-12. Nucleic Acids Res (1982) 3.24
Genetic mapping of the regulator and operator genes of the lac operon. J Mol Biol (1968) 3.19
One-step purification of mouse monoclonal antibodies from ascitic fluid by DEAE Affi-Gel blue chromatography. J Immunol Methods (1982) 3.06
Enzymatic Adenylylation of Streptomycin and Spectinomycin by R-Factor-Resistant Escherichia coli. Infect Immun (1970) 3.02
Reconstitution of a protein translocation system containing purified SecY, SecE, and SecA from Escherichia coli. Proc Natl Acad Sci U S A (1991) 3.02
Phenotypic suppression and misreading Saccharomyces cerevisiae. Nature (1979) 3.01
An SNP map of human chromosome 22. Nature (2000) 2.99
Accumulation of glyceride-containing precursor of the outer membrane lipoprotein in the cytoplasmic membrane of Escherichia coli treated with globomycin. J Biol Chem (1980) 2.91
Resistance of Haemophilus influenzae to trimethoprim. Br Med J (1972) 2.89
Gene transfer between distantly related bacteria. Annu Rev Genet (1991) 2.88
Separation by density gradient centrifugation of two types of membranes from spheroplast membrane of Escherichia coli K12. Biochim Biophys Acta (1968) 2.86
A placental clock controlling the length of human pregnancy. Nat Med (1995) 2.86
Large scale identification of genes involved in cell surface biosynthesis and architecture in Saccharomyces cerevisiae. Genetics (1997) 2.81
Simultaneous presence of different Borrelia burgdorferi genospecies in biological fluids of Lyme disease patients. J Clin Microbiol (1995) 2.77
The evolutionary history of chromosomal super-integrons provides an ancestry for multiresistant integrons. Proc Natl Acad Sci U S A (2001) 2.77
Construction and characterization of a deletion mutant lacking micF, a proposed regulatory gene for OmpF synthesis in Escherichia coli. J Bacteriol (1985) 2.77
Mechanism of inhibition of eukaryotic protein synthesis by trichothecene fungal toxins. Proc Natl Acad Sci U S A (1974) 2.67
Interactions of outer membrane proteins O-8 and O-9 with peptidoglycan sacculus of Escherichia coli K-12. J Biochem (1976) 2.61
Signal transduction and gene regulation through the phosphorylation of two regulatory components: the molecular basis for the osmotic regulation of the porin genes. Mol Microbiol (1990) 2.57
Isolation of outer membrane proteins of Escherchia coli and their characterization on polyacrylamide gel. Biochim Biophys Acta (1975) 2.55
Inhibition of protein synthesis by spectinomycin. Science (1965) 2.54
Enzymatic modification of aminoglycoside antibiotics: 3-N-acetyltransferase with broad specificity that determines resistance to the novel aminoglycoside apramycin. Antimicrob Agents Chemother (1978) 2.53
Purification and characterization of the OmpR protein, a positive regulator involved in osmoregulatory expression of the ompF and ompC genes in Escherichia coli. J Biol Chem (1986) 2.50
Transfer of phosphoryl group between two regulatory proteins involved in osmoregulatory expression of the ompF and ompC genes in Escherichia coli. J Biol Chem (1989) 2.50
Nasal acquisition of Staphylococcus aureus in a subdivided and mechanically ventilated ward: endemic prevalence of a single staphylococcal strain. J Hyg (Lond) (1970) 2.48
Enzymatic inactivation of streptomycin by R factor-resistant Escherichia coli. Nature (1968) 2.45
Antibiotic inhibition of group I ribozyme function. Nature (1991) 2.44
Separation and properties of outer and cytoplasmic membranes in Escherichia coli. Biochim Biophys Acta (1969) 2.43
The DNA sequence and biological annotation of human chromosome 1. Nature (2006) 2.42
The genetics of bacterial ribosomes. Annu Rev Genet (1972) 2.41
Periodic emission from the gamma-ray binary 1FGL J1018.6-5856. Science (2012) 2.40
Misreading of ribonucleic acid code words induced by aminoglycoside antibiotics. The effect of drug concentration. J Biol Chem (1968) 2.38
Enzymatic acetylation as a means of determining serum aminoglycoside concentrations. Antimicrob Agents Chemother (1973) 2.37
Molecular analysis of mutant ompR genes exhibiting different phenotypes as to osmoregulation of the ompF and ompC genes of Escherichia coli. Mol Gen Genet (1986) 2.36
