Published in Cancer Res on December 01, 1969
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Biosynthesis of tetrahydrobiopterin by de novo and salvage pathways in adrenal medulla extracts, mammalian cell cultures, and rat brain in vivo. Proc Natl Acad Sci U S A (1983) 1.27
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A rapid and sensitive assay for tyrosine-3-monooxygenase based upon the release of 3H2O and adsorption of [3H]-tyrosine by charcoal. Life Sci (1986) 1.12
Metabolism of trimethoprim in man and measurement of a new metabolite: a new fluorescence assay. J Infect Dis (1973) 1.09
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Cofactor activity of dihydroflavin mononucleotide and tetrahydrobiopterin for murine epididymal indoleamine 2,3-dioxygenase. Biochem Biophys Res Commun (1986) 0.94
Analysis of folate cofactor levels in tissues using high-performance liquid chromatography. Anal Biochem (1983) 0.94
Utilization of dihydroflavin mononucleotide and superoxide anion for the decyclization of L-tryptophan by murine epididymal indoleamine 2,3-dioxygenase. Arch Biochem Biophys (1987) 0.91
Elevation of brain histamine levels by diaminopyrimidine inhibitors of histamine N-methyl transferase. Biochem Pharmacol (1978) 0.87
Interaction of drugs inhibiting different steps in the synthesis of DNA. Cancer Res (1972) 0.87
Studies on dihydrofolate reductase related to the drug sensitivity of microbial and neoplastic cells. Adv Enzyme Regul (1968) 0.87
Inhibition of histamine-metabolizing enzymes and elevation of histamine levels in tissues by lipid-soluble anticancer folate antagonists. Mol Pharmacol (1980) 0.86
On the mode of action of 7-deaza-adenosine (tubercidin). Biochim Biophys Acta (1967) 0.85
Mammalian deoxyuridine 5'-triphosphate pyrophosphatase. Biochim Biophys Acta (1971) 0.84
Effects of pregnancy on several cortisol-responsive enzymes in rat liver. Am J Physiol (1966) 0.83
A sensitive high-performance liquid chromatographic-fluorometric assay for dihydrofolate reductase in adult rat brain, using 7,8-dihydrobiopterin as substrate. Anal Biochem (1984) 0.83
Quantitative thin-layer chromatography of pyrimethamine and related diaminopyrimidines in body fluids and tissues. J Chromatogr (1975) 0.82
Antitumor phthalanilides active in acute and chronic Trypanosoma brucei brucei murine infections. Am J Trop Med Hyg (1984) 0.82
Two new tetrahydropterin intermediates in the adrenal medullary de novo biosynthesis of tetrahydrobiopterin. Biochem Biophys Res Commun (1984) 0.81
Regulation of tetrahydrobiopterin biosynthesis in cultured adrenal cortical tumor cells by adrenocorticotropin and adenosine 3',5'-cyclic monophosphate. Endocrinology (1986) 0.80
Regulation of guanosine triphosphate cyclohydrolase and tetrahydrobiopterin levels and the role of the cofactor in tyrosine hydroxylation in primary cultures of adrenomedullary chromaffin cells. J Neurochem (1986) 0.80
Dihydrofolate reductase in primary brain tumors, cell cultures of central nervous system origin, and normal brain during fetal and neonatal growth. Cancer Res (1979) 0.80
Inhibition of ribosephosphate pyrophosphokinase activity by decoinine, an adenine nucleoside. Biochem Biophys Res Commun (1964) 0.80
Differences in the metabolism of the aromatic amino acid hydroxylase cofactor, tetrahydrobiopterin, in mutant mice with neurological and immunological defects. Biochem Genet (1986) 0.79
Synthesis, utilization, and structure of the tetrahydropterin intermediates in the bovine adrenal medullary de novo biosynthesis of tetrahydrobiopterin. J Biol Chem (1986) 0.79
Inhibitors of histamine metabolism in vitro and in vivo. Correlations with antitrypanosomal activity. Biochem Pharmacol (1984) 0.79
The manipulation of metabolism by drugs and nutrients. Cancer Res (1969) 0.79
Tetrahydrobiopterin is synthesized by separate pathways from dihydroneopterin triphosphate and from sepiapterin in adrenal medulla preparations. Arch Biochem Biophys (1983) 0.79
