Published in Proc Natl Acad Sci U S A on April 01, 1975
Inhibition of platelet prostaglandin synthetase by oral aspirin. J Clin Invest (1978) 2.40
Ionophores stimulate prostaglandin and thromboxane biosynthesis. Proc Natl Acad Sci U S A (1977) 1.82
Synthesis and biological properties of a 9,11-azo-prostanoid: highly active biochemical mimic of prostaglandin endoperoxides. Proc Natl Acad Sci U S A (1975) 1.64
New aspects of chemotaxis. Specific target-cell attraction by lipid and lipoprotein fractions of Escherichia coli chemotactic factor. Am J Pathol (1975) 1.45
Prostaglandins, bioassay and inflammation. Br J Pharmacol (2006) 1.24
Activation of rabbit platelets by platelet-activating factor derived from IgE-sensitized basophils. Characteristics of the aggregation and its dissociation from secretion. J Clin Invest (1977) 1.20
Neutrophil aggregation and degranulation. Effect of arachidonic acid. Am J Pathol (1979) 1.15
Synergistic activation by collagen and 15-hydroxy-9 alpha,11 alpha-peroxidoprosta-5,13-dienoic acid (PGH2) of phosphatidylinositol metabolism and arachidonic acid release in human platelets. J Clin Invest (1982) 1.14
Release of platelet-derived growth factor from human platelets by arachidonic acid. Proc Natl Acad Sci U S A (1979) 1.11
Ultrastructural features of abnormal blood platelets. A review. Am J Pathol (1976) 1.04
Triene prostaglandins: prostaglandin D3 and icosapentaenoic acid as potential antithrombotic substances. Proc Natl Acad Sci U S A (1979) 1.02
A role for prostaglandins and thromboxanes in the exposure of platelet fibrinogen receptors. J Clin Invest (1981) 1.02
The influence of aspirin and indomethacin on the platelet contractile wave. Am J Pathol (1976) 1.01
Persistence of thromboxane A2-like material and platelet release-inducing activity in plasma. J Clin Invest (1976) 0.96
Prostaglandin endoperoxides, thromboxane A2 and adenosine diphosphate in collagen-induced aggregation of rabbit platelets. Br J Pharmacol (1982) 0.94
Disorders of platelet function: mechanisms, diagnosis and management. West J Med (1981) 0.87
The influence of prostaglandin G2 on platelet ultrastructure and platelet secretion. Am J Pathol (1977) 0.85
In vivo platelet aggregation in the rat: dependence on extracellular divalent cation and inhibition by nonsteroidal anti-inflammatory drugs. Br J Pharmacol (1984) 0.84
Abnormal platelet response to thromboxane A2. J Clin Invest (1981) 0.84
The synergistic effect of aspirin and dipyridamole upon platelet thrombi in living blood vessels. Br J Exp Pathol (1977) 0.83
Vasoconstrictor response to arachidonic acid in the isolated hind limb of the dog. Br J Pharmacol (1977) 0.83
The prostanoids in hemostasis and thrombosis: a review. Am J Pathol (1980) 0.83
Effects of nitroblue tetrazolium and vitamin E on platelet ultrastructure, aggregation, and secretion. Am J Pathol (1977) 0.78
Inhibitory effects of epigallocatechin-3-gallate on microsomal cyclooxygenase-1 activity in platelets. Biomol Ther (Seoul) (2013) 0.77
Role of platelets in hemostasis and thrombosis. West J Med (1976) 0.77
Antiplatelet and antithrombotic effects of cordycepin-enriched WIB-801CE from Cordyceps militaris ex vivo, in vivo, and in vitro. BMC Complement Altern Med (2016) 0.75
Prostaglandin endoperoxides. Novel transformations of arachidonic acid in human platelets. Proc Natl Acad Sci U S A (1974) 8.30
Isolation and structure of two prostaglandin endoperoxides that cause platelet aggregation. Proc Natl Acad Sci U S A (1974) 7.00
Detection and isolation of an endoperoxide intermediate in prostaglandin biosynthesis. Proc Natl Acad Sci U S A (1973) 4.43
