Published in Mol Cell Biol on January 01, 1991
GTPase-activating protein and phosphatidylinositol 3-kinase bind to distinct regions of the platelet-derived growth factor receptor beta subunit. Mol Cell Biol (1992) 2.11
Two signaling molecules share a phosphotyrosine-containing binding site in the platelet-derived growth factor receptor. Mol Cell Biol (1993) 1.91
Signal transduction by normal isoforms and W mutant variants of the Kit receptor tyrosine kinase. EMBO J (1991) 1.58
Differential activation of the Ras/extracellular-signal-regulated protein kinase pathway is responsible for the biological consequences induced by the Axl receptor tyrosine kinase. Mol Cell Biol (1996) 1.50
Distinct utilization of effectors and biological outcomes resulting from site-specific Ras activation: Ras functions in lipid rafts and Golgi complex are dispensable for proliferation and transformation. Mol Cell Biol (2006) 1.46
Tyrosine mutations within the alpha platelet-derived growth factor receptor kinase insert domain abrogate receptor-associated phosphatidylinositol-3 kinase activity without affecting mitogenic or chemotactic signal transduction. Mol Cell Biol (1991) 1.42
Molecular portraits of B cell lineage commitment. Proc Natl Acad Sci U S A (2002) 1.32
Hereditary cutaneomucosal venous malformations are caused by TIE2 mutations with widely variable hyper-phosphorylating effects. Eur J Hum Genet (2009) 1.17
Biological function of PDGF-induced PI-3 kinase activity: its role in alpha PDGF receptor-mediated mitogenic signaling. J Cell Biol (1994) 0.85
Ligand stimulation of transfected and endogenous growth factor receptors enhances cytokine production by mast cells. EMBO J (1991) 0.81
Platelet-derived growth factor (PDGF)-AB-mediated phosphorylation of PDGF beta receptors. Biochem J (1994) 0.75
Isolation of biologically active ribonucleic acid from sources enriched in ribonuclease. Biochemistry (1979) 180.95
Enzymatic amplification of beta-globin genomic sequences and restriction site analysis for diagnosis of sickle cell anemia. Science (1985) 95.08
Prediction of the secondary structure of proteins from their amino acid sequence. Adv Enzymol Relat Areas Mol Biol (1978) 29.77
The labelling of proteins to high specific radioactivities by conjugation to a 125I-containing acylating agent. Biochem J (1973) 22.93
Signal transduction by receptors with tyrosine kinase activity. Cell (1990) 22.72
Selection for animal cells that express the Escherichia coli gene coding for xanthine-guanine phosphoribosyltransferase. Proc Natl Acad Sci U S A (1981) 22.21
Protein-tyrosine kinases. Annu Rev Biochem (1985) 14.83
The c-fms proto-oncogene product is related to the receptor for the mononuclear phagocyte growth factor, CSF-1. Cell (1985) 10.17
Simian sarcoma virus onc gene, v-sis, is derived from the gene (or genes) encoding a platelet-derived growth factor. Science (1983) 9.06
Structure of the receptor for platelet-derived growth factor helps define a family of closely related growth factor receptors. Nature (1986) 7.90
Human proto-oncogene c-kit: a new cell surface receptor tyrosine kinase for an unidentified ligand. EMBO J (1987) 7.32
Association of phosphatidylinositol kinase activity with polyoma middle-T competent for transformation. Nature (1985) 7.10
Common elements in growth factor stimulation and oncogenic transformation: 85 kd phosphoprotein and phosphatidylinositol kinase activity. Cell (1987) 5.87
Overexpression of the human EGF receptor confers an EGF-dependent transformed phenotype to NIH 3T3 cells. Cell (1987) 5.11
Direct activation of the serine/threonine kinase activity of Raf-1 through tyrosine phosphorylation by the PDGF beta-receptor. Cell (1989) 4.86
PDGF beta-receptor stimulates tyrosine phosphorylation of GAP and association of GAP with a signaling complex. Cell (1990) 4.85
cDNA sequence and chromosomal localization of human platelet-derived growth factor A-chain and its expression in tumour cell lines. Nature (1986) 4.81
