Published in J Biol Chem on February 25, 1981
Ubiquitin is a heat shock protein in chicken embryo fibroblasts. Mol Cell Biol (1985) 3.31
ATP-dependent degradation of ubiquitin-protein conjugates. Proc Natl Acad Sci U S A (1984) 1.92
Role of the alpha-amino group of protein in ubiquitin-mediated protein breakdown. Proc Natl Acad Sci U S A (1984) 1.49
Ubiquitin at Fox Chase. Proc Natl Acad Sci U S A (2005) 1.48
ATP serves two distinct roles in protein degradation in reticulocytes, one requiring and one independent of ubiquitin. J Cell Biol (1983) 1.35
The E2 ubiquitin-conjugating enzymes direct polyubiquitination to preferred lysines. J Biol Chem (2010) 1.28
The multiple layers of ubiquitin-dependent cell cycle control. Chem Rev (2009) 1.22
The Cul3/Klhdc5 E3 ligase regulates p60/katanin and is required for normal mitosis in mammalian cells. J Biol Chem (2009) 1.02
E3 ligases determine ubiquitination site and conjugate type by enforcing specificity on E2 enzymes. J Biol Chem (2011) 0.97
Copper: from neurotransmission to neuroproteostasis. Front Aging Neurosci (2014) 0.89
Role of E3 ubiquitin ligases in lung cancer. World J Clin Oncol (2013) 0.86
Intracellular Protein Degradation: From a Vague Idea through the Lysosome and the Ubiquitin-Proteasome System and onto Human Diseases and Drug Targeting. Rambam Maimonides Med J (2012) 0.78
ATP-induced loss of Alz-50 immunoreactivity with the A68 proteins from Alzheimer brain is mediated by ubiquitin. Proc Natl Acad Sci U S A (1990) 0.76
The Autophagoproteasome a Novel Cell Clearing Organelle in Baseline and Stimulated Conditions. Front Neuroanat (2016) 0.76
Recognition of ubiquitinated nucleosomes. Curr Opin Struct Biol (2016) 0.75
The Role of Ubiquitination and Hepatocyte Growth Factor-Regulated Tyrosine Kinase Substrate in the Degradation of the Adrenomedullin Type I Receptor. Sci Rep (2017) 0.75
The ubiquitin system. Annu Rev Biochem (1998) 43.36
SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27. Nat Cell Biol (1999) 9.92
The ubiquitin system for protein degradation. Annu Rev Biochem (1992) 8.84
pH and the recycling of transferrin during receptor-mediated endocytosis. Proc Natl Acad Sci U S A (1983) 8.41
Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown. J Biol Chem (1983) 7.03
Ubiquitin dependence of selective protein degradation demonstrated in the mammalian cell cycle mutant ts85. Cell (1984) 6.81
Ubiquitin ligase activity and tyrosine phosphorylation underlie suppression of growth factor signaling by c-Cbl/Sli-1. Mol Cell (1999) 6.79
The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis. Mol Biol Cell (1995) 6.23
Thermolability of ubiquitin-activating enzyme from the mammalian cell cycle mutant ts85. Cell (1984) 5.70
Mechanisms of intracellular protein breakdown. Annu Rev Biochem (1982) 4.89
"Pleiotypic response". Nat New Biol (1971) 4.85
Kinetics of internalization and recycling of transferrin and the transferrin receptor in a human hepatoma cell line. Effect of lysosomotropic agents. J Biol Chem (1983) 4.55
Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation. Genes Dev (1999) 4.07
Basic Medical Research Award. The ubiquitin system. Nat Med (2000) 4.03
Regulation of stability and function of the epithelial Na+ channel (ENaC) by ubiquitination. EMBO J (1997) 4.01
A heat-stable polypeptide component of an ATP-dependent proteolytic system from reticulocytes. Biochem Biophys Res Commun (1978) 3.92
The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27. Nat Cell Biol (2001) 3.87
Proposed role of ATP in protein breakdown: conjugation of protein with multiple chains of the polypeptide of ATP-dependent proteolysis. Proc Natl Acad Sci U S A (1980) 3.75
The mechanism of ubiquitin activating enzyme. A kinetic and equilibrium analysis. J Biol Chem (1982) 3.69
Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death Differ (2009) 3.44
Inhibition of ubiquitin/proteasome-dependent protein degradation by the Gly-Ala repeat domain of the Epstein-Barr virus nuclear antigen 1. Proc Natl Acad Sci U S A (1997) 3.31
