Published in Biochemistry on December 01, 1969
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Studies on sequencing of peptides from the carboxyl terminus by using the thiocyanate method. Biochem J (1976) 0.86
Automated carboxy-terminal sequence analysis of peptides. Protein Sci (1992) 0.84
Efficient transfer of large DNA fragments from agarose gels to diazobenzyloxymethyl-paper and rapid hybridization by using dextran sulfate. Proc Natl Acad Sci U S A (1979) 72.18
Method for detection of specific RNAs in agarose gels by transfer to diazobenzyloxymethyl-paper and hybridization with DNA probes. Proc Natl Acad Sci U S A (1977) 40.24
Jak-STAT pathways and transcriptional activation in response to IFNs and other extracellular signaling proteins. Science (1994) 26.02
Detection of specific RNAs or specific fragments of DNA by fractionation in gels and transfer to diazobenzyloxymethyl paper. Methods Enzymol (1979) 18.24
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Transfer of small DNA fragments from polyacrylamide gels to diazobenzyloxymethyl-paper and detection by hybridization with DNA probes. Biochem Biophys Res Commun (1978) 12.71
Nucleic acid hybridization using DNA covalently coupled to cellulose. Cell (1975) 11.26
Transcriptional and posttranscriptional regulation of interferon-induced gene expression in human cells. Cell (1984) 8.32
Use of dimethyl suberimidate, a cross-linking reagent, in studying the subunit structure of oligomeric proteins. Proc Natl Acad Sci U S A (1970) 7.37
Regulation of the G2/M transition by p53. Oncogene (2001) 7.02
Transfer of proteins from gels to diazobenzyloxymethyl-paper and detection with antisera: a method for studying antibody specificity and antigen structure. Proc Natl Acad Sci U S A (1979) 6.93
A single phosphotyrosine residue of Stat91 required for gene activation by interferon-gamma. Science (1993) 6.44
Autoregulation of simian virus 40 gene A by T antigen. Proc Natl Acad Sci U S A (1976) 6.38
Gene amplification causes overproduction of the first three enzymes of UMP synthesis in N-(phosphonacetyl)-L-aspartate-resistant hamster cells. J Biol Chem (1979) 6.31
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Quantitative analysis of specific labelled RNA'S using DNA covalently linked to diazobenzyloxymethyl-paper. Nucleic Acids Res (1979) 5.66
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T antigen binds to simian virus 40 DNA at the origin of replication. Proc Natl Acad Sci U S A (1975) 5.22
A protein tyrosine kinase in the interferon alpha/beta signaling pathway. Cell (1992) 4.96
Defective TNF-alpha-induced apoptosis in STAT1-null cells due to low constitutive levels of caspases. Science (1997) 4.37
Complementation of a mutant cell line: central role of the 91 kDa polypeptide of ISGF3 in the interferon-alpha and -gamma signal transduction pathways. EMBO J (1993) 4.35
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Complementation by the protein tyrosine kinase JAK2 of a mutant cell line defective in the interferon-gamma signal transduction pathway. Nature (1993) 4.20
Interferon response element of the human gene 6-16. EMBO J (1988) 4.11
High-frequency mutagenesis of human cells and characterization of a mutant unresponsive to both alpha and gamma interferons. Proc Natl Acad Sci U S A (1991) 3.83
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Use of a selectable marker regulated by alpha interferon to obtain mutations in the signaling pathway. Mol Cell Biol (1989) 3.49
Characterization of the autoregulation of simian virus 40 gene A. J Virol (1977) 3.45
Selective loss of type I interferon-induced STAT4 activation caused by a minisatellite insertion in mouse Stat2. Nat Immunol (2000) 3.38
A single DNA response element can confer inducibility by both alpha- and gamma-interferons. Proc Natl Acad Sci U S A (1989) 3.33
The p53 network. J Biol Chem (1998) 3.19
Isolation of specific RNA's using DNA covalently linked to diazobenzyloxymethyl cellulose or paper. Methods Enzymol (1979) 3.04
Activation of phosphatidylinositol 3-kinase in response to interleukin-1 leads to phosphorylation and activation of the NF-kappaB p65/RelA subunit. Mol Cell Biol (1999) 2.86