Stimulation of tyrosine-specific phosphorylation by platelet-derived growth factor. Nature (1982) 4.74
Autophosphorylation of the PDGF receptor in the kinase insert region regulates interactions with cell proteins. Cell (1989) 4.52
PDGF induction of tyrosine phosphorylation of GTPase activating protein. Nature (1989) 4.36
Role of phosphatidylinositol kinase in PDGF receptor signal transduction. Science (1989) 4.21
Isolation of a novel receptor cDNA establishes the existence of two PDGF receptor genes. Science (1989) 4.08
Demonstration of permanent factor-dependent multipotential (erythroid/neutrophil/basophil) hematopoietic progenitor cell lines. Proc Natl Acad Sci U S A (1983) 3.76
Nucleotide sequence and expression of a novel human receptor-type tyrosine kinase gene (flt) closely related to the fms family. Oncogene (1990) 3.66
Transforming potential of the c-fms proto-oncogene (CSF-1 receptor). Nature (1987) 3.37
Attachment of smooth muscle cells to collagen and their migration toward platelet-derived growth factor. Proc Natl Acad Sci U S A (1981) 3.31
The colony stimulating factor-1 receptor associates with and activates phosphatidylinositol-3 kinase. Nature (1989) 3.09
cDNA cloning and expression of a human platelet-derived growth factor (PDGF) receptor specific for B-chain-containing PDGF molecules. Mol Cell Biol (1988) 2.88
Early changes in phosphatidylinositol and arachidonic acid metabolism in quiescent swiss 3T3 cells stimulated to divide by platelet-derived growth factor. J Biol Chem (1981) 2.77
Platelet-derived growth factor (PDGF)-dependent association of phospholipase C-gamma with the PDGF receptor signaling complex. Mol Cell Biol (1990) 2.71
cDNA cloning and expression of the human A-type platelet-derived growth factor (PDGF) receptor establishes structural similarity to the B-type PDGF receptor. Proc Natl Acad Sci U S A (1989) 2.33
Signal transduction through the EGF receptor transfected in IL-3-dependent hematopoietic cells. Science (1988) 2.29
A PDGF receptor domain essential for mitogenesis but not for many other responses to PDGF. Nature (1988) 2.13
Cloning and expression of a cDNA coding for the human platelet-derived growth factor receptor: evidence for more than one receptor class. Proc Natl Acad Sci U S A (1988) 2.06
Platelet-derived growth factor: identification of constituent polypeptide chains. Biochem Biophys Res Commun (1982) 2.00
Phospholipase C-gamma, a substrate for PDGF receptor kinase, is not phosphorylated on tyrosine during the mitogenic response to CSF-1. EMBO J (1989) 1.81
Structural features of the colony-stimulating factor 1 receptor that affect its association with phosphatidylinositol 3-kinase. EMBO J (1990) 1.72
Autocrine interaction between TGF alpha and the EGF-receptor: quantitative requirements for induction of the malignant phenotype. Oncogene (1989) 1.57
Evidence that the v-sis gene product transforms by interaction with the receptor for platelet-derived growth factor. Science (1985) 1.39
Macrophage colony-stimulating factor-induced tyrosine phosphorylation of c-fms proteins expressed in FDC-P1 and BALB/c 3T3 cells. Mol Cell Biol (1990) 1.38
The unique insert of cellular and viral fms protein tyrosine kinase domains is dispensable for enzymatic and transforming activities. EMBO J (1989) 1.29
Deletion of the kinase insert sequence of the platelet-derived growth factor beta-receptor affects receptor kinase activity and signal transduction. Mol Cell Biol (1990) 1.27
Identification of tyrosine 706 in the kinase insert as the major colony-stimulating factor 1 (CSF-1)-stimulated autophosphorylation site in the CSF-1 receptor in a murine macrophage cell line. Mol Cell Biol (1990) 1.25
Phosphatidylinositol kinase activities in normal and Rous sarcoma virus-transformed cells. Mol Cell Biol (1985) 1.21
Thrombin-dependent association of phosphatidylinositol-3 kinase with p60c-src and p59fyn in human platelets. Mol Cell Biol (1990) 1.21
