Published in Nature on July 20, 1968
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Enzymatic phosphorylation of streptomycin by extracts of streptomycin-producing strains of Streptomyces. J Bacteriol (1969) 1.29
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Mutations in Escherichia coli K-12 decreasing the rate of streptomycin uptake: synergism with R-factor-mediated capacity to inactivate streptomycin. Antimicrob Agents Chemother (1974) 1.12
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Lividomycin resistance in staphylococci by enzymatic phosphorylation. Antimicrob Agents Chemother (1973) 0.89
Antibacterial activity of lividomycin toward R factor-resistant strains of Escherichia coli. Antimicrob Agents Chemother (1972) 0.87
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Production of volatile nitrogenous compounds from the degradation of streptomycin by Pseudomonas maltophilia. J Bacteriol (1973) 0.84
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Transposition of R factor genes to bacteriophage lambda. Proc Natl Acad Sci U S A (1975) 9.28
Plasmid-determined resistance to antimicrobial agents. Annu Rev Microbiol (1978) 8.35
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Primary LAMP-2 deficiency causes X-linked vacuolar cardiomyopathy and myopathy (Danon disease). Nature (2000) 5.71
The problems of drug-resistant pathogenic bacteria. R factors: biochemical mechanisms of resistance to aminoglycoside antibiotics. Ann N Y Acad Sci (1971) 5.52
Aminoglycoside antibiotic-inactivating enzymes in actinomycetes similar to those present in clinical isolates of antibiotic-resistant bacteria. Proc Natl Acad Sci U S A (1973) 5.20
Enzymatic acetylation of aminoglycoside antibiotics by Escherichia coli carrying an R factor. Biochemistry (1971) 5.01
"Infectious" transplantation tolerance. Science (1993) 4.98
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Antibiotic inhibitors of the bacterial ribosome. Bacteriol Rev (1968) 4.56
Metastasis suppressor gene KiSS-1 encodes peptide ligand of a G-protein-coupled receptor. Nature (2001) 4.55
Misreading of RNA codewords induced by aminoglycoside antibiotics. Mol Pharmacol (1965) 4.45
Detection of an unstable fragment of DNA specific to individuals with myotonic dystrophy. Nature (1992) 4.44
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Small adenocarcinoma of the lung. Histologic characteristics and prognosis. Cancer (1995) 3.83
Gentamicin resistance in strains of Pseudomonas aeruginosa mediated by enzymatic N-acetylation of the deoxystreptamine moiety. Biochemistry (1972) 3.56
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A new form of amyloid protein associated with chronic hemodialysis was identified as beta 2-microglobulin. Biochem Biophys Res Commun (1985) 3.40
The isolation and partial characterization of a new restriction endonuclease from Providencia stuartii. Nucleic Acids Res (1976) 3.30
R-factor mediated gentamicin resistance: A new enzyme which modifies aminoglycoside antibiotics. FEBS Lett (1971) 3.28
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Apoptosis inhibitory activity of cytoplasmic p21(Cip1/WAF1) in monocytic differentiation. EMBO J (1999) 3.22
Genetic mapping of the regulator and operator genes of the lac operon. J Mol Biol (1968) 3.19
Enzymatic Adenylylation of Streptomycin and Spectinomycin by R-Factor-Resistant Escherichia coli. Infect Immun (1970) 3.02
Phenotypic suppression and misreading Saccharomyces cerevisiae. Nature (1979) 3.01
An SNP map of human chromosome 22. Nature (2000) 2.99
Molecular cloning of a porcine gene syk that encodes a 72-kDa protein-tyrosine kinase showing high susceptibility to proteolysis. J Biol Chem (1991) 2.89
Resistance of Haemophilus influenzae to trimethoprim. Br Med J (1972) 2.89
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A placental clock controlling the length of human pregnancy. Nat Med (1995) 2.86
Large scale identification of genes involved in cell surface biosynthesis and architecture in Saccharomyces cerevisiae. Genetics (1997) 2.81
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Early stages of motor neuron differentiation revealed by expression of homeobox gene Islet-1. Science (1992) 2.70
Mechanism of inhibition of eukaryotic protein synthesis by trichothecene fungal toxins. Proc Natl Acad Sci U S A (1974) 2.67
Cloning and characterization of the gene for immunogenic protein MPB64 of Mycobacterium bovis BCG. Infect Immun (1989) 2.62
Actinin-4, a novel actin-bundling protein associated with cell motility and cancer invasion. J Cell Biol (1998) 2.62
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Inhibition of protein synthesis by spectinomycin. Science (1965) 2.54
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Total synthesis of the gene for an alanine transfer ribonucleic acid from yeast. Nature (1970) 2.51