Specific chemical cleavage in high yield at the amino peptide bonds of cysteine and cystine residues. J Biol Chem (1973) 2.83
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Rapid activation by interferon alpha of a latent DNA-binding protein present in the cytoplasm of untreated cells. Proc Natl Acad Sci U S A (1989) 2.74
Use of genetic suppressor elements to dissect distinct biological effects of separate p53 domains. Proc Natl Acad Sci U S A (1996) 2.66
Biologic consequences of Stat1-independent IFN signaling. Proc Natl Acad Sci U S A (2001) 2.56
A major role for the protein tyrosine kinase JAK1 in the JAK/STAT signal transduction pathway in response to interleukin-6. EMBO J (1995) 2.52
Molecular analysis of a human interferon-inducible gene family. Eur J Biochem (1991) 2.46
IRAK-M is a novel member of the Pelle/interleukin-1 receptor-associated kinase (IRAK) family. J Biol Chem (1999) 2.43
Charomids: cosmid vectors for efficient cloning and mapping of large or small restriction fragments. Proc Natl Acad Sci U S A (1986) 2.42
Aspartate transcarbamylase. Interaction with the transition state analogue N-(phosphonacetyl)-L-aspartate. J Biol Chem (1971) 2.36
Role of STAT2 in the alpha interferon signaling pathway. Mol Cell Biol (1995) 2.34
How Stat1 mediates constitutive gene expression: a complex of unphosphorylated Stat1 and IRF1 supports transcription of the LMP2 gene. EMBO J (2000) 2.33
Contribution of STAT SH2 groups to specific interferon signaling by the Jak-STAT pathway. Science (1995) 2.25
Differential regulation of interferon-induced mRNAs and c-myc mRNA by alpha- and gamma-interferons. Eur J Biochem (1985) 2.23
Single-copy and amplified CAD genes in Syrian hamster chromosomes localized by a highly sensitive method for in situ hybridization. Mol Cell Biol (1982) 2.21
Structure of amplified DNA in different Syrian hamster cell lines resistant to N-(phosphonacetyl)-L-aspartate. Mol Cell Biol (1983) 2.20
Stable mutants of mammalian cells that overproduce the first three enzymes of pyrimidine nucleotide biosynthesis. Cell (1976) 2.19
Aspartate transcarbamylase. Kinetic studies of the catalytic subunit. J Biol Chem (1969) 2.18
Regulation of c-myc expression by IFN-gamma through Stat1-dependent and -independent pathways. EMBO J (2000) 2.11
Transgenic mice with p53-responsive lacZ: p53 activity varies dramatically during normal development and determines radiation and drug sensitivity in vivo. EMBO J (1997) 1.96
Stat1-independent regulation of gene expression in response to IFN-gamma. Proc Natl Acad Sci U S A (2001) 1.96
N-(Phosphonacetyl)-L-aspartate-resistant hamster cells overaccumulate a single mRNA coding for the multifunctional protein that catalyzes the first steps of UMP synthesis. J Biol Chem (1979) 1.95
Transcriptional induction by double-stranded RNA is mediated by interferon-stimulated response elements without activation of interferon-stimulated gene factor 3. J Biol Chem (1995) 1.94
Interactions between STAT and non-STAT proteins in the interferon-stimulated gene factor 3 transcription complex. Mol Cell Biol (1996) 1.94
Interleukin-1 (IL-1) receptor-associated kinase leads to activation of TAK1 by inducing TAB2 translocation in the IL-1 signaling pathway. Mol Cell Biol (2001) 1.93
Characterization of beta-R1, a gene that is selectively induced by interferon beta (IFN-beta) compared with IFN-alpha. J Biol Chem (1996) 1.92
Complex roles of Stat1 in regulating gene expression. Oncogene (2000) 1.87
Overlapping sites for constitutive and induced DNA binding factors involved in interferon-stimulated transcription. EMBO J (1989) 1.87
Purification from hamster cells of the multifunctional protein that initiates de novo synthesis of pyrimidine nucleotides. J Biol Chem (1977) 1.87
Regulation of STAT-dependent pathways by growth factors and cytokines. FASEB J (1996) 1.85
Distinctive chromosomal structures are formed very early in the amplification of CAD genes in Syrian hamster cells. Cell (1990) 1.85
Transcription factor ISGF-3 formation requires phosphorylated Stat91 protein, but Stat113 protein is phosphorylated independently of Stat91 protein. Proc Natl Acad Sci U S A (1994) 1.83
Characterization of a human gene inducible by alpha- and beta-interferons and its expression in mouse cells. EMBO J (1986) 1.81
