Published in Proc Natl Acad Sci U S A on November 01, 1984
Red light-induced formation of ubiquitin-phytochrome conjugates: Identification of possible intermediates of phytochrome degradation. Proc Natl Acad Sci U S A (1987) 2.72
A novel site for ubiquitination: the N-terminal residue, and not internal lysines of MyoD, is essential for conjugation and degradation of the protein. EMBO J (1998) 2.31
Effect of heat shock on protein degradation in mammalian cells: involvement of the ubiquitin system. EMBO J (1987) 1.74
The rhp6+ gene of Schizosaccharomyces pombe: a structural and functional homolog of the RAD6 gene from the distantly related yeast Saccharomyces cerevisiae. EMBO J (1990) 1.66
Intrinsic disorder drives N-terminal ubiquitination by Ube2w. Nat Chem Biol (2014) 1.57
Towards a functional understanding of protein N-terminal acetylation. PLoS Biol (2011) 1.51
The structure of ubiquitinated histone H2B. EMBO J (1987) 1.40
N alpha acetylation is required for normal growth and mating of Saccharomyces cerevisiae. J Bacteriol (1989) 1.20
Post-translational modifications of rat liver mitochondrial outer membrane proteins identified by mass spectrometry. Biochim Biophys Acta (2007) 1.11
Role of N-terminal residues in the ubiquitin-independent degradation of human thymidylate synthase. Biochem J (2006) 1.09
The human N-alpha-acetyltransferase 40 (hNaa40p/hNatD) is conserved from yeast and N-terminally acetylates histones H2A and H4. PLoS One (2011) 1.02
The intrinsically disordered N-terminal domain of thymidylate synthase targets the enzyme to the ubiquitin-independent proteasomal degradation pathway. J Biol Chem (2009) 0.99
Two N-terminal acetyltransferases antagonistically regulate the stability of a nod-like receptor in Arabidopsis. Plant Cell (2015) 0.98
Mutation of an Arabidopsis NatB N-alpha-terminal acetylation complex component causes pleiotropic developmental defects. PLoS One (2013) 0.97
Arrest-defective-1 protein (ARD1): tumor suppressor or oncoprotein? Am J Transl Res (2010) 0.95
The "normal" brain. "Abnormal" ubiquitinilated deposits highlight an age-related protein change. Am J Pathol (1989) 0.90
Molecular dynamics simulations of the native and partially folded states of ubiquitin: influence of methanol cosolvent, pH, and temperature on the protein structure and dynamics. Protein Sci (2007) 0.89
The biological functions of Naa10 - From amino-terminal acetylation to human disease. Gene (2015) 0.87
Molecular identification and functional characterization of the first Nα-acetyltransferase in plastids by global acetylome profiling. Proteomics (2015) 0.87
The N-terminal acetyltransferase Naa10 is essential for zebrafish development. Biosci Rep (2015) 0.85
Lysine 269 is essential for cyclin D1 ubiquitylation by the SCF(Fbx4/alphaB-crystallin) ligase and subsequent proteasome-dependent degradation. Oncogene (2009) 0.84
New roles for old modifications: emerging roles of N-terminal post-translational modifications in development and disease. Protein Sci (2014) 0.83
Endogenous inhibitor of nonlysosomal high molecular weight protease and calcium-dependent protease. Proc Natl Acad Sci U S A (1986) 0.83
A simple fluorescence labeling method for studies of protein oxidation, protein modification, and proteolysis. Free Radic Biol Med (2011) 0.81
Pharmacological Modulation of the N-End Rule Pathway and Its Therapeutic Implications. Trends Pharmacol Sci (2015) 0.80
Absence of N-terminal acetyltransferase diversification during evolution of eukaryotic organisms. Sci Rep (2016) 0.78
Amphipathic tail-anchoring peptide is a promising therapeutic agent for prostate cancer treatment. Oncotarget (2014) 0.78
Depletion of histone N-terminal-acetyltransferase Naa40 induces p53-independent apoptosis in colorectal cancer cells via the mitochondrial pathway. Apoptosis (2016) 0.78
Positional proteomics reveals differences in N-terminal proteoform stability. Mol Syst Biol (2016) 0.77
Linking post-translational modifications and variation of phenotypic traits. Mol Cell Proteomics (2012) 0.76
Development of a novel strategy to isolate lipophilic allergens (oleosins) from peanuts. PLoS One (2015) 0.76
N-Terminal Acetylation-Targeted N-End Rule Proteolytic System: The Ac/N-End Rule Pathway. Mol Cells (2016) 0.76