Prostaglandin endoperoxides. A new concept concerning the mode of action and release of prostaglandins. Proc Natl Acad Sci U S A (1974) 4.10
Platelet aggregation induced by arachidonic acid is accompanied by release of potential inflammatory mediators distinct from PGE2 and PGF2. Nat New Biol (1973) 3.41
Prostaglandin endoperoxides. VII. Novel transformations of arachidonic acid in guinea pig lung. Biochem Biophys Res Commun (1974) 2.56
An enzymatic mechanism for the antithrombotic and antihemostatic actions of aspirin. Science (1974) 2.08
Formation of prostaglandins during the aggregation of human blood platelets. J Clin Invest (1973) 1.96
Effect of prostaglandin E 2 and aspirin on the secondary aggregation of human platelets. Nat New Biol (1972) 1.85
Formation of an intermediate in prostaglandin biosynthesis and its association with the platelet release reaction. J Clin Invest (1974) 1.76
Relationship between chemical structure and platelet-aggregation activity of prostaglandins. Biochim Biophys Acta (1969) 1.75
Arachidonic acid-induced human platelet aggregation and prostaglandin formation. Prostaglandins (1973) 1.69
Isolation of a chemical trigger for thrombosis. Prostaglandins (1974) 1.57
Further evidence for a deficient storage pool of adenine nucleotides in platelets from some patients with thrombocytopathia--"storage pool disease". Blood (1972) 1.23
A congenital defect in platelet prostaglandin production associated with impaired hemostasis in storage pool disease. Prostaglandins (1973) 1.17
Cyclic 3',5'-adenosine monophosphate in human blood platelets. IV. Regulatory role of cyclic amp in platelet function. Ann N Y Acad Sci (1972) 1.17
Platelet aggregation, adhesion and adenosine diphosphate release in thrombopathia (platelet factor 3 deficiency). A comparison with Glanzmann's thrombasthenia and von Willebrand's disease. Am J Med (1967) 1.16
Thrombocytopathia due to abnormalities in platelet release reaction--studies on six unrelated patients. Blood (1972) 1.12
Effects of prostaglandin E2 on human platelet adenyl cyclase and aggregation. Nature (1974) 0.98
Inhibition of ADP-induced platelet aggregation by furosemide. J Lab Clin Med (1973) 0.84
Thromboxanes: a new group of biologically active compounds derived from prostaglandin endoperoxides. Proc Natl Acad Sci U S A (1975) 10.82
Leukotrienes: mediators of immediate hypersensitivity reactions and inflammation. Science (1983) 9.51
Leukotrienes and lipoxins: structures, biosynthesis, and biological effects. Science (1987) 8.36
Prostaglandin endoperoxides. Novel transformations of arachidonic acid in human platelets. Proc Natl Acad Sci U S A (1974) 8.30
Isolation and structure of two prostaglandin endoperoxides that cause platelet aggregation. Proc Natl Acad Sci U S A (1974) 7.00
Arachidonic acid metabolism in polymorphonuclear leukocytes: effects of ionophore A23187. Proc Natl Acad Sci U S A (1979) 6.34
Leukotriene C: a slow-reacting substance from murine mastocytoma cells. Proc Natl Acad Sci U S A (1979) 5.33
Detection and isolation of an endoperoxide intermediate in prostaglandin biosynthesis. Proc Natl Acad Sci U S A (1973) 4.43
Prostaglandin endoperoxides. A new concept concerning the mode of action and release of prostaglandins. Proc Natl Acad Sci U S A (1974) 4.10
Leukotrienes are potent constrictors of human bronchi. Nature (1980) 4.04
Transformation of arachidonic acid and homo-gamma-linolenic acid by rabbit polymorphonuclear leukocytes. Monohydroxy acids from novel lipoxygenases. J Biol Chem (1976) 3.82
Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target. Proc Natl Acad Sci U S A (1999) 3.61
Prostaglandins and thromboxanes. Annu Rev Biochem (1978) 3.47
