Published in Nature on February 04, 1982
Mutation of NH2-terminal glycine of p60src prevents both myristoylation and morphological transformation. Proc Natl Acad Sci U S A (1985) 4.87
A noncatalytic domain conserved among cytoplasmic protein-tyrosine kinases modifies the kinase function and transforming activity of Fujinami sarcoma virus P130gag-fps. Mol Cell Biol (1986) 4.00
Phosphotyrosine-containing proteins are concentrated in focal adhesions and intercellular junctions in normal cells. Proc Natl Acad Sci U S A (1985) 3.76
Blood platelets express high levels of the pp60c-src-specific tyrosine kinase activity. Proc Natl Acad Sci U S A (1986) 3.22
cDNA cloning and expression of a human platelet-derived growth factor (PDGF) receptor specific for B-chain-containing PDGF molecules. Mol Cell Biol (1988) 2.88
Platelet-derived growth factor induces rapid and sustained tyrosine phosphorylation of phospholipase C-gamma in quiescent BALB/c 3T3 cells. Mol Cell Biol (1989) 2.78
Platelet-derived growth factor (PDGF) binding promotes physical association of PDGF receptor with phospholipase C. Proc Natl Acad Sci U S A (1989) 2.75
Isolation of antibodies for phosphotyrosine by immunization with a v-abl oncogene-encoded protein. Mol Cell Biol (1985) 2.74
Characterization and use of monoclonal antibodies for isolation of phosphotyrosyl proteins from retrovirus-transformed cells and growth factor-stimulated cells. Mol Cell Biol (1983) 2.70
The Croonian Lecture 1997. The phosphorylation of proteins on tyrosine: its role in cell growth and disease. Philos Trans R Soc Lond B Biol Sci (1998) 2.53
Novel protein-tyrosine kinase gene (hck) preferentially expressed in cells of hematopoietic origin. Mol Cell Biol (1987) 2.52
p185, a product of the neu proto-oncogene, is a receptorlike protein associated with tyrosine kinase activity. Mol Cell Biol (1986) 2.52
Tyrosine-specific protein kinase activity is associated with the purified insulin receptor. Proc Natl Acad Sci U S A (1983) 2.49
Activation of cultured rat hepatic lipocytes by Kupffer cell conditioned medium. Direct enhancement of matrix synthesis and stimulation of cell proliferation via induction of platelet-derived growth factor receptors. J Clin Invest (1989) 2.46
Platelet-derived growth factor stimulates tyrosine-specific protein kinase activity in Swiss mouse 3T3 cell membranes. Proc Natl Acad Sci U S A (1982) 2.39
Novel tyrosine kinase identified by phosphotyrosine antibody screening of cDNA libraries. Mol Cell Biol (1988) 2.31
Diverse mitogenic agents induce the phosphorylation of two related 42,000-dalton proteins on tyrosine in quiescent chick cells. Mol Cell Biol (1984) 2.28
Tumor promoters block tyrosine-specific phosphorylation of the epidermal growth factor receptor. Proc Natl Acad Sci U S A (1984) 2.28
Platelet-derived growth factor-induced alterations in vinculin and actin distribution in BALB/c-3T3 cells. J Cell Biol (1985) 2.26
The product of the protooncogene c-src is modified during the cellular response to platelet-derived growth factor. Proc Natl Acad Sci U S A (1985) 2.19
Association of phorbol ester-induced hyperphosphorylation and reversible regulation of transferrin membrane receptors in HL60 cells. Proc Natl Acad Sci U S A (1984) 2.14
Down regulation of epidermal growth factor receptors: direct demonstration of receptor degradation in human fibroblasts. J Cell Biol (1984) 2.12
Characterization of cDNA clones for the human c-yes gene. Mol Cell Biol (1987) 2.11
Cell surface expression of v-fms-coded glycoproteins is required for transformation. Mol Cell Biol (1984) 2.09
A protein kinase from Xenopus eggs specific for ribosomal protein S6. Proc Natl Acad Sci U S A (1985) 2.03
