The nucleotide sequence at the 5'-terminus of the Q RNA minus trand.

Polyadenylic acid at the 3'-terminus of poliovirus RNA. Proc Natl Acad Sci U S A (1972) 5.42

Bacteriophage Q replicase contains the protein biosynthesis elongation factors EF Tu and EF Ts. Proc Natl Acad Sci U S A (1972) 2.88

Genome trimming: a unique strategy for replication control employed by Borna disease virus. Proc Natl Acad Sci U S A (2005) 1.61

Initiation of phi 29 DNA replication occurs at the second 3' nucleotide of the linear template: a sliding-back mechanism for protein-primed DNA replication. Proc Natl Acad Sci U S A (1992) 1.57

Alteration of polynucleotide secondary structure by ribosomal protein S1. Proc Natl Acad Sci U S A (1976) 1.49

Translation of the genome of a ribonucleic acid bacteriophage. Bacteriol Rev (1972) 1.40

Site-directed mutagenesis: effect of an extracistronic mutation on the in vitro propagation of bacteriophage Qbeta RNA. Proc Natl Acad Sci U S A (1975) 1.13

Stucture of the amino-acid accepting 3'-end of high-molecular-weight eggplant mosaic virus RNA. Proc Natl Acad Sci U S A (1976) 0.97

Nucleotide sequences in bacteriophage ribonucleic acid. The eighth hopkins memorial lecture. Biochem J (1971) 0.93

Location of the coat cistron on the RNA of phage Q-beta. Proc Natl Acad Sci U S A (1970) 0.82

A two-dimensional fractionation procedure for radioactive nucleotides. J Mol Biol (1965) 20.83

Polypeptide chain initiation: nucleotide sequences of the three ribosomal binding sites in bacteriophage R17 RNA. Nature (1969) 8.64

Specific template requirments of RNA replicases. Proc Natl Acad Sci U S A (1965) 5.90

Factor fraction required for the synthesis of bacteriophage Qbeta-RNA. Nature (1968) 4.02

An extracellular Darwinian experiment with a self-duplicating nucleic acid molecule. Proc Natl Acad Sci U S A (1967) 3.99

Nucleotide sequences from the low molecular weight ribosomal RNA of Escherichia coli. J Mol Biol (1967) 3.06

Comparison of two serologically distinct ribonucleic acid bacteriophages. I. Properties of the viral particles. J Bacteriol (1966) 2.52

Terminal sequences of bacteriophage RNAs. Nature (1968) 2.37

Sequence of a ribosome binding site in bacteriophage Q-beta-RNA. Nature (1969) 2.06

Sequence of the first 175 nucleotides from the 5' terminus of Qbeta RNA synthesized in vitro. Nature (1969) 1.84

Nucleotide sequence from the polypeptide chain termination region of the coat protein cistron in bacteriophage R17 RNA. Nature (1970) 1.71

Replication of viral RNA. XI. Synthesis of viral "minus" strands in vitro. Proc Natl Acad Sci U S A (1966) 1.60

Studies on extracellular ribonucleases of Ustilago sphaerogena. Characterization of substrate specificity with special reference to purine-specific ribonucleases. Biochem J (1968) 1.51

Replication of viral RNA. 13. The early product of phage RNA synthesis in vitro. Proc Natl Acad Sci U S A (1967) 1.49

THE REPLICATIVE FORM OF MS2 RNA: AN X-RAY DIFFRACTION STUDY. Proc Natl Acad Sci U S A (1964) 1.42

Replication of RNA viruses. X. Replication of a natural 6 s RNA by the Q-beta RNA polymerase. J Mol Biol (1969) 1.42

Amino acid sequence studies on the tryptic peptides of the coat protein of the bacteriophage R17. Biochemistry (1967) 1.39

Studies on the bacteriophage MS2. IV. The 3'-OH terminal undecanucleotide sequence of the viral RNA chain. J Mol Biol (1967) 1.37

The dissociation of Q-beta-replicase and the relation of one of the components to a poly-C-dependent poly-G-polymerase. Proc Natl Acad Sci U S A (1967) 1.37

Structural analysis of polynucleotides by sequential base elimination. The sequence of the terminal decanucleotide fragment of the ribonucleic acid from bacteriophage f2. J Am Chem Soc (1967) 1.36

Gene order in the bacteriophage R17 RNA: 5'-a protein-coat protein-synthetase-3'. Nature (1970) 1.34

Untranslated nucleotide sequence at the 5'-end of R17 bacteriophage RNA. Nature (1970) 1.33

The 3'-termini of bacteriophage Q-beta plus and minus strands. J Mol Biol (1970) 1.28