Leukotrienes promote plasma leakage and leukocyte adhesion in postcapillary venules: in vivo effects with relevance to the acute inflammatory response. Proc Natl Acad Sci U S A (1981) 3.42
Formation of malonaldehyde from phospholipid arachidonate during microsomal lipid peroxidation. Eur J Biochem (1968) 3.41
On the specificity of the oxygenation of unsaturated fatty acids catalyzed by soybean lipoxidase. J Biol Chem (1967) 3.30
Transformation of arachidonic acid by rabbit polymorphonuclear leukocytes. Formation of a novel dihydroxyeicosatetraenoic acid. J Biol Chem (1979) 3.16
Arachidonic acid metabolism in polymorphonuclear leukocytes: unstable intermediate in formation of dihydroxy acids. Proc Natl Acad Sci U S A (1979) 3.14
Metabolism of arachidonic acid in polymorphonuclear leukocytes. Structural analysis of novel hydroxylated compounds. J Biol Chem (1979) 3.08
Oxygenation of unsaturated fatty acids by the vesicular gland of sheep. J Biol Chem (1967) 2.93
Trends in childhood type 1 diabetes incidence in Europe during 1989-2008: evidence of non-uniformity over time in rates of increase. Diabetologia (2012) 2.85
Identification of an enzyme in platelet microsomes which generates thromboxane A2 from prostaglandin endoperoxides. Nature (1976) 2.83
Leukotriene D: a slow reacting substance from rat basophilic leukemia cells. Proc Natl Acad Sci U S A (1980) 2.77
Increased concentrations of nonesterified arachidonic acid, 12L-hydroxy-5,8,10,14-eicosatetraenoic acid, prostaglandin E2, and prostaglandin F2alpha in epidermis of psoriasis. Proc Natl Acad Sci U S A (1975) 2.75
Changes in job strain in relation to changes in physiological state. A longitudinal study. Scand J Work Environ Health (1988) 2.57
Prostaglandin endoperoxides. VII. Novel transformations of arachidonic acid in guinea pig lung. Biochem Biophys Res Commun (1974) 2.56
Lipoxins: novel series of biologically active compounds formed from arachidonic acid in human leukocytes. Proc Natl Acad Sci U S A (1984) 2.46
Structure of leukotriene C. Identification of the amino acid part. Biochem Biophys Res Commun (1979) 2.30
Biosynthesis of prostaglandins. Fed Proc (1972) 2.23
Biosynthesis of prostaglandins from arachidonic acid in guinea pig lung. Prostaglandins and related factors. 38. J Biol Chem (1965) 2.23
On the formation of thromboxane B2 and 12l-hydroxy-5,8,10,14-eicosatetraenoic acid (12 ho-20:4) in tissues from the guinea pig. Biochim Biophys Acta (1976) 2.12
Prostaglandins. Annu Rev Biochem (1975) 2.09
Steric analysis of hydroperoxides formed by lipoxygenase oxygenation of linoleic acid. Anal Biochem (1971) 2.09
Enzyme with dual lipoxygenase activities catalyzes leukotriene A4 synthesis from arachidonic acid. Proc Natl Acad Sci U S A (1984) 2.05
Leukotriene B4 is a potent and stereospecific stimulator of neutrophil chemotaxis and adherence. Blood (1981) 2.05
Identification and biological activity of novel omega-oxidized metabolites of leukotriene B4 from human leukocytes. FEBS Lett (1981) 2.04
On the mechanism of the biosynthesis of prostaglandins E-1 and F-1-alpha. J Biol Chem (1967) 2.02
Caesarean section is associated with an increased risk of childhood-onset type 1 diabetes mellitus: a meta-analysis of observational studies. Diabetologia (2008) 2.01
Single protein from human leukocytes possesses 5-lipoxygenase and leukotriene A4 synthase activities. Proc Natl Acad Sci U S A (1986) 1.97
The chemical composition of the cytoplasmic membrane of Bacillus subtilis. Eur J Biochem (1967) 1.96
Metabolism of prostaglandin E2 in guinea pig liver. I. Identification of seven metabolites. J Biol Chem (1970) 1.92
On the nature of the 5-lipoxygenase reaction in human leukocytes: enzyme purification and requirement for multiple stimulatory factors. Proc Natl Acad Sci U S A (1985) 1.91