Evidence for the physiological importance of the phosphotransfer between the two regulatory components, EnvZ and OmpR, in osmoregulation in Escherichia coli. J Biol Chem (1989) 2.35
Specific identification of Bordetella pertussis by the polymerase chain reaction. Res Microbiol (1989) 2.33
Increased rates of illness and death from asthma in Canada. CMAJ (1987) 2.31
Evaluation of liver tumors using fluorine-18-fluorodeoxyglucose PET: characterization of tumor and assessment of effect of treatment. J Nucl Med (1992) 2.30
A new selective agent for eukaryotic cloning vectors. Am J Trop Med Hyg (1980) 2.28
Synthetic D(-)penicillamine in rheumatoid arthritis. Double-blind controlled study of a high and low dosage regimen. Ann Rheum Dis (1975) 2.27
Effective dose from cone beam CT examinations in dentistry. Br J Radiol (2008) 2.25
Plasmid-medicated aminoglycoside phosphotransferase of broad substrate range that phosphorylates amikacin. Antimicrob Agents Chemother (1977) 2.22
Drosophila ninaA gene encodes an eye-specific cyclophilin (cyclosporine A binding protein). Proc Natl Acad Sci U S A (1989) 2.20
Methyl 4-mercaptobutyrimidate as a cleavable cross-linking reagent and its application to the Escherichia coli 30S ribosome. Biochemistry (1973) 2.14
SecD is involved in the release of translocated secretory proteins from the cytoplasmic membrane of Escherichia coli. EMBO J (1993) 2.14
Heat flow and distribution during induction of general anesthesia. Anesthesiology (1995) 2.12
CFTR biomarkers: time for promotion to surrogate end-point. Eur Respir J (2012) 2.11
Enzymatic modification of aminoglycoside antibiotics: a new 3-N-acetylating enzyme from a Pseudomonas aeruginosa isolate. Antimicrob Agents Chemother (1976) 2.10
Characterization of major outer membrane proteins O-8 and O-9 of Escherichia coli K-12. Evidence that structural genes for the two proteins are different. J Biochem (1978) 2.09
Antibiotic resistance in the ECOR collection: integrons and identification of a novel aad gene. Antimicrob Agents Chemother (2000) 2.09
Spinal interneurone excitation by conformationally restricted analogues of L-glutamic acid. Nature (1974) 2.09
2-Amino-5-phosphonovalerate (2APV), a potent and selective antagonist of amino acid-induced and synaptic excitation. Neurosci Lett (1981) 2.08
Reconstitution of Escherichia coli 30 S ribosomal subunits from purified molecular components. J Biol Chem (1973) 2.07
A major outer membrane protein (O-8) of Escherichia coli K-12 exists as a trimer in sodium dodecyl sulfate solution. FEBS Lett (1979) 2.07
Promoter exchange between ompF and ompC, genes for osmoregulated major outer membrane proteins of Escherichia coli K-12. J Bacteriol (1984) 2.07
Microcloning reveals a high frequency of repetitive sequences characteristic of chromosome 4 and the beta-heterochromatin of Drosophila melanogaster. Proc Natl Acad Sci U S A (1988) 2.06
Glial-cell-line-derived neurotrophic factor is required for bud initiation from ureteric epithelium. Development (1997) 2.05
Detection of antigen-antibody binding events with the atomic force microscope. Biochemistry (1997) 2.05
Mode of action of thiolutin, an inhibitor of macromolecular synthesis in Saccharomyces cerevisiae. Antimicrob Agents Chemother (1973) 2.04
SecA interacts with secretory proteins by recognizing the positive charge at the amino terminus of the signal peptide in Escherichia coli. J Biol Chem (1990) 1.99
Three different mRNAs encoding human granulocyte colony-stimulating factor receptor. Proc Natl Acad Sci U S A (1990) 1.97
Cytokine gene expression in Helicobacter pylori associated antral gastritis. Gut (1994) 1.97
Clinical features of fifteen patients with the hypereosinophilic syndrome. Q J Med (1983) 1.96
Interaction of antibiotics with A- and P-site-specific bases in 16S ribosomal RNA. EMBO J (1991) 1.96
A study of iterative type II polyketide synthases, using bacterial genes cloned from soil DNA: a means to access and use genes from uncultured microorganisms. J Bacteriol (1997) 1.95
Neuroblastoma in adults and adolescents: an indolent course with poor survival. Cancer (1997) 1.94