Stimulation by ATP-Mg2+ and inactivation by cyclic-AMP-dependent phosphorylation of a cytosolic monkey brain aminopeptidase. Biochem J (1989) 0.75
N-Alpha-Acetyltransferases and Regulation of CFTR Expression. PLoS One (2016) 0.75
The age-associated loss of ischemic preconditioning in the kidney is accompanied by mitochondrial dysfunction, increased protein acetylation and decreased autophagy. Sci Rep (2017) 0.75
Distinct sequences and post-translational modifications in cardiac atrial and ventricular myosin light chains revealed by top-down mass spectrometry. J Mol Cell Cardiol (2017) 0.75
Fluorometric assay of proteins in the nanogram range. Arch Biochem Biophys (1973) 7.81
Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown. J Biol Chem (1983) 7.03
Ubiquitin dependence of selective protein degradation demonstrated in the mammalian cell cycle mutant ts85. Cell (1984) 6.81
Labeling of proteins by reductive methylation using sodium cyanoborohydride. J Biol Chem (1979) 5.42
Mechanisms of intracellular protein breakdown. Annu Rev Biochem (1982) 4.89
A heat-stable polypeptide component of an ATP-dependent proteolytic system from reticulocytes. Biochem Biophys Res Commun (1978) 3.92
Proposed role of ATP in protein breakdown: conjugation of protein with multiple chains of the polypeptide of ATP-dependent proteolysis. Proc Natl Acad Sci U S A (1980) 3.75
Potassium cyanate as an inhibitor of the sickling of erythrocytes in vitro. Proc Natl Acad Sci U S A (1971) 3.27
Ubiquitin: roles in protein modification and breakdown. Cell (1983) 3.19
In vivo chemical modification of proteins (post-translational modification). Annu Rev Biochem (1981) 2.91
Ubiquitin-activating enzyme. Mechanism and role in protein-ubiquitin conjugation. J Biol Chem (1982) 2.65
Isopeptide linkage between nonhistone and histone 2A polypeptides of chromosomal conjugate-protein A24. Proc Natl Acad Sci U S A (1977) 2.61
"Covalent affinity" purification of ubiquitin-activating enzyme. J Biol Chem (1982) 2.15
Evidence that approximately eighty per cent of the soluble proteins from Ehrlich ascites cells are Nalpha-acetylated. J Biol Chem (1976) 1.96
Acetylation of Protein N-terminal amino groups structural observations on alpha-amino acetylated proteins. J Theor Biol (1975) 1.93
ATP-dependent degradation of ubiquitin-protein conjugates. Proc Natl Acad Sci U S A (1984) 1.92
The metabolism of myosin, the meromyosins, actin and tropomyosin in the rabbit. Biochim Biophys Acta (1956) 1.81
Reactions of cyanate with functional groups of proteins. 3. Reactions with amino and carboxyl groups. Biochemistry (1965) 1.72
ATP serves two distinct roles in protein degradation in reticulocytes, one requiring and one independent of ubiquitin. J Cell Biol (1983) 1.35
Identification of the active amino acid residue of the polypeptide of ATP-dependent protein breakdown. J Biol Chem (1981) 1.14
Effects of temperature on the degradation of proteins in rabbit reticulocyte lysates and after injection into HeLa cells. Proc Natl Acad Sci U S A (1984) 1.11
Intracellular degradation of hemoglobin transferred into fibroblasts by fusion with red blood cells. J Cell Physiol (1980) 1.07
Chemical derivatives of chymotrypsinogen. II. Reaction with O-methylisourea. J Biol Chem (1956) 1.05
Protein modification by reaction with N-carboxyamino acid anhydrides. J Biol Chem (1953) 1.00
Preparation of hemoglobin carbamylated at specific NH2-terminal residues. Methods Enzymol (1981) 1.00
A comparison of the turnover of alpha-N-acetylated and nonacetylated mouse L-cell proteins. J Biol Chem (1979) 1.00
Degradation of microinjected methylated and unmethylated proteins in hepatoma tissue culture cells. J Biol Chem (1983) 0.96
Stabilization of proteins by guanidination. J Biol Chem (1980) 0.89
Gas chromatographic determination of the carbamylation of hemoglobin S by cyanate. J Lab Clin Med (1973) 0.82
SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27. Nat Cell Biol (1999) 9.92
Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown. J Biol Chem (1983) 7.03
Studies concerning the alimentary absorption of water and tissue hydration in relation to diuresis. J Physiol (1932) 6.29
The mechanism of water diuresis in normal rats and rabbits as analysed by inulin and diodone clearances. J Physiol (1945) 6.29