Ubiquitin: roles in protein modification and breakdown. Cell (1983) 3.19
ATP-dependent conjugation of reticulocyte proteins with the polypeptide required for protein degradation. Proc Natl Acad Sci U S A (1980) 2.96
Studies on the degradation of tyrosine aminotransferase in hepatoma cells in culture. Influence of the composition of the medium and adenosine triphosphate dependence. J Biol Chem (1971) 2.83
Functional interaction between SEL-10, an F-box protein, and the nuclear form of activated Notch1 receptor. J Biol Chem (2001) 2.71
The ubiquitin-proteasome pathway and pathogenesis of human diseases. Annu Rev Med (1999) 2.68
Ubiquitin-activating enzyme. Mechanism and role in protein-ubiquitin conjugation. J Biol Chem (1982) 2.65
Stimulation-dependent I kappa B alpha phosphorylation marks the NF-kappa B inhibitor for degradation via the ubiquitin-proteasome pathway. Proc Natl Acad Sci U S A (1995) 2.61
Mitochondrial hexokinase. Release, rebinding, and location. J Biol Chem (1967) 2.58
The ubiquitin conjugation system is required for ligand-induced endocytosis and degradation of the growth hormone receptor. EMBO J (1996) 2.58
Occurrence of a polyubiquitin structure in ubiquitin-protein conjugates. Biochem Biophys Res Commun (1985) 2.56
Immunochemical analysis of the turnover of ubiquitin-protein conjugates in intact cells. Relationship to the breakdown of abnormal proteins. J Biol Chem (1982) 2.56
Functional heterogeneity of ubiquitin carrier proteins. J Biol Chem (1985) 2.53
Ubiquitin-aldehyde: a general inhibitor of ubiquitin-recycling processes. Proc Natl Acad Sci U S A (1987) 2.52
Reversible phosphorylation controls the activity of cyclosome-associated cyclin-ubiquitin ligase. Proc Natl Acad Sci U S A (1995) 2.48
Resolution of the ATP-dependent proteolytic system from reticulocytes: a component that interacts with ATP. Proc Natl Acad Sci U S A (1979) 2.37
A Chinese hamster cell cycle mutant arrested at G2 phase has a temperature-sensitive ubiquitin-activating enzyme, E1. J Biol Chem (1988) 2.33
A novel site for ubiquitination: the N-terminal residue, and not internal lysines of MyoD, is essential for conjugation and degradation of the protein. EMBO J (1998) 2.31
Mutation of the E6-AP ubiquitin ligase reduces nuclear inclusion frequency while accelerating polyglutamine-induced pathology in SCA1 mice. Neuron (1999) 2.25
"Covalent affinity" purification of ubiquitin-activating enzyme. J Biol Chem (1982) 2.15
Ubiquitin-dependent degradation of certain protein substrates in vitro requires the molecular chaperone Hsc70. J Biol Chem (1997) 2.14
The ubiquitin-mediated proteolytic pathway and mechanisms of energy-dependent intracellular protein degradation. J Cell Biochem (1984) 2.10
The asialoglycoprotein receptor internalizes and recycles independently of the transferrin and insulin receptors. Cell (1983) 2.10
Dominant-negative cyclin-selective ubiquitin carrier protein E2-C/UbcH10 blocks cells in metaphase. Proc Natl Acad Sci U S A (1997) 2.08
Ubiquitin carboxyl-terminal hydrolase acts on ubiquitin carboxyl-terminal amides. J Biol Chem (1985) 2.08
Specificity of binding of NH2-terminal residue of proteins to ubiquitin-protein ligase. Use of amino acid derivatives to characterize specific binding sites. J Biol Chem (1988) 2.04
The state of magnesium in cells as estimated from the adenylate kinase equilibrium. Proc Natl Acad Sci U S A (1968) 2.03
The ubiquitin pathway for the degradation of intracellular proteins. Prog Nucleic Acid Res Mol Biol (1986) 1.98
Mechanism of aconitase action. I. The hydrogen transfer reaction. J Biol Chem (1967) 1.95
Phosphorylation of the cyclosome is required for its stimulation by Fizzy/cdc20. Biochem Biophys Res Commun (1999) 1.93
ATP-dependent degradation of ubiquitin-protein conjugates. Proc Natl Acad Sci U S A (1984) 1.92
Basal and human papillomavirus E6 oncoprotein-induced degradation of Myc proteins by the ubiquitin pathway. Proc Natl Acad Sci U S A (1998) 1.88
ATP-dependent incorporation of 20S protease into the 26S complex that degrades proteins conjugated to ubiquitin. Proc Natl Acad Sci U S A (1989) 1.82