The role of individual cysteine residues in the structure and function of the v-sis gene product. Science (1987) 1.12
Thrombin induces serotonin secretion and aggregation independently of inositol phospholipids hydrolysis and protein phosphorylation in human platelets permeabilized with saponin. J Biol Chem (1985) 1.09
Separation and characterization of a phosphatidylinositol kinase activity that co-purifies with the epidermal growth factor receptor. J Biol Chem (1985) 1.05
Functional expression of the human receptor for colony-stimulating factor 1 (CSF-1) in hamster fibroblasts: CSF-1 stimulates Na+/H+ exchange and DNA-synthesis in the absence of phosphoinositide breakdown. Growth Factors (1990) 0.83
XBP1 mRNA is induced by ATF6 and spliced by IRE1 in response to ER stress to produce a highly active transcription factor. Cell (2001) 18.68
Murine sarcoma and leukemia viruses: assay using clonal lines of contact-inhibited mouse cells. J Virol (1969) 11.78
In vitro cultivation of human tumors: establishment of cell lines derived from a series of solid tumors. J Natl Cancer Inst (1973) 11.26
Multiple factors required for accurate initiation of transcription by purified RNA polymerase II. J Biol Chem (1980) 10.78
Multiple factors are required for the accurate transcription of purified genes by RNA polymerase III. J Biol Chem (1980) 10.63
Development of 3T3-like lines from Balb-c mouse embryo cultures: transformation susceptibility to SV40. J Cell Physiol (1968) 10.54
The small GTP-binding proteins Rac1 and Cdc42 regulate the activity of the JNK/SAPK signaling pathway. Cell (1995) 9.82
Simian sarcoma virus onc gene, v-sis, is derived from the gene (or genes) encoding a platelet-derived growth factor. Science (1983) 9.06
Identification of the hepatocyte growth factor receptor as the c-met proto-oncogene product. Science (1991) 8.68
A rapid in vitro assay for quantitating the invasive potential of tumor cells. Cancer Res (1987) 7.43
Integrin function: molecular hierarchies of cytoskeletal and signaling molecules. J Cell Biol (1995) 6.74
Induction of murine C-type viruses from clonal lines of virus-free BALB-3T3 cells. Science (1971) 6.71
Amplification of a novel v-erbB-related gene in a human mammary carcinoma. Science (1985) 6.56
erbB-2 is a potent oncogene when overexpressed in NIH/3T3 cells. Science (1987) 6.36
Expression of cellular homologues of retroviral onc genes in human hematopoietic cells. Proc Natl Acad Sci U S A (1982) 5.80
G-protein-coupled receptor of Kaposi's sarcoma-associated herpesvirus is a viral oncogene and angiogenesis activator. Nature (1998) 5.24
Overexpression of the human EGF receptor confers an EGF-dependent transformed phenotype to NIH 3T3 cells. Cell (1987) 5.11
Cellular genes analogous to retroviral onc genes are transcribed in human tumour cells. Nature (1982) 5.11
Purification and characterization of a newly identified growth factor specific for epithelial cells. Proc Natl Acad Sci U S A (1989) 5.10
Mast cell lines produce lymphokines in response to cross-linkage of Fc epsilon RI or to calcium ionophores. Nature (1989) 5.10
Characterization of murine sarcoma virus (Kirsten) transformation of mouse and human cells. J Gen Virol (1971) 5.01
Human KGF is FGF-related with properties of a paracrine effector of epithelial cell growth. Science (1989) 4.79
T24 human bladder carcinoma oncogene is an activated form of the normal human homologue of BALB- and Harvey-MSV transforming genes. Nature (1982) 4.54
Determination of ligand-binding specificity by alternative splicing: two distinct growth factor receptors encoded by a single gene. Proc Natl Acad Sci U S A (1992) 4.50
Independent segregation of loci for activation of biologically distinguishable RNA C-type viruses in mouse cells. Proc Natl Acad Sci U S A (1973) 4.39
Novel mechanism of Wnt signalling inhibition mediated by Dickkopf-1 interaction with LRP6/Arrow. Nat Cell Biol (2001) 4.38
Differential expression of the amv gene in human hematopoietic cells. Proc Natl Acad Sci U S A (1982) 4.37