Pharmacokinetics: selectivity of action related to physicochemical properties and kinetic patterns of anticancer drugs. Cancer (1977) 0.79
Evaluation of combination chemotherapy in vivo and in culture with l- -D-arabinofuranosylcytosine and 1-formylisoquinoline thiosemicarbazone. Cancer Res (1972) 0.78
Prevention by polyamines of the curative effect of amicarbalide and imidocarb for Trypanosoma brucei infections in mice. Biochem Pharmacol (1981) 0.78
Hormonal regulation of guanosine triphosphate cyclohydrolase activity and biopterin levels in the rat adrenal cortex. Endocrinology (1983) 0.77
Synthesis and biological activity of some new N6-substituted purine nucleosides. J Med Chem (1969) 0.77
Determination of biopterin and other pterins in tissues and body fluids by high-performance liquid chromatography. J Chromatogr (1983) 0.76
Studies on the nature and specificity of the induction of several adaptive enzymes responsive to cortisol. Adv Enzyme Regul (1964) 0.76
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Effect of partial hepatectomy and pregnancy on tumor growth and alanine-alpha-ketoglutarate transaminase activity. Proc Soc Exp Biol Med (1966) 0.75
Long plasma half-life of pyrimethamine. Lancet (1973) 0.75
Urinary excretion of biopterin and neopterin in psychiatric disorders. Psychiatry Res (1984) 0.75
Synthesis and antagonist properties of pyridoxol analogs modified in the 5 position. J Med Chem (1967) 0.75
Studies on the biologic activity and mode of action of 7-deazainosine. Cancer Res (1969) 0.75
A tribute to Dr. Gerald Burr Grindey, 1940-1993. Invest New Drugs (1996) 0.75
Adamantane derivatives of p-aminobenzamide and sulfanilamide. J Med Chem (1968) 0.75
Specific TLC tissue residue determination of sulfadiazine following fluorescamine derivatization. J Pharm Sci (1975) 0.75
Antitumor effects of methylglyoxal-bis(N-4-methylthiosemicarbazone) and their potentiation in pyridoxine-deficient animals. Cancer Res (1965) 0.75
Stimulation of retinal dopamine biosynthesis in vivo by exogenous tetrahydrobiopterin: relationship to tyrosine hydroxylase activation. Brain Res (1985) 0.75
Roswell Park Cancer Institute Symposium: molecular approaches to cancer therapeutics. Cancer Res (1997) 0.75
Evaluation of the lipid-soluble diaminopyrimidines, metoprine and etoprine, in the avian sarcoma virus rat glioma model. Cancer Treat Rep (1982) 0.75
Biosynthesis of tetrahydrobiopterin in the presence of dihydrofolate reductase inhibitors. Mol Pharmacol (1983) 0.75
Combinations of drugs which interact as inhibitors of DNA biosynthesis. Adv Enzyme Regul (1972) 0.75
Effects of cortisol on DNA metabolism in the sensitive and resistant lines of mouse lymphoma P1798. Cancer Res (1970) 0.75
Synthetic analogues of tetrahydrobiopterin with cofactor activity for aromatic amino acid hydroxylases. J Med Chem (1987) 0.75
A model system for detecting drug impairment of antitumor host defenses. Cancer Res (1970) 0.75
Endocrine-dependent regulation of tetrahydrobiopterin levels and guanosine triphosphate cyclohydrolase activity. Mol Cell Endocrinol (1986) 0.75
Urinary biopterin and neopterin excretion and pituitary-adrenal activity in psychiatric patients. Psychiatry Res (1985) 0.75
Kethoxal bis(thiosemicarbazone). I. Effects against experimental tumors. Cancer Res (1965) 0.75
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Some pharmacologic considerations concerning the control of acute leukemia. Cancer Res (1965) 0.75
The C-6 proton of tetrahydrobiopterin is acquired from water, not NADPH, during de novo biosynthesis. J Biol Chem (1985) 0.75
On the substrate specificity of bovine liver dihydrofolate reductase: new unconjugated dihydropterin substrates. Arch Biochem Biophys (1987) 0.75
Inhibitory effects of 4-deoxypyridoxine on the endogenous activity and induction of tyrosine-alpha-ketoglutarate transaminase by cortisol. Ann N Y Acad Sci (1969) 0.75
Specific TLC determination of trimethoprim and sulfamethoxazole in plasma. J Pharm Sci (1974) 0.75