Modes of regulation of ubiquitin-mediated protein degradation. J Cell Physiol (2000) 1.82
Inhibition of NF-kappa-B cellular function via specific targeting of the I-kappa-B-ubiquitin ligase. EMBO J (1997) 1.78
Itch: a HECT-type E3 ligase regulating immunity, skin and cancer. Cell Death Differ (2008) 1.77
Phosphorylation of Cdc20/fizzy negatively regulates the mammalian cyclosome/APC in the mitotic checkpoint. Biochem Biophys Res Commun (2000) 1.74
The protein substrate binding site of the ubiquitin-protein ligase system. J Biol Chem (1986) 1.72
Protein synthesis elongation factor EF-1 alpha is essential for ubiquitin-dependent degradation of certain N alpha-acetylated proteins and may be substituted for by the bacterial elongation factor EF-Tu. Proc Natl Acad Sci U S A (1994) 1.72
The mouse and human genes encoding the recognition component of the N-end rule pathway. Proc Natl Acad Sci U S A (1998) 1.72
Role of arginine-tRNA in protein degradation by the ubiquitin pathway. Nature (1987) 1.71
Requirement for protein synthesis in the regulation of protein breakdown in cultured hepatoma cells. Biochemistry (1975) 1.71
E2-C, a cyclin-selective ubiquitin carrier protein required for the destruction of mitotic cyclins. Proc Natl Acad Sci U S A (1996) 1.70
Degradation of the E7 human papillomavirus oncoprotein by the ubiquitin-proteasome system: targeting via ubiquitination of the N-terminal residue. Oncogene (2000) 1.67
How are substrates recognized by the ubiquitin-mediated proteolytic system? Trends Biochem Sci (1989) 1.66
A multicomponent system that degrades proteins conjugated to ubiquitin. Resolution of factors and evidence for ATP-dependent complex formation. J Biol Chem (1988) 1.60
Activators of yeast hexokinase. J Biol Chem (1971) 1.55
SCF(beta)(-TrCP) ubiquitin ligase-mediated processing of NF-kappaB p105 requires phosphorylation of its C-terminus by IkappaB kinase. EMBO J (2000) 1.55
The isotope trapping method: desorption rates of productive E.S complexes. Methods Enzymol (1980) 1.53
Hemin inhibits ATP-dependent ubiquitin-dependent proteolysis: role of hemin in regulating ubiquitin conjugate degradation. Proc Natl Acad Sci U S A (1981) 1.53
Characterization of the heat-stable polypeptide of the ATP-dependent proteolytic system from reticulocytes. J Biol Chem (1980) 1.51
Degradation of ornithine decarboxylase in reticulocyte lysate is ATP-dependent but ubiquitin-independent. J Biol Chem (1989) 1.50
Role of the alpha-amino group of protein in ubiquitin-mediated protein breakdown. Proc Natl Acad Sci U S A (1984) 1.49
A ubiquitin C-terminal isopeptidase that acts on polyubiquitin chains. Role in protein degradation. J Biol Chem (1992) 1.48
Degradation of the proto-oncogene product c-Fos by the ubiquitin proteolytic system in vivo and in vitro: identification and characterization of the conjugating enzymes. Mol Cell Biol (1995) 1.48
Activation of the heat-stable polypeptide of the ATP-dependent proteolytic system. Proc Natl Acad Sci U S A (1981) 1.48
Complete switch from Mdm2 to human papillomavirus E6-mediated degradation of p53 in cervical cancer cells. Proc Natl Acad Sci U S A (2001) 1.47
Degradation of ornithine decarboxylase in mammalian cells is ATP dependent but ubiquitin independent. Eur J Biochem (1989) 1.45
Inverse relation between levels of p27(Kip1) and of its ubiquitin ligase subunit Skp2 in colorectal carcinomas. Cancer (2001) 1.44
Affinity purification of ubiquitin-protein ligase on immobilized protein substrates. Evidence for the existence of separate NH2-terminal binding sites on a single enzyme. J Biol Chem (1990) 1.43
Mechanism of ubiquitin carboxyl-terminal hydrolase. Borohydride and hydroxylamine inactivate in the presence of ubiquitin. J Biol Chem (1986) 1.43
Post-translational cleavage of polypeptide chains: role in assembly. Annu Rev Biochem (1975) 1.42
Degradation of myogenic transcription factor MyoD by the ubiquitin pathway in vivo and in vitro: regulation by specific DNA binding. Mol Cell Biol (1998) 1.41