Reorganization of alpha-actinin and vinculin induced by a phorbol ester in living cells. J Cell Biol (1986) 1.98
Only site-directed antibodies reactive with the highly conserved src-homologous region of the v-abl protein neutralize kinase activity. J Virol (1984) 1.93
Tyrosine phosphorylation of specific proteins after mitogen stimulation of chicken embryo fibroblasts. Mol Cell Biol (1983) 1.92
Characterization of the protein apparently responsible for the elevated tyrosine protein kinase activity in LSTRA cells. Mol Cell Biol (1984) 1.92
pp60c-src in the developing cerebellum. Mol Cell Biol (1985) 1.90
Phosphorylation of the nicotinic acetylcholine receptor by an endogenous tyrosine-specific protein kinase. Proc Natl Acad Sci U S A (1984) 1.82
Phospholipase C-gamma, a substrate for PDGF receptor kinase, is not phosphorylated on tyrosine during the mitogenic response to CSF-1. EMBO J (1989) 1.81
Spontaneous expression of the c-sis gene and release of a platelet-derived growth factorlike molecule by human alveolar macrophages. J Clin Invest (1986) 1.80
A lysine in the ATP-binding site of P130gag-fps is essential for protein-tyrosine kinase activity. EMBO J (1986) 1.77
Covalently bound myristate in a lymphoma tyrosine protein kinase. Proc Natl Acad Sci U S A (1984) 1.76
Nerve growth factor induces protein-tyrosine phosphorylation. Proc Natl Acad Sci U S A (1988) 1.73
Protein tyrosine phosphorylation in the cell cycle of BALB/c 3T3 fibroblasts. Proc Natl Acad Sci U S A (1986) 1.69
Interactions between the receptors for platelet-derived growth factor and epidermal growth factor. J Cell Biol (1983) 1.68
Structure of the murine lck gene and its rearrangement in a murine lymphoma cell line. Mol Cell Biol (1988) 1.66
Structural and functional studies on platelet-derived growth factor. EMBO J (1992) 1.64
Characterization of the TPR-MET oncogene p65 and the MET protooncogene p140 protein-tyrosine kinases. Proc Natl Acad Sci U S A (1988) 1.64
A 20-kDa protein associated with the murine T-cell antigen receptor is phosphorylated in response to activation by antigen or concanavalin A. Proc Natl Acad Sci U S A (1985) 1.62
B-type receptor for platelet-derived growth factor mediates a chemotactic response by means of ligand-induced activation of the receptor protein-tyrosine kinase. Proc Natl Acad Sci U S A (1990) 1.60
Cell lines and peripheral blood leukocytes derived from individuals with chronic myelogenous leukemia display virtually identical proteins phosphorylated on tyrosine residues. Proc Natl Acad Sci U S A (1987) 1.53
Receptor-mediated phosphorylation of the hepatic insulin receptor: evidence that the Mr 95,000 receptor subunit is its own kinase. Proc Natl Acad Sci U S A (1983) 1.49
Immunofluorescent localization of a 39,000-dalton substrate of tyrosine protein kinases to the cytoplasmic surface of the plasma membrane. J Cell Biol (1983) 1.49
Phosphotyrosyl protein phosphatases. Biochem J (1989) 1.49
Injury induces in vivo expression of platelet-derived growth factor (PDGF) and PDGF receptor mRNAs in skin epithelial cells and PDGF mRNA in connective tissue fibroblasts. Proc Natl Acad Sci U S A (1991) 1.48
Interleukin 3-specific tyrosine phosphorylation of a membrane glycoprotein of Mr 150,000 in multi-factor-dependent myeloid cell lines. EMBO J (1987) 1.45
PDGF and PDGF receptors in glioma. Ups J Med Sci (2012) 1.43
Mouse NIH 3T3 cells expressing human colony-stimulating factor 1 (CSF-1) receptors overgrow in serum-free medium containing human CSF-1 as their only growth factor. Proc Natl Acad Sci U S A (1989) 1.39
Platelet-derived growth factor. Structure, function, and roles in normal and transformed cells. J Clin Invest (1984) 1.38