PDGF induction of tyrosine phosphorylation of GTPase activating protein. Nature (1989) 4.36
Acquisition of transforming properties by alternative point mutations within c-bas/has human proto-oncogene. Nature (1983) 4.34
Exogenous expression of N-cadherin in breast cancer cells induces cell migration, invasion, and metastasis. J Cell Biol (2000) 4.33
Integrins can collaborate with growth factors for phosphorylation of receptor tyrosine kinases and MAP kinase activation: roles of integrin aggregation and occupancy of receptors. J Cell Biol (1996) 4.21
Isolation and characterization of ERBB3, a third member of the ERBB/epidermal growth factor receptor family: evidence for overexpression in a subset of human mammary tumors. Proc Natl Acad Sci U S A (1989) 4.17
gag Gene of mammalian type-C RNA tumour viruses. Nature (1976) 4.11
Cooperative signaling of ErbB3 and ErbB2 in neoplastic transformation and human mammary carcinomas. Oncogene (1995) 4.10
Phosphotyrosine-dependent activation of Rac-1 GDP/GTP exchange by the vav proto-oncogene product. Nature (1997) 4.05
Ras-dependent activation of MAP kinase pathway mediated by G-protein beta gamma subunits. Nature (1994) 4.05
Basis for the acquisition of malignant potential by mouse cells cultivated in vitro. Science (1968) 4.00
Cbl-b regulates the CD28 dependence of T-cell activation. Nature (2000) 3.89
Nonproducer clones of murine sarcoma virus transformed BALB-3T3 cells. Virology (1970) 3.85
Separation of murine cellular and murine leukaemia virus DNA polymerases. Nat New Biol (1971) 3.71
Expression cDNA cloning of the KGF receptor by creation of a transforming autocrine loop. Science (1991) 3.69
Catalysis of guanine nucleotide exchange on the CDC42Hs protein by the dbl oncogene product. Nature (1991) 3.68
Induction of WAF1/CIP1 by a p53-independent pathway. Cancer Res (1994) 3.54
G-protein-coupled receptors and signaling networks: emerging paradigms. Trends Pharmacol Sci (2001) 3.49
Guidelines for the use and interpretation of assays for monitoring cell death in higher eukaryotes. Cell Death Differ (2009) 3.44
RNA-dependent DNA polymerase activity in five RNA viruses: divalent cation requirements. Proc Natl Acad Sci U S A (1970) 3.25
Role of IRS-2 in insulin and cytokine signalling. Nature (1995) 3.23
Restoration of contractile function in isolated cardiomyocytes from failing human hearts by gene transfer of SERCA2a. Circulation (1999) 3.19
Nucleotide sequence evidence for relationship of AIDS retrovirus to lentiviruses. Nature (1985) 3.13
Identification of a putative target for Rho as the serine-threonine kinase protein kinase N. Science (1996) 3.09
High dose radiation delivered by intensity modulated conformal radiotherapy improves the outcome of localized prostate cancer. J Urol (2001) 3.06
Cellular transformation and guanine nucleotide exchange activity are catalyzed by a common domain on the dbl oncogene product. J Biol Chem (1994) 3.03
Structural and immunological similarities between simian sarcoma virus gene product(s) and human platelet-derived growth factor. Nature (1983) 3.01
Oncogenes in solid human tumours. Nature (1982) 3.00
Characterization of murine leukaemia virus-specific DNA present in normal mouse cells. Nat New Biol (1973) 2.98
Endogenous type-C RNA viruses of mammalian cells. Biochim Biophys Acta (1976) 2.95
Nucleotide sequence of the simian sarcoma virus genome: demonstration that its acquired cellular sequences encode the transforming gene product p28sis. Proc Natl Acad Sci U S A (1983) 2.95
TMPRSS2-ERG fusion, a common genomic alteration in prostate cancer activates C-MYC and abrogates prostate epithelial differentiation. Oncogene (2008) 2.94
Nucleotide sequence analysis of the transforming region and large terminal redundancies of Moloney murine sarcoma virus. Proc Natl Acad Sci U S A (1980) 2.93
Linkage of G protein-coupled receptors to the MAPK signaling pathway through PI 3-kinase gamma. Science (1997) 2.86