Prostaglandins in human seminal plasma. Prostaglandins and related factors 46. J Biol Chem (1966) 1.91
Phospholipid precursors of prostaglandins. Biochim Biophys Acta (1968) 1.90
Stress-induced accumulation and tissue-specific localization of dehydrins in Arabidopsis thaliana. Plant Mol Biol (2001) 1.89
Prostaglandin endoperoxides IV. Effects on smooth muscle. Life Sci (1975) 1.89
Thromboxane A2: effects on airway and vascular smooth muscle. Prostaglandins (1977) 1.82
Molecular cloning of allene oxide cyclase. The enzyme establishing the stereochemistry of octadecanoids and jasmonates. J Biol Chem (2000) 1.72
On the metabolism of prostaglandins E 1 and E 2 in man. J Biol Chem (1971) 1.71
Leukotriene A4 hydrolase in human leukocytes. Purification and properties. J Biol Chem (1984) 1.70
Leukotriene B4 is a complete secretagogue in human neutrophils: a kinetic analysis. Biochem Biophys Res Commun (1982) 1.69
Synthesis and biological properties of a 9,11-azo-prostanoid: highly active biochemical mimic of prostaglandin endoperoxides. Proc Natl Acad Sci U S A (1975) 1.64
Leukotriene A: stereochemistry and enzymatic conversion to leukotriene B. Biochem Biophys Res Commun (1980) 1.62
The distribution of 15-hydroxy prostaglandin dehydrogenase and prostaglandin-delta 13-reductase in tissues of the swine. Acta Physiol Scand (1971) 1.60
Diabetic ketoacidosis at the onset of type 1 diabetes is associated with future HbA1c levels. Diabetologia (2013) 1.58
Biosynthesis of 9-alpha,15-dihydroxy-11-ketoprost-13-enoic acid. J Biol Chem (1968) 1.57
Thromboxane generation by human peripheral blood polymorphonuclear leukocytes. J Exp Med (1978) 1.57
Reduced field-of-view MRI using outer volume suppression for spinal cord diffusion imaging. Magn Reson Med (2007) 1.57
Prostaglandin d2 as a potential antithrombotic agent. Prostaglandins (1975) 1.47
Early mortality in EURODIAB population-based cohorts of type 1 diabetes diagnosed in childhood since 1989. Diabetologia (2007) 1.46
Serum-coated zymosan stimulates the synthesis of leukotriene B4 in human polymorphonuclear leukocytes. Inhibition by cyclic AMP. Biochem Biophys Res Commun (1981) 1.45
On the nature of the 5-lipoxygenase reaction in human leukocytes: characterization of a membrane-associated stimulatory factor. Proc Natl Acad Sci U S A (1985) 1.45
Molecular cloning and amino acid sequence of human 5-lipoxygenase. Proc Natl Acad Sci U S A (1988) 1.45
Human thioredoxin reductase directly reduces lipid hydroperoxides by NADPH and selenocystine strongly stimulates the reaction via catalytically generated selenols. J Biol Chem (1995) 1.45
Formation of novel hydroxylated eicosatetraenoic acids in preparations of human polymorphonuclear leukocytes. FEBS Lett (1981) 1.44
Nomenclature for leukotrienes. Prostaglandins (1980) 1.43
Inhibition of prostaglandin synthesis in man. Biochem Biophys Res Commun (1972) 1.43
Preparation, isolation, and characterization of a derivative of malonaldehyde. Anal Biochem (1968) 1.42
Some biological effects of prostaglandin endoperoxide analogs. Life Sci (1976) 1.40
PEEP ventilation does not cause humorally mediated cardiac output depression in pigs. Intensive Care Med (1994) 1.39
Increased nerve stimulation induced release of noradrenaline from the rabbit heart after inhibition of prostaglandin synthesis. Acta Physiol Scand (1971) 1.38
Activation of protein kinase C by lipoxin A and other eicosanoids. Intracellular action of oxygenation products of arachidonic acid. Biochem Biophys Res Commun (1986) 1.37
Cerebral perfusion assessment by bolus tracking using hyperpolarized 13C. Magn Reson Med (2004) 1.36