The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis. Mol Biol Cell (1995) 6.23
Familial Mediterranean fever. A survey of 470 cases and review of the literature. Am J Med (1967) 5.88
Studies concerning the alimentary absorption of water and tissue hydration in relation to diuresis. J Physiol (1932) 5.36
The fate of the antidiuretic principle of postpituitary extracts in vivo and in vitro. J Physiol (1935) 5.04
Mechanisms of intracellular protein breakdown. Annu Rev Biochem (1982) 4.89
"Pleiotypic response". Nat New Biol (1971) 4.85
The renal function of newborn infants. J Physiol (1944) 4.14
Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation. Genes Dev (1999) 4.07
A heat-stable polypeptide component of an ATP-dependent proteolytic system from reticulocytes. Biochem Biophys Res Commun (1978) 3.92
The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27. Nat Cell Biol (2001) 3.87
Proposed role of ATP in protein breakdown: conjugation of protein with multiple chains of the polypeptide of ATP-dependent proteolysis. Proc Natl Acad Sci U S A (1980) 3.75
The mechanism of ubiquitin activating enzyme. A kinetic and equilibrium analysis. J Biol Chem (1982) 3.69
Ubiquitin: roles in protein modification and breakdown. Cell (1983) 3.19
ATP-dependent conjugation of reticulocyte proteins with the polypeptide required for protein degradation. Proc Natl Acad Sci U S A (1980) 2.96
Studies on the degradation of tyrosine aminotransferase in hepatoma cells in culture. Influence of the composition of the medium and adenosine triphosphate dependence. J Biol Chem (1971) 2.83
Ubiquitin-activating enzyme. Mechanism and role in protein-ubiquitin conjugation. J Biol Chem (1982) 2.65
Mitochondrial hexokinase. Release, rebinding, and location. J Biol Chem (1967) 2.58
Occurrence of a polyubiquitin structure in ubiquitin-protein conjugates. Biochem Biophys Res Commun (1985) 2.56
Immunochemical analysis of the turnover of ubiquitin-protein conjugates in intact cells. Relationship to the breakdown of abnormal proteins. J Biol Chem (1982) 2.56
Functional heterogeneity of ubiquitin carrier proteins. J Biol Chem (1985) 2.53
Ubiquitin-aldehyde: a general inhibitor of ubiquitin-recycling processes. Proc Natl Acad Sci U S A (1987) 2.52
Reversible phosphorylation controls the activity of cyclosome-associated cyclin-ubiquitin ligase. Proc Natl Acad Sci U S A (1995) 2.48
The significance of the pituitary in parturition. J Physiol (1932) 2.40
Resolution of the ATP-dependent proteolytic system from reticulocytes: a component that interacts with ATP. Proc Natl Acad Sci U S A (1979) 2.37
Components of a system that ligates cyclin to ubiquitin and their regulation by the protein kinase cdc2. J Biol Chem (1994) 2.34
The arthritis of familial Mediterranean fever (FMF). Arthritis Rheum (1966) 2.32
The state in the blood and the excretion by the kidney of the antidiuretic principle of posterior pituitary extracts. J Physiol (1937) 2.21
"Covalent affinity" purification of ubiquitin-activating enzyme. J Biol Chem (1982) 2.15
Dominant-negative cyclin-selective ubiquitin carrier protein E2-C/UbcH10 blocks cells in metaphase. Proc Natl Acad Sci U S A (1997) 2.08
Ubiquitin carboxyl-terminal hydrolase acts on ubiquitin carboxyl-terminal amides. J Biol Chem (1985) 2.08
Specificity of binding of NH2-terminal residue of proteins to ubiquitin-protein ligase. Use of amino acid derivatives to characterize specific binding sites. J Biol Chem (1988) 2.04
The state of magnesium in cells as estimated from the adenylate kinase equilibrium. Proc Natl Acad Sci U S A (1968) 2.03
The ubiquitin pathway for the degradation of intracellular proteins. Prog Nucleic Acid Res Mol Biol (1986) 1.98
Mechanism of aconitase action. I. The hydrogen transfer reaction. J Biol Chem (1967) 1.95
Phosphorylation of the cyclosome is required for its stimulation by Fizzy/cdc20. Biochem Biophys Res Commun (1999) 1.93
ATP-dependent degradation of ubiquitin-protein conjugates. Proc Natl Acad Sci U S A (1984) 1.92
The renal action of posterior pituitary extract and its fractions as analysed by clearance experiments on rats. J Physiol (1946) 1.83
ATP-dependent incorporation of 20S protease into the 26S complex that degrades proteins conjugated to ubiquitin. Proc Natl Acad Sci U S A (1989) 1.82