Membranes from T and B lymphocytes have different patterns of tyrosine phosphorylation. Proc Natl Acad Sci U S A (1984) 1.38
Tyrosyl protein kinases in normal rat liver: identification and partial characterization. Proc Natl Acad Sci U S A (1983) 1.35
Protein kinase activity of the insulin receptor. Biochem J (1986) 1.31
Platelet-derived growth factor-modulated translatable mRNAs. Mol Cell Biol (1983) 1.30
Protein stabilization explains the gag requirement for transformation of lymphoid cells by Abelson murine leukemia virus. J Virol (1985) 1.29
Deletion of the kinase insert sequence of the platelet-derived growth factor beta-receptor affects receptor kinase activity and signal transduction. Mol Cell Biol (1990) 1.27
Induction of platelet-derived growth factor receptor expression in smooth muscle cells and fibroblasts upon tissue culturing. J Cell Biol (1988) 1.25
Effects of epidermal growth factor and 12-O-tetradecanoylphorbol-13-acetate on metabolism of the epidermal growth factor receptor in normal human fibroblasts. Mol Cell Biol (1984) 1.24
Phosphatidylinositol turnover and transformation of cells by Abelson murine leukaemia virus. EMBO J (1985) 1.24
Purified human platelet-derived growth factor receptor has ligand-stimulated tyrosine kinase activity. Proc Natl Acad Sci U S A (1986) 1.24
Alpha-thrombin-induced tyrosine phosphorylation of 43,000- and 41,000-Mr proteins is independent of cytoplasmic alkalinization in quiescent fibroblasts. Biochem J (1986) 1.23
Phosphorylation of ribosomal protein S6 on serine after microinjection of the Abelson murine leukemia virus tyrosine-specific protein kinase into Xenopus oocytes. Proc Natl Acad Sci U S A (1985) 1.23
Receptor tyrosine kinases: legacy of the first two decades. Cold Spring Harb Perspect Biol (2014) 1.23
Isolation and chromosomal localization of the human fgr protooncogene, a distinct member of the tyrosine kinase gene family. Proc Natl Acad Sci U S A (1985) 1.22
Insulin and growth factors stimulate the phosphorylation of a Mr-22000 protein in 3T3-L1 adipocytes. Biochem J (1983) 1.20
Platelet-derived growth factor stimulates mouse 3T3 cell mitogenesis and leukocyte chemotaxis through different structural determinants. J Clin Invest (1983) 1.19
Platelet-derived growth factor agonist activity of a secreted form of the v-sis oncogene product. Proc Natl Acad Sci U S A (1985) 1.18
Isolation and sequence of a cDNA corresponding to a src-related gene expressed in murine hemopoietic cells. Proc Natl Acad Sci U S A (1987) 1.17
Antibodies of predetermined specificity detect two retroviral oncogene products and inhibit their kinase activities. Proc Natl Acad Sci U S A (1983) 1.17
Different effects of homo- and heterodimers of platelet-derived growth factor A and B chains on human and mouse fibroblasts. EMBO J (1988) 1.17
Identification, purification, and characterization of phosphotyrosine-specific protein phosphatases from cultured chicken embryo fibroblasts. Mol Cell Biol (1984) 1.16
Phosphorylation of the ribosomal protein S6 is elevated in cells transformed by a variety of tumor viruses. J Virol (1984) 1.13
Platelet-derived growth factor mimics phorbol diester action on epidermal growth factor receptor phosphorylation at threonine-654. Proc Natl Acad Sci U S A (1985) 1.12
Deletion or substitution within the alpha platelet-derived growth factor receptor kinase insert domain: effects on functional coupling with intracellular signaling pathways. Mol Cell Biol (1991) 1.12
Receptor-mediated endocytosis. J Clin Invest (1986) 1.11
Membrane protein phosphotyrosine phosphatase in rabbit kidney. Proteolysis activates the enzyme and generates soluble catalytic fragments. Biochem J (1987) 1.10