IL-1-induced NFkappa B and c-Jun N-terminal kinase (JNK) activation diverge at IL-1 receptor-associated kinase (IRAK). Proc Natl Acad Sci U S A (2001) 1.81
N-(phosphonacetyl)-L-aspartate, a potent transition state analog inhibitor of aspartate transcarbamylase, blocks proliferation of mammalian cells in culture. J Biol Chem (1974) 1.81
Function of Stat2 protein in transcriptional activation by alpha interferon. Mol Cell Biol (1996) 1.79
General method for cloning amplified DNA by differential screening with genomic probes. Mol Cell Biol (1982) 1.78
Reactions of cyanate with functional groups of proteins. 3. Reactions with amino and carboxyl groups. Biochemistry (1965) 1.72
Roles of phosphatidylinositol 3-kinase in interferon-gamma-dependent phosphorylation of STAT1 on serine 727 and activation of gene expression. J Biol Chem (2001) 1.71
2-5A synthetase: assay, distribution and variation with growth or hormone status. Nature (1979) 1.71
Kinase-negative mutants of JAK1 can sustain interferon-gamma-inducible gene expression but not an antiviral state. EMBO J (1996) 1.71
Act1, an NF-kappa B-activating protein. Proc Natl Acad Sci U S A (2000) 1.70
Inhibition of the cellular response to interferons by products of the adenovirus type 5 E1A oncogene. Nucleic Acids Res (1991) 1.66
Formation of STAT1-STAT2 heterodimers and their role in the activation of IRF-1 gene transcription by interferon-alpha. J Biol Chem (1996) 1.65
Expression of the terminal protein region of hepatitis B virus inhibits cellular responses to interferons alpha and gamma and double-stranded RNA. Proc Natl Acad Sci U S A (1991) 1.64
Roles of JAKs in activation of STATs and stimulation of c-fos gene expression by epidermal growth factor. Mol Cell Biol (1996) 1.64
DNA amplification is rare in normal human cells. Proc Natl Acad Sci U S A (1990) 1.63
A JAK1/JAK2 chimera can sustain alpha and gamma interferon responses. Mol Cell Biol (1997) 1.62
Mutant U5A cells are complemented by an interferon-alpha beta receptor subunit generated by alternative processing of a new member of a cytokine receptor gene cluster. EMBO J (1995) 1.61
Differential response of the human 6-16 and 9-27 genes to alpha and gamma interferons. Nucleic Acids Res (1991) 1.60
Isolation and characterization of a new mutant human cell line unresponsive to alpha and beta interferons. Mol Cell Biol (1991) 1.52
Cleavage at cysteine after cyanylation. Methods Enzymol (1977) 1.52
DNA amplification in drug resistant cells and in tumours. Cancer Surv (1986) 1.50
Structure of the gene for CAD, the multifunctional protein that initiates UMP synthesis in Syrian hamster cells. Mol Cell Biol (1982) 1.46
Fusions near telomeres occur very early in the amplification of CAD genes in Syrian hamster cells. Proc Natl Acad Sci U S A (1992) 1.44
Specific association of simian virus 40 tumor antigen with simian virus 40 chromatin. J Virol (1980) 1.44
Aspartate transcarbamylase. Stereospecific restrictions on the binding site for L-aspartate. J Biol Chem (1970) 1.44
Functional subdomains of STAT2 required for preassociation with the alpha interferon receptor and for signaling. Mol Cell Biol (1997) 1.44
Coordinate overproduction of orotate phosphoribosyltransferase and orotidine-5'-phosphate decarboxylase in hamster cells resistant to pyrazofurin and 6-azauridine. J Biol Chem (1979) 1.43
A p53-dependent S-phase checkpoint helps to protect cells from DNA damage in response to starvation for pyrimidine nucleotides. Proc Natl Acad Sci U S A (1998) 1.42
Combinatorial association and abundance of components of interferon-stimulated gene factor 3 dictate the selectivity of interferon responses. Proc Natl Acad Sci U S A (1995) 1.40
Cell type-specific signaling in response to interferon-gamma. Curr Top Microbiol Immunol (2007) 1.40
Filtering noise from images with wavelet transforms. Magn Reson Med (1991) 1.39
Molecular analysis of G1B and G3A IFN gamma mutants reveals that defects in CIITA or RFX result in defective class II MHC and Ii gene induction. Immunity (1994) 1.39
Transcription factors induced by interferons alpha and gamma. Nucleic Acids Res (1990) 1.37
Mechanisms of G2 arrest in response to overexpression of p53. Mol Biol Cell (1999) 1.33