Spiral computerized tomography in the evaluation of acute flank pain: a replacement for excretory urography. J Urol (1997) 1.77
Phosphorylation of Cdc20/fizzy negatively regulates the mammalian cyclosome/APC in the mitotic checkpoint. Biochem Biophys Res Commun (2000) 1.74
Isolation of a chloroplast N,N'-dicyclohexylcarbodiimide-binding proteolipid, active in proton translocation. Proc Natl Acad Sci U S A (1977) 1.73
The protein substrate binding site of the ubiquitin-protein ligase system. J Biol Chem (1986) 1.72
The mouse and human genes encoding the recognition component of the N-end rule pathway. Proc Natl Acad Sci U S A (1998) 1.72
Requirement for protein synthesis in the regulation of protein breakdown in cultured hepatoma cells. Biochemistry (1975) 1.71
E2-C, a cyclin-selective ubiquitin carrier protein required for the destruction of mitotic cyclins. Proc Natl Acad Sci U S A (1996) 1.70
A multicomponent system that degrades proteins conjugated to ubiquitin. Resolution of factors and evidence for ATP-dependent complex formation. J Biol Chem (1988) 1.60
Activators of yeast hexokinase. J Biol Chem (1971) 1.55
SCF(beta)(-TrCP) ubiquitin ligase-mediated processing of NF-kappaB p105 requires phosphorylation of its C-terminus by IkappaB kinase. EMBO J (2000) 1.55
The isotope trapping method: desorption rates of productive E.S complexes. Methods Enzymol (1980) 1.53
Hemin inhibits ATP-dependent ubiquitin-dependent proteolysis: role of hemin in regulating ubiquitin conjugate degradation. Proc Natl Acad Sci U S A (1981) 1.53
Characterization of the heat-stable polypeptide of the ATP-dependent proteolytic system from reticulocytes. J Biol Chem (1980) 1.51
A ubiquitin C-terminal isopeptidase that acts on polyubiquitin chains. Role in protein degradation. J Biol Chem (1992) 1.48
Activation of the heat-stable polypeptide of the ATP-dependent proteolytic system. Proc Natl Acad Sci U S A (1981) 1.48
Antidiuretic hormone in pituitary glands of new-born rats. J Physiol (1947) 1.45
Inverse relation between levels of p27(Kip1) and of its ubiquitin ligase subunit Skp2 in colorectal carcinomas. Cancer (2001) 1.44
Affinity purification of ubiquitin-protein ligase on immobilized protein substrates. Evidence for the existence of separate NH2-terminal binding sites on a single enzyme. J Biol Chem (1990) 1.43
Mechanism of ubiquitin carboxyl-terminal hydrolase. Borohydride and hydroxylamine inactivate in the presence of ubiquitin. J Biol Chem (1986) 1.43
Post-translational cleavage of polypeptide chains: role in assembly. Annu Rev Biochem (1975) 1.42
The response of newborn rats to administration of water by the stomach. J Physiol (1947) 1.42
Relationship of the pool of intracellular valine to protein synthesis and degradation in cultured cells. J Biol Chem (1976) 1.40
The posterior pituitary principles of a species of reptile (Tropidonotus natrix) with some remarks on the comparative physiology of the posterior pituitary gland generally. J Physiol (1942) 1.38
The effect of the hydrogen-ion concentration on the stability of the antidiuretic and vasopressor activities of posterior pituitary extracts. J Physiol (1939) 1.36
Resolution and reconstitution of ion-transport systems. Ann N Y Acad Sci (1975) 1.32
Ubiquitin adenylate: structure and role in ubiquitin activation. Biochemistry (1983) 1.31
Specificity for the glucose-6-P inhibition site of hexokinase. Arch Biochem Biophys (1974) 1.30
Effects of dehydration on adult and newborn rats. J Physiol (1949) 1.30
The distribution of the pituitary antidiuretic hormone throughout the vertebrate series. J Physiol (1941) 1.29
Determination of the rate of hexokinase-glucose dissociation by the isotope-trapping method. J Biol Chem (1974) 1.29
Ubiquitin C-terminal hydrolase activity associated with the 26 S protease complex. J Biol Chem (1993) 1.28
The action of the antidiuretic principle of posterior pituitary extracts on the urine excretion of anaesthetized animals. J Physiol (1940) 1.28
Binding sites of ubiquitin-protein ligase. Binding of ubiquitin-protein conjugates and of ubiquitin-carrier protein. J Biol Chem (1989) 1.27
Control of glycolysis in the human red blood cell. J Biol Chem (1966) 1.27
A stereochemical method for detection of ATP terminal phosphate transfer in enzymatic reactions. Glutamine synthetase. J Biol Chem (1976) 1.26