Replication of viral RNA. XIV. Single-stranded minus strands as template for the synthesis of viral plus strands in vitro. Proc Natl Acad Sci U S A (1967) 1.26

The cloning of a self-replicating RNA molecule. Proc Natl Acad Sci U S A (1968) 1.22

The 3'-terminus and the replication of phage RNA. Nature (1969) 1.18

Replication of viral RNA, XVI. Enzymatic synthesis of infectious virual RNA with noninfectious Q-beta minus strands as template. Proc Natl Acad Sci U S A (1968) 1.17

Replication of phage RNA. Prog Nucleic Acid Res Mol Biol (1967) 1.15

Nucleotide sequence analysis of an enzymatically synthesized RNA corresponding to the 5'-terminal region of Q beta RNA. Cold Spring Harb Symp Quant Biol (1969) 1.14

Direct participation of a host protein in the replication of viral RNA in vitro. Proc Natl Acad Sci U S A (1968) 1.11

Replication of RNA viruses. V. Template activity of synthetic ribopolymers in the Q-beta RNA polymerase reaction. Proc Natl Acad Sci U S A (1967) 1.11

Infectivity of bacteriophage R17 RNA after sequential removal of 3' terminal nucleotides. Nature (1969) 1.10

Amino-acid sequence of the "Qbeta" coat protein. Nature (1970) 1.05

Nucleotide sequences at the 5'-linked ends of viral ribonucleic acids. Biochim Biophys Acta (1968) 1.02

Comparison of RNA terminal sequences of phages f2 and Q-beta: chemical and sedimentation equilibrium studies. Science (1968) 0.96

Polynucleotide sequence analysis by sequential base elimination: 3'-terminus of phage Q-beta RNA. Science (1969) 0.89

Replication of RNA viruses. 8. Direction of chain growth in the Q-beta RNA polymerase reaction. J Mol Biol (1969) 0.86

Replication of the RNA genome. J Cell Physiol (1969) 0.86

A new approach to determination of the nucleotide sequence of a viral RNA. J Cell Physiol (1969) 0.78

A rapid, sensitive, and specific method for the determination of protein in dilute solution. Anal Biochem (1973) 31.32

Mapping of RNA by a modification of the Berk-Sharp procedure: the 5' termini of 15 S beta-globin mRNA precursor and mature 10 s beta-globin mRNA have identical map coordinates. Nucleic Acids Res (1979) 31.23

High resolution two-dimensional electrophoresis of basic as well as acidic proteins. Cell (1977) 30.04

Analysis of endonuclease R-EcoRI fragments of DNA from lambdoid bacteriophages and other viruses by agarose-gel electrophoresis. J Virol (1974) 23.54

Rat insulin genes: construction of plasmids containing the coding sequences. Science (1977) 17.05

DNA nucleotide sequence restricted by the RI endonuclease. Proc Natl Acad Sci U S A (1972) 15.71

Mice devoid of PrP are resistant to scrapie. Cell (1993) 11.46

Specificity of substrate recognition by the EcoRI restriction endonuclease. Proc Natl Acad Sci U S A (1975) 11.07

Nucleotide sequence of a mutant eukaryotic gene: the yeast tyrosine-inserting ochre suppressor SUP4-o. Proc Natl Acad Sci U S A (1977) 10.64

Replication and transcription of eukaryotic DNA in Escherichia coli. Proc Natl Acad Sci U S A (1974) 10.51

Three regions upstream from the cap site are required for efficient and accurate transcription of the rabbit beta-globin gene in mouse 3T6 cells. Cell (1983) 9.51

Normal development and behaviour of mice lacking the neuronal cell-surface PrP protein. Nature (1992) 9.01

Nopaline synthase: transcript mapping and DNA sequence. J Mol Appl Genet (1982) 8.73

Isolation of the Arabidopsis ABI3 gene by positional cloning. Plant Cell (1992) 8.36

Sequence and analysis of chromosome 2 of the plant Arabidopsis thaliana. Nature (1999) 8.04

Nucleotide sequence and amplification in bacteria of structural gene for rat growth hormone. Nature (1977) 7.97

Rescue of measles viruses from cloned DNA. EMBO J (1995) 7.87

Molecular cloning and characterization of avian sarcoma virus circular DNA molecules. J Virol (1980) 7.37

Human growth hormone as a reporter gene in regulation studies employing transient gene expression. Mol Cell Biol (1986) 7.11

Ligation of EcoRI endonuclease-generated DNA fragments into linear and circular structures. J Mol Biol (1975) 6.95

Comparison of total sequence of a cloned rabbit beta-globin gene and its flanking regions with a homologous mouse sequence. Science (1979) 6.94

Deficient signaling in mice devoid of double-stranded RNA-dependent protein kinase. EMBO J (1995) 6.94

