PubRank

A Hershko

Author PubWeight™ 131.95‹?›

Top papers

Rank Title Journal Year PubWeight™‹?›
1 SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27. Nat Cell Biol 1999 9.92
2 Components of ubiquitin-protein ligase system. Resolution, affinity purification, and role in protein breakdown. J Biol Chem 1983 7.03
3 The cyclosome, a large complex containing cyclin-selective ubiquitin ligase activity, targets cyclins for destruction at the end of mitosis. Mol Biol Cell 1995 6.23
4 Mechanisms of intracellular protein breakdown. Annu Rev Biochem 1982 4.89
5 "Pleiotypic response". Nat New Biol 1971 4.85
6 Ubiquitination of p27 is regulated by Cdk-dependent phosphorylation and trimeric complex formation. Genes Dev 1999 4.07
7 A heat-stable polypeptide component of an ATP-dependent proteolytic system from reticulocytes. Biochem Biophys Res Commun 1978 3.92
8 The cell-cycle regulatory protein Cks1 is required for SCF(Skp2)-mediated ubiquitinylation of p27. Nat Cell Biol 2001 3.87
9 Proposed role of ATP in protein breakdown: conjugation of protein with multiple chains of the polypeptide of ATP-dependent proteolysis. Proc Natl Acad Sci U S A 1980 3.75
10 Ubiquitin: roles in protein modification and breakdown. Cell 1983 3.19
11 ATP-dependent conjugation of reticulocyte proteins with the polypeptide required for protein degradation. Proc Natl Acad Sci U S A 1980 2.96
12 Studies on the degradation of tyrosine aminotransferase in hepatoma cells in culture. Influence of the composition of the medium and adenosine triphosphate dependence. J Biol Chem 1971 2.83
13 Ubiquitin-activating enzyme. Mechanism and role in protein-ubiquitin conjugation. J Biol Chem 1982 2.65
14 Occurrence of a polyubiquitin structure in ubiquitin-protein conjugates. Biochem Biophys Res Commun 1985 2.56
15 Immunochemical analysis of the turnover of ubiquitin-protein conjugates in intact cells. Relationship to the breakdown of abnormal proteins. J Biol Chem 1982 2.56
16 Ubiquitin-aldehyde: a general inhibitor of ubiquitin-recycling processes. Proc Natl Acad Sci U S A 1987 2.52
17 Reversible phosphorylation controls the activity of cyclosome-associated cyclin-ubiquitin ligase. Proc Natl Acad Sci U S A 1995 2.48
18 Resolution of the ATP-dependent proteolytic system from reticulocytes: a component that interacts with ATP. Proc Natl Acad Sci U S A 1979 2.37
19 "Covalent affinity" purification of ubiquitin-activating enzyme. J Biol Chem 1982 2.15
20 Dominant-negative cyclin-selective ubiquitin carrier protein E2-C/UbcH10 blocks cells in metaphase. Proc Natl Acad Sci U S A 1997 2.08
21 Specificity of binding of NH2-terminal residue of proteins to ubiquitin-protein ligase. Use of amino acid derivatives to characterize specific binding sites. J Biol Chem 1988 2.04
22 The ubiquitin pathway for the degradation of intracellular proteins. Prog Nucleic Acid Res Mol Biol 1986 1.98
23 Phosphorylation of the cyclosome is required for its stimulation by Fizzy/cdc20. Biochem Biophys Res Commun 1999 1.93
24 ATP-dependent degradation of ubiquitin-protein conjugates. Proc Natl Acad Sci U S A 1984 1.92
25 ATP-dependent incorporation of 20S protease into the 26S complex that degrades proteins conjugated to ubiquitin. Proc Natl Acad Sci U S A 1989 1.82
26 Phosphorylation of Cdc20/fizzy negatively regulates the mammalian cyclosome/APC in the mitotic checkpoint. Biochem Biophys Res Commun 2000 1.74
27 The protein substrate binding site of the ubiquitin-protein ligase system. J Biol Chem 1986 1.72
28 The mouse and human genes encoding the recognition component of the N-end rule pathway. Proc Natl Acad Sci U S A 1998 1.72
29 Requirement for protein synthesis in the regulation of protein breakdown in cultured hepatoma cells. Biochemistry 1975 1.71
30 E2-C, a cyclin-selective ubiquitin carrier protein required for the destruction of mitotic cyclins. Proc Natl Acad Sci U S A 1996 1.70
31 A multicomponent system that degrades proteins conjugated to ubiquitin. Resolution of factors and evidence for ATP-dependent complex formation. J Biol Chem 1988 1.60
32 Characterization of the heat-stable polypeptide of the ATP-dependent proteolytic system from reticulocytes. J Biol Chem 1980 1.51
33 Role of the alpha-amino group of protein in ubiquitin-mediated protein breakdown. Proc Natl Acad Sci U S A 1984 1.49
34 A ubiquitin C-terminal isopeptidase that acts on polyubiquitin chains. Role in protein degradation. J Biol Chem 1992 1.48
35 Activation of the heat-stable polypeptide of the ATP-dependent proteolytic system. Proc Natl Acad Sci U S A 1981 1.48
36 Inverse relation between levels of p27(Kip1) and of its ubiquitin ligase subunit Skp2 in colorectal carcinomas. Cancer 2001 1.44
37 Affinity purification of ubiquitin-protein ligase on immobilized protein substrates. Evidence for the existence of separate NH2-terminal binding sites on a single enzyme. J Biol Chem 1990 1.43