Parasympathetic innervation maintains epithelial progenitor cells during salivary organogenesis. Science (2010) 2.83
Radiommunoassays for the 70,000-molecular-weight glycoproteins of endogenous mouse type C viruses: viral antigen expression in normal mouse tissues and sera. J Virol (1976) 2.82
Isolation of temperature-sensitive mutants of murine leukemia virus. Virology (1972) 2.78
MAP kinases and the control of nuclear events. Oncogene (2007) 2.74
Molecular cloning of integrated simian sarcoma virus: genome organization of infectious DNA clones. Proc Natl Acad Sci U S A (1981) 2.74
Immunological characterization of primate C-type virus reverse transcriptases. Nat New Biol (1972) 2.73
Mouse leukemia virus: "spontaneous" release by mouse embryo cells after long-term in vitro cultivation. Proc Natl Acad Sci U S A (1969) 2.68
Immunological relationships of reverse transcriptases from ribonucleic acid tumor viruses. J Virol (1972) 2.65
Overexpression of protein kinase C-delta and -epsilon in NIH 3T3 cells induces opposite effects on growth, morphology, anchorage dependence, and tumorigenicity. J Biol Chem (1993) 2.62
Neoplastic transformation of mast cells by Abelson-MuLV: abrogation of IL-3 dependence by a nonautocrine mechanism. Cell (1985) 2.59
Complete nucleotide sequence and organization of the Moloney murine sarcoma virus genome. Science (1981) 2.51
BRCA1 regulates p53-dependent gene expression. Proc Natl Acad Sci U S A (1998) 2.50
Structural basis of the membrane-targeting and unmasking mechanisms of the radixin FERM domain. EMBO J (2000) 2.49
Development of a highly efficient expression cDNA cloning system: application to oncogene isolation. Proc Natl Acad Sci U S A (1991) 2.48
Nature and distribution of feline sarcoma virus nucleotide sequences. J Virol (1979) 2.47
Novel source of 1,2-diacylglycerol elevated in cells transformed by Ha-ras oncogene. Nature (1987) 2.46
Adenoviral gene transfer of SERCA2a improves left-ventricular function in aortic-banded rats in transition to heart failure. Proc Natl Acad Sci U S A (2000) 2.45
B cell stimulatory factor-1/interleukin-4 mRNA is expressed by normal and transformed mast cells. Cell (1987) 2.44
Glycogen synthase kinase-3beta is a negative regulator of cardiomyocyte hypertrophy. J Cell Biol (2000) 2.40
Properties of clonal lines of murine sarcoma virus transformed Balb-3T3 cells. Virology (1969) 2.40
ACE inhibitors and pneumonia. Lancet (1998) 2.38
RNA dependent DNA polymerase activity in mammalian cells. Nature (1971) 2.37
A 13 kb resolution cosmid map of the 14 Mb fission yeast genome by nonrandom sequence-tagged site mapping. Cell (1993) 2.36
Genetic factors influencing C-type RNA virus induction. J Exp Med (1972) 2.36
Purification and molecular cloning of a secreted, Frizzled-related antagonist of Wnt action. Proc Natl Acad Sci U S A (1997) 2.36
Responses of plasma adrenocorticotropic hormone, cortisol, and cytokines during and after upper abdominal surgery. Anesthesiology (1992) 2.35
Abelson murine leukemia virus: molecular cloning of infectious integrated proviral DNA. Proc Natl Acad Sci U S A (1981) 2.34
Akt participation in the Wnt signaling pathway through Dishevelled. J Biol Chem (2001) 2.31
Regulation of reactive-oxygen-species generation in fibroblasts by Rac1. Biochem J (1996) 2.31
Signal transduction through the EGF receptor transfected in IL-3-dependent hematopoietic cells. Science (1988) 2.29
Major pol gene progenitors in the evolution of oncoviruses. Science (1984) 2.28
Widespread natural occurrence of high titers of neutralizing antibodies to a specific class of endogenous mouse type-C virus. Proc Natl Acad Sci U S A (1974) 2.27
Molecular cloning of Moloney murine sarcoma virus: arrangement of virus-related sequences within the normal mouse genome. Proc Natl Acad Sci U S A (1979) 2.27
Neoplastic transformation of human epidermal keratinocytes by AD12-SV40 and Kirsten sarcoma viruses. Science (1985) 2.23