Prion protein (PrP) with amino-proximal deletions restoring susceptibility of PrP knockout mice to scrapie. EMBO J (1996) 6.66

The intervening sequence of a mouse beta-globin gene is transcribed within the 15S beta-globin mRNA precursor. Proc Natl Acad Sci U S A (1978) 6.20

Nucleotide sequence of the gene coding for the major protein of hepatitis B virus surface antigen. Nature (1979) 6.10

Isolation and characterization of a cloned rat insulin gene. Cell (1979) 6.05

DNA substrate site for the EcoRII restriction endonuclease and modification methylase. Nat New Biol (1973) 5.90

Sequence of the human insulin gene. Nature (1980) 5.76

Hybrid plasmids containing an active thymidine kinase gene of Herpes simplex virus 1. Nucleic Acids Res (1979) 5.55

Nucleotide sequence heterogeneity of an RNA phage population. Cell (1978) 5.55

A minimal intron length but no specific internal sequence is required for splicing the large rabbit beta-globin intron. Cell (1984) 5.37

Synthetic lac operator DNA is functional in vivo. Nature (1976) 5.36

DNA sequences preceding the rabbit beta-globin gene are required for formation in mouse L cells of beta-globin RNA with the correct 5' terminus. Proc Natl Acad Sci U S A (1981) 5.26

Nucleotide sequence of an avian sarcoma virus oncogene (src) and proposed amino acid sequence for gene product. Nature (1980) 5.22

Effects of ionizing radiation on a plant genome: analysis of two Arabidopsis transparent testa mutations. Plant Cell (1992) 5.16

Nucleotide sequences at the cleavage sites of two restriction endonucleases from Hemophilus parainfluenzae. Biochem Biophys Res Commun (1974) 5.14

Mx protein: constitutive expression in 3T3 cells transformed with cloned Mx cDNA confers selective resistance to influenza virus. Cell (1986) 4.92

The Arabidopsis abscisic acid response locus ABI4 encodes an APETALA 2 domain protein. Plant Cell (1998) 4.92

Biased hypermutation and other genetic changes in defective measles viruses in human brain infections. Cell (1988) 4.90

Analysis of Arabidopsis mutants deficient in flavonoid biosynthesis. Plant J (1995) 4.87

The nucleotide sequence complexity of avian tumor virus RNA. Proc Natl Acad Sci U S A (1974) 4.86

Isolation of the Arabidopsis GA4 locus. Plant Cell (1995) 4.86

The structure of one of the eight or more distinct chromosomal genes for human interferon-alpha. Nature (1980) 4.82

Scrapie and cellular PrP isoforms are encoded by the same chromosomal gene. Cell (1986) 4.82

A cyclic AMP- and phorbol ester-inducible DNA element. Nature (1986) 4.60

Physical identity of the SV40 deoxyribonucleic acid sequence recognized by the Eco RI restriction endonuclease and modification methylase. Biochemistry (1974) 4.58

A physical map of the Rous sarcoma virus genome. J Mol Biol (1976) 4.56

Molecular cloning and sequence analysis of adult chicken betal globin cDNA. Nucleic Acids Res (1979) 4.49

Sequence requirements for splicing of higher eukaryotic nuclear pre-mRNA. Cell (1986) 4.40

Unusual splice sites revealed by mutagenic inactivation of an authentic splice site of the rabbit beta-globin gene. Nature (1983) 4.38

Tumor DNA structure in plant cells transformed by A. tumefaciens. Science (1980) 4.36

Normal host prion protein necessary for scrapie-induced neurotoxicity. Nature (1996) 4.25

Restriction and modification of a self-complementary octanucleotide containing the EcoRI substrate. J Mol Biol (1975) 4.21

Human growth hormone DNA sequence and mRNA structure: possible alternative splicing. Nucleic Acids Res (1981) 4.03

Mapping of biological functions on RNA of avian tumor viruses: location of regions required for transformation and determination of host range. Proc Natl Acad Sci U S A (1975) 4.01

Transcription of DNA from the 70S RNA of Rous sarcoma virus. I. Identification of a specific 4S RNA which serves as primer. J Virol (1974) 3.90

A double-stranded RNA-activated protein kinase-dependent pathway mediating stress-induced apoptosis. Proc Natl Acad Sci U S A (1997) 3.88

Rabbit beta-globin mRNA production in mouse L cells transformed with cloned rabbit beta-globin chromosomal DNA. Nature (1979) 3.88

Comparison of cloned rabbit and mouse beta-globin genes showing strong evolutionary divergence of two homologous pairs of introns. Nature (1978) 3.86

Cloning and sequence of two different cDNAs encoding 1-aminocyclopropane-1-carboxylate synthase in tomato. Proc Natl Acad Sci U S A (1990) 3.85

