Detection of leukotriene A4 as an intermediate in the biosynthesis of leukotrienes C4 and D4.

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Published in FEBS Lett on December 15, 1980

Authors

S Hammerström, B Samuelsson

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Stereochemistry of leukotriene C-1. Biochem Biophys Res Commun (1980) 1.14

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The structure of a urinary metabolite of prostaglandin E2 in the guinea pig. Biochem Biophys Res Commun (1969) 1.12

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