Conversion of a phosphoseryl/threonyl phosphatase into a phosphotyrosyl phosphatase. Biochem J (1988) 1.07
Autocrine stimulation by the v-sis gene product requires a ligand-receptor interaction at the cell surface. J Cell Biol (1988) 1.07
Stimulation of glucose uptake by transforming growth factor beta: evidence for the requirement of epidermal growth factor-receptor activation. Proc Natl Acad Sci U S A (1985) 1.07
Genetic mapping of a major site of phosphorylation in adenovirus type 2 E1A proteins. J Virol (1986) 1.06
pp60c-src is expressed in human fetal and adult brain. Am J Pathol (1985) 1.06
Two different protein kinase activities are associated with the insulin receptor. Biochem J (1983) 1.04
Regulation of the transcript for a lysosomal protein: evidence for a gene program modified by platelet-derived growth factor. Mol Cell Biol (1985) 1.04
Phosphorylation of the rat hepatic polymeric IgA receptor. Proc Natl Acad Sci U S A (1986) 1.02
Modulation of p36 phosphorylation in human cells: studies using anti-p36 monoclonal antibodies. Mol Cell Biol (1986) 1.02
Catecholamines are mitogenic in 3T3 and bovine aortic endothelial cells. J Clin Invest (1984) 1.01
Identification of the tyrosine protein kinase from LSTRA cells by use of site-specific antibodies. Proc Natl Acad Sci U S A (1984) 1.01
Antipeptide antiserum identifies a widely distributed cellular tyrosine kinase related to but distinct from the c-fps/fes-encoded protein. Mol Cell Biol (1986) 1.00
Complexing of the CD-3 subunit by a monoclonal antibody activates a microtubule-associated protein 2 (MAP-2) serine kinase in Jurkat cells. Biochem J (1989) 0.99
Isolation of chicken cellular DNA sequences with homology to the region of viral oncogenes that encodes the tyrosine kinase domain. Mol Cell Biol (1986) 0.98
Ionic responses rapidly elicited by porcine platelet-derived growth factor in Swiss 3T3 cells. EMBO J (1984) 0.95
Neoplastic human fibroblast proteins are related to epidermal growth factor precursor. Proc Natl Acad Sci U S A (1984) 0.92
Phosphorylation differences among proteins of bloodstream developmental stages of Trypanosoma brucei brucei. Biochem J (1991) 0.92
Embryonal carcinoma-derived growth factor activates protein kinase C in vivo and in vitro. EMBO J (1987) 0.92
Colony-stimulating factor 1-mediated regulation of a chimeric c-fms/v-fms receptor containing the v-fms-encoded tyrosine kinase domain. Proc Natl Acad Sci U S A (1988) 0.91
Tyrosine-specific phosphorylation of calmodulin by the insulin receptor kinase purified from human placenta. Biochem J (1989) 0.90
Abnormality of insulin binding and receptor phosphorylation in an insulin-resistant melanoma cell line. J Cell Biol (1984) 0.89
An Mr 180,000 protein is an endogenous substrate for the insulin-receptor-associated tyrosine kinase in human placenta. Biochem J (1987) 0.89
Platelet-derived growth factor is structurally related to the putative transforming protein p28sis of simian sarcoma virus. Nature (1983) 8.60
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PDGF-C is a new protease-activated ligand for the PDGF alpha-receptor. Nat Cell Biol (2000) 3.81
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Activation of p70/p85 S6 kinase by a pathway independent of p21ras. Nature (1994) 3.67
Cloning of a TGF beta type I receptor that forms a heteromeric complex with the TGF beta type II receptor. Cell (1993) 3.57
A method for the determination of the molecular weight and molecular-weight distribution of chondroitin sulphate. J Chromatogr (1971) 3.51
Identification of type I receptors for osteogenic protein-1 and bone morphogenetic protein-4. J Biol Chem (1994) 3.49
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