Specific excision of the inserted DNA segment from hybrid plasmids constructed by the poly(dA). poly (dT) method. Biochim Biophys Acta (1976) 3.79

Induction of mRNA for a serine protease and a beta-thromboglobulin-like protein in mitogen-stimulated human leukocytes. J Immunol (1987) 3.78

Synthesis in E. coli of a polypeptide with human leukocyte interferon activity. Nature (1980) 3.78

Human growth hormone: complementary DNA cloning and expression in bacteria. Science (1979) 3.67

Cloning of hormone genes from a mixture of cDNA molecules. Methods Enzymol (1979) 3.62

Expression of amino-terminally truncated PrP in the mouse leading to ataxia and specific cerebellar lesions. Cell (1998) 3.59

Human leukocyte and fibroblast interferons are structurally related. Nature (1980) 3.57

Sequence of the cell division gene CDC2 from Schizosaccharomyces pombe; patterns of splicing and homology to protein kinases. Gene (1984) 3.50

CpG methylation inhibits proenkephalin gene expression and binding of the transcription factor AP-2. Nucleic Acids Res (1990) 3.46

Deficient cytokine signaling in mouse embryo fibroblasts with a targeted deletion in the PKR gene: role of IRF-1 and NF-kappaB. EMBO J (1997) 3.34

RNA-directed DNA polymerase of Rous sarcoma virus: initiation of synthesis with 70 S viral RNA as template. J Mol Biol (1973) 3.32

Tumor induction by Agrobacterium tumefaciens: analysis of the boundaries of T-DNA. J Mol Appl Genet (1982) 3.28

Measles virus editing provides an additional cysteine-rich protein. Cell (1989) 3.22

Organization of the murine Mx gene and characterization of its interferon- and virus-inducible promoter. Mol Cell Biol (1988) 3.19

Characterization of the low-molecular-weight RNAs associated with the 70S RNA of Rous sarcoma virus. J Virol (1973) 3.19

The nucleotide sequence of an untranslated but conserved domain at the 3' end of the avian sarcoma virus genome. Nucleic Acids Res (1980) 3.16

Construction and analysis of recombinant DNA for human chorionic somatomammotropin. Nature (1977) 3.13

QB DNA-containing hybrid plasmids giving rise to QB phage formation in the bacterial host. Nature (1978) 3.11

Synthesis of hepatitis B surface and core antigens in E. coli. Nature (1981) 3.11

Cloning of human satellite III DNA: different components are on different chromosomes. Nucleic Acids Res (1979) 3.01

The isolation of plasmids containing DNA complementary to messenger RNA for variant surface glycoproteins of Trypanosoma brucei. Gene (1980) 2.99

Amber suppression: a nucleotide change in the anticodon of a tyrosine transfer RNA. Nature (1968) 2.98

Molecular cloning of the avian myelocytomatosis virus genome and recovery of infectious virus by transfection of chicken cells. J Virol (1981) 2.95

A quantitative, highly sensitive cell-based infectivity assay for mouse scrapie prions. Proc Natl Acad Sci U S A (2003) 2.94

Infectivity in mouse fibroblasts of polyoma DNA integrated into plasmid pBR322 or lambdoid phage DNA. Nature (1979) 2.92

Localization of Q-beta maturation cistron ribosome binding site. Nat New Biol (1971) 2.91

The proportion of revertant and mutant phage in a growing population, as a function of mutation and growth rate. Gene (1976) 2.77

Transcription of DNA from the 70S RNA of Rous sarcoma virus. II. Structure of a 4S RNA primer. J Virol (1974) 2.73

5' cleavage site in eukaryotic pre-mRNA splicing is determined by the overall 5' splice region, not by the conserved 5' GU. Cell (1987) 2.69

Altered transcription of a defective measles virus genome derived from a diseased human brain. EMBO J (1987) 2.67

DNA sequence of the rat growth hormone gene: location of the 5' terminus of the growth hormone mRNA and identification of an internal transposon-like element. Nucleic Acids Res (1981) 2.67

Nucleotide sequence at the 5' terminus of the avian sarcoma virus genome. Proc Natl Acad Sci U S A (1977) 2.66

A 46-nucleotide promoter segment from an IFN-alpha gene renders an unrelated promoter inducible by virus. Cell (1985) 2.65

Map-based cloning of a gene controlling omega-3 fatty acid desaturation in Arabidopsis. Science (1992) 2.59

Avian myeloblastosis virus RNA is terminally redundant: implications for the mechanism of retrovirus replication. Cell (1977) 2.55

Biased hypermutation of viral RNA genomes could be due to unwinding/modification of double-stranded RNA. Cell (1989) 2.54