Published in Nature on December 13, 1969
Structure-independent nucleotide sequence analysis. Proc Natl Acad Sci U S A (1979) 8.65
Use of DNA polymerase I primed by a synthetic oligonucleotide to determine a nucleotide sequence in phage fl DNA. Proc Natl Acad Sci U S A (1973) 7.11
A replicating RNA molecule suitable for a detailed analysis of extracellular evolution and replication. Proc Natl Acad Sci U S A (1972) 1.55
Translation of the genome of a ribonucleic acid bacteriophage. Bacteriol Rev (1972) 1.40
The nucleotide sequence at the 5'-terminus of the Q RNA minus trand. Proc Natl Acad Sci U S A (1970) 1.28
Site-directed mutagenesis: effect of an extracistronic mutation on the in vitro propagation of bacteriophage Qbeta RNA. Proc Natl Acad Sci U S A (1975) 1.13
Characterization of the initial peptide of Q-beta RNA polymerase and control of its synthesis. Proc Natl Acad Sci U S A (1971) 1.08
The leader sequence from the 5'-terminus to the A-protein initiation codon in MS2-virus RNA. Proc Natl Acad Sci U S A (1971) 1.01
A thermostable, sequence-specific restriction endonuclease from Bacillus stearothermophilus: BstPI. Nucleic Acids Res (1979) 1.00
Nucleotide sequences in bacteriophage ribonucleic acid. The eighth hopkins memorial lecture. Biochem J (1971) 0.93
Formation of a mammalian initiation complex with reovirus messenger RNA, methionyl-tRNA F , and ribosomal subunits. Proc Natl Acad Sci U S A (1972) 0.91
Ribonucleoside triphosphate-dependent pyrophosphate exchange of Reovirus cores. J Virol (1970) 0.89
Minimal requirements for template recognition by bacteriophage Qbeta replicase: approach to general RNA-dependent RNA synthesis. Proc Natl Acad Sci U S A (1975) 0.83
Location of the coat cistron on the RNA of phage Q-beta. Proc Natl Acad Sci U S A (1970) 0.82
A new insight into Sanger's development of sequencing: from proteins to DNA, 1943-1977. J Hist Biol (2010) 0.81
Measurements of translation initiation from all 64 codons in E. coli. Nucleic Acids Res (2017) 0.77
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A rapid, sensitive, and specific method for the determination of protein in dilute solution. Anal Biochem (1973) 31.32
Mapping of RNA by a modification of the Berk-Sharp procedure: the 5' termini of 15 S beta-globin mRNA precursor and mature 10 s beta-globin mRNA have identical map coordinates. Nucleic Acids Res (1979) 31.23
High resolution two-dimensional electrophoresis of basic as well as acidic proteins. Cell (1977) 30.04
Analysis of endonuclease R-EcoRI fragments of DNA from lambdoid bacteriophages and other viruses by agarose-gel electrophoresis. J Virol (1974) 23.54
Rat insulin genes: construction of plasmids containing the coding sequences. Science (1977) 17.05
DNA nucleotide sequence restricted by the RI endonuclease. Proc Natl Acad Sci U S A (1972) 15.71
Mice devoid of PrP are resistant to scrapie. Cell (1993) 11.46
Specificity of substrate recognition by the EcoRI restriction endonuclease. Proc Natl Acad Sci U S A (1975) 11.07
Nucleotide sequence of a mutant eukaryotic gene: the yeast tyrosine-inserting ochre suppressor SUP4-o. Proc Natl Acad Sci U S A (1977) 10.64
Replication and transcription of eukaryotic DNA in Escherichia coli. Proc Natl Acad Sci U S A (1974) 10.51
Three regions upstream from the cap site are required for efficient and accurate transcription of the rabbit beta-globin gene in mouse 3T6 cells. Cell (1983) 9.51
Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein. Nature (1992) 9.01
Nopaline synthase: transcript mapping and DNA sequence. J Mol Appl Genet (1982) 8.73
Isolation of the Arabidopsis ABI3 gene by positional cloning. Plant Cell (1992) 8.36
Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Nature (1999) 8.04
Nucleotide sequence and amplification in bacteria of structural gene for rat growth hormone. Nature (1977) 7.97
Rescue of measles viruses from cloned DNA. EMBO J (1995) 7.87
Molecular cloning and characterization of avian sarcoma virus circular DNA molecules. J Virol (1980) 7.37
Human growth hormone as a reporter gene in regulation studies employing transient gene expression. Mol Cell Biol (1986) 7.11
Ligation of EcoRI endonuclease-generated DNA fragments into linear and circular structures. J Mol Biol (1975) 6.95
Comparison of total sequence of a cloned rabbit beta-globin gene and its flanking regions with a homologous mouse sequence. Science (1979) 6.94
Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase. EMBO J (1995) 6.94
Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie. EMBO J (1996) 6.66
The intervening sequence of a mouse beta-globin gene is transcribed within the 15S beta-globin mRNA precursor. Proc Natl Acad Sci U S A (1978) 6.20
Small ribonucleic acids of Escherichia coli. I. Characterization by polyacrylamide gel electrophoresis and fingerprint analysis. J Biol Chem (1973) 6.10
Nucleotide sequence of the gene coding for the major protein of hepatitis B virus surface antigen. Nature (1979) 6.10
Isolation and characterization of a cloned rat insulin gene. Cell (1979) 6.05
DNA substrate site for the EcoRII restriction endonuclease and modification methylase. Nat New Biol (1973) 5.90
Sequence of the human insulin gene. Nature (1980) 5.76
Hybrid plasmids containing an active thymidine kinase gene of Herpes simplex virus 1. Nucleic Acids Res (1979) 5.55
Nucleotide sequence heterogeneity of an RNA phage population. Cell (1978) 5.55
A minimal intron length but no specific internal sequence is required for splicing the large rabbit beta-globin intron. Cell (1984) 5.37
Synthetic lac operator DNA is functional in vivo. Nature (1976) 5.36
Specific inactivation of 16S ribosomal RNA induced by colicin E3 in vivo. Proc Natl Acad Sci U S A (1971) 5.28
DNA sequences preceding the rabbit beta-globin gene are required for formation in mouse L cells of beta-globin RNA with the correct 5' terminus. Proc Natl Acad Sci U S A (1981) 5.26
Nucleotide sequence of an avian sarcoma virus oncogene (src) and proposed amino acid sequence for gene product. Nature (1980) 5.22
RNA synthesis startpoints in bacteriophage lambda: are the promoter and operator transcribed? Nat New Biol (1972) 5.18
Effects of ionizing radiation on a plant genome: analysis of two Arabidopsis transparent testa mutations. Plant Cell (1992) 5.16
Nucleotide sequences at the cleavage sites of two restriction endonucleases from Hemophilus parainfluenzae. Biochem Biophys Res Commun (1974) 5.14
A primer ribonucleic acid for initiation of in vitro Rous sarcarcoma virus deoxyribonucleic acid synthesis. J Biol Chem (1975) 5.08
Mx protein: constitutive expression in 3T3 cells transformed with cloned Mx cDNA confers selective resistance to influenza virus. Cell (1986) 4.92
The Arabidopsis abscisic acid response locus ABI4 encodes an APETALA 2 domain protein. Plant Cell (1998) 4.92
Biased hypermutation and other genetic changes in defective measles viruses in human brain infections. Cell (1988) 4.90
Analysis of Arabidopsis mutants deficient in flavonoid biosynthesis. Plant J (1995) 4.87
The nucleotide sequence complexity of avian tumor virus RNA. Proc Natl Acad Sci U S A (1974) 4.86
Isolation of the Arabidopsis GA4 locus. Plant Cell (1995) 4.86
The structure of one of the eight or more distinct chromosomal genes for human interferon-alpha. Nature (1980) 4.82
Scrapie and cellular PrP isoforms are encoded by the same chromosomal gene. Cell (1986) 4.82
A cyclic AMP- and phorbol ester-inducible DNA element. Nature (1986) 4.60
Physical identity of the SV40 deoxyribonucleic acid sequence recognized by the Eco RI restriction endonuclease and modification methylase. Biochemistry (1974) 4.58
A physical map of the Rous sarcoma virus genome. J Mol Biol (1976) 4.56
Molecular cloning and sequence analysis of adult chicken betal globin cDNA. Nucleic Acids Res (1979) 4.49
Sequence requirements for splicing of higher eukaryotic nuclear pre-mRNA. Cell (1986) 4.40
Unusual splice sites revealed by mutagenic inactivation of an authentic splice site of the rabbit beta-globin gene. Nature (1983) 4.38
Tumor DNA structure in plant cells transformed by A. tumefaciens. Science (1980) 4.36
Normal host prion protein necessary for scrapie-induced neurotoxicity. Nature (1996) 4.25
Restriction and modification of a self-complementary octanucleotide containing the EcoRI substrate. J Mol Biol (1975) 4.21
Proofreading and aminoacylation of tRNAs before export from the nucleus. Science (1998) 4.08
Human growth hormone DNA sequence and mRNA structure: possible alternative splicing. Nucleic Acids Res (1981) 4.03
Change in methylation of 16S ribosomal RNA associated with mutation to kasugamycin resistance in Escherichia coli. Nat New Biol (1971) 4.01
Mapping of biological functions on RNA of avian tumor viruses: location of regions required for transformation and determination of host range. Proc Natl Acad Sci U S A (1975) 4.01