Nasal acquisition of Staphylococcus aureus in a subdivided and mechanically ventilated ward: endemic prevalence of a single staphylococcal strain. J Hyg (Lond) (1970) 2.48
Antibiotic inhibition of group I ribozyme function. Nature (1991) 2.44
The DNA sequence and biological annotation of human chromosome 1. Nature (2006) 2.42
The genetics of bacterial ribosomes. Annu Rev Genet (1972) 2.41
Exacerbation of autoimmune thyroid dysfunction after unilateral adrenalectomy in patients with Cushing's syndrome due to an adrenocortical adenoma. N Engl J Med (1990) 2.40
Misreading of ribonucleic acid code words induced by aminoglycoside antibiotics. The effect of drug concentration. J Biol Chem (1968) 2.38
Enzymatic acetylation as a means of determining serum aminoglycoside concentrations. Antimicrob Agents Chemother (1973) 2.37
Osteoarthritis development in novel experimental mouse models induced by knee joint instability. Osteoarthritis Cartilage (2005) 2.36
Organization of rRNA genes in Mycobacterium bovis BCG. J Bacteriol (1987) 2.33
Increased rates of illness and death from asthma in Canada. CMAJ (1987) 2.31
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Synthetic D(-)penicillamine in rheumatoid arthritis. Double-blind controlled study of a high and low dosage regimen. Ann Rheum Dis (1975) 2.27
Effective dose from cone beam CT examinations in dentistry. Br J Radiol (2008) 2.25
Plasmid-medicated aminoglycoside phosphotransferase of broad substrate range that phosphorylates amikacin. Antimicrob Agents Chemother (1977) 2.22
The nasopharyngeal bacterial flora in children with otitis media with effusion. Eur Arch Otorhinolaryngol (1996) 2.16
CFTR biomarkers: time for promotion to surrogate end-point. Eur Respir J (2012) 2.11
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Antibiotic resistance in the ECOR collection: integrons and identification of a novel aad gene. Antimicrob Agents Chemother (2000) 2.09
Spinal interneurone excitation by conformationally restricted analogues of L-glutamic acid. Nature (1974) 2.09
2-Amino-5-phosphonovalerate (2APV), a potent and selective antagonist of amino acid-induced and synaptic excitation. Neurosci Lett (1981) 2.08
Microcloning reveals a high frequency of repetitive sequences characteristic of chromosome 4 and the beta-heterochromatin of Drosophila melanogaster. Proc Natl Acad Sci U S A (1988) 2.06
Cloning and expression of the gene for the cross-reactive alpha antigen of Mycobacterium kansasii. Infect Immun (1990) 2.06
Glial-cell-line-derived neurotrophic factor is required for bud initiation from ureteric epithelium. Development (1997) 2.05
Detection of antigen-antibody binding events with the atomic force microscope. Biochemistry (1997) 2.05
Mode of action of thiolutin, an inhibitor of macromolecular synthesis in Saccharomyces cerevisiae. Antimicrob Agents Chemother (1973) 2.04
High dose rate brachytherapy for carcinoma of the uterine cervix: comparison of two different fractionation regimens. Int J Radiat Oncol Biol Phys (1995) 2.02
Immunologic reactions in amyotrophic lateral sclerosis brain and spinal cord tissue. Am J Pathol (1992) 2.01
Investigating the relationship between stroke and obstructive sleep apnea. Stroke (1996) 2.00
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Involvement of oxygen-sensitive pyruvate formate-lyase in mixed-acid fermentation by Streptococcus mutans under strictly anaerobic conditions. J Bacteriol (1982) 1.97
Modulation of EphA receptor function by coexpressed ephrinA ligands on retinal ganglion cell axons. Neuron (1999) 1.97
Cytokine gene expression in Helicobacter pylori associated antral gastritis. Gut (1994) 1.97
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Pgp-1hi T lymphocytes accumulate with age in mice and respond poorly to concanavalin A. Eur J Immunol (1989) 1.95
Embryotoxic effects of ethylene glycol monomethyl ether in mice. Toxicology (1981) 1.95
A study of iterative type II polyketide synthases, using bacterial genes cloned from soil DNA: a means to access and use genes from uncultured microorganisms. J Bacteriol (1997) 1.95
Effect of spectinomycin on polypeptide synthesis in extracts of Escherichia coli. J Mol Biol (1967) 1.93
The roles of the C-terminal domain and type III domains of chitinase A1 from Bacillus circulans WL-12 in chitin degradation. J Bacteriol (1994) 1.91
Studies on polynucleotides. 103. Total synthesis of the structural gene for an alanine transfer ribonucleic acid from yeast. J Mol Biol (1972) 1.90
Trichodermin resistance--mutation affecting eukaryotic ribosomes. Nature (1974) 1.90
Molecular cloning of a novel melanocortin receptor. J Biol Chem (1993) 1.89
Comparison of azathioprine, cyclophosphamide, and gold in treatment of rheumatoid arthritis. Br Med J (1974) 1.87
Actions of D and L forms of 2-amino-5-phosphonovalerate and 2-amino-4-phosphonobutyrate in the cat spinal cord. Brain Res (1982) 1.86