38 Post-translational cleavage of polypeptide chains: role in assembly. Annu Rev Biochem 1975 1.42
39 Relationship of the pool of intracellular valine to protein synthesis and degradation in cultured cells. J Biol Chem 1976 1.40
40 Ubiquitin C-terminal hydrolase activity associated with the 26 S protease complex. J Biol Chem 1993 1.28
41 Binding sites of ubiquitin-protein ligase. Binding of ubiquitin-protein conjugates and of ubiquitin-carrier protein. J Biol Chem 1989 1.27
42 Regulation of the synthesis of 5-phosphoribosyl-I-pyrophosphate in intact red blood cells and in cell-free preparations. Biochim Biophys Acta 1969 1.22
43 A ubiquitin-protein ligase specific for type III protein substrates. J Biol Chem 1990 1.16
44 Identification of the active amino acid residue of the polypeptide of ATP-dependent protein breakdown. J Biol Chem 1981 1.14
45 Purification and characterization of arginyl-tRNA-protein transferase from rabbit reticulocytes. Its involvement in post-translational modification and degradation of acidic NH2 termini substrates of the ubiquitin pathway. J Biol Chem 1988 1.13
46 Influence of protease inhibitors and energy metabolism on intracellular protein breakdown in starving Escherichia coli. Biochem Biophys Res Commun 1973 1.12
47 A high molecular weight protease in liver cytosol. J Biol Chem 1979 1.09
48 Assembly of the 26 S complex that degrades proteins ligated to ubiquitin is accompanied by the formation of ATPase activity. J Biol Chem 1990 1.08
49 Turnover of purine nucleotides in rabbit erythrocytes. I. Studies in vivo. Biochim Biophys Acta 1967 1.06
50 Binding of activated cyclosome to p13(suc1). Use for affinity purification. J Biol Chem 1997 1.03
51 The pleiotypic response in mammalian cells: search for an intracellular mediator. Biochem Biophys Res Commun 1972 0.98
52 Role of Suc1 in the activation of the cyclosome by protein kinase Cdk1/cyclin B. Biochem Biophys Res Commun 1999 0.94
53 Regulation of intracellular protein breakdown in stringent and relaxed strains of E. coli,. Cell 1974 0.94
54 Protein turnover in senescent cultured chick embryo fibroblasts. J Cell Physiol 1978 0.90
55 Turnover of purine nucleotides in rabbit erythrocytes. II. Studies in vitro. Biochim Biophys Acta 1967 0.89
56 Roles of protein synthesis and tRNA aminoacylation in the regulation of intracellular protein breakdown in E. coli. Biochem Biophys Res Commun 1974 0.86
57 Paroxetine associated hepatotoxicity: a report of 3 cases and a review of the literature. Pharmacopsychiatry 2002 0.85
58 Antibodies against the VRT101 laminin epitope correlate with human SLE disease activity and can be removed by extracorporeal immunoadsorption. Rheumatology (Oxford) 2007 0.84
59 Increased formation of 5-phosphoriboxyl-1-pyrophosphate in red blood cells of some gouty patients. Isr J Med Sci 1969 0.84
60 The oxidant effect of isouramil on red cell glutathione and its synergistic enhancement by ascorbic acid or 3,4-dihydroxyphenylalanine. Possible relation to the pathogenesis of favism. Isr J Med Sci 1969 0.81
61 Cornea recipients: are their opinions and attitudes toward organ donation different from those of the general population? Transplant Proc 2004 0.79
62 Alterations in components of the ubiquitin-protein ligase system following maturation of reticulocytes to erythrocytes. Biochem Biophys Res Commun 1987 0.78
63 Relevance of protease "inhibitor" to the ATP-ubiquitin proteolytic system. Biochem Biophys Res Commun 1984 0.77
64 Probing CpG methylation at CACGTG with BbrPI restriction enzyme. Nucleic Acids Res 1993 0.76
65 Preparation of clam oocyte extracts for cell cycle studies. Methods Enzymol 1997 0.76
66 Proceedings: Energy requirement of the breakdown of RNA in cultured hepatoma cells. Isr J Med Sci 1975 0.76
67 The ATP-ubiquitin proteolytic pathway. Prog Clin Biol Res 1985 0.75
68 Interconversion of multiple forms of tyrosine aminotransferase in vitro and in vivo in cultured hepatoma cells. Biochim Biophys Acta 1977 0.75
69 Early effects of serum on phospholipid metabolism in untransformed and oncogenic virus-transformed cultured fibroblasts. Biochem Biophys Res Commun 1976 0.75
70 Inhibition of hexokinase in glucose-6-phosphate dehydrogenase deficient erythrocytes by acetylphenylhydrazine. Isr J Med Sci 1965 0.75
71 Control of biochemical processes associated with cellular growth by insulin in transformed and untransformed cultured mouse fibroblasts. Isr J Med Sci 1972 0.75
72 Oral surgical treatment of patients with hemophilia "A", treated by cryoprecipitated factor 8. Refuat Hapeh Vehashinayim 1970 0.75
73 Studies on red cell nucleoside triphosphate pyrophosphohydrolases. Isr J Med Sci 1970 0.75
74 Influence of ATP depletion on the degradation of rapidly labeled RNA in cultured hepatoma cells. Biochem Biophys Res Commun 1975 0.75