Mechanism of kasugamycin resistance in Escherichia coli. Nat New Biol (1972) 3.94
tRNA genes are found between 16S and 23S rRNA genes in Bacillus subtilis. Nucleic Acids Res (1982) 3.93
Transcription of DNA from the 70S RNA of Rous sarcoma virus. I. Identification of a specific 4S RNA which serves as primer. J Virol (1974) 3.90
A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosis. Proc Natl Acad Sci U S A (1997) 3.88
Rabbit beta-globin mRNA production in mouse L cells transformed with cloned rabbit beta-globin chromosomal DNA. Nature (1979) 3.88
Comparison of cloned rabbit and mouse beta-globin genes showing strong evolutionary divergence of two homologous pairs of introns. Nature (1978) 3.86
Cloning and sequence of two different cDNAs encoding 1-aminocyclopropane-1-carboxylate synthase in tomato. Proc Natl Acad Sci U S A (1990) 3.85
Specific excision of the inserted DNA segment from hybrid plasmids constructed by the poly(dA). poly (dT) method. Biochim Biophys Acta (1976) 3.79
Induction of mRNA for a serine protease and a beta-thromboglobulin-like protein in mitogen-stimulated human leukocytes. J Immunol (1987) 3.78
Synthesis in E. coli of a polypeptide with human leukocyte interferon activity. Nature (1980) 3.78
Human growth hormone: complementary DNA cloning and expression in bacteria. Science (1979) 3.67
Cloning of hormone genes from a mixture of cDNA molecules. Methods Enzymol (1979) 3.62
3' end formation of U1 snRNA precursors is coupled to transcription from snRNA promoters. Cell (1986) 3.61
Expression of amino-terminally truncated PrP in the mouse leading to ataxia and specific cerebellar lesions. Cell (1998) 3.59
Human leukocyte and fibroblast interferons are structurally related. Nature (1980) 3.57
Sequence of the cell division gene CDC2 from Schizosaccharomyces pombe; patterns of splicing and homology to protein kinases. Gene (1984) 3.50
CpG methylation inhibits proenkephalin gene expression and binding of the transcription factor AP-2. Nucleic Acids Res (1990) 3.46
Deficient cytokine signaling in mouse embryo fibroblasts with a targeted deletion in the PKR gene: role of IRF-1 and NF-kappaB. EMBO J (1997) 3.34
RNA-directed DNA polymerase of Rous sarcoma virus: initiation of synthesis with 70 S viral RNA as template. J Mol Biol (1973) 3.32
Tumor induction by Agrobacterium tumefaciens: analysis of the boundaries of T-DNA. J Mol Appl Genet (1982) 3.28
Small RNAs of Rous sarcoma virus: characterization by two-dimensional polyacrylamide gel electrophoresis and fingerprint analysis. J Virol (1973) 3.28
Measles virus editing provides an additional cysteine-rich protein. Cell (1989) 3.22
Organization of the murine Mx gene and characterization of its interferon- and virus-inducible promoter. Mol Cell Biol (1988) 3.19
Structure of an inducibly methylatable nucleotide sequence in 23S ribosomal ribonucleic acid from erythromycin-resistant Staphylococcus aureus. Biochemistry (1973) 3.19
Characterization of the low-molecular-weight RNAs associated with the 70S RNA of Rous sarcoma virus. J Virol (1973) 3.19
The nucleotide sequence of an untranslated but conserved domain at the 3' end of the avian sarcoma virus genome. Nucleic Acids Res (1980) 3.16
Nucleotide sequence evidence for relationship of AIDS retrovirus to lentiviruses. Nature (1985) 3.13
Construction and analysis of recombinant DNA for human chorionic somatomammotropin. Nature (1977) 3.13
QB DNA-containing hybrid plasmids giving rise to QB phage formation in the bacterial host. Nature (1978) 3.11
Synthesis of hepatitis B surface and core antigens in E. coli. Nature (1981) 3.11
The constitutive transport element (CTE) of Mason-Pfizer monkey virus (MPMV) accesses a cellular mRNA export pathway. EMBO J (1997) 3.10
The primer tRNA for Moloney murine leukemia virus DNA synthesis. Nucleotide sequence and aminoacylation of tRNAPro. J Biol Chem (1979) 3.10
Structure-specific endonucleolytic cleavage of nucleic acids by eubacterial DNA polymerases. Science (1993) 3.04
Cloning of human satellite III DNA: different components are on different chromosomes. Nucleic Acids Res (1979) 3.01
The isolation of plasmids containing DNA complementary to messenger RNA for variant surface glycoproteins of Trypanosoma brucei. Gene (1980) 2.99
Low-molecular-weight RNAs of Moloney murine leukemia virus: identification of the primer for RNA-directed DNA synthesis. J Virol (1977) 2.99
Amber suppression: a nucleotide change in the anticodon of a tyrosine transfer RNA. Nature (1968) 2.98